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Prosser R S RS School of Environmental Sciences, University of Guelph, Guelph, Ontario, Canada. Electronic address: - - 2014
Amending soil with biosolids or livestock manure provides essential nutrients in agriculture. Irrigation with wastewater allows for agriculture in regions where water resources are limited. However, biosolids, manure and wastewater have all been shown to contain pharmaceuticals and personal care products (PPCPs). Studies have shown that PPCPs can accumulate in ...
Arbuckle Tye E TE Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa ON, Canada. Electronic address: - - 2014
Results of recent national surveys have shown the high prevalence of exposure to bisphenol A (BPA) and triclosan (TCS) among the general population; however biomonitoring data for pregnant women and infants are limited. Women (n=80) were recruited from early prenatal clinics and asked to collect urine samples multiple times during ...
Liu Xiping X CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, - - 2014
Butenoic acid is a C4 short-chain unsaturated fatty acid mainly used in the preparation of resins, pharmaceuticals, and fine chemicals. However, butenoic acid derived from petroleum is costly and unfriendly to the environment. Here, we report a novel biosynthetic strategy to produce butenoic acid by utilizing the intermediate of fatty ...
Lombardo Andrea A LASA - Environmental Systems Analysis Lab, Department of Industrial Engineering, University of Padova, via Marzolo 9, 35131 Padova, - - 2014
Conventional approaches to estimating protective ecotoxicological thresholds of chemicals, i.e. predicted no-effect concentrations (PNEC), for an entire ecosystem are based on the use of assessment factors to extrapolate from single-species toxicity data derived in the laboratory to community-level effects on ecosystems. Aquatic food web models may be a useful tool ...
Jiang Jin - - 2014
Recent studies have shown that manganese dioxide (MnO2) can significantly accelerate the oxidation kinetics of phenolic compounds such as triclosan and chlorophenols by potassium permanganate (Mn(VII)) in slightly acidic solutions. However, the role of MnO2 (i.e., as an oxidant vs catalyst) is still unclear. In this work, it was demonstrated ...
Kim S-H SH Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of - - 2014
Triclosan (Tri) is one of many endocrine-disrupting chemicals (EDCs) that are scattered with environment agents, such as toothpastes, deodorants, and cleaning supplies. As a phytoestrogen, kaempferol (Kae) is one of bioflavonoids, which has been found in a variety of vegetables including broccoli, tea, and tomatoes. Although Kae may have anti-cancer ...
Lavilla Lerma Leyre L Área de Microbiología, Departamento de Ciencias de la Salud, Facultad de Ciencias Experimentales, Universidad de Jaén, 23071 Jaén, - - 2014
Enterococcus faecalis and Enterococcus faecium isolated from various traditional fermented foods of both animal and vegetable origins have shown multidrug resistance to several antibiotics and tolerance to biocides. Reduced susceptibility was intra and inter-species dependent and was due to specific and unspecific mechanisms such as efflux pumps. EfrAB, a heterodimeric ...
Beier R C RC Southern Plains Agricultural Research Center, Agricultural Research Service, U.S. Department of Agriculture, 2881 F&B Road, College Station, TX, 77845, - - 2014
Evaluate susceptibility of Pseudomonas aeruginosa veterinary isolates to antibiotics and disinfectants METHODS AND RESULTS: Pseudomonas aeruginosa isolates collected from dogs (n=155) and other animals (n=20) from sixteen states during 1994-2003 were tested for susceptibility. Most isolates were resistant to twenty-one antimicrobials tested, and the highest prevalence of resistance was to ...
Jung Kuk Hyun KH Department of Surgery, Bundang Jesaeng Hospital, Seongnam, - - 2014
Surgical site infection (SSI) after open abdominal surgery is still a frequently reported nosocomial infection. To reduce the incidence of SSI, triclosan-coated sutures with antiseptic activity (Vicryl Plus) were developed. The aim of this study was to analyze the effect of Vicryl Plus on SSI after gastric cancer surgery via ...
Cullinan Mary P MP School of Medicine, University of Queensland, Prince Charles Hospital, Rode Road, Chermside, Queensland 4032, Australia; Sir John Walsh Research Institute, University of Otago, 310 Great King Street, Dunedin 9016, New Zealand. Electronic address: - - 2014
Adverse effects of long-term usage of triclosan-containing toothpaste in humans are currently unknown. We assessed the effect of long-term use of 0.3% triclosan-toothpaste on serious adverse events (SAEs) in patients with cardiovascular disease (CVD). 438 patients with a history of stable CVD were entered into the 5-year longitudinal Cardiovascular and ...
Emnet Philipp P Department of Chemistry, University of Canterbury, Christchurch 8140, Private Bag 4800, New - - 2014
Pharmaceutical and personal care products (PPCPs) are a major source of micropollutants to the aquatic environment. Despite intense research on the fate and effects of PPCPs in temperate climates, there is a paucity of data on their presence in polar environments. This study reports the presence of selected PPCPs in ...
Hines Erin P EP Office of Research and Development, National Center for Environmental Assessment, U.S. Environmental Protection Agency, RTP, NC. Electronic address: - - 2014
Phenols and parabens show some evidence for endocrine disruption in laboratory animals. The goal of the Methods Advancement for Milk Analysis (MAMA) Study was to develop or adapt methods to measure parabens (methyl, ethyl, butyl, propyl) and phenols (bisphenol A (BPA), 2,4- and 2,5-dichlorophenol, benzophenone-3, triclosan) in urine, milk and ...
Arbuckle Tye E TE Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, - - 2014
Bisphenol A (BPA) and triclosan (TCS) are two non-persistent chemicals that have been frequently measured in spot urine samples from the general population but less so in pregnant women; however, data are limited on the free (bioactive) and conjugated forms of these phenols. The Maternal-Infant Research on Environmental Chemicals (MIREC) ...
Arlos M J MJ Department of Civil and Environmental Engineering, University of Waterloo, Waterloo, ON, Canada N2L 3G1; Department of Biology, University of Waterloo, Waterloo, ON, Canada N2L 3G1. Electronic address: - - 2014
Endocrine disruption and high occurrences of intersex have been observed in wild fish associated with municipal wastewater treatment plant (WWTP) effluents in urbanized reaches of rivers around the globe. These reproductive effects have often been attributed to the presence of estrogen receptor agonists in effluents. However, recent studies have isolated ...
Fang Jia-Long JL Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, 72079, - - 2014
Triclosan is used as an antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Humans can receive lifelong exposures to triclosan; however, data on the toxicity and carcinogenicity after topical application are lacking. This study determined the absorption, distribution, metabolism, and excretion of triclosan after application ...
Evans A A School of Dentistry, The University of Queensland, 200 Turbot Street, Brisbane, QLD, 4000, - - 2014
As suppression of Streptococcus mutans in young children may prevent or delay colonisation of the oral cavity, toothbrushing with dentifrices containing anti-S. mutans activity may aid in preventing caries. The aims of this study were to compare the effects of children's dentifrices on the growth of S. mutans and non-mutans ...
Watkins Deborah J DJ Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United - - 2014
Phenols and parabens are used in a multitude of consumer products resulting in ubiquitous human exposure. Animal and in vitro studies suggest that exposure to these compounds may be related to a number of adverse health outcomes, as well as potential mediators such as oxidative stress and inflammation. We examined ...
Yueh Mei-Fei MF Laboratory of Environmental Toxicology, Departments of Chemistry & Biochemistry and Pharmacology, - - 2014
Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a synthetic, broad-spectrum antibacterial chemical used in a wide range of consumer products including soaps, cosmetics, therapeutics, and plastics. The general population is exposed to TCS because of its prevalence in a variety of daily care products as well as through waterborne contamination. TCS is linked ...
Zenobio Jenny E JE Purdue University, Department of Forestry and Natural Resources, West Lafayette, IN 47907, - - 2015
Pharmaceuticals and personal care products (PPCPs) have raised concerns due to their potential effects to aquatic organisms. These chemicals appear in mixtures at very low concentrations thus making their detection and quantification difficult. Polar organic chemical integrative samplers (POCIS) concentrate trace levels of chemicals over time increasing method sensitivity and ...
Holas Ondrej O Department of Pharmaceutical Chemistry and Drug Control - - 2014
Abstract Mycobacterial enoyl-ACP-reductase, an enzyme contributing in mycolic acids biosynthesis, has been established as promising target of novel antimycobacterial drugs. The development of inhibitors active without previous activation by catalase/peroxidase system (e.g. isoniazid), seems to be rational approach. Catalase/peroxidase system is frequently responsible for resistance. We hereby present a review ...
Khan Raees - - 2014
Triclosan, the widely used biocide, specifically targets enoyl-acyl carrier protein reductase (ENR) in the bacterial fatty acid synthesis system. While the fish pathogen Aeromonas salmonicida subsp. salmonicida exhibits triclosan resistance, the nature of this resistance has not been elucidated. Here, we aimed to characterize the triclosan resistance of A. salmonicida ...
Mailler R R LEESU (UMR MA 102, Université Paris-Est, AgroParisTech), 61 avenue du Général de Gaulle, 94010 Créteil Cedex, France. Electronic address: - - 2014
The efficacy of a fluidized powdered activated carbon (PAC) pilot (CarboPlus(®)) was studied in both nominal (total nitrification + post denitrification) and degraded (partial nitrification + no denitrification) configuration of the Seine Centre WWTP (Colombes, France). In addition to conventional wastewater parameters 54 pharmaceuticals and hormones (PhPHs) and 59 other emerging pollutants were monitored ...
Alvarino T T Department of Chemical Engineering, Institute of Technology, University of Santiago de Compostela, E-15782 Santiago de Compostela, - - 2014
Pharmaceutical and personal care products (PPCPs) are extensively used and can therefore find their way into surface, groundwater and municipal and industrial effluents. In this work, the occurrence, fate and removal mechanisms of 19 selected PPCPs was investigated in an 'ELiminación Autótrofa de Nitrógeno' (ELAN(®)) reactor of 200 L. In this ...
Périamé Marina M UMR-MD-1, Aix-Marseille Université, IRBA, Transporteurs Membranaires, Chimiorésistance et Drug Design, Marseille, - - 2014
The objective of this study was to understand the adaptive mechanisms in Enterobacter gergoviae which are involved in recurrent contaminations in cosmetic products that are incorporated with preservatives. Bacterial strains from two backgrounds were examined for a profound understanding of the mechanisms of adaptation against preservatives. It included a series ...
DeLorenzo M E ME National Oceanic and Atmospheric Administration, National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Environmental Health and Biomolecular Research, Charleston, South Carolina, - - 2014
Antimicrobial compounds are widespread, emerging contaminants in the aquatic environment and may threaten ecosystem and human health. This study characterized effects of antimicrobial compounds common to human and veterinary medicine, aquaculture, and consumer personal care products [erythromycin (ERY), sulfamethoxazole (SMX), oxytetracycline (OTC), and triclosan (TCS)] in the grass shrimp Palaemonetes ...
Thomaidi Vasiliki S VS Department of Environment, University of the Aegean, 81100 Mytilene, - - 2014
The ecological threat associated with emerging pollutants detected in wastewater was estimated in country level. Treated wastewater was analyzed for pharmaceuticals and illicit drugs; whereas the concentrations of all emerging contaminants determined in Greek Sewage Treatment Plants were recorded through literature review. Toxicity data was collected after literature review or ...
Zhao Congcong C School of Environmental Science and Engineering, Shandong University, Jinan 250100, - - 2014
Triclosan (TCS) is a broad-spectrum synthetic antimicrobial agent that is toxic to microbes and other aquatic organisms. Constructed wetlands (CWs) are now popular in TCS removal. However, knowledge on the effects of TCS on the bacterial community and microbial removal mechanism in CWs is lacking. The effects of TCS (60μgL(-1)) ...
Randall J J School of Dentistry, The University of Queensland, Queensland, - - 2014
Streptococcus mutans is an important bacterial species implicated in dental caries. This laboratory study compared the antimicrobial activity of a number of fluoride-containing and herbal dentifrices and their components against S. mutans. An agar diffusion method was used with Mueller-Hinton agar. Wells were filled with either 10 commercial fluoride or ...
Sadowski Martin C MC Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, - - 2014
Inhibition of FASN has emerged as a promising therapeutic target in cancer, and numerous inhibitors have been investigated. However, severe pharmacological limitations have challenged their clinical testing. The synthetic FASN inhibitor triclosan, which was initially developed as a topical antibacterial agent, is merely affected by these pharmacological limitations. Yet, little ...
Dall'Oglio F F Section of Dermatology, Department of Medical and Surgical Specialties, University of Catania,Catania, Italy - - - 2014
The aim of this review was to evaluate, by a thorough revision of the literature, the true efficacy of currently available topic and systemic cosmetic acne agents will be suggested. The efficacy of currently available cosmetic acne agents has been retrospectively evaluated via thorough revision of the literature on matched ...
Schnug Lisbeth L Bioforsk - Norwegian Institute for Agricultural and Environmental Research, Frederik A. Dahls Vei 20, 1430 Ås, Norway. Electronic address: - - 2014
The study aimed at investigating effects of three differently acting biocides; the insecticide esfenvalerate, the fungicide picoxystrobin and the bactericide triclosan, applied individually and as a mixture, on an earthworm community in the field. A concentration-response design was chosen and results were analyzed using univariate and multivariate approaches. Effects on ...
Chen Linxi L Department of Biomedical, Chemical and Environmental Engineering, University of Cincinnati, 701B ERC building, 2901 Woodside Dr., Cincinnati, OH 45221, United - - 2014
Chlorinated oligomer intermediates formed during the anodic electrochemical oxidation of phenol with a boron-doped diamond electrode were studied at two different concentrations of chloride (5mM and 50mM). Under the same ionic strength, with sodium sulfate being the make-up ion, a 10-fold increase in Cl(-) led to removal rates 10.8, 1.5, ...
Jachero Lourdes L Departamento de Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago, - - 2014
A new biomimetic approach for triclosan (TCS) was developed based on the leaching of the analyte from different biosolid-amended agricultural soils and the subsequent extraction of the leachates, using a rotating disk sorptive extraction (RDSE) procedure. The leaching equilibrium for TCS was reached at 3h when the ISO method (ISO/TS ...
Ibrahim Hisham R HR Department of Biochemistry and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan. Electronic address: - - 2014
Synthetic antibiotics and antimicrobial agents, such as sulfonamide and triclosan (TCS), have provided new avenues in the treatment of bacterial infections, as they target lethal intracellular pathways. Sulfonamide antibiotics block synthesis of folic acid by inhibiting dihydrofolate reductase (DHFR) while TCS block fatty acid synthesis through inhibition of enoyl-ACP reductase ...
Szychowski Konrad A KA Department of Animal Biotechnology, Animal Sciences Faculty, University of Agriculture, Redzina 1B, 30-248 Krakow, Poland. Electronic address: - - 2014
Triclosan (TCS) is a commonly used antimicrobial agent in personal care and sanitizing products, as well as in household items. Numerous studies have demonstrated the presence of TCS in various human tissues. Several studies have reported the accumulation of TCS in fish and human brain tissue. The aim of the ...
Chen Xijuan X Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Wenhua Road 72, 110016 Shenyang, China; Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 49, 9000 Aalborg, Denmark; Department of Environmental Science, Aarhus University, Frederiksborgsvej 399, 4000 Roskilde, - - 2014
Aerobic degradation experiments of Triclosan were performed in activated sludge to identify possible transformation products for this compound. During 7days, the formation of biotransformation products such as 2,4-Dichlorophenol, 4-Chlorocatechol, 5-Hydroxy-Triclosan and other Monohydroxy-Triclosan derivatives as well as Dihydroxy-Triclosan-derivatives were observed. The structure of 5-Hydroxy-Triclosan was elucidated by NMR data for ...
Wu Chenxi C State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, People's Republic of China, - - 2014
Occurrence of five endocrine-disrupting chemicals (EDCs)-bisphenol-A (BPA), triclosan (TCS), 17α-ethinyl estradiol (EE2), benzophenone-3, and 4-methylbenzylidene camphor-were monitored in East Lake, the largest urban lake in China. Other than EE2, all selected EDCs were detected at least once in the lake water with concentrations ≤89.1 ng/L. EDCs were detected with greater occurrence ...
Sippel Katherine H KH From the Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030 - - 2014
Human fatty acid synthase (FAS) is a large, multidomain protein that synthesizes long chain fatty acids. Because these fatty acids are primarily provided by diet, FAS is normally expressed at low levels; however, it is highly up-regulated in many cancers. Human enoyl-acyl carrier protein-reductase (hER) is one of the FAS ...
El-Zawawy Lobna A LA Medical Parasitology Department, Faculty of Medicine, Alexandria University, - - 2014
The preventative effect of triclosan (TS) and TS liposomal nanoparticles was studied on the early establishment of chronic infection with Toxoplasma gondii (T. gondii). Swiss albino mice were orally infected with ten cysts of avirulent ME49 strain of T. gondii, and two weeks later they were orally treated with dual ...
Altenburg Andreas A Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Pharmacy, Dessau Medical Center, Department of Dermatology and Andrology, Faculty of Medicine, Ain Shams University, Cairo - - 2014
Chronic recurrent oral aphthous ulcers are the most common type of inflammatory efflorescence of the oral mucosa, with a prevalence of 2% to 10% in Caucasian populations. To treat them properly, physicians should know their clinical appearance and course, conditioning factors, underlying causes, and differential diagnosis. This review is based ...
Lee Melissa M Department of Paediatrics, University Children's Medical Institute, Yong Loo Lin School of Medicine, Singapore 119077, - - 2014
The skin of individuals with atopic dermatitis has a susceptibility to be colonized with Staphylococcus aureus. This has been associated with increased frequency and severity of exacerbations of atopic dermatitis. Therefore, there is a growing interest in the use of antiseptic agents to target primary bacterial colonization and infection. Antiseptic ...
Vogs Carolina C UFZ-Helmholtz Centre for Environmental Research, Department Bioanalytical Ecotoxicology, Leipzig, Germany; Rheinisch-Westfälische Technische Hochschule Aachen University, Department of Ecosystem Analyses, Institute for Environmental Research, Aachen, - - 2014
The toxic potency of chemicals is determined well by using the internal effect concentration accounting for differences in toxicokinetic processes and mechanisms of toxic action. This present study examines toxicokinetics of specifically acting and reactive chemicals in the green algae Scenedesmus vacuolatus by using an indirect method. Concentration depletion in ...
Andrade Natasha A NA Department of Civil and Environmental Engineering, University of Maryland, College Park, MD 20742, USA. Electronic address: - - 2014
In the US, land application of biosolids has been utilized in government-regulated programs to recycle valuable nutrients and organic carbon that would otherwise be incinerated or buried in landfills. While many benefits have been reported, there are concerns that these practices represent a source of organic micropollutants to the environment. ...
Halden Rolf U RU Center for Environmental Security, The Biodesign Institute, Security and Defense Systems Initiative, Arizona State University, 781 E. Terrace Mall, Tempe, AZ 85287, USA; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: - - 2015
A meta-analysis was conducted to inform the epistemology, or theory of knowledge, of contaminants of emerging concern (CECs). The CEC terminology acknowledges the existence of harmful environmental agents whose identities, occurrences, hazards, and effects are not sufficiently understood. Here, data on publishing activity were analyzed for 12 CECs, revealing a ...
Sperling H H Urologische Klinik, Kliniken Maria Hilf GmbH, Viersener Straße 450, 41063, Mönchengladbach, Deutschland, - - 2014
This article presents the first randomized, double blind, multicenter, placebo-controlled, non-interventional trial with a medical product after approval by the ethical committee of the medical council of North-Rhine. The study investigated the use of the antimicrobial agent triclosan (Farco-fill® Protect) as a liquid for inflation of catheter balloons in patients ...
ZieliƄska Katarzyna K Laboratory of Physical Chemistry and Colloid Science, Wageningen University, Dreijenplein 6, 6703HB Wageningen, The Netherlands. Electronic address: - - 2014
In this work we present a new approach for protection of the fiber in solid phase microextraction (SPME) from interfering charged particles present in the sample medium. It involves coating of commercial poly(dimethylsiloxane) extraction phase with polyelectrolyte layer composed of poly(diallyldimethylammonium chloride), and poly(sodium 4-styrenesulfonate). The modified fiber provides reproducible, ...
Manevski Nenad N Novartis - - 2014
Human aldehyde oxidase (AO) is a molybdo-flavoenzyme that commonly oxidizes azaheterocycles in therapeutic drugs. Although high metabolic clearance by AO resulted in several drug failures, existing in vitro-in vivo correlations are often poor and extrahepatic role of AO practically unknown. This study investigated enzymatic activity of AO in fresh human ...
Souchier Marine M UMR HydroSciences 5569, Montpellier Université, 15 Avenue Ch. Flahault, 34093 Montpellier cedex 5, France; Veolia Recherche et Innovation, 36, Avenue Kleber, 75116 Paris 16ème arrondissement, - - 2014
An analytical method was developed and validated for the target screening of triclosan (TCS), triclocarban (TCC) and its lesser and higher chlorinated congeners namely, 4,4'-dichlorocarbanilide (DCC) 3,3',4,4'-tetrachlorocarbanilide (3-Cl-TCC) and 2,3',4,4'-tetrachlorocarbanilide (2-Cl-TCC) in river sediment. Sediment samples were extracted by pressurized liquid extraction and quantification and identification of target compounds were ...
Ibrahim N A NA Textile Research Division, National Research Center, Cairo, Egypt. Electronic address: - - 2015
Several bio-active agents namely choline chloride, triclosan derivative, PEG-600 and 4-hydroxybenzophenone were successfully included into solvent-free pigment formulations, in a single-stage process, followed by screen printing and microwave-fixation to obtain antibacterial functionalized cellulosic/wool pigment prints. Results obtained signify that both the improvement in functionalization and coloration properties are governed by ...
Ribalta Carla - - 2014
The interaction of emerging contaminants with the xenobiotic and endogenous metabolising system of deep-sea fish was compared. The drugs diclofenac, fluoxetine and gemfibrozil belong to different pharmaceutical classes with diverse mechanistic actions and the personal care products triclosan, galaxolide and nonylphenol are representative of antibacterial agents, nitro musks and surfactants, ...
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