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Sioufi A - - 1980
The determination of alpha-tribenoside at concentrations down to 10 ng/ml and beta-tribenoside at concentrations down to 5 ng/ml in human plasma is described. After addition of an internal standard, alpha- and beta-tribenosides are extracted at basic pH into benzene. Both compounds are derivatized with N-heptafluorobutyrylimidazole. The derivatives are determined by ...
Relevancy Score: Relevancy Score: 1000
Kalbhen D A - - 1979
An experimental model of chemically induced osteoarthrosis in the knee joint of adult hens was used to investigate the possible anti-arthrotic potency of the D-glucofuranose derivative tribenoside (Glyvenol). Development and intensity of progressing degenerative processes in the articular tissue were controlled and quantitatively determined by radiographic and macroscopic methods. Tribenoside ...
Relevancy Score: Relevancy Score: 900
Kalbhen D A - - 1981
Animal experiments with chemically induced osteoarthrosis in the knee joint of adult hens have shown that the daily treatment with tribenoside (Glyvenol(R)) using single oral doses of 50 mg/kg or 150 mg/kg, will result in a marked reduction of the intensity and frequency of joint degenerations. This anti-arthrotic effect was ...
Relevancy Score: Relevancy Score: 858
Majer H - - 1975
Incubation of washed rat erythrocytes with minute glass particles results in haemolysis varying in degree according to the concentration of particles in the incubation medium. Cells pre-incubated with tribenoside1) display resistance to the destructive action of the glass particles. This protective effect is demonstrable at constant concentrations of tribenoside and ...
Relevancy Score: Relevancy Score: 855
Sioufi A - - 1982
In an experiment on three healthy volunteers, plasma levels of tribenoside and the elimination of benzoic acid in plasma and urine were followed up during a 7-day period of daily oral medication with tribenoside. Plasma levels of tribenoside, and plasma and urine concentrations of free and total benzoic acid were ...
Relevancy Score: Relevancy Score: 842
Kikkawa Yamato - - 2010
Tribenoside has been used clinically for hemorrhoidal disease associated with coagulation, inflammation, and wounds. However, the pharmacological mechanism of tribenoside activity has never been clear. In this study we examined whether tribenoside affected expression and deposition of laminins that are required for reconstruction of basement membranes (BMs) during wound healing ...
Relevancy Score: Relevancy Score: 838
Wilhelmi G - - 1976
Tribenoside in a dose of 100 mg/kg i.p. significantly accelerates the regeneration of puncture wounds in the caudal membrane of Amblystoma mexicanum. A dose of 200 mg/kg exerts a less-pronounced vulnerary effect and is occasionally toxic. Tribenoside also stimulates regeneration in this species when added to bath fluid in a ...
Relevancy Score: Relevancy Score: 837
Kalbhen D A - - 1983
Experiments in adult hens with chemically induced osteoarthrosis or osteoarthritis (OA) of the knee joint have shown that daily treatment with tribenoside (Glyvenol) in single oral doses of 50 mg/kg or 150 mg/kg markedly reduced the intensity and frequency of joint degeneration. We investigated the inhibitory effect of tribenoside on ...
Relevancy Score: Relevancy Score: 778
Wilhelmi G - - 1977
Tribenoside, a D-glucofuranose derivative, was administered prophylactically over a period of ten months to six-month-old mice of the C 57 Black strain (Animal Breeding Unit, Sisseln), which are known to have a predisposition to spontaneous gonarthrosis. The preparation was given once daily for five consecutive days every other week in ...
Relevancy Score: Relevancy Score: 764
Wilhelmi G - - 1976
1. In 15- to 21-month-old male mice of the C 57 black strain that had been treated with a placebo (olive oil), the incidence of gonarthrosis was found to be 19% in the youngest and 61% in the older animals. If the very early stages are included, the incidences range ...
Relevancy Score: Relevancy Score: 719
Endo H - - 1999
Relevancy Score: Relevancy Score: 673
Wilhelmi G - - 1978
Tribenoside administered in moderate doses over periods of three or ten months, inhibited the development of spontaneous arthrosis in mice of the C 57 black strain. Acetylsalicylic acid administered once daily in oral doses of 50 and 150 mg/kg for five months, had a distinctly promoting effect on the development ...
Relevancy Score: Relevancy Score: 667
Horváth M - - 1982
The in vitro effects of azathioprine, clofibrate and tribenoside on the cell-mediated immune response was studied in some vascular diseases. Imuran decreased leucocyte migration inhibition induced by vascular antigens in patients with myocardial infarction, peripheral arterial disease or superficial thrombophlebitis. Clofibrate also moderated the cellular immune response in patients with ...
Relevancy Score: Relevancy Score: 604
Inoue Ayumi - - 2009
Relevancy Score: Relevancy Score: 601
Jaques R - - 1977
Ethyl-3,5,6-tri-O-benzyl-D-glucofuranoside (RBGF) the active substance of Glyvenol displays a unique spectrum of activities. It possesses anti-inflammatory, mild analgesic, antitoxic, wound-healing, fibrinolysis-promoting, anti-arthrotic, amine-release-inhibitory, membrane-stabilizing and venotropic properties. Unlike corticosteroids or nonsteroidal anti-inflammatory agents, TBGF dose not exert untoward effects on the gastrointestinal system, the connective tissue or the body's defence ...
Relevancy Score: Relevancy Score: 595
Kubicsek Tamás - - 2010
Tribenoside is used for the treatment of haemorrhoids and varicose veins, frequently in pregnant women as well, but published data regarding its possible teratogenic effect are not available. Thus the risk of congenital abnormalities (CAs) was estimated in cases of pregnant women with oral tribenoside treatment (TT) in the Hungarian ...
Relevancy Score: Relevancy Score: 590
Wilhelmi G - - 1976
Histological studies in male C57 black mice revealed a high incidence (39-61%) of osteo-arthrotic changes in the knee joint from about the 17th month of life. In animals of the same strain aged 15 1/2 months the incidence was only 19%. The incidence of gonarthroses in 16-month-old female mice was ...
Relevancy Score: Relevancy Score: 528
Plenis Alina - - 2013
A new liquid chromatographic (LC) method for simultaneous determination of lidocaine hydrochloride (LH) and tribenoside (TR) along with their related compounds in pharmaceutical preparations is described. Satisfactory LC separation of all analytes after the liquid-liquid extraction (LLE) procedure with ethanol was performed on a C18 column using a gradient elution ...
Relevancy Score: Relevancy Score: 425
Goi A - - 1979
A series of 3-O-derivatives of 1,2,5,6-di-O-isopropylidene-alpha-D-glucofuranose were prepared and tested for their pharmacological activity in comparison with tribenoside, a well known drug structurally related, and with other anti-inflammatory agents. Almost all the compounds had a very low toxicity and few of them showed a notable antiinflammatory and antipyretic activity and ...
Relevancy Score: Relevancy Score: 288
Aliev S A - - 2008
The work presents an analysis of results of conservative treatment of 48 patients aged from 32 through 76 years having postthrombophlebitic syndrome with symptoms of chronic venous insufficiency. The system of complex pharmacotherapy included phlebothropic medicines of flavonoid series (detralex) and of synthetic origin (tribenosid). The course of treatment was ...
Relevancy Score: Relevancy Score: 272
Chayen J - - 1996
Up to nine out of 10 male STR/ORT mice develop osteoarthritis (OA) of the medial tibial cartilage at an early age. This has now been shown to be related to changes in the activity and distribution of monoamine oxidase which is related to the metabolism of catecholamines. Treatment with diclofenac ...
Relevancy Score: Relevancy Score: 251
Hashizume Hideo - - 2005
We report a case of tribenoside-induced hypersensitivity syndrome associated with cytomegalovirus reactivation and investigation of the immunological characteristics of the circulating and skin-infiltrating lymphocytes. Activated CD8+ T cells outnumbered CD4+ cells in both the circulation and the skin lesions. Upon in vitro stimulation with the drug, CD4+ cells proliferated and ...
Relevancy Score: Relevancy Score: 240
Diebschlag V W - - 1975
For a quantitative evaluation of foot or leg volume and its alterations, a new type of instrument is presented. With this apparatus exact results will be achieved in a simple and quick method, which has proved true in several previous investigations. The apparatus is also suitable for the evaluation of ...
Relevancy Score: Relevancy Score: 216
Colombo C - - 1983
A battery of drugs with antirheumatic properties was tested for effects on the progress of osteoarthritis induced by a lateral meniscectomy procedure in knee joint cartilage of rabbits. Oral administration of the potent glucocorticoids, paramethasone acetate or triamcinolone, resulted in dramatic inhibition of cartilage degeneration. Significant protection against development of ...
Relevancy Score: Relevancy Score: 216
Wilhelmi G - - 1988
Male mice of the C57 black strain were given 1 mg/kg body weight of riboflavin (vitamin B2) in their drinking water daily for 4 months, in addition to the vitamin B2 contained in their standard pellet feed. Controls received the standard feed only. Histological examination of the joints at the ...
Relevancy Score: Relevancy Score: 184
Hermel B - - 1981
Relevancy Score: Relevancy Score: 82
Modin A Iu - - 1988
Glivenol was found to produce no changes in volumetric parameters of the central hemodynamics within the first 1.5 hours after its intake but to increase moderately hydraulic resistance of peripheral vessels which is more pronounced when the patient is in an upright position.
Relevancy Score: Relevancy Score: 82
Poprzen V - - 1989
Spectrodensitometric method was used in determination of lidocaine-chloride in some antihemorrhoidal agents after thermomicrodetection and its direct thin layer coating. This procedure is based on transference of the studied substance into the gaseous state, its quantitative transference on the basic layer of silicagel GF254, isolation in the benzene-methanol mixture and ...
Relevancy Score: Relevancy Score: 66
Cepeláková H - - 1979
Methods used in clinical and clinical pharmacological assessments of phlebotropic drugs are outlined. The knowledge of the pharmacokinetics and metabolism of phlebotropic drugs in human organism is far from complete as yet. Of objective methods proving haemodynamic effects of phlebotropic drugs, the authors have the best experiences with the strain-gauge ...
Relevancy Score: Relevancy Score: 66
Iakovlev G M - - 1981
The investigation of the peripheral circulation by using the all-purpose occlusion rheoplethysmography enables the reaction of rising the venous tone in response to the action exerted by the tissue ischemia products to be quantitatively estimated along with a one-time determination of the arterial and venous hemodynamics of the crus at ...
Relevancy Score: Relevancy Score: 66
Khadzhaĭ Ia I - - 1983
According to the rheo- and photoplethysmography data, ethyl-3,5,6-tri-O-benzyl-D-glucofuranoside (glivenol, tribenol; 25,250 and 4000 mg/kg i.p.) markedly increases the blood content in hind limbs of rabbits, displaying a tendency towards a decrease in systemic arterial pressure and negligibly raises the body temperature when given in maximal doses, without affecting cardiac activity ...
Relevancy Score: Relevancy Score: 66
Roztocil K - - 1979
The authors describe two types of test. Their aim was to verify the therapeutic potency of drugs used in the treatment of chronic venous disorders. The tests were carried out using both a single prescription and using successive prescriptions. The results showed that with strict clinical surveillance, phlebotropic drugs had ...
Relevancy Score: Relevancy Score: 66
Chaĭka L A - - 1981
A study was made on the mechanism of action of the antivaricose agent tribenol (ethyl-3,5,6-tri-O-benzyl-D-glucofuranozide; glivenol) on the activity of hydroxyreductase on the Krebs cycle and glycolysis during occlusion of the femoral vein and its inflammation in rats. It was shown histochemically that on the 5th day of traumatic phlebitis ...
Relevancy Score: Relevancy Score: 57
Kalbhen D A - - 1983
Due to their pharmacological properties most antiphlogistic/antirheumatic drugs are successfully used for treatment of inflammatory rheumatic diseases, but they are not able to counteract cartilage degeneration in osteoarthrosis. For specific therapy of osteoarthrosis only those drugs are suitable, which are able to inhibit enzymatic breakdown of articular cartilage, stimulate anabolic ...
Relevancy Score: Relevancy Score: 57
Chong Nyuk Jet - - 2013
We aimed to assess the efficacy of Centella asiatica for improvement of the signs and symptoms of chronic venous insufficiency (CVI). We searched 13 electronic databases including the Cochrane Central Register of Controlled Trials for randomised controlled trials assessing the efficacy of Centella asiatica for CVI. Two review authors independently ...
Relevancy Score: Relevancy Score: 39
Guindic Luis Charúa LC Coloproctology Unit, General Hospital of México, México City, - - 2014
Hemorrhoids are one of the most common ailments known. Often described as "varicose veins of the anus and rectum", hemorrhoids are enlarged, bulging blood vessels in, and about the anus and lower rectum. About 75% of people will have hemorrhoids at some point in their lives. This paper shares the ...
Relevancy Score: Relevancy Score: 37
Iwata Munetaka - - 2013
Obesity and high body mass index are associated with a higher incidence of osteoarthritis (OA). The aim of this study is to investigate the involvement of the infrapatellar fat pad (IPFP) in the sub-acute effect of a high fat diet (HFD) on the development of knee-OA. C57BL/6J male mice were ...
Relevancy Score: Relevancy Score: 28
Eltawil N M - - 2009
To generate and validate a murine model of joint surface repair following acute mechanical injury. Full thickness defects were generated in the patellar groove of C57BL/6 and DBA/1 mice by microsurgery. Control knees were either sham-operated or non-operated. Outcome was evaluated by histological scoring systems. Apoptosis and proliferation were studied ...
Relevancy Score: Relevancy Score: 23
Szulfer Jarosław - - 2013
This paper investigates the performance of a column classification system developed at the Katholieke Universiteit Leuven applied to pharmaceutical chromatographic analyses. The liquid chromatography assay of lamotrigine and related compounds was carried out according to the method prescribed in the European Pharmacopoeia monograph, using 28 brands of stationary phases. A ...
Relevancy Score: Relevancy Score: 23