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Liu Yan Y Department of Geriatrics, The First Hospital of Shijiazhuang City, Shijiazhuang, Hebei 050011, P.R. - - 2014
The aim of the present study was to investigate the effects of spironolactone and losartan on the early healing stage of acute myocardial infarction (AMI) in rats. An AMI rat model was established and the rats were randomly divided into four groups: AMI (n=12), AMI + spironolactone (AMI + S; ...
Zhang Xin X Xin Zhang, Shu-Zhen Wang, Jun-Fu Zheng, Wen-Min Zhao, Peng Li, Chun-Lei Fan, Bing Li, Pei-Ling Dong, Lei Li, Hui-Guo Ding, Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Affiliated with Capital Medical University, Beijing 100069, - - 2014
To evaluate the efficacy and safety of tolvaptan to treat refractory ascites in decompensated liver cirrhosis patients with or without further complications, such as hepatorenal syndrome and/or hepatocellular carcinoma. Thirty-nine patients (mean age 55 years, males: 32) with decompensated liver cirrhosis and refractory ascites were enrolled. All patients received a ...
Riester Anna A A Riester, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, - - 2014
Primary aldosteronism (PA) is the most common cause of secondary hypertension. In this review we discuss the diagnosis and management of PA during pregnancy based on the literature. As aldosterone and renin are physiologically increased during pregnancy and confirmation tests are not recommended, the diagnosis of PA during pregnancy relies ...
Magiera Sylwia S Department of Inorganic, Analytical Chemistry and Electrochemistry, Silesian University of Technology, 7 M. Strzody Str., 44-100, Gliwice, - - 2014
A novel analytical approach has been developed for the determination of selected drugs (milrinone, enalapril, carvedilol, spironolactone, acenocumarol, ticlopidine, cilazapril) and their metabolites (2-oxoticlopidine, cilazaprilat, canrenone, 5'-hydroxycarvedilol, O-desmethyl-carvedilol, enalaprilat) in human urine, based on a miniaturized extraction technique; semi-automatic microextraction by packed sorbent, using a new digitally controlled syringe, followed ...
Herold T R TR Department of Ophthalmology, University Eye Hospital - LMU, Campus Innenstadt, Klinikum der Universität München, Mathildenstrasse 8, D-80336, Munich, Germany, - - 2014
The pathogenesis of central serous chorioretinopathy (CSC) is still poorly understood. An animal model of CSC proved that the mineralocorticoid receptor [1] of the choroid also plays a role in CSC. Since there is still no evidence-based therapy for non-self-limiting CSC, this case series evaluates the effect of oral spironolactone ...
Simopoulos V V Department of Cardiovascular and Thoracic Surgery, University Hospital of Larissa Medical School, University of Thessaly, Larissa, - - 2014
Postoperative atrial fibrillation (POAF) is the most common arrhythmia after cardiac surgery. There exist consistent experimental and clinical data suggesting that aldosterone antagonists (AAs) may exert beneficial effects regarding electrical and structural remodeling in failing myocardium. Recently, eplerenone (EPL) has been found to reduce the incidence of nonsurgical AF when ...
Inder Warrick J WJ Department of Diabetes and Endocrinology and University of Queensland, Princess Alexandra Hospital, Brisbane, - - 2014
Addison's disease may be complicated by hypertension and less commonly by heart failure. We review the pathophysiology of the renin-angiotensin-aldosterone axis in Addison's disease and how this is altered in the setting of hypertension and heart failure. An essential first step in management in both conditions is optimising glucocorticoid replacement ...
Garg Rajesh R Division of Endocrinology, Diabetes and - - 2014
Reduced coronary flow reserve (CFR), an indicator of coronary microvascular dysfunction, is seen in type 2 diabetes mellitus (T2DM) and predicts cardiac mortality. Since aldosterone plays a key role in vascular injury, the aim of this study was to determine whether mineralocorticoid receptor (MR) blockade improves CFR in individuals with ...
Narula Harmeet S HS Medical Service, Veterans Affairs Medical Center, 6900 Pecos Road, North Las Vegas, NV 89086, - - 2014
Gynaecomastia (enlargement of the male breast tissue) is a common finding in the general population. Most cases of gynaecomastia are benign and of cosmetic, rather than clinical, importance. However, the condition might cause local pain and tenderness, could occasionally be the result of a serious underlying illness or a medication, ...
Patel Kishan A - - 2014
Spironolactone is often used to treat hypertension caused by hyperaldosteronism, and as a result, can form concentrically laminated electron dense spironolactone body inclusions within the adrenal gland. Spironolactone bodies have not been investigated in a contemporary cohort or in patients treated with the more recently approved aldosterone antagonist, eplerenone. Spironolactone ...
Couraud Sébastien - - 2014
Two studies have reported statistically significant associations between the use of cardiac glycosides (CGs) and an increased risk of lung cancer. However, these studies had a number of methodological limitations. Thus, the objective of this study was to assess this association in a large population-based cohort of patients. We used ...
Dabare Panthihage Ruvini - - 2014
Access to medicines is a universal right. Low availability and low affordability of medicines are issues that deny this right to a significant proportion of the world population. The objective of this study was to determine the availability, price and affordability of essential medicines prescribed to treat non communicable diseases ...
Zhang Xiaolu X Department of pharmacology, Xi'an Jiaotong University School of Medicine, Xi'an 710061, - - 2014
Atherosclerosis is a chronic inflammatory disease in the vessel. As a representative inflammatory cytokine, C-reactive protein (CRP) participates in atherogenesis. Although hyperaldosteronism is known to evoke inflammatory response in several tissues and cell types, there is no direct evidence to demonstrate the proinflammatory effect of aldosterone on vascular smooth muscle ...
Persu Alexandre A Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium, - - 2014
After three years of excessive confidence, overoptimistic expectations and performance of 15 to 20,000 renal denervation procedures in Europe, the failure of a single well-designed US trial-Symplicity HTN-3-to meet its primary efficacy endpoint has cast doubt on renal denervation as a whole. The use of a sound methodology, including randomisation ...
Burch Druin D Public Library of Science, Cambridge, United - - 2014
Please see later in the article for the Editors' Summary.
McNeice Andrew H AH Craigavon Cardiac Centre, Southern Trust, Northern Ireland, BT63 5QQ, - - 2014
Multiple, potentially practice-changing cardiology trials have been presented or published over the past year. In this paper, we summarize and place in clinical context, new data regarding management of acute coronary syndrome and ST-elevation myocardial infarction (copeptin assessment, otamixaban, cangrelor, prasugrel, sodium nitrite, inclacumab, ranolazine, preventive coronary intervention of non-culprit ...
Ni Xiaoying X Department of Nephrology, People's Hospital of Yinzhou, College of Medicine, Ningbo University, Ningbo, - - 2014
The purpose of this study was to evaluate the effects of spironolactone on dialysis patients with refractory hypertension and possible adverse effects. This was a 12-week prospective, randomized, double-blind trial of 82 patients randomly assigned to 12-week treatment with 25 mg/d spironolactone or placebo as add-on therapy. Visits were scheduled at ...
Verbrugge Frederik H FH Department of Cardiology, Ziekenhuis Oost Limburg, Genk, Belgium; Doctoral School for Medicine and Life Sciences, Hasselt University, Diepenbeek, - - 2014
-The urinary composition including sodium (Na(+)) and chloride (Cl(-)) concentrations might provide useful information in addition to urine output during decongestive treatment in heart failure (HF). -Consecutive HF patients (n=61) with ejection fraction ≤45%, worsening symptoms, and scheduled treatment with intravenous loop diuretics were included. Patients received protocol driven therapy ...
Scali Maria Chiara - - 2014
There is increasing interest in guiding Heart Failure (HF) therapy with Brain Natriuretic Peptide (BNP) or N-terminal prohormone of Brain Natriuretic Peptide (NT-proBNP), with the goal of lowering concentrations of these markers (and maintaining their suppression) as part of the therapeutic approach in HF. However, recent European Society of Cardiology ...
Tseng Min-Hua - - 2014
Hyponatremia is known to be a marker of poor prognosis in many clinical conditions. The association between hyponatremia and clinical outcomes in peritoneal dialysis-related peritonitis (PDRP) has not been studied. We evaluated the association between hyponatremia and clinical parameters of patients with PDRP. We conducted a retrospective analysis of medical ...
John Anitha S AS Division of Cardiology, Children's National Medical Center, George Washington University School of Medicine, Washington, DC; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota. Electronic address: - - 2014
Patients with protein-losing enteropathy (PLE) following the Fontan operation have a reported 50% mortality at 5 years after diagnosis. The aim of this study was to review outcomes in patients with PLE following the Fontan operation. From 1992 to 2010, 42 patients (55% male) with PLE following the Fontan operation ...
Hassan Mona M Department of Internal Medicine, Henry Ford Hospital/Wayne State University, - - 2014
Aldosterone antagonists may mediate their effects on heart failure through parathyroid hormone (PTH) in chronic kidney disease (CKD) patients. Patients with CKD on spironolactone were selected and matched for age, gender, race, use of a vitamin D analogue, the number of antihypertensive medications, and CKD stage. PTH levels before and ...
Kota Sunil Kumar SK Department of Endocrinology, Medwin Hospital, Hyderabad, - - 2014
Liddle's syndrome is a rare cause of secondary hypertension. Identification of this disorder is important because treatment differs from other forms of hypertension. We report an interesting case of a 35-year-old lady, a known diabetic and hypertensive patient, who presented with features of hypertensive encephalopathy. The family history was unremarkable. ...
Lam Charlene C Department of Dermatology, Penn State University/Hershey Medical Center, Hershey, - - 2014
Acne vulgaris is an inflammatory disorder of the pilosebaceous follicle. It is well established that androgen hormones play a major role in sebum production and excretion, and are vital in the pathogenesis of acne. Isotretinoin notwithstanding, hormonal therapies such as combined oral contraceptives (COCs) and spironolactone are the only treatments ...
Martínez Javier J Servicio de Gastroenterología y Hepatología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, CIBERehd, IRYCIS, Madrid, - - 2014
Ascites is a common complication of hepatic cirrhosis and portal hypertension. Patients present systemic and splanchnic circulation disorders, which cause central hypovolemia and arterial hypotension, with the subsequent activation of vasoconstrictor systems and increased renal reabsorption of sodium and water. Approximately 5%-10% of patients present refractory ascites. Refractory ascites is ...
Khan Javed J Department of Pulmonary Medicine, King Fahd Armed Forced Hospital, Jeddah, Saudi - - 2014
Pregnancy in pulmonary hypertension (PH) is known to be associated with high morbidity and mortality. The physiological changes occur during normal pregnancy, such as increase blood volume and cardiac output (CO) may be detrimental in PH patients. Several practice guidelines advise against pregnancy and even recommend termination of pregnancy. Occasionally ...
Sánchez Gómez E E Servicio de Farmacia Hospitalaria. Hospital Juan Ramón Jiménez. Huelva. España.. - - 2014
To identify the pharmacologic interactions of oral anti-cancer drugs provided at an outpatient clinic. Anti-cancer drugs included in the Phamacotherapeutic Guideline of the Hospital were identified. A literature search was carried out on the pharmacologic interactions in MEDLINE® and EMBASE® (with the filer language English or Spanish, and the descriptors: ...
Azizi Michel M aAssistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Hypertension Unit, F75015, Paris bInserm, Clinical Investigation Centre, F75015, Paris cUniversité Paris-Descartes, F75006 Paris dAssistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Department of Cardiology, F75015, Paris eInserm, CIE 4, Paris, - - 2014
We report the results of an echocardiographic substudy carried out in a trial comparing the effects of two different treatment strategies - mineralocorticoid receptor blockade (MRB) and dual renin-angiotensin system blockade (RASB) - in patients with resistant hypertension. Both strategies reduce left ventricular mass index (LVMI), but they have not ...
Vizzardi Enrico E Section of Cardiovascular Diseases, Department of Medical and Surgical, Radiological Sciences and Public Health Specialties, University of Study of Brescia, Brescia, - - 2014
Many studies proved the prognostic importance of aortic stiffness as an independent predictor of cardiovascular morbidity and all-cause mortality. The decrease of arterial compliance has a high prevalence in patients with heart failure and affects both hemodynamics and prognosis. Aortic stiffness is partially caused by excessive activation of the renin-angiotensin-aldosterone ...
Kasznicki Jacek J Department of Internal Disease, Diabetology and Clinical Pharmacology, Medical University of Lodz, - - 2014
Evidence from clinical trials repeatedly confirms the association of diabetes with heart failure, independent of hypertension, atherosclerosis, coronary artery disease and valvular heart disease. However, the importance of coexistence of diabetes and heart failure is not universally recognized, despite the fact that it may significantly contribute to morbidity and mortality ...
Jensen Janni M - - 2014
Renal handling of sodium and water is abnormal in chronic kidney disease (CKD). The aim of this study was to test the hypothesis that abnormal activity of the aquaporin-2 water channels (AQP2), the sodium-potassium-2chloride transporter (NKCC2) and/or the epithelial sodium channels (ENaC) contribute to this phenomenon. 23 patients with CKD ...
Al Therwani Safa - - 2014
Tolvaptan is a selective vasopressin receptor antagonist (V2R) that increases free water excretion. We wanted to test the hypotheses that tolvaptan changes both renal handling of water and sodium and systemic hemodynamics during basal conditions and during nitric oxide (NO)-inhibition with L-NG-monomethyl-arginine (L-NMMA). Nineteen healthy subjects were enrolled in a ...
Rizwan Azra - - 2014
Cushing's syndrome results from exposure to excess glucocorticoids. Ectopic Cushings is endogenous ACTH dependant form of Cushing's associated with markedly raised ACTH and cortisol levels. This leads to an impaired immune response, setting the stage for occurrence of opportunistic infections. Nocardiosis is a gram positive bacterial infection caused by aerobic ...
Maisel Alan A Division of Cardiology, University of California San Diego, San Diego, California. Electronic address: - - 2014
The aim of our study is to investigate the effect of spironolactone on 30-day outcomes in patients with acute heart failure (AHF) and the association between treatment and outcomes stratified by biomarkers. We conducted a secondary analysis of the biomarker substudy of the multicenter COACH (Co-ordinating Study Evaluating Outcomes of ...
Muschart X - - 2014
Objective: Hyperkalaemia is a potentially lethal electrolyte disorder. The objective of this study was to determine if the causes of hyperkalaemia-related visits to the emergency department (ED) have changed since 25 years. Methods: All patients presenting to the ED with hyperkalaemia between January 2009 and August 2011 were included in ...
Alzahrani Ali S AS Department of Medicine, King Faisal Specialist Hospital & Research Center Department of Molecular Oncology, King Faisal Specialist Hospital & Research - - 2014
Objective: To present a case of apparent mineralocorticoid excess (AME) due to a novel mutation in HSD11B2 gene and describe the response to therapy.Methods: Clinical, biochemical and genetic features of the proband and his family are presented. For the genetic study, DNA was extracted from peripheral leucocytes. The exons and ...
Souza Adriana Sebba Barroso de - - 2014
Background: Treatment with stem cells in several cardiomyopathies may be related to the increase in arrhythmias. Objectives: To determine whether intracoronary injection of stem cells in patients with Chagas cardiomyopathy is associated with increased incidence of ventricular arrhythmias, compared to the Control Group. Methods: A retrospective cohort study that evaluated ...
Vongpatanasin Wanpen W Hypertension Section, Cardiology Division, University of Texas Southwestern Medical Center, - - 2014
Resistant hypertension-uncontrolled hypertension with 3 or more antihypertensive agents-is increasingly common in clinical practice. Clinicians should exclude pseudoresistant hypertension, which results from nonadherence to medications or from elevated blood pressure related to the white coat syndrome. In patients with truly resistant hypertension, thiazide diuretics, particularly chlorthalidone, should be considered as ...
Schmitz Boris B Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, University Hospital Muenster, Horstmarer Landweg 39, 48149 Muenster, Germany; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, - - 2014
The steroid hormone aldosterone regulates the reabsorption of water and ions in the kidney and plays a central role in blood pressure regulation and homeostasis. In recent years, the vascular endothelium has been established as an important aldosterone target organ with major implications in renal and cardiovascular health and disease. ...
Somani Najwa N Department of Dermatology, Indiana University School of Medicine, 550 N. University Blvd., Suite 3240, Indianapolis, IN, 46202, USA, - - 2014
Hirsutism has a relatively high prevalence among women. Depending upon societal and ethnic norms, it can cause significant psychosocial distress. Importantly, hirsutism may be associated with underlying disorders and co-morbidities. Hirsutism should not simply be looked upon as an issue of cosmesis. Patients require appropriate evaluation so that underlying etiologies ...
Shamma Rehab R Faculty of Pharmacy, Cairo University , Cairo , - - 2014
Abstract Spironolactone (SL) is a poorly water-soluble drug. Being poorly soluble affects its dissolution rate which in turn affects its oral bioavailability. This work aimed to prepare freeze-dried SL-Soluplus®/polyvinyl alcohol (PVA) oral thin film in an attempt to enhance the drug solubility on one hand and at the same time ...
Kurrelmeyer Karla M KM Methodist DeBakey Heart and Vascular Center, Houston, TX. Electronic address: - - 2014
Although spironolactone has been shown to decrease morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction , its role in patients with heart failure and preserved left ventricular ejection fraction (HFpEF) is not well defined. In this study we investigate the mechanisms involved when elderly ...
Achterberg E J Marijke EJ aDepartment of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University bDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands cDepartment of Science, Section of Biomedical Sciences and Technologies, University 'Roma Tre', Rome, - - 2014
Reconsolidation is the process whereby consolidated memories are destabilized upon retrieval and restabilized to persist for later use. Although the neurobiology of the reconsolidation of both appetitive and aversive memories has been intensively investigated, reconsolidation of memories of physiologically relevant social rewards has received little attention. Social play, the most ...
Kato Yoshiro Y Division of Diabetes, Department of Internal Medicine, Diabetes Center , Nagakute , Japan - - 2014
Abstract The effect of spironolactone (SPIR) on lipopolysaccharide (LPS)-induced production of proinflammatory mediators was examined using RAW 264.7 macrophage-like cells and mouse peritoneal macrophages. SPIR significantly inhibited LPS-induced production of nitric oxide (NO), tumor necrosis factor-α and prostaglandin E2. The inhibition was not mediated by cell death. SPIR reduced the ...
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