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Svenningsen Per P Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, - - 2014
Serine proteases, both soluble and cell-attached, can activate the epithelial sodium channel (ENaC) proteolytically through release of a putative 43-mer inhibitory tract from the ectodomain of the γ-subunit. ENaC controls renal Na(+) excretion and loss-of-function mutations lead to low blood pressure, while gain-of-function mutations lead to impaired Na(+) excretion, hypertension, ...
Holaj Robert R a3rd Department of Medicine b1st Department of Surgery cDepartment of Urology, Centre for Hypertension General University Hospital and 1st Faculty of Medicine, Charles University in Prague dDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech - - 2014
Aldosterone has been shown to substantially contribute to the accumulation of different types of collagen fibres and growth factors in the arterial wall, thus increasing wall thickness. A previous study showed reduction of increased common carotid intima-media thickness (IMT) in patients with primary aldosteronism 1 year after adrenalectomy. Our study ...
Goto Atsushi A Department of Gastroenterology and Hepatology, Hagi Civil Hospital, Tsubaki 3460-3, Hagi, Yamaguchi, 758-0061, - - 2014
Tolvaptan is a new drug used for treating ascites induced by liver cirrhosis, and it is covered by health insurance in Japan. In the present report, we describe the case of a 74-year-old man with type C liver cirrhosis and refractory ascites. He was receiving furosemide and spironolactone daily, but still ...
Bagherani Nooshin N Dr. Nooshin Bagherani's Office, Khoramshahr, Khuzestan Province, - - 2014
Kusche-Vihrog Kristina K Institute of Physiology II, University of Muenster, Robert-Koch-Str. 27b, 48149, Muenster, Germany, - - 2014
High salt (NaCl) intake promotes the development of vascular diseases independent of a rise in blood pressure, whereas reduction of salt consumption has beneficial effects for the arterial system. This article summarizes our current understanding of the molecular mechanisms of high salt-induced alterations of the endothelial phenotype, the impact of ...
Edelmann Frank F Department of Cardiology and Pneumology, Heart Center, University of Göttingen, Göttingen, Germany; German Center for Cardiovascular Research (DZHK), University of Göttingen, Göttingen, - - 2014
Galectin-3 is a marker of myocardial fibrosis and mediates aldosterone-induced cardiovascular inflammation and fibrosis. Characteristics of galectin-3 and its response to spironolactone have not been evaluated in heart failure with preserved ejection fraction (HFpEF). The aim of this study was to determine the association between galectin-3 levels and patient characteristics ...
Rosa Ján J From the 3rd Department of Medicine, Centre for Hypertension, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic (J.R., O.P., T.Z., R.H., B.Š., Z.Š., J.W.); Cardiocentre, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic (J.R., P.W., P.T., K.Č., F.B.); Department of Anesthesiology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W.); Department of Internal Medicine I, University Hospital Olomouc, Czech Republic (M.T., J.V., E.K.); and Cardiocentre, Nemocnice Podlesí, Třinec, Czech Republic (M.B., I.N., O.J.). - - 2014
This prospective, randomized, open-label multicenter trial evaluated the efficacy of catheter-based renal denervation (Symplicity, Medtronic) versus intensified pharmacological treatment including spironolactone (if tolerated) in patients with true-resistant hypertension. This was confirmed by 24-hour ambulatory blood pressure monitoring after excluding secondary hypertension and confirmation of adherence to therapy by measurement of ...
Alansari Ahmed A Department of Internal Medicine, Metropolitan Hospital Center, New York Medical College, New York, - - 2014
A 77-year-old woman presented to the emergency department with a 2-day history of nausea and vomiting. Her medical history included diabetes mellitus, hypertension, atrial fibrillation, dilated cardiomyopathy, and coronary artery disease. Her home medications included aspirin, clopidogrel, warfarin, digoxin, metoprolol, losartan, simvastatin, isosorbide dinitrate, furosemide, and spironolactone. Initial physical examination ...
Akpek Mahmut M Erciyes University, Department of Cardiology, Kayseri, - - 2014
The protective effect of beta-blockers, ACE inhibitors, and ARBs on anthracycline cardiotoxicity has already been demonstrated, but the effect of aldosterone antagonism, which inhibits the last step of the renin-angiotensin-aldosterone system (RAAS), was questioned. This study sought to investigate whether spironolactone protects the heart against anthracycline-induced cardiotoxicity. Eighty-three female patients ...
Denolle Thierry T Société française d'hypertension artérielle, 75012 Paris, France. Electronic address: - - 2014
To improve the management of resistant hypertension, the French Society of Hypertension, an affiliate of the French Society of Cardiology, has published a set of eleven recommendations. The primary objective is to provide the most up-to-date information, based on the strongest scientific rationale and which is easily applicable to daily ...
Hallouard François F Université de Rennes I, Laboratoire de Pharmacie Galénique, Biopharmacie et Pharmacie Clinique, Rennes, - - 2014
In neonates as well as in adults having swallowing difficulty, oral medication is given through a nasogastric tube making liquid formulations preferable. In this study, we present the high potential of nanometric emulsions formulated by spontaneous surfactant diffusion, as extemporaneous formulations of hydrophobic drug. Spironolactone used as hydrophobic drug model, ...
Pfeffer Marc A MA Cardiovascular Division, Brigham and Women 's Hospital, 75 Francis Street, Boston, Massachusetts 02115 - - 2014
-Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) patients with heart failure and preserved left ventricular ejection fraction assigned to spironolactone did not achieve a significant reduction in the primary composite outcome (time to cardiovascular death, aborted cardiac arrest, or hospitalization for management of heart failure) ...
Gilet Alexandre A University of Lorraine, UMR_S U1116 (ex-U961 UHP-INSERM), Vandoeuvre-les-Nancy, - - 2014
Aldosterone and mineralocorticoid receptors are important regulators of inflammation. During this process, chemokines and extracellular matrix degradation by matrix metalloproteases, such as MMP-9, help leukocytes reaching swiftly and infiltrating the injured tissue, two processes essential for tissue repair. Leukocytes, such as neutrophils, are a rich source of MMP-9 and possess ...
Duarte Daniella B DB School of Medicine, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, School of Medicine, Hospital Universitário Walter Cantídio, Universidade Federal do - - 2014
Abstract The aim of this study is to investigate renal involvement in schistosomiasis. This is a retrospective cohort of 60 consecutive patients with schistosomiasis admitted to a university hospital in Maceió, Brazil. The patients were divided into 2 groups: patients with and without acute kidney injury (AKI) according to the ...
Otero María José MJ ISMP-España, Complejo Asistencial Universitario de Salamanca-IBSAL, Salamanca, Spain. Electronic address: - - 2014
Patients with chronic diseases often receive multiple medications and are associated with increased vulnerability to medication errors. Identifying high-alert medications for them would help to prioritize the interventions with greatest impact for improving medication safety. The aim of this study was to develop a list of high-alert medications for patients ...
Lax Antonio A Cardiology Department, University Hospital Virgen de la Arrixaca, Murcia, Spain; Department of Internal Medicine, School of Medicine, University of Murcia, Murcia, - - 2014
This study aimed to evaluate the specific role of the 2 available MRAs, eplerenone and spironolactone, on the modulation of galectin-3 (Gal-3) and interleukin (IL)-33/ST2 signaling in an experimental model of left ventricular systolic dysfunction after acute MI. The molecular mechanisms of benefits of mineralocorticoid receptor antagonists (MRAs) in patients ...
Calvier Laurent L INSERM, Université de Lorraine UMR 1116, Vandoeuvre-Lès-Nancy, - - 2014
This study investigated whether galectin (Gal)-3 inhibition could block aldosterone-induced cardiac and renal fibrosis and improve cardiorenal dysfunction. Aldosterone is involved in cardiac and renal fibrosis that is associated with the development of cardiorenal injury. However, the mechanisms of these interactions remain unclear. Gal-3, a β-galactoside-binding lectin, is increased in ...
Knight John J aThe George Institute for Global Health bSydney Medical School, University of Sydney cRoyal North Shore Hospital, Sydney, New South Wales, - - 2014
Because advanced chronic kidney disease (CKD) is often an exclusion criterion for large randomized trials of the management of hypertension, clinical decision making for these patients has relied on a few small, specific studies and much extrapolation. Several blood pressure treatment guidelines have recently been reissued. This review explores the ...
Park Yae Min YM Division of Cardiology, Heart Center, Gachon University Gil Hospital, Incheon, Korea.; Gachon Cardiovascular Research Institute, Gachon University Gil Hospital, Incheon, - - 2014
Pulmonary arterial hypertension (PAH) is an orphan disease showing poor prognosis. The purpose of study was to evaluate clinical factors influencing outcomes in PAH. Patients who were diagnosed with PAH at a single center were reviewed retrospectively. Forty patients (34.9±14.5 years, 80% of female) were enrolled. Causes were congenital heart ...
Uyar Belkiz B Department of Dermatology, Sifa University, Basmane, Izmir, - - 2014
Aquagenic syringeal acrokeratoderma is a rare, transient, and usually bilaterally symmetric, palmoplantar keratoderma. Patients complain of tingling and pain in the hands starting a few minutes after exposure to water and lasting for 20-30 minutes after removal. Clinically, there is marked wrinkling with edematous white papules on the palms or, ...
Vogel Susanne S 1] Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands [2] Radboud University Medical Center, Department of Cognitive Neuroscience, Nijmegen, the - - 2014
Two research lines argue for rapid stress-induced reallocations of neural network activity involving the amygdala. One focuses on the role of norepinephrine in mediating the shift towards the salience network and improving vigilance processing, while the other focuses on the role of cortisol in enhancing automatic, habitual responses. It has ...
Hofni Amal A Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, 61511 Minia, Egypt. Electronic address: - - 2014
Diabetic nephropathy is one of the most common causes of end-stage kidney disease. Aldosterone and angiotensin II appear to play a crucial role in the pathogenesis of this disease. The present study aimed to investigate effects of the combination therapy with spironolactone and candesartan on diabetic nephropathy and elucidate the ...
Pelliccia Francesco F Department 'Attilio Reale', Sapienza University, Rome, Italy. Electronic address: - - 2014
The mineralocorticoid receptor antagonists have been shown to have favourable safety and cost-effectiveness profiles across a broad range of clinical indications, including heart failure, primary aldosteronism and resistant hypertension. The clinical biology of the first aldosterone blocker, i.e. spironolactone, and its effects in several organ systems has been well elucidated ...
Hosoya Kozi K Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, - - 2014
In this study, we examined the association between chronic kidney disease (CKD) and insulin resistance. In a patient cohort with nondiabetic stages 2-5 CKD, estimated glomerular filtration rate (eGFR) was negatively correlated and the plasma aldosterone concentration was independently associated with the homeostasis model assessment of insulin resistance. Treatment with ...
Young Morag M M Young, Cardiovascular Endocrinology, MIMR-PHI Research Institute, Clayton, Australia - - 2014
The clinical impact of cardiovascular disease cannot be underestimated. Equally, the importance of cost effective management of cardiac failure is a pressing issue in the face of ageing populations and increasing incidence of metabolic disorders worldwide. Targeting the mineralocorticoid receptor (MR) offers one approach for the treatment of heart failure ...
Eschalier Romain R Nancy, France; Clermont-Ferrand, - - 2014
Lugtenberg Marjolein - - 2014
BackgroundComputerized decision support systems (CDSSs) are increasingly used to improve quality of care. There is evidence for moderate to large effects from randomized controlled trials (RCTs), but evidence on their effectiveness when implemented at a national level is lacking. In the Netherlands, the Dutch College of General Practitioners (NHG) initiated ...
Leelaphiwat Supatra S Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, - - 2014
To compare the effects of ethinyl estradiol (EE) 30 mcg/desogestrel 150 mcg plus spironolactone 25 mg/day (group A) versus EE 35 mcg/cyproterone acetate 2 mg (group B) on hyperandrogenism and metabolism in PCOS. This was a randomized clinical study. Eighteen women in groups A and B received medications for three cycles. Acne score, androgens and ...
Buzney Elizabeth E Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2014
Dermatologists are in a key position to treat the manifestations of polycystic ovary syndrome (PCOS). The management of PCOS should be tailored to each woman's specific goals, reproductive interests, and particular constellation of symptoms. Therefore, a multidisciplinary approach is recommended. In part II of this continuing medical education article, we ...
Hermidorff Milla Marques MM a Laboratory of Hypertesion, Research Center in Biological Science (NUPEB), Institute of Exact and Biological Sciences (ICEB), Federal University of Ouro Preto (UFOP), Campus Morro do Cruzeiro, 35400-000 Ouro Preto, Minas Gerais, - - 2014
Mineralocorticoid receptor (MR) antagonists of aldosterone (spironolactone and eplerenone) display beneficial effects in the treatment of cardiopathies; however, many of these responses are independent of this antagonism. The mechanisms of action of these drugs are not well known; few studies have comparatively evaluated whether eplerenone as well as spironolactone display ...
Navarro-Zaragoza Javier J Group of Cellular and Molecular Pharmacology, University School of Medicine, Murcia, Spain; Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain. Electronic address: - - 2014
Pharmacological evidence has accumulated showing that glucocorticoids and glucocorticoid receptor (GR) facilitate several responses to different drugs of abuse. Recent findings have attributed a prominent role to the mineralocorticoid receptor (MR) in modulating behavior during the addictive process. The purpose of this study was to investigate the effects of MR ...
Barsheshet Alon A Cardiology Department, Rabin Medical Center, Petach Tikva, - - 2014
Long QT syndrome is a genetic disorder associated with life threatening ventricular arrhythmias and sudden death. This inherited arrhythmic disorder exhibits genetic heterogeneity, incomplete penetrance, and variable expressivity. During the past two decades there have been major advancements in understanding the genotype-phenotype correlations in LQTS. This genotype-phenotype relationship can lead ...
Altay Servet - - 2014
The definition of glomerular hyperfiltration has not been agreed upon and the pathophysiological mechanisms have not been well explored. Low serum creatinine concentrations may be associated with increased risk of coronary heart disease (CHD) or cardiopulmonary events the impact of which needs further study. Consecutive applicants to a cardiovascular hospital ...
Jhaveri Binit N BN Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, - - 2014
To evaluate the use of potentially inappropriate medicines in elderly inpatients in a tertiary care teaching hospital. Retrospective analysis was performed for cases of elderly patients admitted between January 2010 and December 2010. Data on age, gender, diagnosis, duration of hospital stay, treatment, and outcome were collected. Prescriptions were assessed ...
Zhang S-H SH Department of Senile Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, China. - - 2014
This study aimed to explore the possible mechanism of spironolactone in reduction of atrial fibrosis in elderly patients with atrial fibrillation. 67 patients with atrial fibrillation and 30 matching patients with sinus rhythm were included into this study, in which the former patients were randomly divided into the conventional treatment ...
Del Rosso James Q JQ - - 2014
Acne vulgaris (AV) in adult women is commonly encountered in clinical dermatology practice. This patient subset often experiences psychosocial effects that differ in some ways from those experienced by adolescent females with AV, as they were not expecting to have to deal with this disorder beyond their adolescent years. Most ...
Indra Tomáš T Third Department of Internal Medicine, General University Hospital, Prague, Czech Republic; and First Faculty of Medicine, Charles University, Prague, Czech Republic - - 2014
Primary aldosteronism (PA) represents the most common cause of secondary hypertension. Beyond increased blood pressure, additional harmful effects of aldosterone excess including inappropriate left ventricle (LV) hypertrophy were found. We evaluated the effect of adrenalectomy and spironolactone on blood pressure and myocardial remodelling in a long-term follow-up study. Thirty-one patients ...
Driscoll Andrea - - 2014
Beta-adrenergic blockade has been shown to improve left ventricular function, reduce hospital admissions and improve survival in chronic heart failure with reduced ejection fraction (HFrEF), with mortality reduction starting early after beta-adrenergic receptor blocker initiation and being dose-related. The aim of this pilot study was to determine the effectiveness of ...
Celtik Coskun C *Istanbul University, Istanbul Faculty of Medicine, Pediatric Gastroenterology and Hepatology †Sifa University, Faculty of Medicine, Pediatric Gastroenterology and Hepatology ‡Istanbul University, Istanbul Faculty of Medicine, Pediatric Cardiology §Bezm-i Alem University, Faculty of Medicine, Pediatric Gastroenterology and Hepatology ||Kocaeli University, Faculty of Medicine, Pediatric Gastroenterology and Hepatology ¶Selcuk University, Faculty of Medicine, Pediatric Gastroenterology and - - 2014
AIM:: Cirrhotic cardiomyopathy (CCMP) is a functional disorder characterized by electrophysiological disturbances, and diastolic and/or systolic dysfunction in patients with liver disease. This disorder is a well-defined entity in adults, but pediatric data are limited. Aim of the study is to determine the incidence, features and risk factors of CCMP ...
Adel Heba H Department of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, Minia, 61511, - - 2014
Endothelial dysfunction is a critical initiator for developing diabetic vascular complications. Substantial clinical and experimental evidence suggests that aldosterone plays a crucial role in its pathogenesis. The present study aimed to investigate the effect of the mineralocorticoid receptor (MR) blocker, spironolactone, on diabetes-associated endothelial dysfunction and address the underlying mechanism(s) ...
Gupta A A Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, - - 2014
We have previously shown rapid reversal of left ventricular hypertrophy (LVH) with 6 months of spironolactone therapy in patients with resistant hypertension (HTN), preserved left ventricular ejection fraction and no history of heart failure. In this substudy, we investigated the effect of mineralocorticoid receptor blockade with spironolactone on pre-clinical diastolic ...
Thomason J D JD Department of Veterinary Clinical Sciences, Veterinary Health Center, Kansas State University, 1800 Dension Ave., Manhattan, KS 66506, USA. Electronic address: - - 2014
The combination of an angiotensin-converting enzyme inhibitor (ACEI) with an aldosterone receptor antagonist can increase serum potassium and magnesium and lower serum sodium concentrations. The objective of this study was to retrospectively determine whether an ACEI and spironolactone can be co-administered to Doberman pinschers with occult dilated cardiomyopathy without serious ...
Queisser Nina N Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, - - 2014
Mineralocorticoid receptor blockers show antifibrotic potential in hepatic fibrosis. The mechanism of this protective effect is not known yet, although reactive oxygen species seem to play an important role. Here, we investigated the effects of elevated levels of aldosterone (Ald), the primary ligand of the mineralocorticoid receptor, on livers of ...
Yongsiri Somchai S Facutly of Medicine, Burapha University, Mueng Chonburi, - - 2014
The incidence of hypokalemia in continuous ambulatory peritoneal dialysis (CAPD) patients is about 15-60%, leading to significant complications. There is no standard treatment other than potassium supplement in this setting. The aim of this study was to evaluate effect of spironolactone 25 mg/day in CAPD patients who have a history of ...
D Almeida Karina Sm - - 2014
Although half of all patients with heart failure (HF) have a normal or near-normal ejection fraction and their prognosis differs little from that of patients with a reduced ejection fraction, the pathophysiology of HF with preserved ejection fraction (HF-PEF) is still poorly understood, and its management poorly supported by clinical ...
Liu Yan Y Department of Geriatrics, The First Hospital of Shijiazhuang City, Shijiazhuang, Hebei 050011, P.R. - - 2014
The aim of the present study was to investigate the effects of spironolactone and losartan on the early healing stage of acute myocardial infarction (AMI) in rats. An AMI rat model was established and the rats were randomly divided into four groups: AMI (n=12), AMI + spironolactone (AMI + S; ...
Pliquett Rainer U - - 2014
Cardiovascular comorbidities regularly determine renal function. We report a case of acute kidney injury (Acute Kidney Injury Network stage 3) due to an intermittent third-degree atrioventricular block, which had not been diagnosed before. A 76-year-old Caucasian man with liver cirrhosis due to non-alcoholic fatty liver disease, and type-2 diabetes was ...
Chen Ying Y Emergency Department, First Hospital of Hebei Medical University, Hebei Medical University, No. 89 Donggang Road, Shijiazhuang 050032, Hebei Province, - - 2014
The relationship between lipids and coronary artery disease has been well established. However, this is not the case between lipids and heart failure. Ironically, high lipid levels are associated with better outcomes in heart failure, but the mechanisms underlying the phenomenon are not fully understood. This study was performed to ...
Kim Soo-Han SH Division of Cardiology, Department of Internal Medicine, Inha University College of Medicine, Incheon, - - 2014
We report a case of hypersensitivity skin reaction to prasugrel. The patient exhibited a generalized skin rash after treatment with prasugrel, which was resolved after discontinuation of prasugrel and substitution to clopidogrel. Clopidogrel was successfully administered as an alternative to prasugrel without any signs of further hypersensitivity.
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