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Knight John J aThe George Institute for Global Health bSydney Medical School, University of Sydney cRoyal North Shore Hospital, Sydney, New South Wales, - - 2014
Because advanced chronic kidney disease (CKD) is often an exclusion criterion for large randomized trials of the management of hypertension, clinical decision making for these patients has relied on a few small, specific studies and much extrapolation. Several blood pressure treatment guidelines have recently been reissued. This review explores the ...
Hosoya Kozi K Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, - - 2014
In this study, we examined the association between chronic kidney disease (CKD) and insulin resistance. In a patient cohort with nondiabetic stages 2-5 CKD, estimated glomerular filtration rate (eGFR) was negatively correlated and the plasma aldosterone concentration was independently associated with the homeostasis model assessment of insulin resistance. Treatment with ...
Young Morag M M Young, Cardiovascular Endocrinology, MIMR-PHI Research Institute, Clayton, Australia - - 2014
The clinical impact of cardiovascular disease cannot be underestimated. Equally, the importance of cost effective management of cardiac failure is a pressing issue in the face of ageing populations and increasing incidence of metabolic disorders worldwide. Targeting the mineralocorticoid receptor (MR) offers one approach for the treatment of heart failure ...
Leelaphiwat Supatra S Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, - - 2014
To compare the effects of ethinyl estradiol (EE) 30 mcg/desogestrel 150 mcg plus spironolactone 25 mg/day (group A) versus EE 35 mcg/cyproterone acetate 2 mg (group B) on hyperandrogenism and metabolism in PCOS. This was a randomized clinical study. Eighteen women in groups A and B received medications for three cycles. Acne score, androgens and ...
Navarro-Zaragoza Javier J Group of Cellular and Molecular Pharmacology, University School of Medicine, Murcia, Spain; Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain. Electronic address: - - 2014
Pharmacological evidence has accumulated showing that glucocorticoids and glucocorticoid receptor (GR) facilitate several responses to different drugs of abuse. Recent findings have attributed a prominent role to the mineralocorticoid receptor (MR) in modulating behavior during the addictive process. The purpose of this study was to investigate the effects of MR ...
Barsheshet Alon A Cardiology Department, Rabin Medical Center, Petach Tikva, - - 2014
Long QT syndrome is a genetic disorder associated with life threatening ventricular arrhythmias and sudden death. This inherited arrhythmic disorder exhibits genetic heterogeneity, incomplete penetrance, and variable expressivity. During the past two decades there have been major advancements in understanding the genotype-phenotype correlations in LQTS. This genotype-phenotype relationship can lead ...
Altay Servet - - 2014
The definition of glomerular hyperfiltration has not been agreed upon and the pathophysiological mechanisms have not been well explored. Low serum creatinine concentrations may be associated with increased risk of coronary heart disease (CHD) or cardiopulmonary events the impact of which needs further study. Consecutive applicants to a cardiovascular hospital ...
Jhaveri Binit N BN Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, - - 2014
To evaluate the use of potentially inappropriate medicines in elderly inpatients in a tertiary care teaching hospital. Retrospective analysis was performed for cases of elderly patients admitted between January 2010 and December 2010. Data on age, gender, diagnosis, duration of hospital stay, treatment, and outcome were collected. Prescriptions were assessed ...
Zhang S-H SH Department of Senile Disease, The Third Hospital of Hebei Medical University, Shijiazhuang, China. - - 2014
This study aimed to explore the possible mechanism of spironolactone in reduction of atrial fibrosis in elderly patients with atrial fibrillation. 67 patients with atrial fibrillation and 30 matching patients with sinus rhythm were included into this study, in which the former patients were randomly divided into the conventional treatment ...
Indra Tomáš T Third Department of Internal Medicine, General University Hospital, Prague, Czech Republic; and First Faculty of Medicine, Charles University, Prague, Czech Republic - - 2014
Primary aldosteronism (PA) represents the most common cause of secondary hypertension. Beyond increased blood pressure, additional harmful effects of aldosterone excess including inappropriate left ventricle (LV) hypertrophy were found. We evaluated the effect of adrenalectomy and spironolactone on blood pressure and myocardial remodelling in a long-term follow-up study. Thirty-one patients ...
Driscoll Andrea - - 2014
Beta-adrenergic blockade has been shown to improve left ventricular function, reduce hospital admissions and improve survival in chronic heart failure with reduced ejection fraction (HFrEF), with mortality reduction starting early after beta-adrenergic receptor blocker initiation and being dose-related. The aim of this pilot study was to determine the effectiveness of ...
Celtik Coskun C *Istanbul University, Istanbul Faculty of Medicine, Pediatric Gastroenterology and Hepatology †Sifa University, Faculty of Medicine, Pediatric Gastroenterology and Hepatology ‡Istanbul University, Istanbul Faculty of Medicine, Pediatric Cardiology §Bezm-i Alem University, Faculty of Medicine, Pediatric Gastroenterology and Hepatology ||Kocaeli University, Faculty of Medicine, Pediatric Gastroenterology and Hepatology ¶Selcuk University, Faculty of Medicine, Pediatric Gastroenterology and - - 2014
AIM:: Cirrhotic cardiomyopathy (CCMP) is a functional disorder characterized by electrophysiological disturbances, and diastolic and/or systolic dysfunction in patients with liver disease. This disorder is a well-defined entity in adults, but pediatric data are limited. Aim of the study is to determine the incidence, features and risk factors of CCMP ...
Adel Heba H Department of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, Minia, 61511, - - 2014
Endothelial dysfunction is a critical initiator for developing diabetic vascular complications. Substantial clinical and experimental evidence suggests that aldosterone plays a crucial role in its pathogenesis. The present study aimed to investigate the effect of the mineralocorticoid receptor (MR) blocker, spironolactone, on diabetes-associated endothelial dysfunction and address the underlying mechanism(s) ...
Gupta A A Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, - - 2014
We have previously shown rapid reversal of left ventricular hypertrophy (LVH) with 6 months of spironolactone therapy in patients with resistant hypertension (HTN), preserved left ventricular ejection fraction and no history of heart failure. In this substudy, we investigated the effect of mineralocorticoid receptor blockade with spironolactone on pre-clinical diastolic ...
Thomason J D JD Department of Veterinary Clinical Sciences, Veterinary Health Center, Kansas State University, 1800 Dension Ave., Manhattan, KS 66506, USA. Electronic address: - - 2014
The combination of an angiotensin-converting enzyme inhibitor (ACEI) with an aldosterone receptor antagonist can increase serum potassium and magnesium and lower serum sodium concentrations. The objective of this study was to retrospectively determine whether an ACEI and spironolactone can be co-administered to Doberman pinschers with occult dilated cardiomyopathy without serious ...
Queisser Nina N Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, - - 2014
Mineralocorticoid receptor blockers show antifibrotic potential in hepatic fibrosis. The mechanism of this protective effect is not known yet, although reactive oxygen species seem to play an important role. Here, we investigated the effects of elevated levels of aldosterone (Ald), the primary ligand of the mineralocorticoid receptor, on livers of ...
Yongsiri Somchai S Facutly of Medicine, Burapha University, Mueng Chonburi, - - 2014
The incidence of hypokalemia in continuous ambulatory peritoneal dialysis (CAPD) patients is about 15-60%, leading to significant complications. There is no standard treatment other than potassium supplement in this setting. The aim of this study was to evaluate effect of spironolactone 25 mg/day in CAPD patients who have a history of ...
D Almeida Karina Sm - - 2014
Although half of all patients with heart failure (HF) have a normal or near-normal ejection fraction and their prognosis differs little from that of patients with a reduced ejection fraction, the pathophysiology of HF with preserved ejection fraction (HF-PEF) is still poorly understood, and its management poorly supported by clinical ...
Liu Yan Y Department of Geriatrics, The First Hospital of Shijiazhuang City, Shijiazhuang, Hebei 050011, P.R. - - 2014
The aim of the present study was to investigate the effects of spironolactone and losartan on the early healing stage of acute myocardial infarction (AMI) in rats. An AMI rat model was established and the rats were randomly divided into four groups: AMI (n=12), AMI + spironolactone (AMI + S; ...
Pliquett Rainer U - - 2014
Cardiovascular comorbidities regularly determine renal function. We report a case of acute kidney injury (Acute Kidney Injury Network stage 3) due to an intermittent third-degree atrioventricular block, which had not been diagnosed before. A 76-year-old Caucasian man with liver cirrhosis due to non-alcoholic fatty liver disease, and type-2 diabetes was ...
Chen Ying Y Emergency Department, First Hospital of Hebei Medical University, Hebei Medical University, No. 89 Donggang Road, Shijiazhuang 050032, Hebei Province, - - 2014
The relationship between lipids and coronary artery disease has been well established. However, this is not the case between lipids and heart failure. Ironically, high lipid levels are associated with better outcomes in heart failure, but the mechanisms underlying the phenomenon are not fully understood. This study was performed to ...
Kim Soo-Han SH Division of Cardiology, Department of Internal Medicine, Inha University College of Medicine, Incheon, - - 2014
We report a case of hypersensitivity skin reaction to prasugrel. The patient exhibited a generalized skin rash after treatment with prasugrel, which was resolved after discontinuation of prasugrel and substitution to clopidogrel. Clopidogrel was successfully administered as an alternative to prasugrel without any signs of further hypersensitivity.
Guo Tong T Goodman Institute of Investment Management, John Molson School of Business, Concordia University, Montreal, Quebec, - - 2014
Pulmonary fibrosis is a progressive and irreversible disorder with no appropriate cure. A practical and effective experimental model that recapitulates the disease will greatly benefit the research community and, ultimately, patients. In this study, we tested the lung slice culture (LSC) system for its potential use in drug screening and ...
Sundaram Vinay - - 2014
Cirrhosis affects millions of people throughout the world. Two of the most serious complications of liver cirrhosis are ascites and spontaneous bacterial peritonitis (SBP). The development of ascites is related to the severity of portal hypertension and is an indicator of increased mortality. Although sodium restriction and diuretic therapy have ...
Ghosh Rajeshwary R Sinha Institute of Medical Science and Technology, Garia 700084, - - 2014
Currently, there is no specific medication for essential hypertension (EH), a major form of the condition, in man. As acetyl salicylic acid (aspirin) is reported to stimulate the synthesis of renal (r)-cortexin, an anti-essential hypertensive protein, and, as aspirin is reported to inhibit dermcidin isoform 2 (dermcidin), a causative protein ...
Hagag Philippe - - 2014
To compare the combination spironolactone-norgestimate-ethinyl estradiol in hirsutism with other protocols including the same dose of estrogen. In this open prospective study, 167 women with hirsutism due to polycystic ovary syndrome (PCOS) were randomly assigned to the following treatment protocols: Group A (n = 72): spironolactone 100 mg-norgestimate 250 mcg-ethinyl ...
Zhang Xin X Xin Zhang, Shu-Zhen Wang, Jun-Fu Zheng, Wen-Min Zhao, Peng Li, Chun-Lei Fan, Bing Li, Pei-Ling Dong, Lei Li, Hui-Guo Ding, Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Affiliated with Capital Medical University, Beijing 100069, - - 2014
To evaluate the efficacy and safety of tolvaptan to treat refractory ascites in decompensated liver cirrhosis patients with or without further complications, such as hepatorenal syndrome and/or hepatocellular carcinoma. Thirty-nine patients (mean age 55 years, males: 32) with decompensated liver cirrhosis and refractory ascites were enrolled. All patients received a ...
Chang Kyung Yoon KY Division of Nephrology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, - - 2014
Riester Anna A A Riester, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, - - 2014
Primary aldosteronism (PA) is the most common cause of secondary hypertension. In this review we discuss the diagnosis and management of PA during pregnancy based on the literature. As aldosterone and renin are physiologically increased during pregnancy and confirmation tests are not recommended, the diagnosis of PA during pregnancy relies ...
Magiera Sylwia S Department of Inorganic, Analytical Chemistry and Electrochemistry, Silesian University of Technology, 7 M. Strzody Str., 44-100, Gliwice, - - 2014
A novel analytical approach has been developed for the determination of selected drugs (milrinone, enalapril, carvedilol, spironolactone, acenocumarol, ticlopidine, cilazapril) and their metabolites (2-oxoticlopidine, cilazaprilat, canrenone, 5'-hydroxycarvedilol, O-desmethyl-carvedilol, enalaprilat) in human urine, based on a miniaturized extraction technique; semi-automatic microextraction by packed sorbent, using a new digitally controlled syringe, followed ...
Herold T R TR Department of Ophthalmology, University Eye Hospital - LMU, Campus Innenstadt, Klinikum der Universität München, Mathildenstrasse 8, D-80336, Munich, Germany, - - 2014
The pathogenesis of central serous chorioretinopathy (CSC) is still poorly understood. An animal model of CSC proved that the mineralocorticoid receptor [1] of the choroid also plays a role in CSC. Since there is still no evidence-based therapy for non-self-limiting CSC, this case series evaluates the effect of oral spironolactone ...
Haghighi Alireza - - 2014
BackgroundSengers syndrome is an autosomal recessive condition characterized by congenital cataract, hypertrophic cardiomyopathy, skeletal myopathy and lactic acidosis. Mutations in the acylglycerol kinase (AGK) gene have been recently described as the cause of Sengers syndrome in nine families.MethodsWe investigated the clinical and molecular features of Sengers syndrome in seven new ...
Simopoulos V V Department of Cardiovascular and Thoracic Surgery, University Hospital of Larissa Medical School, University of Thessaly, Larissa, - - 2014
Postoperative atrial fibrillation (POAF) is the most common arrhythmia after cardiac surgery. There exist consistent experimental and clinical data suggesting that aldosterone antagonists (AAs) may exert beneficial effects regarding electrical and structural remodeling in failing myocardium. Recently, eplerenone (EPL) has been found to reduce the incidence of nonsurgical AF when ...
Inder Warrick J WJ Department of Diabetes and Endocrinology and University of Queensland, Princess Alexandra Hospital, Brisbane, - - 2014
Addison's disease may be complicated by hypertension and less commonly by heart failure. We review the pathophysiology of the renin-angiotensin-aldosterone axis in Addison's disease and how this is altered in the setting of hypertension and heart failure. An essential first step in management in both conditions is optimising glucocorticoid replacement ...
Wei Lai L Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. - - 2014
Cirrhotic rats show higher expression levels of hepatic RhoA and Rho-kinase than normal healthy rats, and the activation of this signaling pathway leads to portal hypertension. Sodium ferulate (SF) has been shown to decrease the production of geranylgeranyl pyrophosphate (GGPP), a substance essential for RhoA activation. In the present study, ...
Garg Rajesh R Division of Endocrinology, Diabetes and - - 2014
Reduced coronary flow reserve (CFR), an indicator of coronary microvascular dysfunction, is seen in type 2 diabetes mellitus (T2DM) and predicts cardiac mortality. Since aldosterone plays a key role in vascular injury, the aim of this study was to determine whether mineralocorticoid receptor (MR) blockade improves CFR in individuals with ...
Narula Harmeet S HS Medical Service, Veterans Affairs Medical Center, 6900 Pecos Road, North Las Vegas, NV 89086, - - 2014
Gynaecomastia (enlargement of the male breast tissue) is a common finding in the general population. Most cases of gynaecomastia are benign and of cosmetic, rather than clinical, importance. However, the condition might cause local pain and tenderness, could occasionally be the result of a serious underlying illness or a medication, ...
Correia Lurdes L Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra e Faculdade de Medicina da Universidade de Coimbra, Portugal. Electronic address: - - 2014
Hyponatremia is common in older people, most often of multifactorial origin, and can be associated with poor clinical outcomes. The aim was to analyze the frequency of severe hyponatremia (sodium concentration below 125mmol/L), risk factors and mortality association in hospitalized older patients. A retrospective study was performed in older patients ...
Patel Kishan A - - 2014
Spironolactone is often used to treat hypertension caused by hyperaldosteronism, and as a result, can form concentrically laminated electron dense spironolactone body inclusions within the adrenal gland. Spironolactone bodies have not been investigated in a contemporary cohort or in patients treated with the more recently approved aldosterone antagonist, eplerenone. Spironolactone ...
Couraud Sébastien - - 2014
Two studies have reported statistically significant associations between the use of cardiac glycosides (CGs) and an increased risk of lung cancer. However, these studies had a number of methodological limitations. Thus, the objective of this study was to assess this association in a large population-based cohort of patients. We used ...
Dabare Panthihage Ruvini - - 2014
Access to medicines is a universal right. Low availability and low affordability of medicines are issues that deny this right to a significant proportion of the world population. The objective of this study was to determine the availability, price and affordability of essential medicines prescribed to treat non communicable diseases ...
Zhang Xiaolu X Department of pharmacology, Xi'an Jiaotong University School of Medicine, Xi'an 710061, - - 2014
Atherosclerosis is a chronic inflammatory disease in the vessel. As a representative inflammatory cytokine, C-reactive protein (CRP) participates in atherogenesis. Although hyperaldosteronism is known to evoke inflammatory response in several tissues and cell types, there is no direct evidence to demonstrate the proinflammatory effect of aldosterone on vascular smooth muscle ...
Persu Alexandre A Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium, - - 2014
After three years of excessive confidence, overoptimistic expectations and performance of 15 to 20,000 renal denervation procedures in Europe, the failure of a single well-designed US trial-Symplicity HTN-3-to meet its primary efficacy endpoint has cast doubt on renal denervation as a whole. The use of a sound methodology, including randomisation ...
Burch Druin D Public Library of Science, Cambridge, United - - 2014
Please see later in the article for the Editors' Summary.
Sarimehmetoglu Ayse Cennetlnce - - 2014
To demonstrate the presence and importance of apoptotic activity in heart failure during acute exacerbations and to investigate the effects of different drugs used and co-morbidities on levels of N-Terminal pro-Brain Natriuretic Peptide and apoptotic activity on admission and during hospitalisation. The descriptive study was conducted at the emergency department ...
McNeice Andrew H AH Craigavon Cardiac Centre, Southern Trust, Northern Ireland, BT63 5QQ, - - 2014
Multiple, potentially practice-changing cardiology trials have been presented or published over the past year. In this paper, we summarize and place in clinical context, new data regarding management of acute coronary syndrome and ST-elevation myocardial infarction (copeptin assessment, otamixaban, cangrelor, prasugrel, sodium nitrite, inclacumab, ranolazine, preventive coronary intervention of non-culprit ...
Ni Xiaoying X Department of Nephrology, People's Hospital of Yinzhou, College of Medicine, Ningbo University, Ningbo, - - 2014
The purpose of this study was to evaluate the effects of spironolactone on dialysis patients with refractory hypertension and possible adverse effects. This was a 12-week prospective, randomized, double-blind trial of 82 patients randomly assigned to 12-week treatment with 25 mg/d spironolactone or placebo as add-on therapy. Visits were scheduled at ...
Verbrugge Frederik H FH Department of Cardiology, Ziekenhuis Oost Limburg, Genk, Belgium; Doctoral School for Medicine and Life Sciences, Hasselt University, Diepenbeek, - - 2014
-The urinary composition including sodium (Na(+)) and chloride (Cl(-)) concentrations might provide useful information in addition to urine output during decongestive treatment in heart failure (HF). -Consecutive HF patients (n=61) with ejection fraction ≤45%, worsening symptoms, and scheduled treatment with intravenous loop diuretics were included. Patients received protocol driven therapy ...
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