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Bates N N Veterinary Poisons Information Service (VPIS), Medical Toxicology and Information Services, Mary Sheridan House, 13 St Thomas Street, London SE1 9RY, - - 2014
Benzalkonium chloride is commonly found in household products. This retrospective study examined 245 cases of feline exposure to benzalkonium chloride-containing products reported to the Veterinary Poisons Information Service (VPIS). A single route of exposure was reported in 188 cats (ingestion 126, skin 58, buccal 4); 57 cats had multiple routes. ...
Salem Hesham H Analytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th October City 11787, - - 2014
High-performance liquid chromatography (HPLC), ultra-performance liquid chromatography (UPLC) and rapid resolution liquid chromatographic (RRLC) methods have been developed and validated for the separation and quantitation of both or either of two ternary mixtures present in ophthalmic solutions. The first mixture contains chloramphenicol, dexamethasone sodium phosphate and tetryzoline HCl (TZH); while ...
Barabino Stefano S Clinica Oculistica, University of Genoa, via Siccardi 14, San Remo, 18038, Italy - - 2014
PURPOSE. To test the hypothesis that benzalkonium chloride (BAK) alters the ocular surface in normal and dry eye mice, and that a BAK-free commercially available anti-glaucoma treatment does not induce the same effects. METHODS. Eight to 12-week-old female C57BL6 mice were used in normal environmental conditions and in a controlled ...
Goldberg Ivan Am IA Discipline of Ophthalmology, University of Sydney, Sydney, Australia; Glaucoma Unit, Sydney Eye Hospital, Sydney, Australia; Eye Associates, Sydney, - - 2014
Ocular surface disease (OSD) is relatively common in glaucoma patients. OSD symptoms could be linked to prolonged exposure to preservatives in anti-glaucoma medications, especially benzalkonium chloride (BAK). The OBSERVE clinical audit was designed to track the impact of intraocular pressure lowering medications in patients with evidence of OSD to test ...
Guzmán Mauricio M Immunology, Institute of Experimental Medicine, National Academy of Medicine/CONICET, Pacheco de Melo 3081, Buenos Aires, C1425AUM, - - 2014
Purpose: To evaluate the role of nuclear factor kappa B (NF-κB) activation in eye drop preservative toxicity and the effect of topical NF-κB inhibitors on preservative-facilitated allergic conjunctivitis. Methods: Balb/c mice were instilled ovalbumin (OVA) combined with benzalkonium chloride (BAK) and/or NF-κB inhibitors in both eyes. After immunization, T cell ...
Sandle Tim T Head of Microbiology, Bio Products Laboratory, Elstree, Hertfordshire, United - - 2014
To determine the Minimum Inhibitory Concentrations (MIC) of a range of cleanroom fungi against three disinfectants common to the pharmaceutical and healthcare sectors: biguanide (Chlorhexidine) and two quaternary ammonium compounds (benzalkonium chloride and Cetrimide). The in vitro fungicidal activities of the three biocides were studied against 112 cleanroom fungal isolates ...
Xu Dongyang D College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, Guangdong, - - 2014
Phenotypic and genotypic tolerance in 71 Listeria monocytogenes isolates from different varieties of foods to benzalkonium chloride (BC) and cadmium were investigated by susceptibility test and molecular methods. To investigate the role of efflux pumps in BC tolerance, reserpine, an efflux pump inhibitor, was added to the BC tolerant strains. ...
Muankaew Chutimon C Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland; Faculty of Pharmacy, Siam University, 38 Petkasem Road, Phasicharoen, Bangkae, Bangkok 10160, - - 2014
In effort to prepare an eye drop formulation of irbesartan, the effect of γ-cyclodextrin complexation on irbesartan solubilization in aqueous solutions was investigated. The optimum cyclodextrin concentration for formation of irbesartan/cyclodextrin inclusion complex was found to be 10% (w/v) and the solubility of ionized irbesartan/γ-cyclodextrin complex (at pH 7.2) was ...
Ortiz Sagrario S Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, - - 2014
Disinfectants, such as benzalkonium chloride (BAC), are commonly used to control Listeria monocytogenes and other pathogens in food processing plants. Prior studies have demonstrated that the resistance to BAC of L. monocytogenes was associated with the prolonged survival of three strains of molecular serotype 1/2a in an Iberian pork processing ...
Salem Hesham H Analytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 11787 6th October City, - - 2014
This work represents a comparative study of different aspects of manipulating ratio spectra, which are: double divisor ratio spectra derivative (DR-DD), area under curve of derivative ratio (DR-AUC) and its novel approach, namely area under the curve correction method (AUCCM) applied for overlapped spectra; successive derivative of ratio spectra (SDR) ...
Lin Zhirong Z Eye institute & affiliated Xiamen Eye Center of Xiamen University, Xiamen, 361005, - - 2014
PURPOSE. To investigate the effects and possible mechanisms of serine protease inhibitor A3K (SERPINA3K) on the formation of ocular surface squamous metaplasia in a mouse dry eye model induced by topical benzalkonium chloride (BAC). METHODS. The eye drops containing SERPINA3K were topically administered during the induction of BAC-induced dry eye. ...
Guzman-Aranguez Ana A Department of Biochemistry and Molecular Biology IV, Faculty of Optics and Optometry, Universidad Complutense de Madrid , Madrid, Spain - - 2014
Abstract Purpose: Treatment with topical eye drops for long-standing ocular diseases like allergy can induce detrimental side effects. The purpose of this study was to investigate in vitro cytotoxicity of commercially preserved and unpreserved anti-allergic eye drops on the viability and barrier function of monolayer and stratified human corneal-limbal epithelial ...
Wagner Justin P JP Department of Surgery, Division of Pediatric Surgery, University of California, Los Angeles, Los Angeles, CA 90095-1749, USA. Electronic address: - - 2014
Hirschsprung's disease is characterized by a developmental arrest of neural crest cell migration, causing distal aganglionosis. Transplanted cells derived from the neural crest may regenerate enteric ganglia in this condition. We investigated the potential of skin-derived precursor cells (SKPs) to engraft and to differentiate into enteric ganglia in aganglionic rat ...
Chen Li-Hong LH Department of Molecular Biology, University of Wyoming, Laramie, Wyoming, United States of - - 2014
We characterized key components and major targets of the c-di-GMP signaling pathways in the foodborne pathogen Listeria monocytogenes, identified a new c-di-GMP-inducible exopolysaccharide responsible for motility inhibition, cell aggregation, and enhanced tolerance to disinfectants and desiccation, and provided first insights into the role of c-di-GMP signaling in listerial virulence. Genome-wide ...
Lim Hong-Gook HG Xenotransplantation Research Center, Seoul National University Hospital Clinical Research Institute ; Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of - - 2014
A preclinical study was conducted for evaluating a valved conduit manufactured with a glutaraldehyde (GA)-fixed bovine pericardium treated using an anticalcification protocol. Bovine pericardia were decellularized, fixed with GA in an organic solvent, and detoxified. We prepared a valved conduit using these bovine pericardia and a specially designed mold. The ...
Chang Caitlin C Department of Ophthalmology, The University of Western Ontario, 339 Windermere Road, London ON, N6A 5A5, - - 2014
Benzalkonium chloride (BAK) is a controversial ophthalmic preservative because of its prominent side effect profile. In this study, we examined the mechanism of BAK toxicity in human trabecular meshwork cells (HTMC) and compared the effects of BAK to tafluprost free acid, which is an active form of tafluprost commercially available ...
Pletzer Daniel - - 2014
The Gram-negative bacterium Erwinia amylovora is the causal agent of the devastating disease fire blight in rosaceous plants such as apple, pear, quince, raspberry, and cotoneaster. In order to survive and multiply in a host, microbes must be able to circumvent the toxic effects of antimicrobial plant compounds, such as ...
Dubey Akhilesh A Research Scholar, Department of Pharmaceutics, Bhagwant University, Ajmer, Rajasthan, - - 2014
Stimuli-sensitive hydrogels are hydrophilic, three-dimensional, polymeric network structure capable of imbibing large amounts of water or biological fluids on stimulation, such as pH, temperature, and ionic change. Owing to the drawback of conventional therapy for ocular delivery, and to provide additive effect on intraocular pressure (IOP) reduction, stimuli sensitive hydrogel ...
Jiao Jian J Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, and Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, - - 2014
Background: The aim of this study was to investigate the effect of the corticosteroids, the antihistamines, and the preservatives benzalkonium chloride (BKC) and potassium sorbate (PS) in intranasal medications on human nasal epithelial ciliary beat frequency (CBF). Methods: Primary ciliated epithelial cell cultures from the human nasal mucosa of chronic ...
Oh Seungdae S School of Civil and Environmental - - 2014
Benzalkonium chlorides (BACs) are disinfectants widely used in a variety of clinical and environmental settings to prevent microbial infections, and are frequently detected in non-target environments such as aquatic and engineered biological systems, even at toxic levels. Therefore, microbial degradation of BACs has important ramifications for alleviating disinfectant toxicity in ...
Dutta Vikrant V Departments of Food, Bioprocessing and Nutrition Sciences - - 2014
The enzyme triphenylmethane reductase (TMR) reduces toxic triphenylmethane dyes into colorless, non-toxic derivatives, and TMR-producing microorganisms have been proposed as bioremediation tools. Analysis of the genome of Listeria monocytogenes H7858 (1998-1999 hot dog outbreak) revealed that the plasmid (pLM80) of this strain harboring a gene cassette (bcrABC) conferring resistance to ...
Wagner Justin P JP Department of Surgery, University of California, Los Angeles, Los Angeles, - - 2014
Enteric neuromuscular disease is a characteristic of several disease states, including Hirschsprung disease, esophageal achalasia, Chagas disease, and gastroparesis. Medical therapy for these conditions is limited, and surgical intervention may incur significant morbidity. Alternatively, transplantation of neural progenitor cells may regenerate enteric ganglia. Existing aganglionosis model systems are limited by ...
Konstas Anastasios G P AG 1st University Department of Ophthalmology, Aristotle University of Thessaloniki, 1 Kyriakidi Street, 546 36, Thessaloniki, Greece, - - 2014
To compare the 24-h intraocular pressure (IOP) control and tolerability of travoprost/timolol benzalkonium chloride (BAK)-free (TTFC) vs. latanoprost/timolol fixed combination preserved with BAK (LTFC) in open-angle glaucoma patients insufficiently controlled with latanoprost 0.005% monotherapy given once in the evening. The authors have conducted a prospective, observer-masked, active-controlled, cross-over, comparison study. ...
Torricelli Andre A M AA Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio; University of Sao Paulo, Sao Paulo, - - 2014
Studies suggest that standard corneal collagen crosslinking (CXL) is a safe and effective treatment to stiffen the cornea for keratoconus and other ectatic corneal disorders. The purpose of the present study was to compare the biomechanical effects of transepithelial benzalkonium chloride-EDTA (BAC-EDTA) riboflavin-UVA crosslinking to standard epithelium-off riboflavin-UVA crosslinking in ...
Caballero A A Department of Microbiology, University of Mississippi Medical Center , Jackson, Mississippi , USA - - 2014
Abstract Purpose: To investigate the effectiveness of a high-affinity human monoclonal antibody Fab fragment to Staphylococcus aureus alpha-toxin (LTM14 Fab) as therapy for S. aureus keratitis. Methods: A single topical drop of the LTM14 Fab antibody to alpha-toxin alone, or in 0.006% benzalkonium chloride (BAK), was applied every 30 min to ...
Sezgin Akçay Betül İlkay BI 1 Umraniye Research and Training Hospital , Eye Clinic, İstanbul, Turkey - - 2014
Abstract Purpose: To compare the toxicity effect of polyquaternium (PQ) and benzalkonium chloride (BAK) preservation of travoprost on the ocular surface. Methods: This prospective study included 44 eyes of 44 patients with newly diagnosed glaucoma. Twenty-two patients used PQ-preserved travoprost (PQ group) and 22 patients used BAK-preserved travoprost (BAK group). ...
Huang Chaoyang - - 2014
Human cytomegalovirus (HCMV) causes serious HCMV-related diseases in immunocompromised people. Vaccination is the most effective measure to control infection with the pathogen, yet no vaccine has been licensed till now. We performed a head-to-head comparison of the protective abilities of multiple DNA vaccines in murine model of murine cytomegalovirus (MCMV) ...
Sanford Mark M Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand, - - 2014
Latanoprost is an ester prodrug prostaglandin F2α analogue that is a selective agonist of endogenous prostanoid FP receptors and that reduces intraocular pressure (IOP) by increasing the uveoscleral outflow of aqueous humour. Preservative-free (PF) latanoprost [Monoprost(®)] is a new formulation of latanoprost that is approved for use in the EU ...
Kim Bryan Y BY University of Illinois Eye and Ear Infirmary, Chicago, - - 2014
To describe the clinical features and management strategies in patients whose limbal stem cell (LSC) disease reversed with medical therapy. Retrospective case series. Twenty-two eyes of 15 patients seen at 3 tertiary referral centers between 2007 and 2011 with 3 months or more of follow-up. Medical records of patients with ...
Wang Shaojuan S Department of Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China ; Department of Gynecology, Maternity and Child Healthcare Hospital, Shenzhen, Guangdong 518172, P.R. - - 2014
Pregnancy is associated with complex immunoreactions. In the present study, the effect of SB-273005, an antagonist of αvβ3 integrin, on the alterations of T helper (Th) cells and their derived cytokines that occur during pregnancy was investigated in mice. Five non-pregnant mice were used as a negative control. Mice were ...
Oğuz Merve M Erciyes University Engineering Faculty Environmental Engineering Department, 38039 Kayseri, Turkey. Electronic address: - - 2014
In this study, environmental risks of selected pharmaceuticals were investigated to assess potential hazards. Ciprofloxacin, Clarithromycin, Cefuroxime axetil, antibiotics, Benzalkoniuman antiseptic, Paracetamol, an analgesic, and Naproxen, an anti-inflammatory, were selected due to their high rate of usage in Turkey. Ciprofloxacin was found to have the highest risk due to its ...
Sunada Atsuko A Department of Medical Technology, Osaka University Hospital, Osaka, Japan; Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan. Electronic address: - - 2014
To evaluate the effectiveness of topical agents for the treatment of Acanthamoeba keratitis (AK). Laboratory research. Fifty-six Acanthamoeba isolates from 56 patients with clinically proven AK were studied. The effectiveness of 7 agents against Acanthamoeba cysts was determined in vitro. The agents were 1.0% povidone-iodine, 0.05% benzalkonium chloride (BZC), 0.02% chlorhexidine ...
Reichel Mirja - - 2014
Worldwide, the emergence of multidrug-resistant gram-negative bacteria is a clinical problem. Surface disinfectant cleaners (SDCs) that are effective against these bacteria are needed for use in high risk areas around patients and on multi-touch surfaces. We determined the efficacy of several SDCs against clinically relevant bacterial species with and without ...
Ghasemzadeh-Moghaddam Hamed H 1 Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia , Serdang, Malaysia - - 2014
The prevalence and spread of mupirocin and antiseptic resistance among colonizing and infectious Staphylococcus aureus were determined. S. aureus isolated from anterior nares and infection sites of patients hospitalized in the largest tertiary care referral hospital in Malaysia was investigated for mupirocin and antiseptic susceptibility testing, and for PCR detection ...
Labbé Antoine A Department of Ophthalmology, Quinze-Vingts National Ophthalmology Hospital, Paris and Ambroise Paré Hospital , AP-HP, Boulogne-Billancourt , France - - 2014
Abstract Objective: To analyze the effect of preserved antiglaucoma eye drops on the expression of extracellular matrix (ECM) metalloproteinase inducer (EMMPRIN) in conjunctival epithelial cells. Methods: A total of 18 patients treated for primary open-angle glaucoma with benzalkonium chloride (BAK) preserved eye drops and eight age-matched controls were included in ...
Oguz Ahmet Serra S Medipol University, Faculty of Dentistry, Department of Prosthodontics , - - 2014
Abstract Objective. The clinical survival rates of the adhesive restorations are limited due to the deterioration of resin-dentin bonds over time, partly due to the endogenous enzymatic activity of dentin. Recently, benzalkonium chloride (BAC) has been shown to effectively inhibit endogenous protease activity of dentin. This study evaluated the effect ...
Saleh Sarah S SS Analytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 11787 6th October City, Egypt. Electronic address: - - 2014
This work represents a comparative study of a novel progressive spectrophotometric resolution technique namely, amplitude center method (ACM), versus the well-established successive spectrophotometric resolution techniques namely; successive derivative subtraction (SDS); successive derivative of ratio spectra (SDR) and mean centering of ratio spectra (MCR). All the proposed spectrophotometric techniques consist of ...
Roberti Gloria G Istituto di Ricerca e Cura a Carattere Scientifico Fondazione GB Bietti, Via Livenza 3, 00198, Rome, - - 2014
Purpose: To study the neuroprotective effect of topical citicoline . Materials and Methods: Experimental phase to evaluate the ability of citicoline eye drops to reach the vitreous and the retina: The right eyes of 5 mice CD1 were treated with two drops per day for three days of citicoline 1% ...
Sharma Sunanda S Department of Prosthodontics, Maulana Azad Institute of Dental Sciences, New Delhi, - - 2014
Injury of the head and neck region can result in substantial morbidity. Comprehensive management of such patients requires team work of several specialties, including dentists. A young female patient with extensive loss of cranium and associated pathological chewing was referred to the dental department. The lost cranium was replaced by ...
Araújo Paula A PA a LEPABE, Faculty of Engineering, Department of Chemical Engineering , University of Porto , Porto , - - 2014
The penetration ability of 12 antimicrobial agents, including antibiotics and biocides, was determined against biofilms of B. cereus and P. fluorescens using a colony biofilm assay. The surfactants benzalkonium chloride (BAC) and cetyltrimethyl ammonium bromide (CTAB), and the antibiotics ciprofloxacin and streptomycin were of interest due to their distinct activities. ...
Riva Ivano I *Centre for the Study of Glaucoma, University of Brescia, Brescia ‡Laboratory of Clinical Research, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Milano ∥DSCMT, University of Tor Vergata, Rome, Italy †Ophthalmology Department, University of Ioannina, Ioannina §Glaucoma Unit, 1st University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, - - 2014
The aim of the study was to evaluate the long-term 24-hour intraocular pressure (IOP) efficacy of travoprost monotherapy in primary open-angle glaucoma patients. A total of 36 previously untreated primary open-angle glaucoma patients were enrolled in this 5-year study. Patients underwent an untreated 24-hour IOP evaluation. Subsequently all patients were ...
McCanna David Joseph DJ School of Optometry and Vision Science, Centre for Contact Lens Research, University of Waterloo , Waterloo, Ontario , Canada - - 2014
Abstract Macrophages play an important role in the elimination of infections, the removal of debris and in tissue repair after infection and trauma. In vitro models that assess ocular biomaterials for toxicity typically focus on the effects of these materials on epithelial or fibroblast cells. This investigation evaluated known ocular ...
Ebrahimi Azizollah A School of Veterinary Science, Shahrekord University, Shahrekord, IR - - 2014
To study chlorhexidine digluconate disinfectant effects on planktonic growth and biofilm formation in some bacterial field isolates from animals. The current study investigated chlorhexidine digluconate effects on planktonic growth and biofilm formation in some field isolates of veterinary bacterial pathogens. Forty clinical isolates of Escherichia coli, Salmonella serotypes, Staphylococcus. aureus ...
Zhang Zhen Z Eye Institute of Xiamen University, Xiamen, 361102, - - 2014
Purpose. To investigate the therapeutic effects and underlying mechanisms of topical doxycycline in a benzalkonium chloride (BAC)-induced mouse dry eye model. Methods. Eye drops containing 0.025%, 0.1% doxycycline or solvent were administered to a BAC-induced dry eye model four times daily. The clinical evaluations including tear break-up time (BUT), fluorescein ...
Lee Sangmi S Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina, - - 2014
Listeria monocytogenes can cause severe foodborne disease (listeriosis). Numerous outbreaks have involved three serotype 4b epidemic clones (ECs): ECI, ECII and ECIa. However, little is known about the population structure of L. monocytogenes serotype 4b from sporadic listeriosis in the United States, even though most cases of human listeriosis are ...
Mahzounieh Mohammadreza M Department of Pathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, IR - - 2014
Quaternary ammonium compounds (QAC), which contain benzalkonium chloride as the most widely used agent, are employed as wound and skin antiseptics, as well as disinfectants in hospitals. The resistance mechanism to disinfectants is usually determine by genes which are related to resistance to quaternary ammonium compounds, namely, qacE, qacΔE1, qacΔE1 ...
Park Seong Bin SB Lab. of aquatic animal Diseases, Research Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju, 660-701, South - - 2014
The olive flounder, Paralichthys olivaceus, is an economically important food fish in Japan and Korea. Scuticociliatosis is a major parasitic disease, and fatal infection with scuticociliates, or mixed infections with scuticociliates and other pathogenic agents (e.g., Vibrio spp.) cause severe mortalities in farmed olive flounders. To date, however, effective chemotherapeutic ...
Passariello Claudio C Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, - - 2014
This work investigated the antibacterial activity of 14 bonding agents to predict their ability to inhibit white-spot development during orthodontic treatment. Standardized, sterilized disks of each material were continuously rinsed (for up to 180 d) in a flow of sterile saline. At predetermined time points, the residual ability of each material ...
Huang Caihong C Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, - - 2014
Benzalkonium chloride (BAC) is the most commonly used preservative in ophthalmic preparations.So far large bodies of clinical and experimental studies have shown that use of topical drugs containing BAC can induce a series of ocular surface diseases, such as apoptosis.However, recently, some clinical studies have shown that ocular toxicity in ...
Elkassas Dina Wafik DW Department of Operative Dentistry, Faculty of Oral and Dental Medicine, Misr International University, Cairo, - - 2014
This study was carried out to examine the effect of application of four different disinfecting agents on the micro-shear bond strength (μ-SBS) of an etch-and-rinse and self-etch adhesive systems. One hundred flat dentin surfaces of human molars were produced by wet grinding the buccal surfaces. Specimens were randomly assigned to ...
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