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Zhang Zhen Z Eye Institute of Xiamen University, Xiamen, 361102, - - 2014
Purpose. To investigate the therapeutic effects and underlying mechanisms of topical doxycycline in a benzalkonium chloride (BAC)-induced mouse dry eye model. Methods. Eye drops containing 0.025%, 0.1% doxycycline or solvent were administered to a BAC-induced dry eye model four times daily. The clinical evaluations including tear break-up time (BUT), fluorescein ...
Lee Sangmi S Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina, - - 2014
Listeria monocytogenes can cause severe foodborne disease (listeriosis). Numerous outbreaks have involved three serotype 4b epidemic clones (ECs): ECI, ECII and ECIa. However, little is known about the population structure of L. monocytogenes serotype 4b from sporadic listeriosis in the United States, even though most cases of human listeriosis are ...
Park Seong Bin SB Lab. of aquatic animal Diseases, Research Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju, 660-701, South - - 2014
The olive flounder, Paralichthys olivaceus, is an economically important food fish in Japan and Korea. Scuticociliatosis is a major parasitic disease, and fatal infection with scuticociliates, or mixed infections with scuticociliates and other pathogenic agents (e.g., Vibrio spp.) cause severe mortalities in farmed olive flounders. To date, however, effective chemotherapeutic ...
Passariello Claudio C Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, - - 2014
This work investigated the antibacterial activity of 14 bonding agents to predict their ability to inhibit white-spot development during orthodontic treatment. Standardized, sterilized disks of each material were continuously rinsed (for up to 180 d) in a flow of sterile saline. At predetermined time points, the residual ability of each material ...
Nemoto Manabu M Epizootic Research Center, Equine Research Institute, Japan Racing - - 2014
Although many disinfectants are commercially available in the veterinary field, information on the virucidal effects of disinfectants against equine group A rotavirus (RVA) is limited. We evaluated the performance of commercially available disinfectants against equine RVA. Chlorine- and iodine-based disinfectants showed virucidal effects, but these were reduced by the presence ...
Hsiao Meng-Hsuan MH Department of Materials Science and Engineering, National Chiao Tung University, 1001 Ta-Hseuh Road, Hsinchu City, Taiwan 300, - - 2014
Hydrogels composed of assembled colloids is a material class that currently receives much interest and shows great promise for use in biomedical applications. This emerging material class presents unique properties derived from the combination of nano-sized domains in the form of colloidal particles with a continuous gel network and an ...
Ortiz Sagrario S 1 National Institute for Agricultural and Food Research and Technology (INIA) , Madrid, Spain - - 2014
Abstract This study aimed to investigate whether Listeria monocytogenes strains with resistance to a commonly used biocide display any cross-resistance to antibiotics. Using pulsed-field gel electrophoresis (PFGE), 29 different PFGE types were previously identified in an Iberian pig abattoir and processing plant. Only three PFGE types were resistant to benzalkonium ...
Abe Ricardo Yuji RY Department of Ophthalmology, University of Campinas , Campinas, Brazil - - 2014
Abstract Purpose: To evaluate the effects of benzalkonium chloride (BAK) on the blood-aqueous (BAB) and blood-retinal barriers (BRB) of pseudophakic eyes. Methods: Prospective, randomized, investigator-masked, comparative study. Patients were randomly assigned to preservative-free artificial tears or BAK-preserved artificial tears. One drop of artificial tears was instilled 4 times a day ...
Ciralsky Jessica B JB Department of Ophthalmology, Weill Cornell Medical College, New York -Presbyterian , New York, NY , - - 2014
Abstract Purpose: To evaluate continuous wear of a fluid-ventilated, gas-permeable scleral PROSE device using a standardized protocol as treatment for refractory persistent corneal epithelial defects in patients with severe ocular surface disease. Methods: Retrospective review of eight eyes of seven consecutive patients with persistent epithelial defects refractory to traditional therapies. ...
Song Jong Suk JS Department of Ophthalmology, Korea University College of Medicine, Seoul, - - 2014
To assess current practice patterns for dry eye patients in South Korea and to evaluate the preference according to the ages and clinic types of physicians. Dry eye patients (n = 1,612) were enrolled in this multicenter cross-sectional, observational study. The severity level of dry eye patients was classified based ...
Marsovszky László L Department of Ophthalmology, Semmelweis University Budapest, Mária u. 39, 1085, Budapest, Hungary, - - 2014
The recently developed confocal cornea microscopy offers the opportunity to examine pathologies of the cornea and to gain insight into the activity of innate immunity. We aimed to investigate the corneal epithelial and Langerhans cell (LC) densities along with dry eye parameters in primary open-angle glaucoma (POAG) subjects, treated with ...
Onizuka Naoko N *Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; and †Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, - - 2014
The aim of this study was to examine the ophthalmic additives responsible for modulating acute corneal epithelial toxicity induced by benzalkonium chloride (BAC) and investigate the ability of polyoxyethylene hydrogenated castor oil 40 (HCO-40) and polysorbate 80 (PS-80) to reduce the corneal toxicity and antimicrobial effects of BAC. Cytotoxicity of ...
Sinobad Tamara - - 2014
Dimensional stability and accuracy of an impression after chemical disinfection by immersion in disinfectants are crucial for the accuracy of final prosthetic restorations. The aim of this study was to assess the deformation of addition and condensation silicone impressions after disinfection in antimicrobial solutions. A total of 120 impressions were ...
He Guixin G University of Massachusetts - - 2014
We isolated a total of 653 strains from 64 community environmental samples in Massachusetts, United States (US). Among these isolates, 9.65% (63 strains) were benzalkonium chloride (BC) resistant Staphylococci. Also, all BC resistant strains were collected from surfaces upon which antibacterial wipes or antibacterial sprays containing 0.02% to 0.12% BC ...
Kumagami Takeshi T 1 Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University , Nagasaki, Japan - - 2014
Abstract Purpose: The benzalkonium chloride (BAK) content of tafluprost ophthalmic solution (Tapros(®): tafluprost) has been reduced to balance corneal safety and preservative effectiveness (old formulation: 0.01%; new formulation: 0.001%). However, no reports have been published on its clinical effect. Therefore, we conducted a clinical research study to compare the safety ...
Jahid Iqbal Kabir IK 1 School of Food Science and Technology, Chung-Ang University , Kyunggido, South Korea - - 2014
Abstract The present article focuses on the inactivation kinetics of various disinfectants including ethanol, sodium hypochlorite, hydrogen peroxide, peracetic acid, and benzalkonium chloride against Aeromonas hydrophila biofilms and planktonic cells. Efficacy was determined by viable plate count and compared using a modified Weibull model. The removal of the biofilms matrix ...
Iester Michele M Laboratorio clinico anatomo-funzionale per la diagnosi e il trattamento del glaucoma e della malattie neurooftalmologiche, Clinica Oculistica, DiNOGMI, University of Genoa, Genoa, - - 2014
Aim: To investigate and compare the effects of topical benzalkonium chloride-preserved prostaglandins (PGAs) on the ocular surface in patients with primary open-angle glaucoma before and after 3 months of treatment with additional 0.5% preservative-free tamarind seed polysaccharide single-dose eyedrops (TSP®, Oftagen, Pisa, Italy). Methods: This was a prospective, longitudinal, multicenter ...
Lotfy Hayam Mahmoud HM Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt. Electronic address: - - 2014
Two smart and novel spectrophotometric methods namely; absorbance subtraction (AS) and amplitude modulation (AM) were developed and validated for the determination of a binary mixture of timolol maleate (TIM) and dorzolamide hydrochloride (DOR) in presence of benzalkonium chloride without prior separation, using unified regression equation. Additionally, simple, specific, accurate and ...
Lotfy Hayam M HM Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, 11562 Cairo, - - 2014
This work represents the application of the isosbestic points present in different absorption spectra. Three novel spectrophotometric methods were developed, the first method is the absorption subtraction method (AS) utilizing the isosbestic point in zero-order absorption spectra; the second method is the amplitude modulation method (AM) utilizing the isosbestic point ...
Boost Maureen V MV *DPhil, FIBMS †BSc, MLT ‡MD §PhD, FAAO Department of Health Technology and Informatics (MVB, JC), and School of Optometry (G-sS, PC), The Hong Kong Polytechnic University, Hong Kong SAR, - - 2014
Acinetobacter has low virulence but causes infections in subjects with reduced immunity. It has been reported in ocular infections including those of patients using contact lenses. Treatment is difficult because Acinetobacter is frequently multidrug resistant. Antibiotic-resistant strains frequently also harbor genes for antiseptic resistance (quaternary ammonium compound [QAC]) genes. Because ...
Beyazyıldız Emrullah E 1 Department of Ophthalmology, Gazi Mustafa Kemal State Hospital , Ankara, Turkey - - 2014
Abstract Purpose: The aim of the current study is to compare the effects of two corticosteroids, prednisolone acetate 1% (PA) and loteprednol etabonate 0.5% (LE), for the treatment of benzalkonium chloride (BAC)-induced dry eye syndrome (DES) in rats. Methods: DES was established by topical administration of 0.2% BAC, a commonly ...
Darshan D D DD Department of Oral Medicine & Radiology, K V G Dental College & Hospital, Sullia, Karnataka, - - 2014
Background: To evaluate the efficacy of topical antiinflammatory agent (amlexanox 5%), along with topical antiseptic, analgesic, and anesthetic agent (benzalkonium chloride 0.01%, choline salicylate 8.7% and lidocaine hydrochloride 2%), in promoting ulcer healing, decreasing ulcer size, erythema, pain and recurrence in minor RAS. Materials & Methods: A randomized control trial ...
Ong Kee-Hean KH a Saint Louis University College for Public Health and Social Justice , St. Louis , MO , - - 2014
ABSTRACT Carpet is known to be a reservoir for biological contaminants, such as dust mites, dust mite allergen, and mold, if it is not kept clean. The accumulation of these contaminants in carpet might trigger allergies or asthma symptoms in both children and adults. The purpose of this study is ...
Heimbuch Brian K BK Applied Research Associates, Panama City, FL. Electronic address: - - 2014
Decontamination, cleaning, and reuse of filtering facepiece respirators (FFRs) has been proposed to mitigate an acute FFR shortage during a public health emergency. Our study evaluates the ability of commercially available wipe products to clean FFRs contaminated with either infectious or noninfectious aerosols. Three models of surgical N95 FFRs were ...
Morrissey Ian I Quotient Bioresearch, Fordham, United - - 2014
To date there are no clear criteria to determine whether a microbe is susceptible to biocides or not. As a starting point for distinguishing between wild-type and resistant organisms, we set out to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) distributions for four common biocides; triclosan, ...
Ramos Pablo Ivan - - 2014
Klebsiella pneumoniae is an important opportunistic pathogen associated with nosocomial and community-acquired infections. A wide repertoire of virulence and antimicrobial resistance genes is present in K. pneumoniae genomes, which can constitute extra challenges in the treatment of infections caused by some strains. K. pneumoniae Kp13 is a multidrug-resistant strain responsible ...
Kampf Günter - - 2014
Reusable surface disinfectant tissue dispensers are used in hospitals in many countries because they allow immediate access to pre-soaked tissues for targeted surface decontamination. On the other hand disinfectant solutions with some active ingredients may get contaminated and cause outbreaks. We determined the frequency of contaminated surface disinfectant solutions in ...
Pletzer Daniel - - 2014
Multidrug efflux pumps are membrane translocases that have the ability to extrude a variety of structurally unrelated compounds from the cell. AcrD, a resistance-nodulation-cell division (RND) transporter, was shown to be involved in efflux of highly hydrophilic aminoglycosides and a limited number of amphiphilic compounds in E. coli. Here, a ...
Nagai Noriaki N Faculty of Pharmacy, Kinki - - 2014
We prepared ophthalmic formulations containing 0.5% tranilast (TL) nanoparticles using 0.005% benzalkonium chloride (BAC), 0.5% D-mannitol, and 2-hydroxypropyl-β-cyclodextrin (HPβCD), and investigated their usefulness in the ophthalmologic field by evaluating corneal toxicity and permeability. TL nanoparticles were prepared using zirconia beads and Bead Smash 12, which allowed the preparation of high ...
Paniagua-Contreras Gloria Luz - - 2014
Methicillin-resistant Staphylococcus aureus (MRSA) are clinically relevant pathogens that cause severe catheter-related nosocomial infections driven by several virulence factors. We implemented a novel model of infection in vitro of reconstituted human epithelium (RHE) to analyze the expression patterns of virulence genes in 21 MRSA strains isolated from catheter-related infections in ...
Feng Mary M MM Department of Ophthalmology, Western University , London, Ontario , Canada - - 2014
Abstract Purpose: Benzalkonium chloride (BAK) is the most commonly found preservative in eye drops, and has been shown to cause ocular surface inflammation and toxicity. Lacritin is a human tear glycoprotein secreted from the lacrimal glands that has been found to be cytoprotective. This study was designed to determine if ...
Sakata Rei R Department of Ophthalmology, Tokyo Metropolitan Geriatric Hospital, University of Tokyo, 35-2, Sakaecho, Itabashi, Tokyo, 173-0015, Japan, - - 2014
Deepening of the upper eyelid sulcus (DUES), one symptom of prostaglandin-associated periorbitopathy, was recently found to be an additional side effect of prostaglandin-related ophthalmic solutions. Here, we prospectively investigated the incidence and factors associated with DUES in Japanese open-angle glaucoma patients initially treated with benzalkonium chloride (BAK)-preserved tafluprost (TAF). In ...
Han Kyung Eun KE Department of Ophthalmology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. - - 2014
Purpose: To compare the epithelial wound healing response of two preservative-free fluoroquinolones, moxifloxacin and levofloxacin, in patients who underwent cataract surgery. Materials and Methods: In this prospective, evaluator-masked, randomized clinical trial, 59 eyes of 50 patients who underwent cataract surgery were enrolled. Patients were randomized to receive moxifloxacin 0.5% (n=32 ...
Lee Ji Hwan JH Vision Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. - - 2014
Purpose: To evaluate changes in clinical outcomes, inflammatory cytokine levels, and tear osmolarity in the tears of patients with moderate to severe dry eye syndrome before and after the application of topical 1% methylprednisolone. Materials and Methods: Thirty-two patients with moderate to severe dry eye unresponsive to previous aqueous enhancement ...
Morita Yuji Y Department of Microbiology, School of Pharmacy, Aichi Gakuin University, Nagoya - - 2014
Infections caused by Pseudomonas aeruginosa often are hard to treat; inappropriate chemotherapy readily selects multidrug-resistant P. aeruginosa. This organism can be exposed to a wide range of concentrations of antimicrobials during treatment; learning more about the responses of P. aeruginosa to antimicrobials is therefore important. We review here responses of ...
McElgunn Cathal J CJ Lumora Ltd, Ely, Cambridgeshire, United - - 2014
Here we describe a method for the detection of Clostridium difficile from stool using a novel low-complexity and rapid extraction process called Heat Elution (HE). The HE method is two-step and takes just 10 minutes, no specialist instruments are required and there is minimal hands-on time. A test method using ...
Bakkar May M MM Eurolens Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom ; Medical Device Biology Group, Faculty of Life Sciences, The University of Manchester, Manchester, United - - 2014
Clinical examination of the ocular surface is commonly carried out after application of sodium fluorescein in both veterinary and medical practice by assessing the resulting 'staining'. Although localized intensely stained regions of the cornea frequently occur after exposure to 'adverse' clinical stimuli, the cell biology underlying this staining is unknown, ...
Ikegami Masaru M Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo, - - 2014
Fear memory is critical for animals to trigger behavioural adaptive responses to potentially threatening stimuli, while too much or inappropriate fear may cause psychiatric problems. Numerous studies have shown that the amygdala, hippocampus and medial prefrontal cortex play important roles in Pavlovian fear conditioning. Recently, we showed that striatal neurons ...
Lin Hui H Eye Institute of Xiamen University, Xiamen, Fujian, China ; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, - - 2014
There are several animal models illustrating dry eye pathophysiology. Current study would like to establish an ex vivo tissue culture model for characterizing dry eye. Human conjunctival explants were cultured under airlift or submerged conditions for up to 2 weeks, and only airlifted conjunctival cultures underwent increased epithelial stratification. Starting ...
Olkowska Ewa E Chemical Faculty, Gdansk University of Technology, G. Narutowicza 11/12 Street, 80-233 Gdansk, - - 2014
Due to the specific structure of surfactants molecules they are applied in different areas of human activity (industry, household). After using and discharging from wastewater treatment plants as effluent stream, surface active agents (SAAs) are emitted to various elements of the environment (atmosphere, waters, and solid phases), where they can ...
Mizoue Shiro S Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, - - 2014
This study aimed to evaluate the effect of travoprost with sofZia® preservative system for lowering the intraocular pressure (IOP) of Japanese normal tension glaucoma (NTG) patients. In this prospective, multicenter, open-label study, Japanese NTG patients with baseline IOPs <20 mmHg were enrolled after three consecutive time measurements taken at screening ...
Kulthanan Kanokvalai K Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, - - 2014
Daily bathing with antiseptic cleansers are proposed by some physicians as an adjunctive management of atopic dermatitis (AD). As atopic skin is sensitive, selection of cleansing products becomes a topic of concern. Our purpose is to evaluate the pH of various antiseptic body cleansers to give an overview for recommendation ...
Pirouzian Amir A Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia ; Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, - - 2014
To review comprehensively the available peer-reviewed published articles in the literature on loteprednol suspension, gel, and ointment in the treatment of ocular inflammation and pain following ocular surgery. We conducted a PubMed literature search review of all published articles on keywords associated with loteprednol etabonate and ocular surgery. A total ...
Niwano Yoshimi Y Tohoku University Graduate School of Dentistry, Sendai, - - 2014
In vitro cytotoxicity of tafluprost, which is the most recently developed anti-glaucoma prostaglandin (PG) analog, in ocular surface cells is addressed in comparison with other PG analogs. Irrespective of cell lines and models, the cytotoxicity of anti-glaucoma PG eyedrops was primarily related to the concentration of benzalkonium chloride (BAK) contained ...
Huang Taomin T Department of Pharmacy, Eye Ear Nose Throat Hospital of Fudan University, Fenyang Road, No, 83, Shanghai 200031, People's Republic of China. - - 2014
A simple, rapid, and accurate stability-indicating reverse phase liquid chromatographic method was developed and validated for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in bulk drugs and pharmaceutical formulations. Optimum chromatographic separations among pheniramine maleate, naphazoline hydrochloride and stress-induced degradation products have been achieved within 10 minutes by ...
Shenoy Amarnath A Department of Conservative Dentistry and Endodontics, Yenepoya Dental College, Mangalore, - - 2014
To evaluate the effect of final rinsing solution on smear layer removal through penetrability of the root canal sealer. Each of the 30 teeth selected was decoronated and the root length standardized at 16 mm measured from the apex of the tooth to the cementoenamel junction (CEJ). A size 10-k ...
Rychli Kathrin K Institute for Milk Hygiene, University of Veterinary Medicine Vienna, Vienna, - - 2014
A large listeriosis outbreak occurred in Austria, Germany and the Czech Republic in 2009 and 2010. The outbreak was traced back to a traditional Austrian curd cheese called "Quargel" which was contaminated with two distinct serovar 1/2a Listeria monocytogenes strains (QOC1 and QOC2). In this study we sequenced and analysed ...
Sharom Frances Jane FJ Department of Molecular and Cellular Biology, University of Guelph , Guelph, ON , - - 2014
Multidrug resistance in cancer is linked to expression of the P-glycoprotein multidrug transporter (Pgp, ABCB1), which exports many structurally diverse compounds from cells. Substrates first partition into the bilayer and then interact with a large flexible binding pocket within the transporter's transmembrane regions. Pgp has been described as a hydrophobic ...
Fung Derrick S DS Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, - - 2014
Glaucoma is a progressive, neurodegenerative optic nerve disease that can cause significant visual morbidity and affects over 60 million people worldwide. The only known modifiable risk factor for glaucoma at this time is elevated intraocular pressure (IOP), which may be treated with medications, laser therapy, and/or incisional surgery. Topical ocular ...
Chen Wensheng W Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Vision Science, Fujian, - - 2014
Prostaglandin (PG) analogs, including latanoprost, travoprost, and bimatoprost, are currently the most commonly used topical ocular hypotensive medications. The purpose of this study was to investigate the corneal alterations in rabbits following exposure to commercial solution of latanoprost, travoprost and bimatoprost. A total of 64 New Zealand albino rabbits were ...
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