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Gancevičienė, Rūta
Background: Acne is a chronic inflammatory disorder of the pilosebaceous unit (PSU). The PSU is an immunocompetent organ, and the sebaceous gland (SG) exhibits an independent peripheral endocrine function and expresses receptors for neuropeptides (NP). The presence of a complete corticotrophin-releasing hormone (CRH)/CRH receptor (CRHR) system in human sebocytes has ...
Giannelou Angeliki A Inflammatory Disease Section, Intramural Research Program, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, - - 2014
Next-generation sequencing is revolutionizing the molecular taxonomy of human disease. Recent studies of patients with unexplained autoinflammatory disorders reveal germline genetic mutations that target important regulators of innate immunity. Whole-exome analyses of previously undiagnosed patients have catalyzed the recognition of two new disease genes. First, a phenotypic spectrum, including livedo ...
Rolfe Heidi M HM Dermatology, Princess Alexandra Hospital, Woolloongabba, Qld, - - 2014
Nicotinamide, also known as niacinamide, is the amide form of vitamin B3. It is a precursor of essential coenzymes for numerous reactions in the body including adenosine triphosphate (ATP) production. Nicotinic acid, also known as niacin, is converted into nicotinamide in the body. The use of topical nicotinamide in the ...
Aschenbrenner Diane S DS Diane S. Aschenbrenner was previously the course coordinator for undergraduate pharmacology at Johns Hopkins University School of Nursing in Baltimore, MD. She currently teaches at Stevenson University in Stevenson, MD. She also coordinates Drug Watch: - - 2014
Miyata Shota - - 2014
Propolis is a natural honeybee hive product with the potential for use in the treatment of dermatological conditions, such as cutaneous abrasions, burns, and acne. In this study, we investigated whether propolis stimulates hair growth in mice. Ethanol-extracted propolis, which contains various physiologically active substances such as caffeic acid and ...
Fernandez-Plana Julen - - 2014
This phase II study aims to evaluate the efficacy and safety of biweekly cetuximab in combination with oxaliplatin, leucovorin, and fluorouracil (FOLFOX-4) as first-line treatment of metastatic wild-type KRAS colorectal cancer. Previously untreated patients with wild-type KRAS tumours received biweekly cetuximab (500 mg/m2 on day 1) plus FOLFOX-4 (oxaliplatin 85 ...
Al-Niaimi Firas - - 2014
Abstract Acne vulgaris is a common condition which remains challenging to treat in some cases. Laser and light-based therapies offer an alternative to medical therapies with the advantage of high compliance and relatively low side-effect profile. Light-based therapies in acne exert their effects through photochemical, photothermal, or a combination of ...
Huang Ji-Jie JJ Department of Medical Oncology, Sun Yat-sen UniversityCancer Center - - 2014
Toxic epidermal necrolysis (TEN) is a rare acute life-threatening mucocutaneous disorder that is mostly drug-related (80%-95%). It is clinically characterized as a widespread sloughing of the skin and mucosa. The AP regimen (pemetrexed plus cisplatin) has been the preferred first-line chemotherapy for metastatic non-squamous non-small cell lung cancer (NSCLC). Gefitinib, ...
Vuckovic Karen M KM Karen M. Vuckovic, PhD, RN, ACNS Assistant Clinical Professor, College of Nursing, Department of Biobehavioral Health Science, University of Illinois at Chicago. Holli A. DeVon, PhD, RN Associate Professor, College of Nursing, Department of Biobehavioral Health Science, University of Illinois at Chicago. Mariann R. Piano, PhD, RN Professor, College of Nursing, Department of Biobehavioral Health Science, University of Illinois at - - 2014
Dyspnea is a burdensome and disabling heart failure (HF) symptom. Few studies examining dyspnea in HF have included African Americans (AAs), despite their developing HF at a younger age and having the highest mortality rates. The purpose of this cross-sectional study was to examine dyspnea in AA patients with HF ...
Rajakumar Govindasamy G Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam, Vellore District, 632 509, Tamil Nadu, - - 2014
Titanium dioxide nanoparticles (TiO2 NPs) are considered to be among the best photocatalytic materials due to their long-term thermodynamic stability, strong oxidizing power, and relative non-toxicity. Nano-preparations with TiO2 NPs are currently under investigation as novel treatments for acne vulgaris, recurrent condyloma acuminata, atopic dermatitis, hyperpigmented skin lesions, and other ...
Brauer Jeremy A JA Laser & Skin Surgery Center of New York, New York, New York2Ronald O. Perelman Department of Dermatology, NYU Langone Medical Center, New York, New - - 2014
Fractional laser technology is routinely used in the treatment of acne scarring, with thermal injury resulting in collagen synthesis and remodeling. Use of a picosecond pulse duration with a diffractive lens array may be a new technologic advancement in the treatment of acne scarring. To investigate the safety and efficacy ...
Wang Lei L Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, - - 2014
Primary cutaneous CD4-positive small/medium pleomorphic T-cell lymphoma (SMPTCL) is an indolent form of cutaneous lymphoma that usually presents in solitary fashion and is histopathologically characterized by nodular infiltration of small to medium-sized pleomorphic T-cells. We report the case of a patient who presented with a 5-year history of acneiform lesions ...
Arfken Ann M - - 2014
Airborne bacteria from hog farms may have detrimental impacts on human health, particularly in terms of antibiotic resistance and pathogen zoonosis. Despite human health risks, very little is known about the composition and diversity of airborne bacteria from hog farms and hog related spray fields. We used pyrosequencing analysis of ...
Wolkenstein Pierre P Department of Dermatology, AP-HP, Henri Mondor Hospital, Université Paris-Est Créteil Val de Marne (UPEC), Créteil, - - 2014
Background: Dietary factors and smoking play a role in acne. Methods: CSA Santé conducted a survey in France in 2012. Each individual answered a questionnaire to report acne, with associated epidemiological variables. Data on subjects between 15 and 24 years of age were extracted. The characteristics of subjects reporting acne ...
Wei Bin B Department of Dermatology, 1st Hospital of Chongqing Medical University, Chongqing, - - 2014
Background: The relationship between serum hormone levels and adolescent acne is not fully clarified. Objective: To determine the relationship between levels of androstenedione, dehydroepiandrosterone sulfate (DHEA-S), testosterone, estradiol and 17α-hydroxyprogesterone (17-OHP) with adolescent acne in Northeast China. Methods: A transversal study included 242 acne cases and 188 controls. All data ...
Sharif Arfa A Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, - - 2014
Vitis vinifera "Muscat hamburg" (Vitaceae) is a blue-black grape variety commonly found in Pakistan. It has been consumed and used in traditional medicine for centuries. Compared to other grapes, M. hamburg records one of the greatest amount of polyphenols and displays potent anti-oxidant activities, which make it a great candidate ...
Farrokhpour Hossein - - 2014
The solvation Gibbs free energies (SGFE) of thirty nine ions were estimated in protic and aprotic solvents including methanol, ethanol, N, N dimethylformamide (DMF) and acetonitrile (ACN) using a proposed approach. In this method, the error of the applied computational method, used for estimating the SGFE of a specific ion ...
Krupková Michaela - - 2014
All-trans retinoic acid (ATRA, tretinoin) is a vitamin A derivative commonly used in the treatment of diverse conditions ranging from cancer to acne. In a fraction of predisposed individuals, the administration of ATRA is accompanied by variety of adverse metabolic effects, particularly by the induction of hyperlipidemia. We have previously ...
Engle Jeff A JA Jeff A. Engle, B.S., is a Pharm.D. student, School of Pharmacy, University of Wisconsin (UW)-Madison, Madison. Jill M. Kolesar, Pharm.D., BCPS, FCCP, is Professor, School of Pharmacy, UW-Madison, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Comprehensive Cancer Center, - - 2014
The pharmacology, pharmacokinetics, clinical efficacy, safety, adverse effects, dosage and administration, and role in therapy of afatinib in the management of non-small-cell lung cancer (NSCLC) are reviewed. Afatinib (Gilotrif, Boehringer Ingelheim) is a novel oral tyrosine kinase inhibitor (TKI) recently approved for the first-line treatment of patients with NSCLC whose ...
Thielitz A A Department of Dermatology and Venereology, Otto-von-Guericke University, Magdeburg, - - 2014
Growing numbers of post-adolescent females are suffering from treatment-resistant or relapsing adult acne forms, therefore requiring the definition of safe and effective treatment options for this burdening disease. To assess the efficacy of azelaic acid 15% gel (AzA) vs. no treatment during maintenance therapy of female adult acne and to ...
Das Shinjita S Department of Dermatology, Harvard Medical School, Boston, MA, - - 2014
Acne pathogenesis is a multifactorial process that occurs at the level of the pilosebaceous unit. While acne was previously perceived as an infectious disease, recent data have clarified it as an inflammatory process in which Propionibacterium acnes and innate immunity play critical roles in propagating abnormal hyperkeratinization and inflammation. Alterations ...
Akaza Narifumi N Research Laboratories, Nippon Menard Cosmetic, Nagoya, Japan; Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Aichi, - - 2014
To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (TG) and free fatty acids (FFA), and the amounts of cutaneous superficial Propionibacterium acnes in acne patients and healthy subjects. The foreheads of 18 female patients, ...
Madan S S Department of Electrical and Computer Engineering, Rutgers University, Piscataway, NJ, - - 2014
Computational skin analysis is revolutionizing modern dermatology. Patterns extracted from image sequences enable algorithmic evaluation. Stacking multiple images to analyze pattern variation implicitly assumes that the images are aligned per-pixel. However, breathing and involuntary motion of the patient causes significant misalignment. Alignment algorithms designed for multimodal and time-lapse skin images ...
Small Leo J - - 2014
The ability of three aryldiazonium salts to spontaneously assemble onto the surface of type 440C stainless steel is investigated in acetonitrile (ACN) and the model hydraulic fluids trib- utyl phosphate (TBP) and hexamethyldisiloxane (HMDS). Competition between native oxide formation and organic film growth at different diazonium salt concentrations is monitored ...
Rohacek Martin M Division of Cardiology, Department of Medicine, Luzerner Kantonsspital, Lucerne, Switzerland; Department of Emergency Medicine, University Hospital Basel, - - 2014
The number of patients with cardiovascular implantable electronic devices (CIEDs) is increasing. The purpose of this study was to compare three methods (sonication, swab cultures, and blood cultures) to detect bacteria in infections of CIEDs. Patients with pocket infection of CIEDs and/or CIED-associated infective endocarditis were prospectively included. Generators and ...
Amato Anthony A AA From Brigham and Women's Hospital and Harvard Medical School (A.A.A., M.S., S.A.G.), Boston; Boston Children's Hospital (S.A.G.); Harvard-Massachusetts Institute of Technology (S.A.G.), Division of Health Sciences and Technology, Cambridge, MA; Barrow Neurological Institute (K.S.), Phoenix AZ; Massachusetts General Hospital (N.G., W.S.D.), Boston; Novartis Institutes for Biomedical Research (E.L.-T., A.-U.T., D.L., D.J.G., R.R., B.S.T.), Cambridge, MA and Basel, Switzerland; and Novartis Pharmaceuticals Corporation (J.P.), East Hanover, - - 2014
To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies and a randomized controlled trial. We measured transforming growth factor β signaling by SMAD2/3 phosphorylation in muscle biopsies of 50 patients with neuromuscular disease (17 with sIBM). We tested inhibition of activin receptors IIA ...
Bilgiç Ozlem O Department of Dermatology - - 2014
Abstract Background: Prior studies have demonstrated lower serum zinc levels in acne vulgaris (AV) patients compared with controls. However, no study has investigated the relationship between AV and erythrocyte zinc levels, which is a superior indicator of body zinc levels. Additionally, the potential influence of isotretinoin use on body zinc ...
Thomasen H H Department of Ophthalmology, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, - - 2014
Careful testing for microbial contamination is essential for corneal transplants. Sterility tests are performed on the antibiotics containing culture medium leaving the problem that antibiotics might compromise the test results. In this study a protocol for the application of the automated BacT/Alert system for sterility testing of corneal cell culture ...
Boschetti Mara - - 2014
This prospective study aimed to evaluate the impact of growth hormone deficiency (GHD) on cardiac autonomic tone and on cardiovascular risk and the changes after 12 months of GH replacement therapy (GHRT). GHD is associated with increased cardiovascular morbidity and mortality. This has been attributed to increased markers of cardiovascular ...
Misery Laurent L Department of Dermatology, University Hospital of Brest, FR-29200 Brest, France. - - 2014
Acne is a common disease among young people, which could have a serious impact on quality of life. Based on a survey using the quotas method on a large sample of the French population, we studied the impact of acne on feelings of stress, fatigue upon waking, sleep disorders and ...
Picardo Mauro M Laboratory of Cutaneous Physiopathology, San Gallicano Dermatologic Institute (IRCCS), Rome, - - 2014
The imbalance and/or the perturbation of the microbial populations that colonize the skin and that contribute to its defense may represent one of the causes of the development of noninfectious skin diseases. Atopic dermatitis, psoriasis, acne, and rosacea can be listed among these kinds of pathologies. In particular, considering that ...
Kawala Christopher - - 2014
Acne vulgaris is a common chronic disease, and evidence-based clinical practice guidelines (CPGs) can provide credible treatment information. A literature search for acne CPGs published between January 2008 and September 2013 was conducted. Two reviewers independently applied the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument. METHODological quality ...
Kim Ji Young JY Department of Dermatology, Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, - - 2014
Recent findings of increased cathelicidin protein and its proteolytic fragments in rosacea suggest a pathogenic role for cathelicidin in this disease. The relationship between cathelicidin and protease-activated receptor 2 (PAR-2) is therefore of interest, as PAR-2, expressed principally in keratinocytes, regulates pro-inflammatory cytokine expression in the skin. The purpose of ...
Moran Katherine J KJ Katherine J. Moran, DNP, RN, CDE, is an Assistant Professor, McAuley School of Nursing, University of Detroit Mercy, Detroit, Michigan, and Co-owner/Director, My Self-Management Team, Inc., Chesterfield, Michigan. Rosanne Burson, DNP, ACNS-BC, CDE, is an Assistant Professor, McAuley School of Nursing, University of Detroit Mercy, Detroit, Michigan, and Co-owner/Director, My Self-Management Team, Inc., Chesterfield, - - 2014
Kiger Tammy T University of Wisconsin Hospital and Clinics (Mss Kiger, Knudsen, Curran, Hunter, Schaub, Williams, and Zechel) and the University of Wisconsin-Madison School of Nursing (Dr Kwekkeboom), Madison, Wisconsin. Tammy Kiger, MSN, RN, is a nursing informatics specialist at the University of Wisconsin Hospital and Clinics in Madison, Wisconsin. Élise Arsenault Knudsen, MS, RN, ACNS-BC, is the clinical nurse specialist for evidence-based practice at the University of Wisconsin Hospital and Clinics. Wendy Curran, MS, RN, OCN®, is a clinical nurse specialist in oncology services at the University of Wisconsin Hospital and Clinics. Julia Hunter, MSN, RN, PNP-BC, is a clinical nurse specialist for the pediatric clinics at the University of Wisconsin Hospital and Clinics. Anna Schaub, MSN, MHA, RN, is a cardiology coordinator in preventive cardiology at the University of Wisconsin Hospital and Clinics. Mary Jane Williams, DNP, MPH, RN, NE-BC, is the clinical nurse manager of the clinical research unit at the University of Wisconsin Hospital and Clinics. Janet Zechel, MSA, RN, CNML, is the former clinical nurse manager of the venous access team at the University of Wisconsin Hospital and Clinics. Kristine Kwekkeboom, PhD, RN, is an associate professor and director of the PhD program at the University of Wisconsin-Madison School of - - 2014
Health care workers at an academic medical center in the Midwest were surveyed to identify common practices regarding heat use during peripheral intravenous (PIV) catheter insertion. Of the 907 who responded, the majority used heat to facilitate PIV insertion at least sometimes, when veins were not easily seen or not ...
Kim Seung Ju SJ Department of Orthopaedics, Korea Electric Power Corporation (KEPCO) Medical Foundation, KEPCO Medical center, Seoul, Republic of - - 2014
Little information is available to guide treatment strategies regarding patients with unexpected positive cultures (UPC), including Propionibacterium acnes (PA), without overt signs of infection in revision shoulder arthroplasty (RSA). The purpose of our study was to analyze the prevalence, clinical meaning, treatment and prognosis of UPC in RSA. We performed ...
Bussel Igor I - - 2014
Central serous chorioretinopathy (CSCR) is an idiopathic disease associated with states of hypercortisolism that causes fluid to collect under the retina resulting in visual impairment. The authors describe an otherwise healthy female patient who presented with headaches and blurry vision after a 2-month history of excessive daily consumption of diindolylmethane ...
Yang Yaling Y Nuffield Department of Primary Care Health Sciences, University of Oxford, New Radcliffe House, Walton Street, Oxford, OX2 6NW, UK, - - 2014
This systematic literature review aims to assess the reliability, validity and responsiveness of three widely used generic preference-based measures of health-related quality of life (HRQL), i.e., EQ-5D, Health Utility Index 3 (HUI3) and SF-6D in patients with skin conditions. A systematic search was conducted to identify studies reporting health state ...
Arici Ceyhun C Cerrahpasa Medical Faculty, Department of Ophthalmology - - 2014
Abstract Purpose: To investigate the in vitro antimicrobial activity of silicone oil against anaerobic agents, specifically Propionibacterium acnes, Peptostreptococcus spp., Peptostreptococcus anaerobius, Bacteroides fragilis, Fuobacterium spp., and Clostridium tertium. Method: A 0.5 McFarland turbidity of Propionibacterium acnes, Peptostreptococcus spp., Peptostreptococcus anaerobius, Bacteroides fragilis, Fuobacterium spp., and Clostridium tertium was prepared, ...
Bindon Keren A - - 2014
To explore the effect of tannin composition on pigment formation, model ferments of purified 3-O-monoglucoside anthocyanins (ACN) were conducted either alone or in the presence of two different tannins. Tannins were isolated from grape seeds (Sd) or skins (Sk) following exhaustive extraction in 70% v/v acetone. The Sd and Sk ...
Kim Hyun Woo HW *Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea; †Department of Dermatology, Asan Medical Center, Seoul, - - 2014
Because acne scarring is associated with substantially reduced quality of life, early initiation of effective treatment is desirable. In previous reports, isotretinoin treatment was associated with increased scarring after cosmetic procedures, such as laser treatment, dermabrasion, and chemical peeling. To evaluate wound healing after ablative carbon dioxide (CO2) fractional resurfacing ...
Deckers I E IE Department of Dermatology, Erasmus University Medical Center, - - 2014
Hidradenitis suppurativa (HS) is a chronic skin disease of the inverse areas of the body such as the axillary, inguinal, genital, and perineal regions. Estimates of the prevalence of HS ranges from 0.33% to 4%. This prevalence is partly based on large questionnaire-based studies. However, with these questionnaires, the severity ...
Kiritsi D D Department of Dermatology, Medical Center - University of Freiburg, Freiburg, - - 2014
Acne is one of the most common skin diseases with a multifactorial etiology and multiple players contributing to its complex pathogenesis. Besides, acne is a feature of several genetic conditions, including monogenic disorders, like autoinflammatory syndromes or the Apert syndrome. Several mosaic forms of acne were clinically described. The underlying ...
Staub J J Department of Dermatology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, - - 2014
The group of autoinflammatory syndromes associated with Pyoderma gangrenosum, Acne, and Suppurative Hidradenitis are poorly defined and difficult to control with currently available treatment modalities. We describe a patient with PASH syndrome and report about the successful multimodal treatment with infliximab, cyclosporine, and dapsone. A review of the available literature ...
Cimadevilla Henar M HM Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, University of Oviedo, Oviedo, - - 2014
A straightforward and common analytical method for α-tocopherol (αT) determination in various biological samples, including plasma, red blood cells (RBC), tissues and cultured cell lines, was developed and validated, using a reverse phase-chromatographic method (RP-HPLC). Even though many chromatographic methods for αT determination have been reported, most of them require ...
Leone Antonio A Department of Radiological Sciences, Catholic University, School of Medicine, Largo A. Gemelli 1, 00168, Rome, Italy, - - 2014
The synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome includes a group of chronic, relapsing, inflammatory musculoskeletal disorders with similar manifestations, in particular synovitis, hyperostosis, and osteitis, which may or may not be associated with neutrophilic skin eruptions such as palmoplantar pustulosis and acne conglobata. The syndrome occurs at any ...
Wen Li L Department of Dermatology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, - - 2014
Previously, acne and its effects on psychological well-being have mostly been studied unilaterally in the western population. This study was aimed to investigate bidirectional relationship between acne and stress using Adolescent Self-Rating Life Events Check (ASLEC) and Hospital Anxiety and Depression Scale (HADS) surveys from inhabitants of central China. An ...
Zhang Huan H - - 2014
ObjectiveTo evaluate the effect of dehydroepiandrosterone (DHEA) on infertility patients with diminished ovarian reserve undergoing in vitro fertilization.MethodsThis is a prospective study. Ninety-five patients with diminished ovarian reserve were included in this study. Of them, 42 patients were randomly allocated to the DHEA group, who received DHEA 75 mg daily ...
Goh Chee Leok CL National Skin Centre, - - 2014
Post-inflammatory hyperpigmentation (PIH) is a problematic and distressing acne sequela. The difficulty of clinically assessing and managing post-inflammatory hyperpigmentation is especially prevalent in Asian populations. The Asian Acne Board conducted a study to evaluate concordance in diagnosis of post-inflammatory hyperpigmentation in patients with active acne, acne scarring, and pigmentation problems. ...
Nandi Nilay N Department of Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX - - 2014
How cellular stresses up-regulate autophagy is not fully understood. One potential regulator is the Drosophila melanogaster protein Acinus (Acn), which is necessary for autophagy induction and triggers excess autophagy when overexpressed. We show that cell type-specific regulation of Acn depends on proteolysis by the caspase Dcp-1. Basal Dcp-1 activity in ...
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