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Sant G R - - 1999
Interstitial cystitis is a complex inflammatory condition of the bladder. The pathophysiology of interstitial cystitis is incompletely understood, although altered epithelial permeability, mast cell activation and sensory afferent nerve upregulation play critical roles. A unified understanding of the pathogenesis of interstitial cystitis is emerging and this will hopefully lead to ...
Relevancy Score: Relevancy Score: 1000
Sant G R - - 1997
Interstitial cystitis is a urologic disorder with protean pelvic manifestations (urologic, gynecologic, gastroenterologic) and variable prevalence. Although current research indicates a non-bacteriologic etiology, interstitial cystitis has features suggestive of autoimmunity, a deficient bladder wall lining, activated bladder sensory neuropeptides and bladder mastocytosis. Pentosan polysulfate sodium is a recently approved oral ...
Relevancy Score: Relevancy Score: 971
Warren John W - - 2002
Appropriate diagnostic tests for interstitial cystitis remain uncertain. One or more promising markers for this disease have been described which may provide a noninvasive means for diagnosis as well as clues to pathogenesis of this disease. Treatment remains empiric.
Relevancy Score: Relevancy Score: 880
Hanus T - - 1996
Interstitial cystitis (IC) is a complex of painful mictional symptomatology of unknown etiology. Is occurs more frequently in women. By cystoscopy the ulcerative and non-ulcerative form is differentiated. A typical diagnosis symptom are glomerulations during cystoscopy under general anaesthesia. There are diagnostic criteria which rule out IC. Histopathologically the following ...
Relevancy Score: Relevancy Score: 864
Rosin R D - - 1979
Twenty histologically proven cases of interstitial cystitis were investigated in an attempt to find evidence of a possible autoimmune mechanism in its aetiology. HLA tissue typing was performed, autoantibody profiles were obtained, and a questionnaire of the patients' past history completed, especially with respect to other autoimmune conditions. An experiment ...
Relevancy Score: Relevancy Score: 863
Johansson S L - - 1994
Morphologic changes, including light microscopy and ultrastructural, immunologic, and immunohistochemical findings in interstitial cystitis are described. The results indicate that biopsies are useful as an aid in the diagnosis of interstitial cystitis.
Relevancy Score: Relevancy Score: 863
Newsome Grace - - 2003
PURPOSE: To describe the pathophysiology, assessment, diagnosis, and management of interstitial cystitis. DATA SOURCES: Selected professional publications and presentations. CONCLUSIONS: Interstitial cystitis (IC) is a chronic and disabling condition. Symptoms include urinary frequency and urgency, pain, dyspareunia, and nocturia. It occurs primarily in women. Onset is predominately in adulthood although ...
Relevancy Score: Relevancy Score: 850
Lépinard V - - 1998
Interstitial cystitis is a particular type of cystitis with clear urine, essentially observed in women. Persistent painful urinary frequency and bladder heaviness are suggestive of the diagnosis. Two different forms have been distinguished according to severity: Hunner's ulcer and small capacity bladder;-bladder distension to 800 ml, followed by haemorrhagic petechiae; ...
Relevancy Score: Relevancy Score: 846
Banerjee Sanjoy - - 2011
ABSTRACT Questions from patients about analgesic pharmacotherapy and responses from authors are presented to help educate patients and make them more effective self-advocates. The topic addressed in this issue is interstitial cystitis and a discussion on pathology, genetics, course of disease, symptoms, and treatments.
Relevancy Score: Relevancy Score: 843
Allan E - - 1998
Interstitial cystitis (IC) is a serious debilitating disease often overlooked by medical and health professionals. This paper describes the elusive aetiology and the painful symptoms of IC and how it affects the patient's life. The author outlines the treatments available and offers guidelines for supporting patients with the disease.
Relevancy Score: Relevancy Score: 838
Bondavalli Candido - - 2004
Interstitial cystitis (IC) is still considered a rare disease, but in the future its incidence will probably be revised if tendency is that of considering interstitial cystitis on the basis of clinical rather than endoscopic-histological criteria. According to some urologists, cystodistension and vesical biopsy, even if not pathognomonic, are still ...
Relevancy Score: Relevancy Score: 837
Cochand-Priollet B - - 1993
Interstitial cystitis, described for many years, remains a mystery for several reasons. Although the clinical and therapeutic understanding of this disease have improved, the histological features are non-specific and the pathogenesis is still unclear. The aim of this article is to briefly review the current state of knowledge and to ...
Relevancy Score: Relevancy Score: 833
Hanno P - - 1990
We reviewed clinical and histological findings in 55 patients with interstitial cystitis and 21 with voiding dysfunction secondary to other pathological conditions. Of our interstitial cystitis patients 36% would fail to meet the research definition proposed at a recent National Institutes of Health workshop. Detrusor mastocytosis was present in 64% ...
Relevancy Score: Relevancy Score: 824
Anjum M I - - 1996
Interstitial cystitis is an uncommon disease reported predominantly in females. Recently we were involved in the management of 4 men who had the clinical, endoscopic and pathological features consistent with the diagnosis of interstitial cystitis. The rarity of occurrence of the disease in males prompted us to report these cases.
Relevancy Score: Relevancy Score: 808
Ito T - - 2000
OBJECTIVE: To determine the prevalence of interstitial cystitis in Japan, and to analyse the diagnostic criteria and treatments most commonly used by Japanese urologists. Materials and methods Questionnaires were sent to 300 urologists at major hospitals, including medical university hospitals, throughout Japan, asking about the number of patients with interstitial ...
Relevancy Score: Relevancy Score: 807
Chung Maurice K - - 2009
Interstitial cystitis is a clinical syndrome characterized by symptoms of pelvic pain, urinary urgency and frequency, and nocturia. It can be difficult to accurately identify interstitial cystitis because the symptoms overlap many other common gynecologic and urologic conditions. Patients with undiagnosed interstitial cystitis may undergo unnecessary procedures, including hysterectomy. A ...
Relevancy Score: Relevancy Score: 803
Singh G - - 1996
Two patients with intractable interstitial cystitis are presented. Both have had substitution enterocystoplasty and in both, unabated symptoms have resulted in ileal loop diversion. In both patients the excised neobladder had shown extensive changes of interstitial cystitis involving all layers, including the muscle layers of the explanted intestine. Also in ...
Relevancy Score: Relevancy Score: 776
Haab François - - 2002
Interstitial cystitis is a disease characterized by pain occurring as the urinary bladder is gradually filling up. Its pathophysiology is unknown. The cause could be either a membrane permeability disorder, a mast cell disturbance in the bladder wall, or an autoimmune process involving the bladder. The diagnosis is essentially clinical ...
Relevancy Score: Relevancy Score: 775
Hanno P M - - 1994
The diagnosis of interstitial cystitis is best based on the techniques necessary to elicit the criteria established at the conferences of the National Institute of Arthritis, Diabetes, Digestive, and Kidney Diseases (NIDDK). Essentially, this requires a thorough patient history, urodynamic evaluation, and cystoscopy carried out under anesthesia with hydrodistention of ...
Relevancy Score: Relevancy Score: 774
Koziol J A - - 1994
This article concerns a survey conducted to determine the origin and history of interstitial cystitis. Information was elicited from 565 patients on demographics, risk factors symptoms, pain, and psychological factors. All those surveyed satisfied the National Institute of Arthritis, Diabetes, Digestive, and Kidney Diseases (NIDDK) criteria for interstitial cystitis and ...
Relevancy Score: Relevancy Score: 770
Vicini D - - 1999
Interstitial cystitis is a chronic disease of the bladder and its etiology is still unknown. In this article we treat the different approaches to this disease, supported by the fact that a clear therapeutic protocol doesn't exist.
Relevancy Score: Relevancy Score: 768
Kelada Ehab - - 2007
Interstitial cystitis is an enigmatic and frustrating condition to manage as a physician and to cope with as a patient. Traditionally, it has been defined as a chronic sterile inflammatory disease of the bladder of unknown aetiology. However, the International Continence Society prefers the term painful bladder syndrome and it ...
Relevancy Score: Relevancy Score: 766
Peters K M - - 2000
Interstitial cystitis is a severe bladder disease of unknown etiology with no cure. The diagnosis and treatment of this difficult disease has frustrated both patients and clinicians alike. Multimodality therapy is the most effective treatment for interstitial cystitis.
Relevancy Score: Relevancy Score: 755
Buffington C A - - 1996
Despite much research on FUS, there still is no consensus regarding its cause, or even its definition. We recently have demonstrated that some cases of FUS are similar to interstitial cystitis in human beings. Exclusion of anatomic defects, behavior abnormalities, neoplasia, urolithiasis, urethral obstruction, and urinary tract infection leads one ...
Relevancy Score: Relevancy Score: 754
Selo-Ojeme D O - - 2004
Interstitial cystitis (IC) is a debilitating chronic inflammatory disorder of the bladder. It affects predominantly middle-aged Caucasian women. The diagnosis, made from the combination of symptoms, cystoscopic findings and bladder biopsies, is often delayed in the gynaecology setting because of a low index of suspicion. The pathophysiology is incompletely understood, ...
Relevancy Score: Relevancy Score: 754
Erickson D R - - 1998
Interstitial cystitis (IC) is a multifactorial syndrome with symptoms of pelvic or perineal pain, urinary frequency and urgency. The etiologies are unknown, but several theories have been proposed. Diagnosis is often delayed because most of the conventional evaluation is normal. Pelvic examination is normal except for bladder tenderness. Urodynamics are ...
Relevancy Score: Relevancy Score: 754
Oravisto K J - - 1980
The autoimmune features of interstitial cystitis are reviewed. Despite some controversy, interstitial cystitis should be grouped to the connective tissue diseases but as a separate entity.
Relevancy Score: Relevancy Score: 753
Hollander D H - - 1994
Interstitial cystitis patients often have a history of allergies, and frequently, a history of gynecological or obstetric operative procedures. Silk is a potent antigen, and so it is suggested that the symptomatology of interstitial cystitis is an allergic reaction to buried silk sutures.
Relevancy Score: Relevancy Score: 747
Lapides J - - 1975
Interstitial cystitis is more common in young women than previously believed. Findings typical of the disease are a history of diurnal and nocturnal pollakiuria, pelvic discomfort increases with bladder distention, marked bladder tenderness on gentle palpation of the anterior later vaginal fornices, less than normal bladder capacity, and a negative ...
Relevancy Score: Relevancy Score: 741
Lazebnik J - - 1973
Relevancy Score: Relevancy Score: 738
- - 1991
Relevancy Score: Relevancy Score: 738
Parsons C L - - 1991
Traditional concepts of impermeability of the bladder have centered around unique cellular tight junctions and ion pumps. However, recent data from our laboratory have shown that the bladder epithelium in animals and humans relies primarily on its surface glycosaminoglycans to maintain its impermeability. This study demonstrates the first disease associated ...
Relevancy Score: Relevancy Score: 735
Ochs R L - - 1994
We have identified and partially characterized autoantibodies from the sera of patients with interstitial cystitis. Our characterization included initial screening by antinuclear antibody testing on human HEp-2 cell substrate and mouse kidney/stomach tissue substrate, titering and subtyping of positive sera, and Western blotting to identify target autoantigens. Of 96 interstitial ...
Relevancy Score: Relevancy Score: 734
Relevancy Score: Relevancy Score: 730
MacDermott J P - - 1991
It has been suggested that interstitial cystitis is an autoimmune disease. The evidence for this hypothesis, based on studies of humoral immune factors, has been contradictory. We assessed the immune response in interstitial cystitis by evaluating lymphocyte populations in the peripheral blood and bladder tissue of interstitial cystitis patients. The ...
Relevancy Score: Relevancy Score: 725
Lotz M - - 1994
We analyzed the presence of the cytokine interleukin-6 in urine samples from interstitial cystitis patients. Interleukin-6 was significantly elevated in patients with interstitial cystitis (169.29 +/- 90.81 pg./ml. versus 34.8 +/- 6.35 pg./ml. in controls). Representative urine samples were analyzed with specific antibody to interleukin-6 and greater than 80% of ...
Relevancy Score: Relevancy Score: 721
Erickson D R - - 1998
PURPOSE: We compared urinary levels of hyaluronic acid in patients who met the National Institute for Diabetes, and Digestive and Kidney Diseases criteria for interstitial cystitis and in age matched healthy female controls. MATERIALS AND METHODS: Urinary hyaluronic acid was measured by solid phase radiometric assay using hyaluronic acid binding ...
Relevancy Score: Relevancy Score: 721
Lechevallier E - - 1995
Interstitial cystitis, first described one hundred years ago, is difficult to classify in urological pathology. It essentially affects middle-aged women. Two main theories are currently proposed to explain its pathogenesis: the permeable epithelium theory and the mast cell theory. However, other factors are also involved: vascular, neurological, infectious and immune. ...
Relevancy Score: Relevancy Score: 718
Oberpenning Frank - - 2002
PURPOSE OF REVIEW: Interstitial cystitis is a chronically progressive, severely debilitating, heterogeneous syndrome affecting the urinary bladder, mainly associated with urgency, frequency and pain. Though known for over a century, its etiology is poorly understood and universally effective treatments are lacking. This review focuses on recently published literature on the ...
Relevancy Score: Relevancy Score: 718
SOMERSET J B - - 1955
Relevancy Score: Relevancy Score: 717
SMITH G G - - 1951
Relevancy Score: Relevancy Score: 717
Lose G - - 1981
Relevancy Score: Relevancy Score: 717
Scholtmeijer R J - - 1973
Relevancy Score: Relevancy Score: 717
BAKER W J - - 1959
Relevancy Score: Relevancy Score: 717
WARRES H L - - 1962
Relevancy Score: Relevancy Score: 717
SMITH G G - - 1952
Relevancy Score: Relevancy Score: 717
BAKER W J - - 1958
Relevancy Score: Relevancy Score: 717
BOWERS J E - - 1957
Relevancy Score: Relevancy Score: 717
POWELL T O - - 1955
Relevancy Score: Relevancy Score: 717
Williams M Jackie - - 2003
Relevancy Score: Relevancy Score: 713
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