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Hendricks J C - - 1987
To establish a natural model of sleep-disordered breathing, we investigated respiration during wakefulness and sleep in the English bulldog. This breed is characterized by an abnormal upper airway anatomy, with enlargement of the soft palate and narrowing of the oropharynx. During sleep, the animals had disordered respiration and episodes of ...
Relevancy Score: Relevancy Score: 1000
Burbidge H M - - 1988
A 22 month old English Bulldog was presented with progressive upper airway obstruction associated with an elongated soft palate, tonsillitis, everted laryngeal saccules and laryngeal malformation. Surgical management of the case consisted of resection of the elongated soft palate and everted laryngeal saccules, unilateral tonsillectomy and correction of the laryngeal ...
Relevancy Score: Relevancy Score: 939
Buchanan J W - - 2001
English Bulldogs are the most common breed to have pulmonic stenosis. Previous studies showed that this congenital heart abnormality in Bulldogs frequently is caused by a circumpulmonary left coronary artery originating from a single right coronary artery. Fetal anasarca also occurs often in Bulldogs and might represent congestive heart failure, ...
Relevancy Score: Relevancy Score: 907
Guevar Julien J School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK; Department of Clinical Science and Services, Royal Veterinary College, University of London, Hatfield, - - 2013
Idiopathic head tremor (IHT) syndrome is a recognized but poorly characterized movement disorder in English bulldogs (EBs). The data analyzed were collected via a detailed online questionnaire and video recordings. Thirty-eight percent of the population demonstrated IHT. The first presentation was early in life. There was no sex or neutered ...
Relevancy Score: Relevancy Score: 880
Goicoa A - - 2002
Separation anxiety in dogs is a complex behavioral syndrome produced by many causes. A hunter 4y-old male Argentinean Bulldog had dental disturbances and gastrointestinal and cutaneous symptoms due to high plasma zinc and low copper and calcium plasma concentration. His behavior made him bite galvanized wire fences in his cage ...
Relevancy Score: Relevancy Score: 871
Hendricks J C - - 1993
Sleep-disordered breathing (SDB) is seen during rapid eye movement (REM) sleep in English bulldogs, but it is absent during non-REM sleep. The SDB during REM sleep is associated with changes in neural drive to the diaphragm (DIA) and to an upper airway dilator, the sternohyoid (SH). In the present study, ...
Relevancy Score: Relevancy Score: 861
Verhoeven G - - 2006
A three-week-old Devon rex kitten and a four-week-old English bulldog puppy were presented with "swimmer syndrome". The owners consulted several veterinarians who suggested euthanasia as the only possible solution for this condition. Physiotherapy in the puppy, and physiotherapy and bandaging in the kitten led to the resolution of the clinical ...
Relevancy Score: Relevancy Score: 844
Shaw Traci Elliott - - 2010
A 10-year-old, neutered male English bulldog died acutely from respiratory distress after a short history of progressive dyspnea. Less than 2 months later, a spayed female full sibling of that dog died suddenly during a nail trim. An aortic body tumor was the cause of death in both dogs based ...
Relevancy Score: Relevancy Score: 831
Sabino Catherine V - - 2013
To describe the successful clinical management of a dog with acute respiratory distress syndrome (ARDS) using airway pressure release ventilation (APRV). An 18-month-old female French Bulldog was presented for routine ovariohysterectomy and correction of brachycephalic airway obstruction syndrome. Following the surgical procedures, the dog developed aspiration pneumonia and ARDS. Her ...
Relevancy Score: Relevancy Score: 777
Fingeroth J M - - 1989
A 3-month-old English Bulldog had excretory incontinence and sensory deficits in the distribution of pudendal nerves. Noncontrast radiography, myelography, and computed tomography revealed spina bifida beginning at L7, an expanded subarachnoid space caudal to L7, and a taut, thick filum terminale. Microsurgical exploration of the lumbosacral spine confirmed the presence ...
Relevancy Score: Relevancy Score: 720
Schmidt M J - - 2012
Our aim was to determine the relative volume of the occipital bone of Cavalier King Charles spaniels with and without syringohydromyelia and normal French bulldogs to reappraise the role of a possible insufficiency of the paraxial mesoderm in the pathogenesis of the caudal occipital malformation syndrome. Analysis of the occipital ...
Relevancy Score: Relevancy Score: 712
Caccamo Roberta - - 2014
Forty dogs presented for brachycephalic airway obstructive syndrome with laryngeal collapse not over 1st degree (saccule eversion) underwent glottis endoscopic and radiographic skull measurements before surgery. Fifteen Pugs, fifteen French and ten English Bulldogs were included. The goals were prospectively to compare three common brachycephalic breeds for anatomical differences regarding ...
Relevancy Score: Relevancy Score: 662
Veasey S C - - 1999
Obstructive sleep apnea hypopnea syndrome (OSAHS) is a prevalent disorder, for which there are no universally effective pharmacotherapeutics. We hypothesized that in OSAHS, excitatory serotoninergic influences are important for maintaining patency of the upper airway in waking, and that in sleep, reduced serotoninergic drive plays a significant role in upper ...
Relevancy Score: Relevancy Score: 625
Veasey S C - - 2001
Serotonin and serotoninergic drugs have significant effects on respiration, at many sites throughout the nervous system, and serotonin has been implicated in the pathogenesis of obstructive sleep apnea. Thus, understanding the serotoninergic mechanisms underlying respiratory control may help discover novel pharmacotherapies for sleep-disordered breathing. Ondansetron, a serotonin (5-HT) antagonist selective ...
Relevancy Score: Relevancy Score: 586
Mellema M S MS Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California - Davis, Davis, - - 2014
Brachycephalic dogs are at risk for arterial hypertension and obstructive sleep apnea, which are both associated with chronic magnesium (Mg) depletion. To compare the period prevalence of hypomagnesemia between Boxers and Bulldogs presented to a referral teaching hospital. To screen a group of Bulldogs for evidence of hypomagnesemia, and to ...
Relevancy Score: Relevancy Score: 575
Hendricks J C - - 1991
Basic mechanisms of sleep-disordered breathing (SDB) during rapid-eye-movement sleep (REMS) have been little investigated, despite the fact that events are often more prolonged and SaO2 nadirs lower during REMS. We predicted that the mechanisms of SDB in REMS would be related to the normal phasic changes in respiratory control in ...
Relevancy Score: Relevancy Score: 559
Petrof B J - - 1994
Recent work indicates that upper airway dilator muscles of individuals with obstructive sleep apnea syndrome (OSAS) demonstrate an increased level of activity during wakefulness compared with normal subjects. In addition, massive bursts of pharyngeal dilator activity are associated with the termination of upper airway occlusive events during sleep. This complex ...
Relevancy Score: Relevancy Score: 554
Sławuta P - - 2011
Brachycephalic syndrome develops as a result of a specific build of splanchnocranium. In dogs of brachycephalic breeds, an impairment of correct gas exchange occurs. 5 French bulldogs at the age of 11-14 months, which suffered from continuous mixed-type dispnoea and lowered effort tolerance, were examined. Apart from the above-mentioned symptoms, ...
Relevancy Score: Relevancy Score: 548
Nganvongpanit Korakot K Animal Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand ; Materials Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, - - 2013
The purpose of this study was to report on the prevalence of swimming puppy syndrome (SPS) and investigate predisposing factors. Data were recorded from 2,443 puppies (1,183 males and 1,260 females) in Thailand, October 2006-September 2012, including breed, sex, number of puppies per litter, type of nest floor, number of ...
Relevancy Score: Relevancy Score: 492
Sarmah Swapnalee - - 2010
Protein transport from endoplasmic reticulum (ER) to Golgi is primarily conducted by coated vesicular carriers such as COPII. Here, we describe zebrafish bulldog mutations that disrupt the function of the cargo adaptor Sec24D, an integral component of the COPII complex. We show that Sec24D is essential for secretion of cartilage ...
Relevancy Score: Relevancy Score: 449
Young Esther L - - 2006
This report describes a 14-year-old male with Simpson-Golabi-Behmel overgrowth syndrome. He was born via cesarean section because of macrocephaly and subsequently exhibited significant developmental delay in motor, language, and cognitive skills with mental retardation and epilepsy. He manifests the characteristic dysmorphic ("bulldog") facial features of Simpson-Golabi-Behmel syndrome. His molecular genetic ...
Relevancy Score: Relevancy Score: 445
Mulvihill J J - - 1980
Among 331 animals with cleft palate in a veterinary clinic-hospital population, cats, mixed breed dogs and German Shepherd Dogs had low risk for cleft palate; high rates were seen in English Bulldogs, some small purebred dogs and Charolais cattle, where cleft palate occurred as part of a syndrome of multiple ...
Relevancy Score: Relevancy Score: 390
Riecks Todd W - - 2007
OBJECTIVE: To assess results of surgical correction of brachycephalic syndrome (including stenotic nares, elongated soft palate, and everted laryngeal saccules) in dogs and determine whether dogs with hypoplastic trachea have a less favorable long-term outcome. DESIGN: Retrospective case series. ANIMALS: 62 dogs with brachycephalic syndrome. PROCEDURES: Medical records from 1991 ...
Relevancy Score: Relevancy Score: 373
Schotland H M - - 1996
Electromyographic studies of patients with sleep apnea and of the English bulldog, an animal model of sleep apnea, indicate that there is increase activity of the airways dilator muscles. The muscles, when biopsied, show both adaptation and muscle injury. In this study we have utilized quantitative magnetic resonance imaging to ...
Relevancy Score: Relevancy Score: 350
Irwin P J - - 1999
A 5.5-year-old French bulldog was presented with acute neck pain and a short history of central vestibular syndrome. A marked neutrophilic pleocytosis and numerous gram-positive cocci were evident on cerebrospinal fluid (CSF) cytology. Streptococcus pneumoniae, a pathogen of humans, was isolated upon CSF microbiological culture. Treatment consisted of intravenous antibiotics, ...
Relevancy Score: Relevancy Score: 328
Chung Benjamin I - - 2009
Nutcracker syndrome is a rare entity caused by extrinsic compression on the left renal vein as it crosses between the superior mesenteric artery and the aorta. It can clinically present with flank pain and hematuria. Accepted treatments include open vascular bypass procedures or endoluminal stenting. We present the first description, ...
Relevancy Score: Relevancy Score: 326
Quilez Javier J Molecular Genetics Veterinary Service (SVGM), Department of Animal and Food Science, Veterinary School, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain. - - 2011
Modern dog breeds display traits that are either breed-specific or shared by a few breeds as a result of genetic bottlenecks during the breed creation process and artificial selection for breed standards. Selective sweeps in the genome result from strong selection and can be detected as a reduction or elimination ...
Relevancy Score: Relevancy Score: 317
Fasanella Frank J - - 2010
To determine the prevalence of individual anatomic components of brachycephalic airway obstructive syndrome (BAOS), including everted tonsils, and analyze the frequency with which each component occurs with 1 or more other components of BAOS in brachycephalic dogs. Retrospective case series. 90 dogs with BAOS. Medical records were reviewed for signalment, ...
Relevancy Score: Relevancy Score: 300
De Lorenzi Davide - - 2009
OBJECTIVE: To detect abnormalities of the lower respiratory tract (trachea, principal bronchi, and lobar bronchi) in brachycephalic dogs by use of endoscopy, evaluate the correlation between laryngeal collapse and bronchial abnormalities, and determine whether dogs with bronchial abnormalities have a less favorable postsurgical long-term outcome following correction of brachycephalic syndrome. ...
Relevancy Score: Relevancy Score: 291
Hardie E M - - 1998
The thoracic bellows mechanism consists of the rib cage and the diaphragm. The purpose of this study was to determine if nontraumatically acquired lesions of the bellows were secondary to underlying disease. Abnormalities of the bellows, specifically stress fractures of the ribs and hiatal hernia, were found in 21 dogs ...
Relevancy Score: Relevancy Score: 277
Bernaerts Fr?d?rique - - 2010
The clinical features of brachycephalic airway obstructive disease in 11 brachycephalic dogs are described in this study. The respiratory strategy was assessed before (n=11) and after (n=6) surgery using barometric whole-body plethysmography (BWBP), with the relationship between BWBP variables and the severity of the clinical signs assessed by the use ...
Relevancy Score: Relevancy Score: 274
Poncet C M - - 2005
OBJECTIVES: To determine the prevalence of gastrointestinal tract lesions in brachycephalic dogs with upper respiratory tract disease. METHODS: The gastrointestinal tract and respiratory disorders of 73 brachycephalic dogs presented with upper respiratory signs were evaluated. Clinical signs and endoscopic and histological anomalies of the upper digestive tract were analysed. RESULTS: ...
Relevancy Score: Relevancy Score: 273
Torrez C V - - 2006
OBJECTIVES: To describe clinical features of brachycephalic airway obstructive disease in dogs, the incidence of laryngeal collapse in dogs presenting for surgery and the outcome after surgery in dogs with laryngeal collapse. METHODS: Basic clinical details were reviewed retrospectively in 73 dogs. Presence of laryngeal collapse and short-term outcomes after ...
Relevancy Score: Relevancy Score: 245
Mastrorilli Cinzia - - 2013
An EDTA-anticoagulated blood sample collected from a 1.5-year-old, intact male, English Bulldog was submitted for a CBC. The CBC data and blood smear evaluation revealed borderline high hematocrit (54%, reference interval 37-55%), inappropriate rubricytosis, moderate leukopenia due to both mature neutropenia and lymphopenia, and mild thrombocytopenia. Numerous leukocytes showed evidence ...
Relevancy Score: Relevancy Score: 236
Roedler Frauke S - - 2013
Brachycephalic syndrome (BS) is a complex canine disease, which is characterized by diverse clinical signs primarily involving the respiratory and gastrointestinal systems. Through a structured owner questionnaire, the present study investigated how owners perceived the frequency and severity of a broad spectrum of welfare-relevant impairments caused by this hereditary disease. ...
Relevancy Score: Relevancy Score: 229
Bernaerts, Frederique
The clinical features of brachycephalic airway obstructive disease in 11 brachycephalic dogs are described in this study. The respiratory strategy was assessed before (n = 11) and after (n = 6) surgery using barometric whole-body plethysmography (BWBP), with the relationship between BWBP variables and the severity of the clinical signs ...
Relevancy Score: Relevancy Score: 216
Ikawa Masamichi - - 2006
We report a 67-year-old woman with idiopathic oromandibular dystonia (OMD). She could neither open the mouth nor take meals due to involuntarily strong mouth-closing. The movement of face, pharynx and tongue were normal, and she could open the mouth slightly when jaw and cheek were touched (sensory trick). Chvostek sign ...
Relevancy Score: Relevancy Score: 215
Kung F T - - 1997
We report a rare case of early-stage endometrial adenocarcinoma in a 22 year old nullipara with polycystic ovaries undergoing conservative treatment. Pretreatment evaluation including tumour grade, depth of myometrial invasion, tumour size, hormone receptor status and flow cytometric analysis indicated a favourable prognosis. The patient underwent repeat endometrial curettage and ...
Relevancy Score: Relevancy Score: 215
Planellas Marta - - 2012
Brachycephalic dogs have unique upper respiratory anatomy with abnormal breathing patterns similar to those in humans with obstructive sleep apnea syndrome (OSAS). The objective of this study was to evaluate the correlation between anatomical components, clinical signs and several biomarkers, used to determine systemic inflammation and myocardial damage (C-reactive protein, ...
Relevancy Score: Relevancy Score: 209
Hoareau G L - - 2012
BACKGROUND: Brachycephalic dogs (BD) are prone to congenital upper airway obstruction (brachycephalic syndrome, BS). In humans suffering from sleep apnea, upper airway obstruction is known to cause hypertension. There is no information regarding the influence of BS in dogs on cardiorespiratory physiology. HYPOTHESIS: BD are prone to lower P(a) O(2) ...
Relevancy Score: Relevancy Score: 205
Veasey S C - - 1996
Recent studies have shown excitatory effects of serotonin on upper airway motoneurons. This excitatory effect is normally present and arises from cells in the caudal raphe nuclei. The firing of these serotonergic neurons is reduced during sleep. To determine the importance of serotonin in the maintenance of patient airways and ...
Relevancy Score: Relevancy Score: 204
Moskalenko Vasiliy - - 2009
INTRODUCTION: The aim of this study was to investigate the regeneration potential of RLN after the compression of the nerve, without disrupting its continuity, using neuromonitoring. METHODS: In the first operation, the RLN and nervus vagus of adult Goettingen minipigs were dissected free, and the neuromonitoring parameters (amplitude, threshold and ...
Relevancy Score: Relevancy Score: 204
Carley David W - - 2002
STUDY OBJECTIVES: Serotonin, acting in the peripheral nervous system, can exacerbate sleep-related apnea, and systemically administered serotonin antagonists reduce sleep-disordered respiration in rats and bulldogs. Because cannabinoid receptor agonists are known to inhibit the excitatory effects of serotonin on nodose ganglion cells, we examined the effects of endogenous (oleamide) and ...
Relevancy Score: Relevancy Score: 204
Bernaerts, Frederique
The clinical features of brachycephalic airway obstructive disease in 11 brachycephalic dogs are described in this study. The respiratory strategy was assessed before (n=11) and after (n=6) surgery using barometric whole-body plethysmography (BWBP), with the relationship between BWBP variables and the severity of the clinical signs assessed by the use ...
Relevancy Score: Relevancy Score: 202
Frazho Jean K - - 2008
CASE DESCRIPTION: A 5-year-old neutered male English Bulldog was evaluated for intermittent closed-mouth jaw locking of approximately 1 week's duration. CLINICAL FINDINGS: Initial physical examination revealed a nonpainful inability to open the jaw with and without manual assistance; however, manipulation of the jaw after the dog was sedated for diagnostic ...
Relevancy Score: Relevancy Score: 187
Farrow T T a Animal Welfare and Biodiversity Research Group, Department of Natural Sciences , Unitec Institute of Technology , Private Bag 92025, Auckland 1025 , New Zealand - - 2014
Abstract AIMS: To explore veterinary perceptions of inherited disorders in pedigree dogs within New Zealand and how these affect animal health and welfare. An online questionnaire was distributed to the 647 members of the Companion Animal Society of the New Zealand Veterinary Association using an online survey system. The questionnaire ...
Relevancy Score: Relevancy Score: 175
Ploumidis Achilles - - 2013
Spontaneous rapture with consequent retroperitoneal hemorrhage (Wunderlich's syndrome) is the complication mostly feared from large renal angiomyolipomas (RAMLs). In hemodynamic stable patients, minimal invasive therapies have superseded open surgery as the mainstay of treatment, with contemporary cases mostly treated by selective arterial embolization. Robotic-assisted laparoscopic partial nephrectomy (RALPN) is an ...
Relevancy Score: Relevancy Score: 172
Coassin Marco - - 2005
BACKGROUND: Preliminary data show that nerve growth factor (NGF) may improve tear production in humans. We evaluated the efficacy of topical NGF treatment in dogs who developed dry eye after the excision of the third eyelid lacrimal gland. METHODS: English Bulldogs (2- to 6-year-old males and females) that had undergone ...
Relevancy Score: Relevancy Score: 158
Gill Jennifer L JL Department of Pharmacology, The School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, - - 2012
Episodic falling syndrome (EFS) is a canine paroxysmal hypertonicity disorder found in Cavalier King Charles spaniels. Episodes are triggered by exercise, stress or excitement and characterized by progressive hypertonicity throughout the thoracic and pelvic limbs, resulting in a characteristic 'deer-stalking' position and/or collapse. We used a genome-wide association strategy to ...
Relevancy Score: Relevancy Score: 143
Olivry Thierry T Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America. - - 2012
In humans, congenital and hereditary skin diseases associated with epidermal cell-cell separation (acantholysis) are very rare, and spontaneous animal models of these diseases are exceptional. Our objectives are to report a novel congenital acantholytic dermatosis that developed in Chesapeake Bay retriever dogs. Nine affected puppies in four different litters were ...
Relevancy Score: Relevancy Score: 139
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