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Smith R A - - 1976
Basophilic stippling of the circulating erythrocytes is characteristic of the Mongolian gerbil. Its enzymatic digestion along with the concomitant removal of diffuse erythrocytic polychromasia by the action of ribonuclease demonstrates that it represents microscopically visible aggregates of cytoplasmic ribonucleoprotein, presumably of ribosomal origin. Up to 40% of the total circulating ...
Relevancy Score: Relevancy Score: 999
- - 1966
Relevancy Score: Relevancy Score: 836
George J W - - 1981
The effect of sample preparation on the amount of basophilic stippling of erythrocytes (BSE) was studied using blood from a calf with chronic experimental lead poisoning. The combination of EDTA anticoagulation and rapid drying of the blood smear resulted in the most BSE. Alcohol prefixation reduced BSE. Wright-Leishman stain was ...
Relevancy Score: Relevancy Score: 751
OTTO W - - 1960
Relevancy Score: Relevancy Score: 731
DISCOMBE G - - 1954
Relevancy Score: Relevancy Score: 731
WILDFUHR G - - 1951
Relevancy Score: Relevancy Score: 720
Munoz Javier J Henry Ford - - 2011
Relevancy Score: Relevancy Score: 707
Cheson B D - - 1984
Basophilic stippling of red blood cells (BSC) has been noted in lead intoxication since 1899 and has been considered a classic laboratory sign of lead poisoning since that time. BSC are inclusions of aggregated ribosomes found only in the red blood cells and may be confused with siderotic (iron) granules. ...
Relevancy Score: Relevancy Score: 630
Kasili E G - - 1977
Relevancy Score: Relevancy Score: 617
Vander Meeren Sam S Department of Laboratory Hematology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium, - - 2014
Relevancy Score: Relevancy Score: 593
Valentine W N - - 1976
Lead intoxication is accompanied by an acquired deficiency of erythrocyte pryimidine-specific, 5'-nucleotidase. Genetically determined deficiency of this enzyme is associated with chronic hemolysis, marked basophilic stippling of erythrocytes on stained blood films, and unique intraerythrocytic accumulations of pyrimidine-containing nucleotides. The present report documents that lead-induced deficiency when sufficiently severe gives ...
Relevancy Score: Relevancy Score: 576
Batlle M - - 1993
A patient is presented who had acute basophilic leukaemia with intense erythroblastic reaction. The patient, a 66 year-old man, complained of general malaise, increased abdominal perimeter and melena. Leucocytosis, as well as severe anaemia and thrombocytopenia, were found in his peripheral blood. Basophils were present in all maturation stages, along ...
Relevancy Score: Relevancy Score: 557
Seip M - - 1999
The disease is caused by a deficiency of the enzyme pyrimidine-5'-nucleotidase in the erythrocytes. About 50 cases have been published. We have diagnosed the disease in a pair of siblings from Numedal, Norway. Although this is a rare disorder it has a world-wide distribution. It is inherited as an autosomal ...
Relevancy Score: Relevancy Score: 455
van der Klooster J M - - 2003
A 25-year-old man with schizophrenia had abdominal complaints and haemolytic anaemia, basophilic stippling and Cabot's rings due to lead poisoning.
Relevancy Score: Relevancy Score: 452
Mikkelsen Susan - - 2010
Subcutaneous Immunotherapy (SCIT) modifies the allergic response and relieves allergic symptoms. SCIT is the only and a very effective treatment for insect venom allergy. We hypothesized that basophil sensitivity, measured through the basophil activation test, would decrease during SCIT up dosing. Expression of CD203c was compared to CD63 as marker ...
Relevancy Score: Relevancy Score: 408
Dillon W G - - 1975
The gerbil displays sex determined differences in packed red-cell volume, haemoglobin level, total leukocyte count and absolute number of circulating lymphocytes. The erythrocytes demonstrate a prominent polychromasia and frequent occurrence of basophilic stippling.
Relevancy Score: Relevancy Score: 390
Frank G - - 1989
The morphology and development of heterophil and basophil granules from the trunk kidneys of Rana esculenta tadpoles were studied at the electron microscopic level. Cells of the heterophils series contain granules displaying either spheroid profiles with homogeneous content (Type A), or elongate profiles with a crystalloid interior (Type B). Type ...
Relevancy Score: Relevancy Score: 373
Modabbernia Mohammad Jafar - - 2009
Little is known about catatonia associated with lead intoxication. A retired printing house worker man presented with one week history of refusal to eat and mutism. He was treated with possible diagnosis of catatonia with administration of Lorazepam 3 mg P.O. daily. Significant improvement occurred after 48 hours. In further ...
Relevancy Score: Relevancy Score: 366
Johansson-Sjöbeck M L - - 1979
The activity of the enzyme delta-aminolevulinic acid dehydratase (ALA-D) was strongly depressed in erythrocytes, spleen and renal tissue of rainbow trouts (Salmo gairdnerii) exposed to sublethal levels of inorganic lead (10, 75 and 300 microgram Pb2+/L) for 30 days. The fish exposed to the highest lead concentration also showed an ...
Relevancy Score: Relevancy Score: 355
Allcott J V JV - - 1987
Acute lead poisoning can present a difficult diagnostic dilemma, with symptoms that mimic those of hepatitis, nephritis, and encephalopathy. We report two cases in intravenous methamphetamine users who presented with abnormal liver function values, low hematocrit values, basophilic stippling of red blood cells, and elevated blood lead levels. Both patients ...
Relevancy Score: Relevancy Score: 355
Tanaka K - - 1996
We report a case of anemia due to chronic lead poisoning. A 46-year-old female was admitted to our hospital because of general fatigue and anemia. A peripheral blood smear showed basophilic stippling. There was basophilic stippling and nuclear dysplasia of erythroblasts in the bone marrow. Laboratory findings were as follows: ...
Relevancy Score: Relevancy Score: 355
de la Serna F J - - 1989
Congenital pyrimidin 5'nucleotidase deficiency manifests as hemolytic anemia with basophilic stippling. In lead poisoning, anemia, basophilic stippling and inhibition of erythrocyte pyrimidin 5' deficiency are also observed. In the present work, we report two cases of hemolytic anemia secondary to congenital deficiency of pyrimidin 5' nucleotidase and another case secondary ...
Relevancy Score: Relevancy Score: 343
Ben-Bassat I - - 1976
Congenital hemolytic anemia associated with pyrimidine 5'-nucleotidase deficiency is reported in two siblings. Both have had moderate chronic hemolytic anemia, splenomegaly, and jaundice since early infancy. The peripheral blood smear is characterized by striking red cell basophilic stippling. As this feature has been found in all previously reported cases, it ...
Relevancy Score: Relevancy Score: 329
George J W - - 1979
The hematologic abnormalities are used to aid in diagnosis and understanding of the pathophysiologic mechanisms of lead poisoning. Erythrocyte shape abnormalities, basophilic stippling, porphyrin abnormalities and normoblastosis have been associated with lead ingestion in many species. This paper reviews literature on these aspects of hematology of lead poisoning in both ...
Relevancy Score: Relevancy Score: 329
Pralle H - - 1985
Arsenic is widely used for the production of insecticides, paints, ceramics and for the preparation of textiles, leather and furs. Nevertheless hematologists are almost unaware of the influence of arsenic on bone marrow morphology. In the case described here we have found slight megaloblastic hemopoiesis, typical karyorrhexis in erythropoietic accompanied ...
Relevancy Score: Relevancy Score: 329
Miwa S - - 1981
A 23-year-old Japanese male with severe lead intoxication accompanied by hemolytic anemia was studied. The patient had taken 12 g to lead in about a month. He had moderate hemolytic anemia (Hb 8.9 g/100 ml) with reticulocytosis ranging from 2.5 to 11.7%. Peripheral blood smear showed nucleated red cells (42/200 ...
Relevancy Score: Relevancy Score: 314
Torrance J D - - 1977
The first South African case of haemolytic anaemia due to erythrocyte pyrimidine 5'-nucleotidase deficiency is reported. The anaemia is characterized by the presence of high erythrocyte pyrimidine nucleotide levels and marked basophilic stippling. The enzyme levels in 20 family members confirm an autosomal recessive mode of inheritance and illustrate the ...
Relevancy Score: Relevancy Score: 312
Ibrahim Abdulsalam S - - 2002
A 56-year-old Indian lady presented with one week history of abdominal pain, jaundice and chronic polyarthralgia. She had evidence of hemolytic anemia and hepatitis. Her blood lead level was high and a peripheral blood film showed dense basophilic stippling. It is believed that the lead toxicity was due to the ...
Relevancy Score: Relevancy Score: 312
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