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Oz Helieh S HS Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA - - 2014
Over 1 billion people globally are estimated to be infected with Toxoplasma gondii with severe or unknown consequences and no safe and effective therapies are available against congenital or persistent chronic infection. We propose that atovaquone and diclazuril synergistically protect against fetal-maternal toxoplasmosis. Programmed pregnant mice were treated with atovaquone ...
Archbald-Pannone Laurie L Department of Internal Medicine, Division of General Medicine, Geriatrics, and Palliative Care, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, - - 2014
The incidence and severity of Clostridium difficile infection (CDI) has been increasing and long-term care facility (LTCF) residents are at high risk given their age, co-morbidities, and high antibiotic exposure. Infection control policies are crucial for controlling CDI, but there are currently no regulatory guidelines in the United States. Therefore, ...
Oz Helieh S HS Department Internal Medicine, University of Kentucky Medical Center, Lexington, - - 2014
Toxoplasmosis is a common cause of foodborne, gastrointestinal and congenital syndrome with particularly severe or unknown health consequences. There is no safe and effective preventive or therapeutic modality against congenital toxoplasmosis or to eliminate the persistent chronic infection. Diclazuril to be safe in pregnancy and effective against gastrointestinal toxoplasmosis. CD1 ...
Sorrell A A Department of Pediatrics, City Hope National Medical Center, Duarte, CA ; Division of Clinical Cancer Genetics, City Hope National Medical Center, Duarte; - - 2012
Deleterious mutations in the RUNX1 gene cause hereditary leukemia due to a rare syndrome called Familial platelet Disorder with Associated Myeloid Malignancy (FPDMM). We describe the characteristics of a family with FPDMM due to a novel RUNX1 mutation (L472X), located in the most 3-prime end of the gene reported to ...
Harirah Hassan M HM Department of Obstetrics & Gynecology, University of Texas Medical Branch, Galveston, - - 2012
To determine the association of apoptosis in the layers of human fetal membranes with labor at term. Human fetal membranes were collected from elective cesarean sections (n = 8) and spontaneous vaginal deliveries (n = 8) at term. The extent of apoptosis within the layers of fetal membranes was determined ...
Urushihara Maki - - 2011
Intrarenal renin-angiotensin system (RAS) activation plays a critical role in the development and progression of renal injury. In the kidney, all of the RAS components are present and intrarenal angiotensin II (Ang II) is formed by multiple independent mechanisms. Angiotensinogen (AGT) is the only known substrate for renin that is ...
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