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Tanomaru Juliane Maria Guerreiro - - 2008
The maximum inhibitory dilution (MID) of triclosan-based mouthwashes against 28 Staphylococcus aureus strains was evaluated. Dilutions ranging from 1/10 to 1/655,360 were prepared. Strains were inoculated using a Steers multipoint inoculator. The MID was considered as the maximum dilution capable of inhibiting microorganism growth. The mouthwashes presented different MIDs.
Relevancy Score: Relevancy Score: 402
Hua Wenyi - - 2005
Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is an antimicroibial disinfectant agent used in a wide array of consumer products. An analytical method based on solid-phase extraction (SPE) followed by reverse phase, liquid chromatography coupled with electrospray ionization (negative)-tandem quadrupole mass spectrometry (LC-ESI(-)-MS/MS; in the multiple reaction monitoring (MRM) mode) was developed, optimized and validated ...
Relevancy Score: Relevancy Score: 401
Rodricks Joseph V - - 2010
Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether) is an antibacterial compound that has been used in consumer products for about 40 years. The tolerability and safety of triclosan has been evaluated in human volunteers with little indication of toxicity or sensitization. Although information in humans from chronic usage of personal care products is not ...
Relevancy Score: Relevancy Score: 401
Paul Katie B - - 2010
Disruption of maternal thyroid hormones during fetal developmental may result in irreversible neurological consequences in offspring. The present study tested the hypothesis that perinatal triclosan exposure of dams decreases thyroxine in dams and offspring prior to weaning. Pregnant Long-Evans rats received triclosan by oral gavage (0-300 mg/kg/d) in corn oil ...
Relevancy Score: Relevancy Score: 401
Vidal Lorena - - 2008
Chemically surface-modified (tosyl-functionalized) carbon nanoparticles (Emperor 2000 from Cabot Corp.) are employed for the extraction and electrochemical determination of phenolic impurities such as benzophenone-3 (2-hydroxy-4-methoxybenzophenone) or triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol). The hydrophilic carbon nanoparticles are readily suspended and separated by centrifugation prior to deposition onto suitable electrode surfaces and voltammetric analysis. Voltammetric ...
Relevancy Score: Relevancy Score: 401
van der Hoeven J S - - 1993
Chlorhexidine, and zinc in combination with triclosan, are used as anti-plaque agents in the prevention of gingivitis. The multifunctional activity of these compounds against bacterial cells has been proposed to include interference with sugar transport and reduction of glycolysis. In this study the ability of the agents to reduce acid ...
Relevancy Score: Relevancy Score: 401
Lobene R R - - 1991
A 6-month, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of a dentifrice containing 0.3% triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride/silica base, as compared to a placebo dentifrice containing 0.243% sodium fluoride in a silica base. Subjects ...
Relevancy Score: Relevancy Score: 401
Moran J - - 2001
BACKGROUND/AIMS: Triclosan containing toothpastes have been noted for their potential to inhibit plaque and gingival inflammation. The aim of this study was to determine whether a toothpaste containing triclosan and an enhanced fluoride system would inhibit de novo plaque formation beyond that of a non-triclosan, conventional fluoride toothpaste. METHODS: This ...
Relevancy Score: Relevancy Score: 401
Mankodi S - - 1992
A total of 294 adult male and female subjects completed a 6-month, double-blind clinical trial designed to evaluate the effects of a dentifrice which contained 0.3% triclosan in conjunction with 2% of a methoxyethylene/maleic acid copolymer in a 0.243% sodium fluoride/silica base, relative to a control dentifrice, on supragingival plaque ...
Relevancy Score: Relevancy Score: 401
Lang Niklaus P - - 2002
A recently reported six-month gingivitis study demonstrated that in subjects with gingivitis, a triclosan/pyrophosphate dentifrice provided supragingival plaque control. The level of plaque reduction was comparable with that reported for other triclosan-containing dentifrices; however, no reductions in gingivitis were observed for triclosan/pyrophosphate relative to the negative control. One possible explanation ...
Relevancy Score: Relevancy Score: 401
Cortez Fernando Sanzi - - 2012
Triclosan (5-Chloro-2-(2,4-dichlorophenoxy) phenol) is an antibacterial compound widely employed in pharmaceuticals and personal care products. Although this emerging compound has been detected in aquatic environments, scarce information is found on the effects of Triclosan to marine organisms. The aim of this study was to evaluate the toxicity of a concentration ...
Relevancy Score: Relevancy Score: 401
Adams S E - - 2003
OBJECTIVE: To compare the antimicrobial efficacy and effect on plaque growth of a new silica-based fluoride toothpaste containing 2% zinc citrate/ 0.3% Triclosan with a silica-based fluoride toothpaste containing 0.3% Triclosan/2% copolymer. METHODS: In Study 1, plaque was collected after one week's use of each toothpaste and assessed for bacterial ...
Relevancy Score: Relevancy Score: 399
Lobene R R - - 1992
A five-day, double-blind parallel clinical study was conducted to determine the effect on plaque removal of a pre-brush rinse containing 0.03 triclosan (Irgacare MP, Ciba-Geigy Corp.) and 0.125% of a copolymer of methoxyethylene and maleic acid (Gantrez, GAF Corp.), as compared to a matching placebo pre-brush rinse. One hundred eleven ...
Relevancy Score: Relevancy Score: 399
Kastbjerg Vicky G VG National Food Institute, Technical University of Denmark, Kongens Lyngby, - - 2014
Exposure of the human food-borne pathogen Listeria monocytogenes to sublethal concentrations of triclosan can cause resistance to several aminoglycosides. Aminoglycoside-resistant isolates exhibit two colony morphologies: normal-size and pinpoint colonies. The purposes of the present study were to characterize the small colonies of L. monocytogenes and to determine if specific genetic ...
Relevancy Score: Relevancy Score: 398
He Tao - - 2013
To compare the relative plaque control efficacy of a marketed 0.454% stabilized stannous fluoride (SnF2) dentifrice relative to a triclosan/copolymer dentifrice using digital plaque imaging analysis (DPIA). This was a randomized, two-treatment, double-blind, parallel group design study that compared SnF2 and triclosan/copolymer dentifrices over a period of 3 weeks. DPIA ...
Relevancy Score: Relevancy Score: 398
Luisa Domínguez-Delgado Clara - - 2011
This work focuses on the preparation and characterization of nanoparticles containing triclosan. Additionally, in vitro percutaneous permeation of triclosan through pig ear skin was performed, and comparisons were made with two commercial formulations: An o/w emulsion and a solution, both of them intended for the treatment of acne. The nanoparticle ...
Relevancy Score: Relevancy Score: 398
Christensen Ellen G - - 2011
The human food-borne pathogen Listeria monocytogenes is capable of persisting in food processing plants despite cleaning and sanitation and is likely exposed to sublethal biocide concentrations. This could potentially affect susceptibility of the bacterium to biocides and other antimicrobial agents. The purpose of the present study was to determine if ...
Relevancy Score: Relevancy Score: 397
Sainulabdeen Sajad - - 2010
The aim of this pilot study was to evaluate the antibacterial activity of glass ionomer cement impregnated with different concentrations (0.5%, 1.25% and 2.5%) of a non releasing bactericide--Triclosan (TC) against two common cariogenic bacteria - Lactobacillus acidophilus and Streptococcus mutans; and to compare Triclosan incorporated GIC with chlorhexidine (CHX) ...
Relevancy Score: Relevancy Score: 397
Waltman Elise Lyn - - 2006
The antimicrobial triclosan was analyzed in unfiltered samples from influent, effluent, and receiving stream and before and after a pilot-scale constructed wetland at a North Texas municipal wastewater treatment plant. Triclosan concentrations were reduced by 97 to 99% by the activated sludge treatment plant. Effluent concentrations were further reduced by ...
Relevancy Score: Relevancy Score: 397
Zarate Frederick M FM - - 2012
Constructed wetlands are a potential method for the removal of two pharmaceutical and personal care products from wastewater effluent. Triclosan (TCS; 5-chloro-2-[2,4-dichlorophenoxy]phenol) and triclocarban (TCC; 3,4,4'-trichlorocarbanillide) are antimicrobial agents added to a variety of consumer products whose accumulation patterns in constructed wetlands are poorly understood. Here, we report the accumulation ...
Relevancy Score: Relevancy Score: 397
Ramos Ana I - - 2013
Solid 1:1 inclusion compounds of triclosan with native and permethylated β-cyclodextrin (β-CD and TRIMEB) were prepared by co-crystallisation and co-evaporation, respectively, and studied by FT-IR and (13)C{(1)H} CP/MAS NMR spectroscopies, thermogravimetric analysis, X-ray diffraction and theoretical calculations. Results showed that triclosan inclusion into TRIMEB afforded an amorphous solid, whilst β-CD·triclosan ...
Relevancy Score: Relevancy Score: 396
Levy C W - - 1999
Relevancy Score: Relevancy Score: 396
Heath R J - - 2000
Relevancy Score: Relevancy Score: 396
Liu Binqiu - - 2002
BACKGROUND AND PURPOSE: Human type I fatty acid synthase has been proposed as a chemotherapeutic target for the treatment of breast cancer based on the inactivation of human beta-ketoacyl synthase activity by cerulenin. Triclosan, a common antibiotic, functions by inhibiting the enoyl-reductase enzymes of type II fatty acid synthases in ...
Relevancy Score: Relevancy Score: 394
Chen Fu F Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198-6025, - - 2010
To develop tooth-binding micelle formulations of triclosan for the prevention and treatment of dental caries. Alendronate (ALN) was conjugated to the chain termini of different Pluronic copolymers to confer tooth-binding ability to the micelles. Using 3 different formulation methods, Pluronics and ALN-modified Pluronics were used to prepare triclosan-loaded tooth-binding micelles. ...
Relevancy Score: Relevancy Score: 394
Sánchez-Brunete Consuelo - - 2010
In this study, a method for the determination of triclosan (TCS) and methyl triclosan (MTCS) in soil and sewage sludge samples from municipal wastewater treatment plants was developed based on the extraction by matrix solid-phase dispersion. After extraction, the analytes were derivatized with N-(tert-butyldimethylsilyl)-N-methyl-trifluoroacetamide for their determination by isotope dilution ...
Relevancy Score: Relevancy Score: 394
Chuanchuen Rungtip - - 2002
Using the biocide triclosan as a selective agent, several triclosan-resistant mutants of a susceptible Pseudomonas aeruginosa strain were isolated. Cloning and characterization of a DNA fragment conferring triclosan resistance from one of these mutants revealed a hitherto uncharacterized efflux system of the resistance nodulation cell division (RND) family, which was ...
Relevancy Score: Relevancy Score: 392
Braoudaki Maria - - 2004
Misuse of biocides has encouraged the emergence of resistance and cross-resistance in certain strains. This study investigated resistance of triclosan-adapted Escherichia coli K-12 and E. coli O55 to antimicrobial agents and compared these to E. coli O157:H7. Cross-resistance in E. coli K-12 and E. coli O55 was observed however to ...
Relevancy Score: Relevancy Score: 392
Sharma N - - 2013
To compare the anti-plaque efficacy of a stabilized 0.454% stannous fluoride (referred to as SnF2) dentifrice versus a 0.3% triclosan dentifrice formulated with a copolymer and sodium fluoride (referred to as triclosan). The study had a randomized, double-blind, two-treatment, parallel-group design, and compared plaque reduction from baseline after both three ...
Relevancy Score: Relevancy Score: 392
Adolfsson-Erici Margaretha - - 2002
High levels of the commonly used, effective bactericide Triclosan was found in three out of five randomly selected human milk samples. It was also found in the bile of fish exposed to municipal wastewater and in wild living fish from the receiving waters of the three wastewater treatment plants.
Relevancy Score: Relevancy Score: 392
Bester K - - 2003
In a German sewage treatment plant that processes 200000 m(3) wastewater per day, the concentrations of 2,4,4'-trichloro, 2'-hydroxy-phenylether (triclosan) in the in-flowing ( approximately 1000 ng x l(-1)) as well as in the out-flowing water ( approximately 50 ng x l(-1)) are compared to the concentrations measured in sludge (1200 ...
Relevancy Score: Relevancy Score: 392
Siddiqui W H - - 1979
The pharmacokinetics of triclosan was studied in sexually mature virgin Wistar rats. 14C-triclosan was injected either via the femoral vein, (iv, 5 mg/kg in polyethylene glycol-400) or into the vaginal orifice (ivg, 5 mg/kg in corn oil). Radioactivity was determined by liquid scintillation spectrophotometry. After iv administration, the dissapearance of ...
Relevancy Score: Relevancy Score: 392
Lear J C - - 2002
Potential development of bacterial tolerance to biocides in the industrial environment is examined in this study. Bacteria tolerant to the phenolic-type agent para-chloro-meta-xylenol (PCMX) and the bis-phenol 2,4,4'-trichloro-2'-hydroxydiphenylether (triclosan) were isolated from industrial sources and identified. Minimum inhibitory concentrations (MICs) were determined and compared with those of culture collection (standard) ...
Relevancy Score: Relevancy Score: 392
Piñón-Segundo E - - 2005
The aim of this work was to produce and characterize triclosan-loaded nanoparticles (NPs) by the emulsification-diffusion process, in an attempt to obtain a novel delivery system adequate for the treatment of periodontal disease. The NPs were prepared using poly(D,L-lactide-co-glycolide) (PLGA), poly(D,L-lactide) (PLA) and cellulose acetate phthalate (CAP). Poly(vinyl alcohol) (PVAL) ...
Relevancy Score: Relevancy Score: 392
Sivaraman Sharada - - 2003
Triclosan, a common antibacterial additive used in consumer products, is an inhibitor of FabI, the enoyl reductase enzyme from type II bacterial fatty acid biosynthesis. In agreement with previous studies [Ward, W. H., Holdgate, G. A., Rowsell, S., McLean, E. G., Pauptit, R. A., Clayton, E., Nichols, W. W., Colls, ...
Relevancy Score: Relevancy Score: 392
Chau W C - - 2008
A gas chromatography-ion trap mass spectrometry method was developed and optimized for the analysis of triclosan in water. Tandem mass spectrometry, along with an isotope dilution internal standard method, was used for the quantitative analysis of triclosan in water at low ng l(-1) levels. The efficiencies obtained from liquid-liquid extraction ...
Relevancy Score: Relevancy Score: 391
Weitgasser H - - 1983
A multicentre, between-patient, comparative trial was carried out to compare the efficacy and tolerability of a cream containing 0.05 halometasone and 1% triclosan with those of a cream with 0.05% betametasone dipropionate and 0.1% gentamicin sulphate in patients suffering from infected acute ezcematous dermatoses. In the evaluable trial population, consisting ...
Relevancy Score: Relevancy Score: 391
Latimer Joe - - 2012
Subeffective exposure of Staphylococcus aureus to the biocide triclosan can reportedly induce a small-colony variant (SCV) phenotype. S. aureus SCVs are characterized by low growth rates, reduced pigmentation, and lowered antimicrobial susceptibility. While they may exhibit enhanced intracellular survival, there are conflicting reports regarding their pathogenicity. The current study reports ...
Relevancy Score: Relevancy Score: 391
Satheeshkumar P S - - 2010
Introduction: Oral care in cancer patients is an important aspect in the quality of life of patients undergoing cancer therpay. Mucositis, trismus, salivary gland dysfunction are the main complications of the cancer therapy, which lead to long-term comlications such as radiation caries, poor oral hygiene and osteoradionecrosis. A timely oral ...
Relevancy Score: Relevancy Score: 391
Kapoor Mili - - 2004
Triclosan, a known antibacterial, acts by inhibiting enoyl-ACP (acyl-carrier protein) reductase (ENR), a key enzyme of the type II fatty acid synthesis (FAS) system. Plasmodium falciparum, the human malaria-causing parasite, harbours the type II FAS; in contrast, its human host utilizes type I FAS. Due to this striking difference, ENR ...
Relevancy Score: Relevancy Score: 391
Cookson B D - - 1991
Relevancy Score: Relevancy Score: 390
Ming Xintian - - 2007
BACKGROUND: This study evaluated the ability of poliglecaprone 25 suture with triclosan to inhibit bacterial colonization by Escherichia coli and Staphylococcus aureus in mouse and guinea pig models. METHODS: Test and control sutures (3-4 cm) were implanted subcutaneously in the dorsal-lateral regions (control on the left side, test on the ...
Relevancy Score: Relevancy Score: 389
Moran J - - 2000
BACKGROUND/AIMS: Toothpastes and mouthrinses containing triclosan have been shown to be of some value at inhibiting both plaque and gingivitis. However much improved activity can be obtained by the addition of other chemicals which increase substantivity or antimicrobial activity. The present study was designed to determine whether a new mouthwash ...
Relevancy Score: Relevancy Score: 389
Renvert S - - 1995
3 triclosan-containing dentifrices were compared in a 6-month, unsupervised tooth brushing study. The effects on plaque, gingival bleeding and certain salivary micro-organisms (mutans streptococci, lactobacilli, total counts of streptococci and total counts of micro-organisms) were evaluated. 123 subjects were divided into 4 groups according to severity of gingival bleeding index. ...
Relevancy Score: Relevancy Score: 389
Chang Wai Keat WK Department of Surgery, South Auckland Clinical School, Middlemore Hospital, University of Auckland, Otahuhu, Auckland, New Zealand. - - 2012
To determine the efficacy and safety of triclosan-impregnated sutures. Surgical-site infections (SSIs) produce considerable morbidity and increase health care costs. A potential strategy to decrease the rates of SSIs may be the use of triclosan-impregnated sutures. These have been endorsed and/or funded by professional and governmental bodies in numerous countries. ...
Relevancy Score: Relevancy Score: 389
Guo Jie-Hong - - 2009
In this study, dispersive liquid-liquid microextraction (DLLME) combined with ultra-high-pressure liquid chromatography (UHPLC)-tunable ultraviolet detection (TUV), has been developed for pre-concentration and determination of triclosan (TCS), triclocarban (TCC) and methyl-triclosan (M-TCS) in aqueous samples. The key factors, including the kind and volume of extraction solvent and dispersive solvent, extraction time, ...
Relevancy Score: Relevancy Score: 389
Ford Henri R - - 2005
BACKGROUND: Coated polyglactin 910 suture with triclosan was developed recently in order to imbue the parent suture, coated polyglactin 910, with antibacterial activity against the most common organisms that cause surgical site infections (SSI). Because such alterations could alter the physical properties of the suture, this study sought to compare ...
Relevancy Score: Relevancy Score: 389
Okada Naoya N Department of Surgery, Teine-Keijinkai Hospital , Teine-ku, Sapporo, Japan - - 2014
Abstract Background: Surgical site infection (SSI) is a serious complication after pancreaticoduodenectomy (PD). To prevent microbial colonization of suture material in operative wounds, triclosan-coated polyglactin sutures with antibacterial activity have been developed recently. Several clinical studies have shown that the use of such suture reduces SSIs in various operations, but ...
Relevancy Score: Relevancy Score: 388
Sreenivasan Prem K - - 2011
Supportive therapy to maintain dental implants is increasingly important. This study examined the effect of a 0.3% triclosan/2% copolymer dentifrice on oral biofilms and gingival inflammation (GI) on dental implants and peri-implant tissues. One hundred and twenty adults with a dental implant and contra-lateral tooth were enrolled in this 6 ...
Relevancy Score: Relevancy Score: 388
Rodrigues Diana - - 2011
Contamination of food contact surfaces by microbes such as Salmonella is directly associated with substantial industry costs and severe foodborne disease outbreaks. Several approaches have been developed to control microbial attachment; one approach is the development of food contact materials incorporating antimicrobial compounds. In the present study, Salmonella enterica Enteritidis ...
Relevancy Score: Relevancy Score: 388
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