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Taniguchi Keiichi - - 2013
Mycobacterium bovis bacillus Calmette Guérin (BCG) vaccine, which has been inoculated to more than one billion people world-wide, has significant effect in preventing tuberculous meningitis and miliary tuberculosis (TB) in neonate and early childhood. However, BCG fails to adequately protect against pulmonary TB and reactivation of latent infections in adults. ...
Relevancy Score: Relevancy Score: 549
Twine Christopher - - 2007
This instructive case describes a 31-day-old female infant presenting with left elbow swelling. Radiographs were initially consistent with non-accidental injury, and she was investigated accordingly. After Paediatric Orthopaedic review, BCG osteitis was considered as a differential diagnosis. By this time it was too late to investigate for this uncommon condition. ...
Relevancy Score: Relevancy Score: 549
Alexander David C - - 2007
Mycobacterium bovis Bacille Calmette-Guérin (BCG) is a live attenuated vaccine for the prevention of tuberculosis. Transcriptome comparison reveals dysregulated expression of two genes, Rv1774 and Rv1775, exclusively in the Pasteur strain of BCG. We show that these genes form a bicistronic operon regulated by Rv1773, a transcriptional repressor deleted during ...
Relevancy Score: Relevancy Score: 548
Luelmo F - - 1982
Relevancy Score: Relevancy Score: 548
Raj B - - 1986
Relevancy Score: Relevancy Score: 548
- - 1983
Relevancy Score: Relevancy Score: 548
- - 1983
Relevancy Score: Relevancy Score: 548
Bhandari B - - 1982
Relevancy Score: Relevancy Score: 548
Long E R - - 1966
Relevancy Score: Relevancy Score: 548
Arain G M - - 1991
Relevancy Score: Relevancy Score: 548
Lattimore W C - - 1975
Relevancy Score: Relevancy Score: 548
Rosenthal S R - - 1972
Relevancy Score: Relevancy Score: 548
- - 1992
Relevancy Score: Relevancy Score: 548
Coates A - - 1977
Relevancy Score: Relevancy Score: 548
Teo Stephen Sze Shing - - 2005
Relevancy Score: Relevancy Score: 548
Henrikson B - - 1974
Relevancy Score: Relevancy Score: 548
Koch-Weser D - - 1985
Relevancy Score: Relevancy Score: 548
Sethi G R - - 1988
Relevancy Score: Relevancy Score: 548
Hsu Jong-Wei JW Department of Urology, University of Rochester, Rochester, New York, - - 2013
Bacillus Calmette-Guérin (BCG), a vaccine against tuberculosis(TB), has been used and proven to be one of the most effective treatments for non-muscle invasive bladder cancer (BCa). However, the mechanisms of BCG action have not been completely understood, thereby limiting the improvement of BCG therapy. Vitamin D deficiency has been associated ...
Relevancy Score: Relevancy Score: 548
Toida I - - 1993
Bacille Calmette-Guérin (BCG) has been widely used as a safe and effective vaccine for the protection of tuberculosis, but recent epidemic of human immunodeficiency virus (HIV) infection evoked serious concerns about the safety of BCG when vaccinated to HIV-infected persons: that is, because BCG is a live, though avirulent, bacterial ...
Relevancy Score: Relevancy Score: 547
Kaasinen E S - - 2000
PURPOSE: To study short-term events in the mechanism of action of BCG with an emphasis on the interaction between BCG and T24 cell line cells. MATERIALS AND METHODS: Peripheral blood mononuclear cells (PBMNC) or/and several tumor cell lines were incubated with BCG (Oncotice) using various clinical and subclinical BCG concentrations. ...
Relevancy Score: Relevancy Score: 547
- - 1996
BACKGROUND: Repeat BCG vaccination is standard practice in many countries for prevention of tuberculosis and leprosy, but its effectiveness has not been evaluated. The addition of Mycobacterium leprae antigens to BCG might improve its effectiveness against leprosy. A double-blind, randomised, controlled trial to evaluate both these procedures was carried out ...
Relevancy Score: Relevancy Score: 547
- - 1948
Relevancy Score: Relevancy Score: 547
GIKOVATE F - - 1950
Relevancy Score: Relevancy Score: 547
IMBERT P - - 1951
Relevancy Score: Relevancy Score: 547
CAIRNS J G - - 1947
Relevancy Score: Relevancy Score: 547
Crowle A J - - 1983
If BCG must replicate well in vivo to immunize, presumably mainly in macrophages, the potency of BCG vaccines in human subjects might be measurable as the ability of the BCG to replicate in cultured human macrophages. We used this assumption to compare 6 different batches of lyophilized BCG with freshly ...
Relevancy Score: Relevancy Score: 547
Choi Jong Su - - 2012
Bacillus Calmette-Guérin (BCG) vaccination has proven to be efficient in immunologically naïve infants; however, it has not been investigated that maternal natural exposure to Mycobacterium and/or BCG vaccine could influence the characteristics of immune responses to BCG in newborns. In this study, we analyzed whether the maternal immune status to ...
Relevancy Score: Relevancy Score: 546
Sato H - - 1967
The authors have attempted to prepare lysed BCG vaccines retaining the protective antigens of the BCG cell wall and yet eliciting in experimental animals limited sensitivity to the tuberculin substances, the advantage sought being to retain the usefulness of the tuberculin following vaccination as an indicator of superinfection.Experimental vaccines were ...
Relevancy Score: Relevancy Score: 546
Wang G Z - - 1988
The objective of this study was to compare four BCG substrains from regional centres in China with BCG-Copenhagen 1331 (Danish strain) for protective and allergenic potencies. The comparisons were made in two different guinea pig models: one, a rational animal model involving aerosol challenge with 5-10 cfu Mycobacterium tuberculosis (strain ...
Relevancy Score: Relevancy Score: 546
Kreider J W - - 1976
We evaluated the potential of the B16 melanoma of mice as a model system for BCG immunotherapy of malignant melanoma. We studied a variety of treatment protocols: a) BCG given simultaneously but separately with a small number of B16 cells significantly inhibited tumor growth in only three of eight experiments. ...
Relevancy Score: Relevancy Score: 546
Zwolska Zofia - - 2004
The attenuated bacilli Calmette-Guerin (BCG) vaccine is administered worldwide to prevent tuberculosis and is considered to have an excellent safety profile. In Poland, since 1955 BCG mass vaccinations have been compulsory. More than 95% newborns and 80% of older children of the population have been vaccinated. Complications of vaccination are ...
Relevancy Score: Relevancy Score: 545
Semple Patricia L - - 2011
While vaccination at birth with Mycobacterium bovis Bacilli Calmette-Guérin (BCG) protects against severe childhood tuberculosis, there is no consensus as to which components of the BCG-induced immune response mediate this protection. However, granulysin and perforin, found in the granules of cytotoxic T lymphocytes and Natural Killer (NK) cells, can kill ...
Relevancy Score: Relevancy Score: 545
ROELSGAARD E - - 1957
The authors outline the development and organization of the BCG-vaccination campaign that was launched in August 1949 by the Government of Pakistan, with assistance from the International Tuberculosis Campaign. They present some statistical data on the work done up to the end of December 1954 and briefly discuss the pattern ...
Relevancy Score: Relevancy Score: 545
CEPERO GARCIA R - - 1956
Relevancy Score: Relevancy Score: 545
Yoo Yung Choon - - 2002
The antimetastatic effect of BCG-CWS, which was emulsified in an oil-in-water form with either Drakeol 6VR mineral oil (BCG-CWS/DK) or squalane (BCG-CWS/SQA), on lung metastasis produced by highly metastatic murine tumor cells, Colon26-M3.1 carcinoma cells and B16-BL6 melanoma cells, was investigated in syngeneic mice. An intravenous (i.v.) administration of BCG-CWS ...
Relevancy Score: Relevancy Score: 544
da Costa Adeliane Castro AC Department of Microbiology, Immunology, Parasitology and Pathology, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás , Goiânia , - - 2014
Bacille Calmette-Guérin (BCG), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against active TB in children, BCG has failed to protect adults against TB infection and active disease development, especially in developing countries where the disease is endemic. Currently, ...
Relevancy Score: Relevancy Score: 544
FUXA SANZ J - - 1956
Relevancy Score: Relevancy Score: 543
LAFAY-COLETSOS L H - - 1952
Relevancy Score: Relevancy Score: 543
KRZYSZKOWSKA A - - 1958
Relevancy Score: Relevancy Score: 543
Downs T M - - 1997
PURPOSE: To determine if BCG and interferon alpha-2B are mutually compatible as mixed intravesical agents for clinical bladder cancer therapy. MATERIALS AND METHODS: Mutual compatibility was assessed by measuring IFN-alpha's effect on BCG metabolic activity, growth rate, and clumping tendency and conversely by observing BCG's effect on IFN-alpha's anti-viral activity. ...
Relevancy Score: Relevancy Score: 543
Lugosi L - - 1992
The protective and immunostimulating effect of the living attenuated BCG vaccine cannot be expressed by bacterial mass (mg/dose). Colony forming units (CFU 10(6)/ml) and 95% confidence limit estimates as precise in vitro potency tests are required for the exact evaluation of the immunogenicity and reactogenicity of the BCG vaccine. The ...
Relevancy Score: Relevancy Score: 543
Nikonenko B V - - 1990
Vaccination with M. bovis (BCG) essentially prolonged survival time (ST) of several strain mice, with the exception, of CBA/N, infected with M. tuberculosis H37Rv. ST of CBA/N, differing from CBA by xid mutation, was not prolonged by vaccination. Mouse strains with alternative alleles of BCG gene (s and r) and ...
Relevancy Score: Relevancy Score: 543
Rahman Mahbubur - - 2003
This paper summarizes Bacillus Calmette-Guerin (BCG) vaccination and revaccination policies in Japan, its cost-effectiveness, side effects, proposed selective vaccination strategy, and present tuberculosis situation in Japanese perspectives based on Medline database and other published reports. Universal BCG vaccination in infants and revaccination among children were not found economically justifiable. Overall ...
Relevancy Score: Relevancy Score: 543
Flynn J L - - 1994
BCG, an attenuated vaccine strain of Mycobacterium bovis, has been engineered for use as an antigen delivery vehicle. Various genetic and molecular biological techniques were recently developed for use in the manipulation of mycobacteria. Vectors for the expression of foreign antigens in BCG have been constructed and used to express ...
Relevancy Score: Relevancy Score: 543
Thilothammal N - - 1996
The reported efficacy of BCG vaccine in preventing pulmonary tuberculosis varies from 0-80%; however, its efficacy in preventing tuberculous meningitis ranges from 52%-84%. A case-control study was conducted to assess the efficacy of BCG in preventing tuberculous meningitis in children. New cases of tuberculous meningitis, confirmed bacteriologically, were registered as ...
Relevancy Score: Relevancy Score: 543
Yang Yucheng Y Department of Otolaryngology, the First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, 400016, - - 2005
To investigate the correlations between tuberculin responses and allergic rhinitis treated by BCG-PSN. A total 60 patients with allergic rhinitis were randomly divided into BCG-PSN treated group and control group. All patients were given purified protein derivate (PPD), and PPD induration were recorded after 72 h, also the eosinophil cationic ...
Relevancy Score: Relevancy Score: 543
Günther J H - - 1999
PURPOSE: Intravesical immunotherapy with bacillus Calmette-Guerin (BCG), which has become the gold standard in the adjuvant treatment of superficial bladder cancer, is hampered by local side effects. Anti-inflammatory drugs may be helpful, but as an undesired side effect, therapeutic efficacy of BCG might be impaired. Therefore, we investigated the effects ...
Relevancy Score: Relevancy Score: 543
Szabó L - - 1988
Relevancy Score: Relevancy Score: 543
Nadasy Krisztina A - - 2008
Intravesical BCG (bacillus Calmette-Guérin) instillation is a first-line treatment for superficial transitional cell carcinoma of the bladder. A rare but severe complication of BCG immunotherapy is the development of disseminated BCG disease, which can result in miliary pneumonitis, granulomatous hepatitis, soft tissue infections, bone marrow involvement, and sepsis. Symptoms can ...
Relevancy Score: Relevancy Score: 543
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