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Sato H - - 1967
The authors have attempted to prepare lysed BCG vaccines retaining the protective antigens of the BCG cell wall and yet eliciting in experimental animals limited sensitivity to the tuberculin substances, the advantage sought being to retain the usefulness of the tuberculin following vaccination as an indicator of superinfection.Experimental vaccines were ...
Relevancy Score: Relevancy Score: 546
ROELSGAARD E - - 1957
The authors outline the development and organization of the BCG-vaccination campaign that was launched in August 1949 by the Government of Pakistan, with assistance from the International Tuberculosis Campaign. They present some statistical data on the work done up to the end of December 1954 and briefly discuss the pattern ...
Relevancy Score: Relevancy Score: 546
Szabó L - - 1988
Relevancy Score: Relevancy Score: 546
Kreider J W - - 1976
We evaluated the potential of the B16 melanoma of mice as a model system for BCG immunotherapy of malignant melanoma. We studied a variety of treatment protocols: a) BCG given simultaneously but separately with a small number of B16 cells significantly inhibited tumor growth in only three of eight experiments. ...
Relevancy Score: Relevancy Score: 546
KRZYSZKOWSKA A - - 1958
Relevancy Score: Relevancy Score: 546
Wang G Z - - 1988
The objective of this study was to compare four BCG substrains from regional centres in China with BCG-Copenhagen 1331 (Danish strain) for protective and allergenic potencies. The comparisons were made in two different guinea pig models: one, a rational animal model involving aerosol challenge with 5-10 cfu Mycobacterium tuberculosis (strain ...
Relevancy Score: Relevancy Score: 545
Hsu Jong-Wei JW Department of Urology, University of Rochester, Rochester, New York, - - 2013
Bacillus Calmette-Guérin (BCG), a vaccine against tuberculosis(TB), has been used and proven to be one of the most effective treatments for non-muscle invasive bladder cancer (BCa). However, the mechanisms of BCG action have not been completely understood, thereby limiting the improvement of BCG therapy. Vitamin D deficiency has been associated ...
Relevancy Score: Relevancy Score: 545
Semple Patricia L - - 2011
While vaccination at birth with Mycobacterium bovis Bacilli Calmette-Guérin (BCG) protects against severe childhood tuberculosis, there is no consensus as to which components of the BCG-induced immune response mediate this protection. However, granulysin and perforin, found in the granules of cytotoxic T lymphocytes and Natural Killer (NK) cells, can kill ...
Relevancy Score: Relevancy Score: 545
Zwolska Zofia - - 2004
The attenuated bacilli Calmette-Guerin (BCG) vaccine is administered worldwide to prevent tuberculosis and is considered to have an excellent safety profile. In Poland, since 1955 BCG mass vaccinations have been compulsory. More than 95% newborns and 80% of older children of the population have been vaccinated. Complications of vaccination are ...
Relevancy Score: Relevancy Score: 545
Choi Jong Su - - 2012
Bacillus Calmette-Guérin (BCG) vaccination has proven to be efficient in immunologically naïve infants; however, it has not been investigated that maternal natural exposure to Mycobacterium and/or BCG vaccine could influence the characteristics of immune responses to BCG in newborns. In this study, we analyzed whether the maternal immune status to ...
Relevancy Score: Relevancy Score: 544
da Costa Adeliane Castro AC Department of Microbiology, Immunology, Parasitology and Pathology, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás , Goiânia , - - 2014
Bacille Calmette-Guérin (BCG), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against active TB in children, BCG has failed to protect adults against TB infection and active disease development, especially in developing countries where the disease is endemic. Currently, ...
Relevancy Score: Relevancy Score: 544
Yoo Yung Choon - - 2002
The antimetastatic effect of BCG-CWS, which was emulsified in an oil-in-water form with either Drakeol 6VR mineral oil (BCG-CWS/DK) or squalane (BCG-CWS/SQA), on lung metastasis produced by highly metastatic murine tumor cells, Colon26-M3.1 carcinoma cells and B16-BL6 melanoma cells, was investigated in syngeneic mice. An intravenous (i.v.) administration of BCG-CWS ...
Relevancy Score: Relevancy Score: 544
Flynn J L - - 1994
BCG, an attenuated vaccine strain of Mycobacterium bovis, has been engineered for use as an antigen delivery vehicle. Various genetic and molecular biological techniques were recently developed for use in the manipulation of mycobacteria. Vectors for the expression of foreign antigens in BCG have been constructed and used to express ...
Relevancy Score: Relevancy Score: 543
Thilothammal N - - 1996
The reported efficacy of BCG vaccine in preventing pulmonary tuberculosis varies from 0-80%; however, its efficacy in preventing tuberculous meningitis ranges from 52%-84%. A case-control study was conducted to assess the efficacy of BCG in preventing tuberculous meningitis in children. New cases of tuberculous meningitis, confirmed bacteriologically, were registered as ...
Relevancy Score: Relevancy Score: 543
Yang Yucheng Y Department of Otolaryngology, the First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, 400016, - - 2005
To investigate the correlations between tuberculin responses and allergic rhinitis treated by BCG-PSN. A total 60 patients with allergic rhinitis were randomly divided into BCG-PSN treated group and control group. All patients were given purified protein derivate (PPD), and PPD induration were recorded after 72 h, also the eosinophil cationic ...
Relevancy Score: Relevancy Score: 543
Rahman Mahbubur - - 2003
This paper summarizes Bacillus Calmette-Guerin (BCG) vaccination and revaccination policies in Japan, its cost-effectiveness, side effects, proposed selective vaccination strategy, and present tuberculosis situation in Japanese perspectives based on Medline database and other published reports. Universal BCG vaccination in infants and revaccination among children were not found economically justifiable. Overall ...
Relevancy Score: Relevancy Score: 543
Holmes E C - - 1980
Thirty-three patients have undergone BCG intralesional injection into pulmonary tumors. Six received the injection by way of the bronchoscope and 27 were injected percutaneously under fluoroscopic control. The toxicity of this treatment is closely related to PPD reactivity. PPD-negative patients have little fever and malaise. However patients with strongly positive ...
Relevancy Score: Relevancy Score: 543
Yamamoto Saburo - - 2007
Bacillus Calmette and Guérin (BCG) was introduced to Japan in 1924 by Kiyoshi Shiga and has been propagated for research purposes ever since propagation is accomplished using a glycerin-bile-potato mixture in the same manner used by Calmette and Guérin. To prepare a stable and safe freeze-dried BCG vaccine, several joint ...
Relevancy Score: Relevancy Score: 543
Lugosi L - - 1986
Hungary has accomplished a resolute BCG programme since 1959 to control tuberculosis in children. High rates of child and adult tuberculosis incidence (over 200 and 300 per hundred thousand respectively) persisted before 1959. At that time the "Budapest" BCG strain received from the Pasteur Institute in 1933 was used for ...
Relevancy Score: Relevancy Score: 543
Nikonenko B V - - 1990
Vaccination with M. bovis (BCG) essentially prolonged survival time (ST) of several strain mice, with the exception, of CBA/N, infected with M. tuberculosis H37Rv. ST of CBA/N, differing from CBA by xid mutation, was not prolonged by vaccination. Mouse strains with alternative alleles of BCG gene (s and r) and ...
Relevancy Score: Relevancy Score: 542
Lugosi L - - 1992
The protective and immunostimulating effect of the living attenuated BCG vaccine cannot be expressed by bacterial mass (mg/dose). Colony forming units (CFU 10(6)/ml) and 95% confidence limit estimates as precise in vitro potency tests are required for the exact evaluation of the immunogenicity and reactogenicity of the BCG vaccine. The ...
Relevancy Score: Relevancy Score: 542
Nadasy Krisztina A - - 2008
Intravesical BCG (bacillus Calmette-Guérin) instillation is a first-line treatment for superficial transitional cell carcinoma of the bladder. A rare but severe complication of BCG immunotherapy is the development of disseminated BCG disease, which can result in miliary pneumonitis, granulomatous hepatitis, soft tissue infections, bone marrow involvement, and sepsis. Symptoms can ...
Relevancy Score: Relevancy Score: 542
Günther J H - - 1999
PURPOSE: Intravesical immunotherapy with bacillus Calmette-Guerin (BCG), which has become the gold standard in the adjuvant treatment of superficial bladder cancer, is hampered by local side effects. Anti-inflammatory drugs may be helpful, but as an undesired side effect, therapeutic efficacy of BCG might be impaired. Therefore, we investigated the effects ...
Relevancy Score: Relevancy Score: 542
Shah Gopitkumar G Department of Urology, Medical College of Wisconsin, Milwaukee, - - 2014
Exposure of urothelial carcinoma (UC) cells to Bacille Calmette Guerin (BCG) affects cellular redox status and tumor cell biology but mechanism(s) remains unclear. This study examined free radical production by BCG, and in tumor cells in response to BCG, using global profiling of Reactive oxygen species/reactive nitrogen species (ROS/RNS). The ...
Relevancy Score: Relevancy Score: 542
Hatherill Mark - - 2010
Novel tuberculosis vaccination strategies hinge on BCG priming, yet newborn BCG vaccination may cause BCG disease in HIV-infected infants. Viral-vectored or subunit prime vaccine, followed by delayed BCG boost only for HIV-uninfected infants, may be a safe alternative for all newborns, regardless of maternal HIV infection. This approach should be ...
Relevancy Score: Relevancy Score: 541
Jaron Barbara - - 2008
BACKGROUND: The functional equilibrium between natural regulatory T cells (Treg) and effector T cells can affect the issue of numerous infections. In unvaccinated mice, the influence of Treg in the control of primary infection with mycobacteria remains controversial. METHODOLOGY: Here, we evaluated the role of Treg during prophylactic vaccination with ...
Relevancy Score: Relevancy Score: 541
Jin Lijie - - 2010
OBJECTIVE: To prepare the hepatitis B-Mycobacterium bovis Bacillus Calmette-Guérin combined vaccine (HB-BCG combined vaccine) and resolve a needle problem of the two kinds of hepatitis B vaccine (HB vaccine) and M. bovis Bacillus Calmette-Guérin (BCG) for the innoculation. METHODS: The hepatitis B surface antigen (HBsAg) was prepared by the genetic ...
Relevancy Score: Relevancy Score: 541
Whelan Kathryn T - - 2011
[This corrects the article on p. e5934 in vol. 4.].
Relevancy Score: Relevancy Score: 541
Toukam Tchakoute Christophe C Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Department of Clinical Laboratory Sciences, University of Cape Town, South - - 2014
 Bacillus Calmette-Guérin (BCG) vaccination prevents disseminated tuberculosis in children, but can also result in severe disease in the context of HIV-infection, and is therefore contraindicated. In tuberculosis endemic regions, BCG is administered soon after birth, before in utero and peripartum HIV infection is excluded. We therefore assessed BCG immunogenicity in ...
Relevancy Score: Relevancy Score: 541
Ryan Anthony A - - 2007
A strain of Mycobacterium bovis BCG that secretes high levels of functional murine monocyte chemotactic protein 3 (BCG(MCP-3)) was developed. Mice vaccinated with BCG(MCP-3) displayed increased lymphocyte migration in vivo and augmented antigen-specific T-cell responses compared to mice vaccinated with BCG alone. The level of protection afforded by BCG(MCP-3) was ...
Relevancy Score: Relevancy Score: 540
Deutschmann K E - - 1977
Three years experience with post operative BCG adjuvant immunotherapy in stage II malignant melanoma is reported. Compared to a historical control group (35 cases), 23 melanoma patients showed a significantly improved remission duration and survival rate. It appears that patients with weak initial BCG reactions, which become gradually positive after ...
Relevancy Score: Relevancy Score: 540
Gill J - - 1998
A survey of selective neonatal BCG immunisation in Bolton in 1993 showed that only 6% of babies in the defined risk groups received BCG. Community medical officers at that time were responsible for administering the BCG. Midwives were trained to take on this role. In 1994, 88% of babies in ...
Relevancy Score: Relevancy Score: 540
Wätzig V - - 1981
98 stage I melanoma patients and 16 stage II melanoma patients were included in this BCG immunotherapy trial. The postoperative treatment was performed by a high dose of BCG (Jena strain) administered by scarification with an intensive schedule. Compared to a similar historical control group treated by surgery alone (69 ...
Relevancy Score: Relevancy Score: 540
Guérin Nicole - - 2005
BCG immunization policies are somewhat uniform in eastern Europe. The incidence rates of tuberculosis are already very high, and are increasing. WHO recommendations, ie. BCG immunization by intradermal injection at birth or as soon as possible after birth are implemented. In western countries, the incidence rates of tuberculosis are not ...
Relevancy Score: Relevancy Score: 540
Krysztopa-Grzybowska Katarzyna - - 2012
In this study we assessed the genomic stability of Mycobacterium bovis BCG Moreau seed lots used in Poland for BCG vaccine production since 1955 by pulsed field gel electrophoresis (PFGE), amplified fragment length polymorphism (AFLP) and random amplification of polymorphic DNA (RAPD). BCG vaccine lots were more closely related the ...
Relevancy Score: Relevancy Score: 540
Satchidanandam Vijaya V Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, - - 2014
We previously reported interferon gamma secretion by human CD4+ and CD8+ T cells in response to recombinant E. coli-expressed Rv1860 protein of Mycobacterium tuberculosis (MTB) as well as protection of guinea pigs against a challenge with virulent MTB following prime-boost immunization with DNA vaccine and poxvirus expressing Rv1860. In contrast, ...
Relevancy Score: Relevancy Score: 540
Kesten S - - 1990
Bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis that has been used in the treatment of malignant disease for over 20 years and for the treatment of bladder cancer since 1976. Major complications of this treatment are infrequent. We report two cases of systemic illness with pulmonary manifestations ...
Relevancy Score: Relevancy Score: 540
Salajka F - - 2002
In patients with urinary bladder carcinoma, the intravesical BCG instillation is widely used. We present two cases of severe pulmonary afflictions developed during this treatment. The possible mechanisms of etiology are discussed and the classification of the intravesical BCG treatment side effects is suggested.
Relevancy Score: Relevancy Score: 540
Baldwin R W - - 1973
Growth of syngeneic transplants of a 3-methylcholanthrene induced rat sarcoma was suppressed when tumour cells were injected in admixture with BCG. Rejection of these mixed inocula resulted in the suppression of growth of a simultaneous challenge with cells of the same tumour at a contralateral subcutaneous site and conditions for ...
Relevancy Score: Relevancy Score: 540
Ambrosch F - - 1978
The possible influence of BCG vaccination on leukemia mortality of infants was investigated by various authors. The methods used were prospective trials, retrospective studies and epidemiological analyses. In some of these studies a protective effect of BCG vaccination was observed, in other studies no influence was found. Up to now ...
Relevancy Score: Relevancy Score: 539
Ritz Nicole - - 2008
With the rise in travel to countries with a high prevalence of tuberculosis (TB), the risk of travel-associated TB is of increasing concern. However, the use of Bacille Calmette-Guérin (BCG) vaccine for the prevention of travel-associated TB is a neglected area. We review and discuss national and international recommendations and ...
Relevancy Score: Relevancy Score: 538
Awad R - - 2001
The relationship between post-BCG complications and the practices of administration and/or use of certain batches of BCG vaccine was investigated. A questionnaire were given to nurses administering BCG vaccination. An abstraction sheet was used to analyse cases with BCG complications among infants (n = 552) and schoolchildren (n = 97). ...
Relevancy Score: Relevancy Score: 538
Sato H - - 1967
As a first step towards the production of a lysed BCG vaccine that would have reduced toxicity and allergenicity and yet be immunogenic, the growth and lysis of BCG bacilli under strictly controlled conditions have been studied.BCG grown in both Dubos and Aldridge liquid media showed an arithmetic linear growth, ...
Relevancy Score: Relevancy Score: 538
Kitamura Y - - 1976
The effects of killed and living BCG on antibody production against hamster erythrocytes (HRBC) and the 2, 4, 6-trinitrophenyl (TNP) group were studied in SL mice. Killed and living BCG, each in doses of 0.008 mg, 0.08 mg, 0.8 mg and 8 mg per mouse, were intravenously inoculated 7 days ...
Relevancy Score: Relevancy Score: 538
Sebe P - - 2000
The authors report a case of unilateral epididymitis with caseous abscess after BCG-therapy for superficial bladder tumour. The severity of the lesions required orchidectomy, followed by four-agent tuberculostatic therapy.
Relevancy Score: Relevancy Score: 538
Martin Frances M - - 2009
Intravesical administration of bacillus Calmette-Guérin (BCG) following resection of non-muscle-invasive bladder tumor is the current 'gold standard'. However, up to 40% of patients will fail therapy within the first year and response rates to salvage intravesical therapy after appropriate trial of BCG (i.e., after induction and one maintenance course) average ...
Relevancy Score: Relevancy Score: 538
Yasumoto K - - 1976
Effect of BCG cell-wall skeleton (BCG-CWS) on the recovery of responsiveness of lymphocytes and the survival period was studied in patients with lung cancer. (a) Responsiveness of lymphocytes as demonstrated by proliferative response to phytohemagglutinin (PHA) or microcytotoxicity test with cultured cells of a bronchogenic carcinoma was depressed in the ...
Relevancy Score: Relevancy Score: 537
Fon G T - - 1981
A clinical trial has been established to evaluate the use of intralesional bacillus Calmette Guérin (BCG) immunotherapy as an adjunct to surgery in resectable pulmonary neoplasms. BCG was injected percutaneously under fluoroscopic guidance into a single nodule in each of 21 patients with resectable primary and metastatic pulmonary neoplasms. Eighteen ...
Relevancy Score: Relevancy Score: 537
Pimm M V - - 1978
Six transplanted rat tumours (three mammary carcinomas and three fibrosarcomas), all of spontaneous origin and of limited immunogenicity, have been examined for susceptibility to immunotherapy with BCG (Glaxo). Growth of limited numbers of cells from five tumours was suppressed when cells were injected subcutaneously in admixture with BCG organisms. There ...
Relevancy Score: Relevancy Score: 537
Witjes J Alfred JA Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The - - 2013
To examine the management of intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC), particularly with regard to the use of bacillus Calmette-Guérin (BCG) therapy, in North America and Europe. To compare NMIBC management practices to European Association of Urology (EAU) and American Urological Association (AUA) guideline recommendations for the management of ...
Relevancy Score: Relevancy Score: 537
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