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Klinge E - - 1984
The pharmacokinetic profile of pipemidic acid was studied in two groups of young healthy volunteers by using a new, sensitive, high-pressure liquid chromatography procedure for quantitation of pipemidic acid in biological fluids. After oral or intravenous administration, the disposition of pipemidic acid may be described as a one- or a ...
Esposito S - - 1984
Three hundred seventy-five Gram-negative bacterial strains were isolated from urine specimens of as many patients affected by symptomatic or asymptomatic urinary tract infections. Susceptibility of bacteria to five chemotherapeutics (norfloxacin, oxolinic acid, pipemidic acid, nalidixic acid and nitrofurantoin) was studied determining minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) ...
Lionsquy G - - 1984
E. coli is the agent most frequently isolated in urinary infection. In 1982, rates of E. coli isolation were 87% in outpatient laboratories, 63% in general hospitals and 41% in specialized hospitals. Susceptibility to ampicillin was less frequent in outpatients (43%) than in hospitalized patients (67%). In both, isolated strains ...
Greenwood D - - 1984
In order to investigate the comparative activity of agents of the nalidixic acid series, cultures of nalidixic acid sensitive strains of E. coli were exposed to the drugs in an in-vitro model that simulates the hydrokinetic aspects of the treatment of bacterial cystitis. Intrinsic activity, as judged by the response ...
Masu C - - 1984
The prophylactic efficacy of long-term, low-dose antimicrobial treatment in urinary tract infection (UTI) was studied. Fifty-eight female adult patients with a history of at least two recurrent episodes of UTI in the past year were entered into this study, and the prophylactic regimen was not started until the existing UTI ...
Männistö P - - 1984
Pipemidic acid in bacteriological screening was more potent than nalidixinic acid, notably against Pseudomonas. In a study in middle-aged female volunteers, the relative bioavailability of a single 500 mg tablet of pipemidic acid was good. The main pharmacokinetic parameters were: tmax, 2.3 h; Cmax, 3.3 micrograms/ml; t1/2, 4.6 h; Varea, ...
Corelli F - - 1984
The synthesis and antibacterial activities of 1-ethyl-1,4-dihydro-4-oxo-7-(1-pyrrolidinyl)quinoline-3-carboxylic acid are reported. The new analog of nalidixic acid has been prepared by standard procedure starting from 1-(3-aminophenyl)pyrrole; it showed a broad spectrum of antibacterial activity and exhibited much higher activity than nalidixic, pipemidic and piromidic acids. The synthesis of 1-ethyl-1,4-dihydro-4-oxo-8-(1-pyrrolyl)quinoline-3-carboxylic acid is ...
Belloli G - - 1984
In the second part of the Authors work, they report the results obtained in the treatment of 85 female children with recurrent non malformative urinary tract infections. The first group of 15 female children had been treated with phenoxybenzamine and urinary chemyotherapycs with little satisfaction. The other two groups, both ...
Heessen F W - - 1984
The in vitro activities of five quinolinecarboxylic acids against two laboratory strains of Chlamydia trachomatis were compared. The minimal inhibitory concentrations of nalidixic acid, cinoxacin, and pipemidic acid were all greater than or equal to 50 micrograms/ml; the activity of norfloxacin was intermediate (minimal inhibitory concentration, 8 to 16 micrograms/ml). ...
Traub W H - - 1984
Addition of phenylbutazone (2 mg/ml) to 55 vol% of fresh defibrinated human blood permitted leukocytic ingestion of Serratia marcescens bacteria, but blocked phagocytic killing activity. The group A (phage tail) bacteriocin bA+ 16 served to kill extraphagocytic test bacteria. Five bacterial DNA gyrase inhibitors (ciprofloxacin, enoxacin, norfloxacin, nalidixic acid and ...
Seibert G - - 1983
The in vitro and in vivo activity of ofloxacin (DL 8280, HOE 280) was compared with that of other antibacterial compounds. Ofloxacin was found to have a broad antibacterial spectrum which includes both gram-positive and gram-negative aerobic and anaerobic species. Its activity is generally higher than that of pipemidic acid ...
Muytjens H L - - 1983
The possible use of pipemidic acid for preventing infections in granulocytopenic patients by selective elimination of the gram-negative rods from the digestive tract was evaluated. Fecal samples were collected before, during, and after therapy from 23 adults who were undergoing treatment of urinary tract infections with pipemidic acid at a ...
Mastandrea P - - 1983
751 stems of Gram-negative bacteria isolated from urinary samples with bacterial charge greater than or equal to 100,000 CFU (Colony Forming Units)/ml gathered from January 1981 to December 1982 have been examined. The sensitivity to the following chemoantibiotics has been tested: ampicillin, cefuroxime, amikacin, gentamicin, tobramycin, nalidixic acid, pipemidic acid, ...
Shah P M - - 1983
Activity of norfloxacin was compared to that of cinnoxacin, nalidixic acid and pipemidi acid in DST-agar and human urine solidified by adding 1.2% agar. Norfloxacin was the most active compound when tested on DST-agar but the MIC values increased from 64 to 128 fold when tested in urine. Other compounds ...
Ohkoshi M - - 1983
Intraoperative wound infection and postoperative pulmonary and urinary tract infections are the major problems that face the transplant surgeon today. These infections are the major cause of the mortality after renal transplantation. Almost any microorganism could be causative. But, in this paper, only bacterial infections will be discussed. Prophylaxis of ...
Deguchi K - - 1983
To investigate the clinical and bacteriological usefulness of orally administered fosfomycin calcium (FOM), the susceptibility of 558 strains to FOM was determined. These strains were isolated at our Center, between Feb. 1982 and Feb. 1983 from otorhinolaryngological infections. Several other drugs were also tested on the same strains for comparison. ...
Muytjens H L - - 1983
An agar dilution method was used to measure the minimal inhibitory concentrations of ciprofloxacin (Bay o 9867), norfloxacin, pipemidic acid, and nalidixic acid against 496 clinical isolates. Ciprofloxacin and norfloxacin were active against all species tested (90% minimal inhibitory concentrations less than or equal to 8 micrograms/ml), although ciprofloxacin was ...
Kouno K - - 1983
AT-2266 [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carbo xylic acid] showed a broad spectrum of antibacterial activity against gram-positive and gram-negative microorganisms, including Pseudomonas aeruginosa. The in vitro antibacterial activity of AT-2266 was in general comparable to that of norfloxacin, but much higher than that of pipemidic or nalidixic acid. The 90% minimal inhibitory concentrations (MIC90s) ...
Brogard J M - - 1983
Serum and urinary levels of Cinoxacin and pipemidic acid were determined at 7-day intervals in the same 10 healthy volunteers after a single oral dose of respectively 500 and 400 mg of the drugs. Comparison of results shows that Cinoxacin was absorbed faster (absorption half-life, ta 1/2cin = 0.25 h) ...
Cantet P - - 1983
Some new quinolones may be used for the treatment of gonococcal urethritis. U. urealyticum is considered as a potential agent of urethritis. This report describes the in vitro antimicrobial activity of seven quinolones against 45 clinical isolates of U. urealyticum. The MIC's geometric mean is (microgram/ml): rosoxacin (1,74), pefloxacin (4,6), ...
Nakamura S - - 1983
AT-2266, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3 -carboxylic acid, is a new pyridonecarboxylic acid derivative with broad and potent antibacterial activity. It inhibited some gram-positive bacteria, such as staphylococci and Bacillus subtilis, and most gram-negative bacteria, including Serratia marcescens, Pseudomonas aeruginosa, Haemophilus influenzae, and Campylobacter jejuni, at concentrations of 0.1 to 0.78 microgram/ml, and most ...
Nakamura S - - 1983
AT-2266 (1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine-3-carboxylic acid) showed marked activity in vivo when administered orally to mice bearing systemic, pulmonary, dermal, or urinary tract infections due to variety of organisms. The activity of AT-2266 was uniformly higher than those of norfloxacin, pipemidic acid, and nalidixic acid against all of the infections. The activity ...
Lévy-Frébault V - - 1983
The study of 52 strains of rapidly growing mycobacteria showed that Mycobacterium fortuitum and M. chelonei were clearly distinguished by the aid of seven key tests (nitrate reductase, iron uptake, beta-glucosidase, penicillinase, growth on fructose, resistance to pipemidic acid, and resistance to capreomycin) and by analysis of their respective mycolic ...
Osada Y - - 1983
Ofloxacin (DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1- pipera-zinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid) showed a broader spectrum and a greater potency of antimycoplasmal activity than did pipemidic acid, norfloxacin, tetracyclines, and lincomycin, but was inferior to erythromycin. Its mycoplasmacidal potency against clinical isolates of Mycoplasma pneumoniae was also greater than that of other quinolones and tetracyclines.
Grimm H - - 1983
The antibiotic sensitivity of 296 strains of Pseudomonas aeruginosa and 294 isolates of other species was measured by the agar diffusion test with 20 micrograms pipemidic acid (Deblaston) discs on Mueller-Hinton agar by the Kirby-Bauer method. The correlation between inhibition zone diameter and minimal inhibitory concentration was worked out by ...
Igari J - - 1983
The present study concern in vitro observation on the susceptibility to 20 antibacterial agents of the strains of Flavobacterium meningosepticum from clinical specimens at Juntendo University Hospital during the 1 year period of 1981. The tests for susceptibility of the 144 strains to the drugs were all performed by the ...
Sirbat D - - 1983
Flumequine (1 200 mg/day) was prescribed as treatment for infection of the urinary tract to three patients with chronic renal failure, who reported positive scotoma three days later. Ophthalmologic examination evinced bilateral symmetrical macular bullae. A characteristic yellow papule was present at foveal level. In all three cases, visual acuity ...
François B - - 1983
pH induced changes of bacteriostatic activity of nalidixic, pipemidic and oxolinic acids have been studied in vitro by the determination of minimal inhibitory concentrations (MIC), on 9 different species and 172 strains, at pH 5, 6, 7 and 8 and with increasing antibiotic concentrations. The bacteriostatic activity of nalidixic acid ...
Casal M J - - 1983
A study was made of the in vitro susceptibility of 37 strains of Mycobacterium fortuitum to 14 antimicrobial agents using disc diffusion techniques on Mueller-Hinton agar plates. Nitro-5-hydroxy-8-quinoleine and pipemidic acid inhibited all strains, while furantoin, mandelamine, metronidazole, nalidixic acid, oxolinic acid and trimethoprim proved to be inactive. In addition, ...
Sato K - - 1982
DL-8280, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H- pyrido-(1,2,3-de)1,4-benzoxazine-6-carboxylic acid, is a new nalidixic acid analog with a broad spectrum of antibacterial activity against gram-negative and gram-positive bacteria, including obligate anaerobes. The activity of DL-8280 against Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, and Clostridium perfringens was roughly comparable to that of norfloxacin and far exceeded ...
Rella M - - 1982
Resistance to high concentrations of nalidixic acid in Pseudomonas aeruginosa PAO was due to mutations in one locus designated nalA, which was mapped by transduction between hex-9001 and leu-10. The nalA mutants were cross-resistant to pipemidic acid, a nalidixic acid analog, at relatively low concentrations. Replicative DNA synthesis was resistant ...
Thabaut A - - 1982
The MIC of the four quinolones were determined for 839 bacterial isolates. The mean in vitro activity of pefloxacin against strains susceptible to nalidixic acid was found to be four times greater than flumequin, eight times greater than pipemidic acid, sixteen times greater than nalidixic acid. On resistant strains pefloxacin, ...
Azanza Perea J R - - 1982
Yamagishi J - - 1981
In Escherichia coli K-12 mutants which had a new nalidixic acid resistance mutation at about 82 min on the chromosome map, cell growth was resistant to or hypersusceptible to nalidixic acid, oxolinic acid, piromidic acid, pipemidic acid, and novobiocin. Deoxyribonucleic acid gyrase activity as tested by supercoiling of lambda phage ...
Casal M J - - 1981
A simple, new test to differentiate species in the Mycobacterium fortuitum complex by determining susceptibility to pipemidic acid is described. A 20-mug pipemidic acid disk provides a rapid and reliable means of distinguishing M. fortuitum from M. chelonei.
Thibault M - - 1981
Authors describe structure-activity relationships in quinolone group and report a study of the antibacterial activity of two new compounds: pefloxacin and its demethyl derivative, AM-715. These two products take place in the field of researches carried out for extending indications of this group of antimicrobial agents by obtaining derivatives more ...
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