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Picard Didier - - 2006
The abundant molecular chaperone Hsp90 functions in association with co-chaperones including p23 to promote the folding and maturation of a subset of cytosolic proteins. "Fluorescence recovery after photobleaching" (FRAP) experiments showed that the dynamics of p23 in live cells is dictated by Hsp90. Since Hsp90 is present in large excess ...
Sebo Paul - - 2006
To identify diabetic patients' characteristics and medical care factors associated with recommended glycaemic control (HbA(1c) < or =7%). As part of a cross-sectional assessment of diabetes care involving 204 Swiss primary care physicians, we identified 366 diabetic patients with a recent HbA(1c) value. Cross-tabulations and X(2) tests were used to ...
Fowler D J - - 2006
The classical ultrastructural features of Gaucher disease include large numbers of intracytoplasmic, membrane-bound lysosomal inclusions containing characteristic tubular structures on an electron-lucent background, representing the periodic acid schiff (PAS)-positive Gaucher cells identifiable on light microscopy. Following enzyme replacement therapy (ERT), many of the manifestations of the condition are ameliorated, but ...
Warden Scott M - - 2006
BACKGROUND: As conservative treatments for retinoblastoma become more prevalent, there will be a greater number of ocular complications developing in eyes that previously would have been enucleated. Pars plana vitrectomy (PPV) is needed to manage some of these complications. METHODS: The authors evaluated three consecutive cases of PPV in eyes ...
Ibn Sellam A - - 2006
BACKGROUND: Sarcoïdosis is a benign systemic granulomatosis whose aetiology remains unknown. Lung is the most frequently involved organ. The pseudoalveolar form of this disease is known to have an acute onset and is quite uncommon. Therefore, diagnosing such a rare variety of sarcoidosis is rather often challenging. OBSERVATIONS: In the ...
Kupelian Patrick A - - 2006
OBJECTIVES: To report biochemical relapse-free survival (bRFS) after radiotherapy (RT) for localized prostate cancer with two separate failure definitions and compare the results with those after radical prostatectomy (RP). METHODS: The study sample comprised 2516 patients with a median follow-up of 78 months. Biochemical relapse after RT was defined as ...
Cluck Michael W - - 2006
STUDY DESIGN: Biomechanical analysis and retrospective chart review. OBJECTIVES: To determine the mechanical properties of cobalt chromium alloy wires and review the clinical application of the wires as sublaminar implants to correct spinal deformity. SUMMARY OF BACKGROUND DATA: Sublaminar wires are commonly used as anchors in spinal deformity surgery. In ...
Killion Mead C - - 2006
Donkin Marcella - - 2006
BACKGROUND: The relationship between accessibility to the full range of subspecialty care available at freestanding pediatric hospitals and organ donor management and recovery rates has not been studied. OBJECTIVE: To examine current rates of recovery of organs from children for transplantation at free-standing pediatric hospitals versus all other hospitals. METHODS: ...
Cole Pamela M - - 2006
Tamang and Brahman Nepali children have culturally specific emotion scripts that may reflect different emotion socialization experiences. To study emotion socialization, the child-adult interactions of 119 children (3-5 years old) were observed and 14 village elders were interviewed about child competence in Tamang and Brahman villages. Tamang rebuke the angry ...
Rider Nicholas L - - 2006
Inhaled corticosteroids are the mainstay of asthma therapy; however, inhaled long-acting beta2-agonists (LABAs) are frequently used in the treatment of patients with asthma. LABAs are combined with high-dose inhaled corticosteroids (ICSs) for patients with severe persistent asthma, and they are combined with low-dose ICSs for patients older than 5 years ...
Devoe Lawrence D - - 2006
OBJECTIVE: The fetal electrocardiogram system for electronic fetal monitoring (EFM) (STAN S21, Neoventa Medical, Moelndal, Sweden) has led to improved perinatal outcomes in other countries. We aimed to assess the ability of United States (US) obstetricians to use this system appropriately for intrapartum care. STUDY DESIGN: A prospective nonrandomized trial ...
Guimarães Ana H C - - 2006
In this study, the in-vitro fibrinolytic efficacy of Tenecteplase, Amediplase and scu-PA was investigated in different external lysis models by measuring the lysis of human plasma clots after the addition of the plasminogen activators (PAs) to the surrounding plasma. The effect of TAFI was examined for each PA by neutralising ...
Karacorlu Serra Arf - - 2006
PURPOSE: To evaluate early changes after photodynamic therapy (PDT) for patients with subfoveal choroidal neovascularization (CNV) due to pathologic myopia by optical coherence tomography (OCT). METHODS: PDT was performed on 10 eyes of 10 patients who presented with subfoveal CNV due to pathologic myopia. OCT was used to evaluate changes ...
Brooks J W - - 2006
Necropsy of 2 white-tailed deer fawns who died acutely revealed diarrhea and melena in case No. 1 and no gross changes in case No. 2. Histologically, the livers of both deer displayed multifocal coagulative necrosis, with infiltrations of neutrophils, macrophages, and lymphocytes. By Warthin-Starry staining, bundles of filamentous bacteria were ...
La Rivière Patrick J - - 2006
In this paper, we derive a monotonic penalized-likelihood algorithm for image reconstruction in X-ray fluorescence computed tomography (XFCT) when the attenuation maps at the energies of the fluorescence X-rays are unknown. In XFCT, a sample is irradiated with pencil beams of monochromatic synchrotron radiation that stimulate the emission of fluorescence ...
Zamboni William C - - 2006
The source of the pharmacokinetic variability of 9-nitrocamptothecin (9NC) and its 9-aminocamptothecin (9AC) metabolite is unknown. ATP-binding cassette (ABC) transporters have been reported to modulate camptothecin analogues, are associated with camptothecin resistance, and might also affect 9NC and 9AC pharmacokinetics. The aim of this study was to evaluate the functional ...
Epperly Michael W - - 2006
Pulmonary irradiation fibrosis involves migration to the lungs of bone marrow origin myofibroblast progenitor cells (marrow stromal cells (MSCs)). Smad3-/- mice display decreased ionizing irradiation-induced skin fibrosis, defective osteochondrogenesis and other abnormalities thought to be associated with a defective stromal cell response(s) to transforming growth factor-beta (TGFFbeta). Clonal bone marrow ...
Cohen Noam A - - 2006
Although much has been elucidated in the past 170 years concerning the precise mechanism of ciliary function in the healthy or diseased human respiratory system, significant questions remain. The first description of ciliary action is credited to Sharpey in 1835. However, the importance of mucosal function was not apparent until ...
Clement Michele R - - 2006
We hypothesized that the calcineurin pathway mediated some of the complex remodeling process that allows a bladder subjected to partial outlet obstruction to adapt to its new workload. Atrial natriuretic factor mRNA expression served as a marker of calcineurin activation. A total of 16 New Zealand White rabbits underwent surgical ...
Eiraldi Ricardo B - - 2006
Despite a significant increase in the number of children and adolescents who receive clinical services for attention deficit hyperactivity disorder (ADHD), there is still a considerable level of unmet need. Children of ethnic minority status continue to lag well behind their non-minority counterparts in the rate of diagnosis and treatment ...
Lowe Thomas - - 2006
STUDY DESIGN: Descriptive study of the Scoliosis Research Society (SRS) Classification for Adult Spinal Deformity using interobserver reliability measures for validation of the system. OBJECTIVES: To propose and validate a classification system for adult spinal deformity that will have utility in reporting on treatment options and outcomes for affected adults. ...
Brühwiler P A - - 2006
Bicycle helmets exhibit complex structures so as to combine impact protection with ventilation. A quantitative experimental measure of the state of the art and variations therein is a first step towards establishing principles of bicycle helmet ventilation. A thermal headform mounted in a climate-regulated wind tunnel was used to study ...
Johnson Ellyn M - - 2006
BACKGROUND: Potential cardiovascular side effects from venlafaxine-XR must be considered when prescribing this medication, especially in geriatric patients, who often present with comorbid medical conditions. METHODS: Participants age 60 and older with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis of a major depressive episode without psychotic ...
Juan Ma - - 2006
Hepatocellular carcinoma (HCC) ranks the sixth among the most common malignancies, with chronic HBV infection being the most common cause. HCC is more common in Africa, China and south-east Asia, but its incidence in the USA, Canada and Australia is rising. Current treatment modalities for HCC are not effective, and ...
Mutlow Adrian G - - 2006
A pair of captive adult giant anteaters (Myrmecophaga tridactyla) presented heavily infested with a flea species (Pulex simulans) commonly found on Virginia opossums (Didelphis virginiana) and raccoons (Procyon lotor) in the central United States. In this case, the flea was demonstrated to have completed its entire life cycle with the ...
Feng Pu - - 2006
Understanding the consequences of drug withdrawal on immune function and host defense to infection is important. We, and others, previously demonstrated that morphine withdrawal results in immunosuppression and sensitizes to lipopolysaccharide-induced septic shock. In the present study, the effect of morphine withdrawal on spontaneous sepsis and on oral infection with ...
Alguel Guelay - - 2006
Limited data are available regarding complications of pregnancy and pregnancy outcome under prophylaxis with low-molecular-weight heparin (LMWH) in women with a history of thromboembolism (TE). We retrospectively evaluated pregnancy complications in a cohort of 80 women. All had a history of TE (76 venous, two arterial and two venous and ...
Rizzo Stanislao - - 2006
PURPOSE: To evaluate the safety and efficacy of intravitreal injection of autologous plasmin enzyme (APE) in inducing a posterior vitreous detachment (PVD). APE was obtained by a modified method 1 hour before surgery. METHODS: APE was obtained by centrifugation of autologous whole blood from the patients 1 hour before surgery ...
Filleul Laurent - - 2006
BACKGROUND: During August 2003, record high temperatures were observed across Europe, and France was the country most affected. During this period, elevated ozone concentrations were measured all over the country. Questions were raised concerning the contribution of O3 to the health impact of the summer 2003 heat wave. METHODS: We ...
Giannoukas Athanasios D - - 2006
The aim of this article is to report our experience in the diagnosis of two cases of iliac artery endofibrosis or arteriopathy, a rare entity occurring in high-performance athletes, presenting with intermittent claudication (right-sided in both) after maximal exercise. External iliac artery endofibrosis or arteriopathy is a likely diagnosis in ...
Paul H A - - 2006
The local crystallography and microstructure within shear bands has been examined in single crystals of {112}<111> orientation of pure copper deformed at 77 K by channel-die compression to true strains of about 1. Setting up a system for making high-resolution orientation maps using transmission electron microscopy has provided advantageous circumstances ...
Wolfe Frederick - - 2006
OBJECTIVE: Administrative data bases provide rapid access to data regarding treatment and morbidity of rheumatoid arthritis (RA). A serious limitation of administrative data bases is the lack of information regarding RA severity, as in the case of lymphoma, where RA severity may contribute to the cause of the adverse outcome. ...
Caprini Joseph A - - 2006
Venous thromboembolism (VTE) remains a significant threat to public health despite the availability of effective and safe prophylactic measures and treatments. Guidelines based on randomized clinical trials are available to improve the management of thromboembolic disease. However, gaps exist between recommendations and clinical practice, and many patients are unnecessarily exposed ...
Fenchel Michael - - 2006
PURPOSE: The aim of the present study was to assess the feasibility of renal magnetic resonance angiography at 3.0 T using a phased-array coil system with 32-coil elements. Specifically, high parallel imaging factors were used for an increased spatial resolution and anatomic coverage of the whole abdomen. MATERIALS AND METHODS: ...
Gao Yanhua - - 2006
Vesicular stomatitis virus (VSV) is being developed for cancer therapy. We created a recombinant replicating VSV (rrVSV) that preferentially infected Her2/neu-expressing breast cancer cells. This rrVSV did not express the native VSV-G glycoprotein (gp). Instead, it expressed a chimeric Sindbis gp which included a single-chain antibody (SCA) directed to the ...
Zaets V N - - 2006
Solar UV-B radiation is an environmental factor which damage and destabilize genomes. UV-B-induced DNA lesions have cytotoxic and genotoxic effects on the cells of pro- and eucaryotes including plants. In addition, such lesions can cause gene mutations in plants. The products of the damages of cellular DNA caused by UV ...
Lee Chris P - - 2006
BACKGROUND: Patients with end-stage renal disease (ESRD) require dialysis to maintain survival. The optimal timing of dialysis initiation in terms of cost-effectiveness has not been established. METHODS: We developed a simulation model of individuals progressing towards ESRD and requiring dialysis. It can be used to analyze dialysis strategies and scenarios. ...
Makuwa Maria - - 2006
An hepatitis B virus (HBV) molecular survey was conducted in five remote villages in the equatorial forest in Gabon, Central Africa. Two hundred seventy out of 311 inhabitants (86.8%) were HBV-infected or had evidence of past HBV infection. Chronic hepatitis corresponding to hepatitis B surface antigen (HBsAg) positivity was suspected ...
Gaynon Michael W - - 2006
PURPOSE: To review systemic modifiable factors that might downregulate pathologic levels of vascular endothelial growth factor (VEGF) in prethreshold retinopathy of prematurity (ROP), and thereby reduce the risk of blindness in affected infants. METHODS: Review of the author's clinical experience as compared to the STOP-ROP study, and discussion and literature ...
Berná-Serna J D - - 2006
PURPOSE: To present a systematic approach to teaching a technique for arthrography of the shoulder. Using an adhesive marker-plate with radiopaque coordinates, precise sites for puncture can be identified and the need for fluoroscopic guidance obviated. MATERIAL AND METHODS: Forty-six glenohumeral arthrograms were performed in 45 patients; in 1 case ...
Palisano Robert J - - 2006
Models of physical therapist service delivery provide a framework for integration of knowledge, research, and assumptions in a clinically relevant context that facilitates evidence-based decision making. In this perspective, a collaborative model of service delivery for children with movement disorders is presented. The focus is on services that address child ...
Wenzel V - - 2006
The new CPR guidelines are based on a scientific consensus which was reached by 281 international experts. Chest compressions (100/min, 4-5 cm deep) should be performed in a ratio of 30:2 with ventilation (tidal volume 500 ml, Ti 1 s, FIO2 if possible 1.0). After a single defibrillation attempt (initially ...
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