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Wibberley Alexandra - - 2006
Non-selective cyclooxygenase (COX) inhibitors exert effects on lower urinary tract function in several species. The exact contributions of COX-1 and COX-2 isozymes have not been studied much. The present studies investigated the effects of non- and selective COX inhibitors on bladder irritation in the cat.Chloralose-anaesthetised female cats were catheterised through ...
Oddy M J - - 2006
We monitored image intensifier use by orthopaedic trainees to assess their exposure to ionising radiation and to investigate the influence of sub-specialty training. Five different orthopaedic registrars recorded their monthly image intensifier screening times and exposure doses for all cases (trauma and elective), for a combined total of 12 non-consecutive ...
Imaeda Toshihiko - - 2006
The Quick Disability of the Arm, Shoulder, and Hand (QuickDASH) questionnaire is a region-specific, self-administered questionnaire, which consists of a disability/symptom (QuickDASH-DS) scale, and the same two optional modules, the work (DASH-W) and the sport/music (DASH-SM) modules, as the DASH. After the Japanese version of DASH (DASH-JSSH) was cross-culturally adapted ...
Reschly E J - - 2006
The NR1I subfamily of nuclear hormone receptors includes the 1,25-(OH)(2)-vitamin D(3) receptor (VDR; NR1I1), pregnane X receptor (PXR; NR1I2), and constitutive androstane receptor (CAR; NR1I3). PXR and VDR are found in diverse vertebrates from fish to mammals while CAR is restricted to mammals. Current evidence suggests that the CAR gene ...
Saigh Philip A - - 2006
This study compared the Wechsler Intelligence Scale for Children-III (WISC-III) scores of traumatized youth with posttraumatic stress disorder (PTSD) to the scores of trauma-exposed and nonexposed comparison groups without PTSD. All groups were free of additional major childhood psychiatric disorders. The PTSD group scored significantly lower than the comparison groups ...
Squires Robert H RH - - 2006
To determine short-term outcome for children with acute liver failure (ALF) as it relates to cause, clinical status, and patient demographics and to determine prognostic factors. A prospective, multicenter case study collecting demographic, clinical, laboratory, and short-term outcome data on children from birth to 18 years with ALF. Patients without ...
Verbeke Philippe - - 2006
Chlamydiae replicate intracellularly in a vacuole called an inclusion. Chlamydial-infected host cells are protected from mitochondrion-dependent apoptosis, partly due to degradation of BH3-only proteins. The host-cell adapter protein 14-3-3beta can interact with host-cell apoptotic signaling pathways in a phosphorylation-dependent manner. In Chlamydia trachomatis-infected cells, 14-3-3beta co-localizes to the inclusion via ...
Harland Robin W - - 2006
The use and misuse of power has been demonstrated. It has been shown that GP education has changed very significantly between 1920 and 1990. Many excellent improvements have been achieved. Nevertheless, despite these gains, it is quite impossible to accept the hypothesis that there has been a constant steady improvement ...
Thavichachart N - - 2006
The objective is to evaluate the efficacy of galantamine when a slow titration regimen is employed in Thai Alzheimer's disease (AD) patients with or without cerebrovascular disease and vascular dementia (VaD). A 6-month, multicentre, open-label, uncontrolled trial was undertaken in 75 AD patients. Eligible patients received an initial galantamine dose ...
Kogan Jennifer R - - 2006
Direct observation of medical students' clinical skills is important, but occurs infrequently. The mini-clinical evaluation exercise (mCEX) is a tool developed for use with internal medicine (IM) residents that can be used to promote direct observation of medical students' clinical skills. It is unknown how many IM core clerkships in ...
Zebrack Brad J - - 2006
To develop and evaluate a new instrument that measures aspects of long-term survivorship not measured by existing tools. In qualitative interviews, 47 long-term cancer survivors (LTS) detailed ways that cancer has impacted their lives. Content analysis resulted in the creation of 325 candidate items for inclusion in a new Impact ...
Hanlon Joseph T - - 2006
Adverse drug reactions (ADR) negatively impact life quality and are sometimes fatal. This study examines the incidence and predictors of all and preventable ADRs in frail elderly persons after hospital discharge, a highly vulnerable but rarely studied population. The design was a prospective cohort study involving 808 frail elderly persons ...
Schnaas Lourdes - - 2006
Low-level postnatal lead exposure is associated with poor intellectual development in children, although effects of prenatal exposure are less well studied. We hypothesized that prenatal lead exposure would have a more powerful and lasting impact on child development than postnatal exposure. We used generalized linear mixed models with random intercept ...
Killian G - - 2006
Methods to limit fertility of feral swine are needed to reduce transmission of diseases and agricultural and ecosystem damage. Method of Study We evaluated a single-shot GnRH immunocontraceptive vaccine in both male and female feral swine for its effect on fertility and functional status of the reproductive tissues. Captive feral ...
Hussar Daniel A DA Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, - - 2006
Luo Xin M XM Department of Nutritional Sciences, 126-S Henderson Building, University Park, PA 16802, - - 2006
Interferon regulatory factor-1 (IRF-1), a transcription factor and tumor suppressor involved in cell growth regulation and immune responses, has been shown to be induced by all-trans retinoic acid (ATRA). However, the factors controlling the cellular location and activity of IRF-1 are not well understood. In this study, we examined the ...
Granata Kevin P KP Musculoskeletal Biomechanics Laboratories, Department of Engineering Science & Mechanics, School of Biomedical Engineering & Science, Virginia Polytechnic Institute & State University, Blacksburg, VA 24061, USA. - - 2006
Nonlinear systems analyses of trunk kinematics were performed to estimate control of dynamic stability during repetitive flexion and extension movements. Determine whether movement pace and movement direction of dynamic trunk flexion and extension influence control of local dynamic stability. Spinal stability has been previously characterized in static, but not in ...
Lu H H College of Pharmacy, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA. - - 2006
The aim was to identify the hepatic cytochromes P450 (CYPs) responsible for the enantioselective metabolism of ifosfamide (IFA). The 4-hydroxylation, N2- and N3-dechloroethylation of IFA enantiomers were monitored simultaneously in the same metabolic systems using GC/MS and pseudoracemate techniques. In human and rat liver microsomes, (R)-IFA was preferentially metabolized via ...
Enosse Sonia S Centro de Investigação em Saúde da Manhiça, Ministério de Saúde, Maputo, - - 2006
The candidate malaria vaccine RTS,S/AS02A is a recombinant protein containing part of the circumsporozoite protein (CSP) sequence of Plasmodium falciparum, linked to the hepatitis B surface antigen and formulated in the proprietary adjuvant system AS02A. In a recent trial conducted in children younger than age five in southern Mozambique, the ...
Atkinson Sarah H SH Medical Research Council Laboratories, Banjul, The Gambia. - - 2006
Anaemia is a major cause of morbidity and mortality for children in Africa. The plasma protein haptoglobin (Hp) binds avidly to free haemoglobin released following malaria-induced haemolysis. Haptoglobin polymorphisms result in proteins with altered haemoglobin-binding capacity and different antioxidant, iron-recycling, and immune functions. Previous studies examined the importance of haptoglobin ...
Jaffee Sara R SR Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA. - - 2006
Individuals with early-emerging conduct problems are likely to become parents who expose their children to considerable adversity. The current study tested the specificity of and alternative explanations for this trajectory. The sample included 246 members of a prospective, 30-year cohort study and their 3-year-old children. Parents who had a history ...
Bäumer Tobias T Department of Neurology, University Medical Centre Hamburg-Eppendorf, Germany. - - 2006
We explored interhemispheric facilitation (IHF) between (a) left and right primary motor cortex (M1) and (b) left dorsal premotor (dPM) and right M1 in 20 right-handed healthy human subjects using a paired pulse transcranial magnetic stimulation (TMS) protocol. A conditioning TMS pulse (CP) applied to left M1 or dPM with ...
Byfield F J FJ Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, - - 2006
To investigate the link between cell stiffness and volume-regulated anion current (VRAC) in aortic endothelium. Bovine aortic endothelial cells (BAECs) were exposed to methyl-beta-cyclodextrin (MbetaCD) to deplete cellular cholesterol and the changes in cellular stiffness were measured by micropipette aspiration. VRAC density was measured electrophysiologically in the same cell populations. ...
Shnyder S D SD Institute of Cancer Therapeutics, School of Health Studies, University of Bradford, Bradford BD7 1DP, UK. - - 2006
Although the in vivo hollow fibre assay (HFA) as utilised by the National Cancer Institute is a highly effective screening tool, it has not been adopted en masse in the cancer pharmacology field. However, in laboratories which have adopted it, the effectiveness of HFA has also been confirmed. If immunocompetent ...
Peaston Anne E AE School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales 2006, Australia. - - 2006
What causes phenotypic variation? By now it is clear that phenotype is a result of the interaction between genotype and environment, in addition to variation not readily attributable to either. Epigenetic phenomena associated with phenotypic variation at the biochemical, cellular, tissue, and organism level are now well recognized and are ...
Simoni Jane M JM Department of Psychology, University of Washington, Seattle, Washington, 98195-1525, Box 351525, USA. - - 2006
A review of 77 studies employing self-report measures of antiretroviral adherence published 1/1996 through 8/2004 revealed great variety in adherence assessment item content, format, and response options. Recall periods ranged from 2 to 365 days (mode = 7 days). The most common cutoff for optimal adherence was 100% (21/48 studies, ...
Lotke Paul A PA Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, - - 2006
Bone loss in revision total knee arthroplasty is a complex and challenging problem. Frequently, the defects encountered are irregular in size and shape. Since 1998, we have been using impaction bone allografting for constrained and unconstrained defects in revision total knee arthroplasty. We prospectively studied the mid-term results of 48 ...
Parvizi Javad J Rothman Institute of Orthopedics at Thomas Jefferson University, Philadelphia, PA 19107, USA. - - 2006
Patellar fracture after total knee arthroplasty is a rare yet challenging complication. Patellar fracture can occur as a result of trauma or it may be atraumatic. A multitude of factors can lead to periprosthetic patellar fracture including patient related factors, surgical technique related factors, and implant specific factors. Understanding the ...
Ginsberg Lawrence D LD Red Oak Psychiatry Associates, PA, Houston, TX 77090, USA. - - 2006
Lamotrigine is approved by the Food and Drug Administration for maintenance therapy in patients with bipolar I disorder. However, several studies of acute-phase and maintenance treatment support the efficacy of lamotrigine for bipolar I and bipolar II disorders. This chart review was performed to assess the efficacy and safety of ...
Ong K L KL Exponent Inc, Philadelphia, PA, - - 2006
The economic burden to Medicare due to revision arthroplasty procedures has not yet been studied systematically. The economic burden of revisions was calculated as annual reimbursements for revision arthroplasties relative to the sum total reimbursements of primary and revision arthroplasties. We evaluated this revision burden for total hip and knee ...
Matas Carla Gentile CG Universidade Federal de São Paulo, Escola Paulista de Medicina. - - 2006
Middle and late latency auditory evoked potentials. to verify the occurrence of middle and late latency auditory evoked potentials disorders in adults with Acquired Immunodeficiency Syndrome (AIDS). Middle and late latency auditory evoked potentials of 8 individuals with AIDS, with ages ranging from 10 to 51 years, with normal hearing, ...
Al Sanosi Abdulrahman A Department of Otolaryngology, King Abdulaziz University Hospital, Riyadh, Kingdom of Saudi - - 2006
To identify those patients with vestibular schwannoma (acoustic neuroma) in whom treatment becomes necessary. Retrospective chart review. A total of 205 patients with small tumors were followed for a mean of 40.8 months. The longest follow-up was 180 months. One hundred and ninety-seven patients had a follow-up of more than ...
Kim Kang-Il KI Rothman Institute of Orthopedics at Jefferson, 925 Chestnut Street, Philadelphia, PA 19107, - - 2006
The management of periprosthetic fracture around the knee remains a challenging problem. The objective of this article was to review the general concepts, treatment algorithms, and the overall treatment outcomes of femoral and tibial periprosthetic fractures after total knee arthroplasty. This article aimed to highlight the deficiencies of the current ...
Gross Paul K PK All from the Lehigh Center for Clinical Research, Allentown, - - 2006
Previous research reports higher rates of depression in Hispanic women than Caucasian or African American women. The effectiveness and tolerability of paroxetine CR (controlled release) was examined in women of Hispanic heritage with depression or anxiety. Thirty-six Hispanic female patients 18 years or older meeting DSM-IV criteria for major depression ...
Kim Yee-Jeong - - 2006
Metaplastic breast carcinoma is very rare, and metaplastic carcinoma with chondroid differentiation is even rarer. Here, we report a case of metaplastic carcinoma with extensive chondroid differentiation mimicking chondrosarcoma that was challenging to diagnose. The tumor was characterized by an abundant chondromyxoid matrix. The definitive area of classic invasive ductal ...
Park Sang Gun - - 2006
The transition between the main subtypes of pemphigus, pemphigus vulgaris (PV), and pemphigus foliaceus (PF) has rarely been reported. Moreover, the development of PV in a patient with PF is much more unusual than that of PF in a patient with PV. We report a 48-year-old man who presented with ...
Sabherwal Yamini - - 2006
We recently characterized an anti-tumor protein termed angiocidin. Here, we report that angiocidin may inhibit angiogenesis by binding collagen and its receptors. Angiocidin bound purified type I collagen and alpha2beta1 with high affinity. K562 cells expressing alpha2beta1 bound and adhered to angiocidin while K562 cells which only expressed alpha5beta1 integrin ...
Shin Cheung Soo - - 2006
The ionized calcium level in blood is known to be falsely decreased when self-prepared liquid heparin anticoagulant is used, due to dilution and binding effects. The effect of liquid heparin on the determination of ionized magnesium is not as well understood. We compared the effect of liquid sodium heparin on ...
Kast Richard E - - 2006
This brief communication focuses on aspects of a recent case report (Yonsei Med J 2005;46:425-30) on a full and sustained remission of Hodgkin's lymphoma (HL) after a single day of chemotherapy. A septic episode required stopping chemotherapy and starting amphotericin B and acyclovir. Remission evidence was seen within days of ...
Liu G Frank - - 2006
To summarize safety data such as clinical adverse experiences in clinical trials with a moderate to long-term follow-up, we may use a measurement which accounts for the potential differences in the follow-up duration between treatment groups. The incidence rate, which uses the total person-time follow-up in a treatment group as ...
Song Jae Woo - - 2006
Procoagulant or impaired fibrinolytic states as well as inflammatory reactions mediated by cytokines are likely involved in the pathogenesis of acute ischemic stroke. We examined the potential relationship between interleukin 6 (IL-6) and hemostatic markers. The procoagulant and fibrinolytic states were assessed in 46 patients with acute stroke by measuring ...
Lee Se-Joon - - 2006
Lipopolysaccharide (LPS), given in vivo, modulates opossum esophageal motor functions by inducing the inducible nitric oxide synthase (iNOS), which increases nitric oxide (NO) production. Superoxide, a NO scavenger, is generated during this endotoxemia. Superoxide is cleared by superoxide dismutase (SOD) and catalase (CAT) to protect the physiological function of NO. ...
Longatti P - - 2006
OBJECTS: Microsurgical resection, stereotactic aspiration and VP shunt have for years been the choice options for the treatment of colloid cysts of the third ventricle. Recently, endoscopic approaches have aroused increasing interest and gained acceptance. Although safer, this minimally invasive approach is considered less efficacious than microsurgery. Relatively long-term results ...
Köhle Christoph - - 2006
The Ah receptor (AhR) is a ligand-activated transcription factor and member of the bHLH/PAS (basic helix-loop-helix/Per-Arnt-Sim) family of chemosensors and developmental regulators. It represents a multifunctional molecular switch involved in regulation of endo- and xenobiotic metabolism, in vascular development and in dioxin-mediated toxicities. Recently, the oxidative stress-protecting Nrf2 has been ...
Miyagi Masayuki - - 2006
The rat L5/6 facet joint, from which low back pain can originate, is multisegmentally innervated from the L1 to L5 dorsal root ganglia (DRG). Sensory fibers from the L1 and L2 DRG are reported to non-segmentally innervate the paravertebral sympathetic trunks, while those from the L3 to L5 DRGs segmentally ...
Keller Tony S - - 2007
Spinal musculature plays a major role in spine stability, but its importance to spinal stiffness is poorly understood. We studied the effects of graded trunk muscle stimulation on the in vivo dynamic dorsoventral (DV) lumbar spine stiffness of 15 adolescent Merino sheep. Constant voltage supramaximal electrical stimulation was administered to ...
Bakker Eric W P - - 2007
A case-control study was conducted to assess the daily loading of the spine as a risk factor for acute non-specific low back pain (acute LBP). Acute LBP is a benign, self-limiting disease, with a recovery rate of 80-90% within 6 weeks irrespective of the treatment type. Unfortunately, recurrence rates are ...
Engel Charles C - - 2006
After the 1991 Gulf War, veterans of the conflict from the United States, United Kingdom, Canada, Australia and other nations described chronic idiopathic symptoms that became popularly known as 'Gulf War Syndrome'. Nearly 15 years later, some 250 million dollars in United States medical research has failed to confirm a ...
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