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Walshe J M - - 1986
A patient who presented with severe hepatic Wilson's disease at age 14 responded well to treatment with penicillamine and remained in good health for a further 20 years, although she became somewhat careless about her medication towards the end of this period. Finally she abandoned treatment altogether and died of ...
Relevancy Score: Relevancy Score: 249
Boers M - - 1990
Irreversible nephrotoxicity has limited the use of cyclosporine in rheumatoid arthritis (RA). In a randomized clinical trial we compared 26 weeks of cyclosporine (5 mg/kg) and D-penicillamine (250 mg) treatment in 92 patients with RA with a serum creatinine less than 100 mumol/l. We adjusted the starting dose according to ...
Relevancy Score: Relevancy Score: 249
Chu C C - - 1996
A 24-year-old man had several episodes of hypokalemic muscle weakness of undetermined etiology since the age of 13 years. Wilson's disease (WD) was not diagnosed until the age of 18 when wing-beating tremor in the left upper limb was noted. Renal function study revealed incomplete proximal renal tubular acidosis. The ...
Relevancy Score: Relevancy Score: 249
Brewer George J - - 2005
Anticopper drugs that have been developed to treat Wilson's disease, a disease of copper toxicity, include tetrathiomolybdate, zinc, penicillamine, and trientine. Lowering copper levels by a modest amount in non-Wilson's patients with tetrathiomolybdate inhibits angiogenesis, fibrosis and inflammation while avoiding clinical copper deficiency. Through this mechanism tetrathiomolybdate has proven effective ...
Relevancy Score: Relevancy Score: 249
Suga S - - 1985
It became increasingly evident that UFTM chemotherapy, a combination of UFT and mitomycin C is one of the most recommendable therapy for advanced gastric cancer, especially for the treatment of Borrmann type 4 gastric cancer. Objective responses were achieved in 18 out of 26 (69.2%) patients with Borrmann type 4 ...
Relevancy Score: Relevancy Score: 249
Strickland G T - - 1976
Efficacy of chelation therapy with intravenous calcium disodium edetate, oral Ca EDTA, and oral penicillamine was tested in 63 subjects with chronic minimal industrial exposure to lead. All three agents increased the urinary lead excretion. The effect was greatest with intravenous Ca EDTA, next with oral penicillamine and least with ...
Relevancy Score: Relevancy Score: 249
Huskisson E C - - 1976
The technetium index was measured in 22 patients with rheumatoid arthritis, before and after 6 months' treatment either with penicillamine or with anti-inflammatory drugs. The index was calculated by dividing the sum of the count rates over both knees and both wrists by the dose of technetium given. In the ...
Relevancy Score: Relevancy Score: 249
Rosenthal M - - 1977
Immune complexes were demonstrated by leucocyte phagocytosis assay in 37 of 55 patients with rheumatoid arthritis. After treatment with gold salts, penicillamine, alpha-mercaptopropionylglycine, immunosuppressive agents or levamisole a substantial fall or elimination of demonstrable circulating immune complexes occurred. In-vitro studies revealed that gold salts in therapeutic concentrations inhibited the phagocytosis ...
Relevancy Score: Relevancy Score: 249
Pedersen B K - - 1984
Natural killer (NK) activity against K 562 target cells was studied in 60 patients with definite or classic rheumatoid arthritis (RA), grouped by medication into 1) Controls not in remission-inducing therapy, 2) Patients treated with penicillamine, and 3) Patients treated with azathioprine. NK activity was found to be completely suppressed ...
Relevancy Score: Relevancy Score: 249
Cheng W S - - 1992
Hepatocellular carcinoma has rarely been reported in Wilson's disease, particularly in women. We describe the case of a female patient who was diagnosed with Wilson's disease at the age of 39 years, after presenting with severe neurological symptoms. She had significant neurological improvement following penicillamine therapy and succumbed to hepatocellular ...
Relevancy Score: Relevancy Score: 249
Thompson J N - - 1987
The unique clinical experience of having to treat simultaneously nine young adults who had ingested the same corrosive substance prompted this investigation in rabbits of the pathophysiology of corrosive esophageal injury and of drugs that might prevent formation of stricture. Treatment of experimental corrosive esophageal injury in these animals consisted ...
Relevancy Score: Relevancy Score: 249
Palatini P - - 1984
Competitive inhibitors have been used to study the kinetic mechanism of action of the multireactant enzyme dopamine beta-hydroxylase (dopamine beta-monooxygenase EC 1.14.17.1). The copper chelator penicillamine, which was found to be a competitive inhibitor of ascorbate, gave noncompetitive inhibition with respect to tyramine. The antidopaminergic drug cis-chlorprothixene, a competitive inhibitor ...
Relevancy Score: Relevancy Score: 249
Tandan R - - 1990
Giant axonal neuropathy (GAN) is a disorder characterized pathologically by distal neurofilament-filled bulbous swellings in axons, and widespread collection of intermediate filaments, including masses of vimentin filaments in cultured skin fibroblasts. A morphologically similar neurofibrillary disorder is produced by acrylamide and the toxic hexacarbons, agents which bind to thiol groups. ...
Relevancy Score: Relevancy Score: 249
Dijkmans B A - - 1990
The efficacy of azathioprine, methotrexate, cyclosporin, and d-penicillamine alone and in combination with chloroquine was quantitated in an in vitro system, with the use of mitogen-stimulated human peripheral blood mononuclear cells. A concentration-dependent effect was found for each of these drugs. The effect of adding chloroquine to azathioprine or methotrexate ...
Relevancy Score: Relevancy Score: 249
Greene M W - - 1988
After removal of an impacted maxillary third molar, an oroantral fistula developed in a patient with Wilson's disease. Management consisted of antibiotics, decongestants, irrigation, and surgical closure. Complications of treatment did not directly involve the disease but, rather, were related to the therapeutic agent penicillamine. Penicillamine causes interference between the ...
Relevancy Score: Relevancy Score: 249
Behrens-Baumann W - - 1986
In an experimental study on rabbits, a standardized eye injury was created by using the "pars-plana incision model." Subsequently, the effect of intravenous application of dexamethasone and penicillamine on traction retinal detachment was investigated. The two drugs were applied in varying concentrations and combinations (single and combined use in varying ...
Relevancy Score: Relevancy Score: 249
Huskisson E C - - 1976
In a controlled study involving thirty-four patients levamisole was shown to be as effective as D-penicillamine and more effective than placebo in the treatment of rheumatoid arthritis. Its action was slow and was accompanied by a reduction in erythrocyte sedimentation-rate, rheumatoid factor, and technetium index. These properties indicate that it ...
Relevancy Score: Relevancy Score: 249
Dickson E R - - 1981
Primary biliary cirrhosis, a chronic systemic disease, likely involves a disturbance in the immune process. The significant alterations in copper metabolism in this disorder are, we believe, related to progressive intrahepatic cholestasis and impairment in normal hepatobiliary copper clearance. A trial of D-penicillamine treatment suggests that this drug may benefit ...
Relevancy Score: Relevancy Score: 249
Grigorean G - - 2001
Protonated complexes involving cyclodextrin hosts and guest compounds that are pharmacologically important are produced in the gas phase and reacted with a gaseous amine. The guest is exchanged to produce a new protonated complex with the amine. The reaction is enantioselective and is used to develop a method for determining ...
Relevancy Score: Relevancy Score: 249
Weber M - - 2000
We report a patient who developed a focal myopathy with prominent contractures of his thigh muscles induced by chronic heroin injection. Muscle biopsy and magnetic resonance imaging (MRI) were indicative of a fibrotic and inflammatory process. Treatment with steroids, D-penicillamine, and physical therapy led to full functional recovery within 6 ...
Relevancy Score: Relevancy Score: 249
Storch W - - 1980
12 patients with Wilson's disease were examined by means of renal biopsy. In 9 of these patients a slight (4 patients) or a strong proteinuria (5 patients) appeared during the therapy with D-penicillamine. A biopsy was performed in 3 patients before the beginning of the therapy with D-penicillamine. The patients ...
Relevancy Score: Relevancy Score: 249
Sugg E E - - 1988
Three cyclic disulfide analogs related to somatostatin, D-Phe(1)-cyclo(Cys(2)-Tyr(3)-D-Trp(4)-Lys(5)-Thr(6)-Xxx(7))-Thr(8)- NH2 (where Xxx = L-Pen 1; L-Cys 3; or D-Pen 4) were examined in DMSO-d6 by one- and two-dimensional proton n.m.r. spectroscopy in order to analyze the conformational influence of the position-7 residue on the 20-membered disulfide ring. From these studies it ...
Relevancy Score: Relevancy Score: 248
Vetter N - - 1980
The treatment with steroids, spironolactone, immunosuppressive drugs and D-Penicillamin is studied in 25 patients suffering from fibrosing alveolitis. A clinical improvement and an improvement of vital-capacity and total-capacity is seen, but no change in atrerial blood gas tensions.
Relevancy Score: Relevancy Score: 246
Kachru D N - - 1989
Seven male silver jewellery workers aged between 25 to 70 years complained of acute abdominal colic, sweet metallic taste, constipation and anorexia. Clinical, hematological examinations and urinalysis confirmed lead poisoning. Oral therapy with D-Penicillamine for seven days led to significant improvement in patients.
Relevancy Score: Relevancy Score: 246
Hautmann R - - 1977
During a 4-year period 9 cases of severe recurrent cystine stones and cystinuria were treated with mercaptopropionylglycine. The oral long-term administration revealed the high effectiveness of the drug and resulted in no further stone formation. Mercaptopropionylglycine is free of side effects and more effective than D-penicillamine.
Relevancy Score: Relevancy Score: 246
Pan S K - - 1980
Elevated urinary methylmercury excretion was observed in a patient poisoned with mercury vapor. When he was treated with D-penicillamine, the urinary methylmercury excretion increased significantly in both cases of twice-repeated 4-day peroral administration, while the urinary total mercury excretion increased significantly only in the first series of administration.
Relevancy Score: Relevancy Score: 246
Liebetrau G - - 1980
D-Penicillamine is increasingly used for the treatment of lung fibrosis. The case-histories of 46 patients from 4 chest hospitals were analysed. All parameters being taken in consideration 13 patients showed an improvement, 17 patients no change and 16 patients a deterioration of their state of health. Side effects were observed ...
Relevancy Score: Relevancy Score: 246
Haberhauer G - - 1989
Anticentromere antibody (ACA) was previously described as a serological marker for CREST, progressive systemic sclerosis (PSS), Raynaud's syndrome (RS) and primary biliary cirrhosis (PBC). We have observed ACA appearing and disappearing during D-penicillamine (DPA) treatment in six patients without any features of CREST, PSS, RS, PBC or related syndromes. ACA ...
Relevancy Score: Relevancy Score: 246
Youngman R J - - 1979
A chelate with superoxide dismutase activity, D-penicillamine copper complex, was shown to inhibit paraquat toxicity in flax cotyledons (Linum usitatissimum var. Reina). Paraquat-stimulated chlorophyll loss and ethane production were markedly reduced by this complex. The role of superoxide in the action of paraquat is briefly discussed.
Relevancy Score: Relevancy Score: 246
Civatte J - - 1989
An overview is given on pemphigus diseases induced by certain drugs. Well known inducers are D-penicillamine, and pyritinol-chlorhydrate. Besides that in some rather rare cases other drugs were connected to pemphigus induction: rifampicin, INH, etambutol, practolol, propranolol, phenylbutazone, aurothiomalate, ibuprofen, heroin, penicillin, ampicillin, captopril, thiopromine, alpha-mercaptopropionylglycine and piroxicam.
Relevancy Score: Relevancy Score: 246
Baratta E - - 1990
A case of drug-provoked fever is described in a scleroderma patient on penicillamine. The drug was withdrawn because of the severity and recurrence of the fever. Both our personal experience and a review of the literature, show this side effect to be markedly less frequent than reported by German researchers.
Relevancy Score: Relevancy Score: 246
Balzer K - - 1980
The history of a 38-year-old, asymptomatic man with primary sclerosing cholangitis is reported. The diagnosis has been suggested by eosinophilia (66%, 27 X 10(9)/l leucocytes) and markedly elevated serum alkaline phosphatase levels (1860 U/l) and has been established by endoscopic retrograde cholangiography. Report of a therapeutic approach with D-Penicillamin. Documentation ...
Relevancy Score: Relevancy Score: 246
Tangsrud S E - - 1979
Scleroderma in a two-year-old boy with gross enlargement of the right inguinal lymph nodes, as an early sign, is reported. Repeated lymph node biopsies revealed non-characteristic reactive changes and hyperplasia, but eventually histological examination of skin and muscle from the right leg were diagnostic. The effect of one year of ...
Relevancy Score: Relevancy Score: 246
Pellecchia M T - - 2003
Thirty patients with Wilson's disease (WD) were observed at a movement disorder clinic between 1970 and 2000. Disease onset was at the mean age (SD) of 14.5 (+/-5.9) years. Presentation with hepatic disease occurred in 12 of 30 patients and with neurologic disease in 15. Three patients were asymptomatic at ...
Relevancy Score: Relevancy Score: 246
Walshe J M - - 1977
The effect of pregnancy has been studied in 10 mothers with Wilson's disease. Three were presymptomatic but had the typical biochemical lesion, two of these were receiving penicillamine treatment at the time of conception, the third had yet to be diagnosed. The remaining seven mothers had had symptoms of Wilson's ...
Relevancy Score: Relevancy Score: 245
Magos L - - 1969
1. (+)-Penicillamine in a dose of 193 mumoles/kg given subcutaneously twice a day on the sixth and seventh days after the administration of 100 mug mercury increased the urinary excretion of rats more than the equimolar dose of N-acetyl-(+)-penicillamine but less than 2,3-dimercaptopropanol 48.3 mumoles/kg.2. Sodium maleate in a dose ...
Relevancy Score: Relevancy Score: 245
Nishikaku F - - 1993
The antiarthritic activity of a novel thiazole derivative, SM-8849, was compared with that of indomethacin and D-penicillamine, in mice with collagen-induced arthritis. SM-8849 reduced the incidence and severity of disease in collagen-immunized mice, as assessed by clinical observation. This efficacy was also confirmed by radiographic and histologic studies. Indomethacin produced ...
Relevancy Score: Relevancy Score: 245
Henderson P - - 1985
Therapy of acute heavy metal poisoning is currently limited to a group of moderately toxic drugs containing sulfhydryl groups. N-Acetylcysteine (NAC) was used in these studies to determine if this sulfhydryl containing amino acid would reduce the overall mortality of a group of heavy metal compounds. D-Penicillamine and dimercaprol (BAL) ...
Relevancy Score: Relevancy Score: 245
Shimono N - - 1991
Wilson's disease associated with hepatic failure is not common and the underlying mechanism triggering the event is not known at present. We treated a 28-year-old Japanese woman with Wilson's disease who developed hepatic failure associated with hemolytic crisis just after delivery. She was diagnosed as having Wilson's disease at 12 ...
Relevancy Score: Relevancy Score: 245
Zitnik R J - - 1990
Drug-induced lung disease presents several diagnostic and therapeutic problems to the clinician. This is especially true in the case of lung disease associated with antirheumatic agents in which pulmonary disease may be due to the underlying disorder. Unfortunately, no specific markers exist to differentiate drug-induced lung disease from other pathologic ...
Relevancy Score: Relevancy Score: 245
Aćimović Jelena M JM Department of Biochemistry, Faculty of Chemistry, University of Belgrade, Studentski trg 16, Belgrade, Serbia. - - 2014
α-Oxoaldehydes, which are produced in higher quantities in diabetes, uremia, oxidative stress, inflammation and aging, react with the amino, guanidine and thiol groups of proteins and cause the formation of advanced glycated end-products and protein cross-linking. To prevent these reactions, the efficiency of low molecular mass thiols with an α-amino-β-mercapto-ethane ...
Relevancy Score: Relevancy Score: 245
Basinger M A - - 1980
The relative efficacy of 14 chelating agents in alleviating acute nickel(II) acetate (ip) intoxication has been determined. The LD50 for ip nickel(II) acetate in mice was found to be 45.7 mg/kg with a 95% confidence limit of 39.2--53.3 mg/kg. For a level of 62 mg/kg ip of nickel(II) acetate (i.e. ...
Relevancy Score: Relevancy Score: 242
Baba N - - 1991
We describe here two patients with rheumatoid arthritis who developed nephrotic syndrome after administration of bucillamine, a novel antirheumatic drug developed in Japan. The nephrotic syndrome occurred after six months' and five months' treatment of bucillamine, respectively. The renal biopsy showed early phase of membranous glomerulonephritis (stage 1) in both ...
Relevancy Score: Relevancy Score: 242
Saji H - - 1980
Chelating agent, such as CaEDTA, CaDTPA, D-penicillamine, DMSA, desferoxamine, NTA, cysteine ethyl ester, BAL, alpha-MPG, phthalein complexone, were tested as a possible contrast enhancing agent for tumor imaging with 67Ga-citrate. The intravenous administration of a chelating agent to Ehrlich's tumor bearing mice, one hour after the injection of 67Ga-citrate, accelerated ...
Relevancy Score: Relevancy Score: 242
Wilson J P - - 1986
A 77-year-old patient is described who developed pemphigus vulgaris temporally with the administration of cefadroxil. The disease improved when the drug was discontinued but was exacerbated with the administration of ampicillin. This may be the first case of possible cefadroxil-induced and only the second case of ampicillin-induced pemphigus vulgaris reported. ...
Relevancy Score: Relevancy Score: 242
McInnes I B - - 1996
We have demonstrated spontaneous nitric oxide (NO) production by primary synovial cultures from rheumatoid (RA) and osteoarthritis patients. Increased NO production followed addition of staphylococcal enterotoxin B. Immunochemical double staining with specific anti-human inducible NO synthase (iNOS) and nonspecific esterase (NSE), or anti-CD68 (markers for tissue macrophages) showed that although ...
Relevancy Score: Relevancy Score: 241
Pullar T - - 1984
The effect of 'second-line' drugs on radiological progression in rheumatoid arthritis is not clear, and previous studies have yielded contradictory results. Sixty-seven patients with rheumatoid arthritis have been followed up clinically and radiologically for approximately 2 years (26 patients were receiving intramuscular gold, 21 penicillamine, 10 levamisole, and there were ...
Relevancy Score: Relevancy Score: 240
Steven M M - - 1982
In a prospective study 88 patients, with rheumatoid arthritis who had stopped taking gold, penicillamine, or levamisole were randomly allocated to one of the alternative drugs and followed up for a minimum of one year. Concurrent studies of the effects of gold, penicillamine, and levamisole prescribed in 123 patients as ...
Relevancy Score: Relevancy Score: 240
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