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Matsuda M - - 1994
A 49-year-old male with primary aldosteronism, accompanied by hypertrophic cardiomyopathy (HCM), underwent our anesthesiological management for resection of a left adrenal tumor. The preoperative examination revealed hypertension, mild nephropathy and hypokalemia. Spilnolactone treatment was discontinued 3 days before surgery. In the operating room, a Swan-Ganz catheter was inserted for monitoring ...
Viby-Mogensen J - - 1994
The available evidence indicates that rocuronium is one of the least potent non-depolarizing muscle relaxants, having a clinical duration, recovery index and reversal time similar to those of atracurium and vecuronium. The onset time, however, is significantly shorter than that of currently used non-depolarizing muscle relaxants. Rocuronium seems to be ...
Suárez M - - 1994
The incidence of memories of events during the total intravenous general anesthesia is studied in a 400 adult patient group in order to establish the influence of the included doses of drugs in this scheme, upon the mentioned incidence. The anesthetic method included propofol, fentanyl and vecuronium. Two groups of ...
Sparr H J - - 1994
After an initial bolus dose (0.6 mg kg-1), 10 patients received a continuous infusion of rocuronium, initially at 0.5 mg kg-1h-1, and then adjusted to maintain 90% twitch depression. Blood samples were analysed for 420 min after switching off the infusion. The dose required to maintain the block was 595 ...
Mahisekar U L - - 1994
STUDY OBJECTIVE: To determine the potential clinical significance of admixtures of thiopental sodium and acidic drugs, which are used during induction of general anesthesia and can cause the formation of particles of thiopental. DESIGN: Using an infusion setup similar to that used for a rapid-sequence induction of general anesthesia, injection ...
Sharpe M D - - 1994
BACKGROUND: The effects of volatile agents and sufentanil anesthesia on the electrophysiologic properties of the accessory pathway and on the incidence of intraoperative tachyarrhythmias in patients with Wolff-Parkinson-White syndrome are unknown. Therefore, we studied these agents for their use in patients undergoing ablative procedures or requiring a general anesthetic for ...
Puura A I - - 1994
Edrophonium (EDR) has the advantages of a quick onset of action and reduced cholinergic effects compared to neostigmine (NST) when they are used to antagonize neuromuscular block (NMB). There are few studies about antagonism of very weak residual NMB. Therefore we compared hemodynamic stability, train-of-four (TOF) characteristics and reversal time ...
Koska J - - 1994
Newer neuromuscular blocking drugs provide optimum blockade and can facilitate ventilation, yet if they are discontinued, they allow predictable reversal. This article documents the use of these drugs in the treatment of two pediatric intensive care unit patients who had different physiologic problems and pharmacologic needs and who were ventilator ...
Lind L - - 1994
The purpose of this study was to evaluate metabolic gas exchange change during surgery performed with general anaesthesia. Metabolic gas exchange was measured continuously (Deltatrac) during 33 gynaecological laparotomies and 22 laparoscopies performed during anaesthesia with propofol, fentanyl and vecuronium in mechanically ventilated patients. In both groups of patients, oxygen ...
van den Broek L - - 1994
The dose-response relationship and the time course of action of Org 7617, a short acting non-depolarizing neuromuscular blocking agent, were evaluated during thiopentone, fentanyl, halothane and N2O anaesthesia. Neuromuscular transmission was monitored mechanomyographically. The ED50 and ED90 were calculated after single bolus doses of the drug. Twelve, seven and three ...
Hofmockel R - - 1994
Rocuronium is a new, intermediate-acting, nondepolarizing relaxant with rapid onset of action leading to both good and very good intubation conditions. It was the aim of our study to investigate the onset of action, the intubation conditions and the course of relaxation using two different dosage regimes. Thirty consenting ASA ...
Feldman S A - - 1994
Many factors influence the minimum time required to achieve an easy and successful tracheal intubation after a non-depolarizing relaxant. The ideal study design has never been achieved in practice: an overall picture of the efficacy of rocuronium depends on careful interpretation of studies with different methodologies, which have usually compared ...
Nishiyama Y - - 1994
This study compares the neuromuscular blocking effect of nondepolarizing relaxants on the thenar and hypothenar muscles in 14 anesthetized patients with nitrous oxide-halothane. Vecuronium (60 micrograms.kg-1 iv) or pancuronium (60 micrograms.kg-1 iv) was given and supramaximal stimulation was applied to ulnar nerve at the wrist. The evoked compound action potentials ...
Pandit S K - - 1994
General anesthesia is the most common form of anesthetic management for ambulatory surgery. Patients, in general, prefer general anesthesia because it is less anxiety provoking. During the last decade, the availability of several short-acting agents with high clearance has made general anesthetic techniques much safer and more predictable for outpatients. ...
Gaggero G - - 1994
Propofol is an intravenous anesthetic agent with a short half-life allowing rapid recovery; it has cerebral hemodynamic effects similar to those of thiopental. The aim of the present study was to describe 83 patients (mean age 50.6 +/- 15.1 yrs) scheduled for intracranial surgery in whom a total intravenous anesthesia ...
Wierda J M - - 1994
The existing human pharmacokinetic studies have been reviewed and compared with data derived from animals. The earliest study confirms the similarity of rocuronium to vecuronium with respect to the variables derived from the plasma concentration decay curves and the proportion excreted renally. Other studies led to the conclusion that concurrent ...
Barbone G - - 1994
For monitoring of vecuronium profound neuromuscular blockade post-tetanic count (PTC) following tetanic stimulation at frequency of 50 and 100 Hz was employed in 25 ASA I-II patients submitted to elective surgery, to evaluate the differences between the two patterns of stimulation and the possible clinical utility of the latter pattern ...
Alvarez-G?mez J A - - 1994
OBJECTIVES: To compare intubation conditions and neuromuscular parameters, patency time, maximum level of block, time and clinical duration of effect for rocuronium bromide 0.6 mg/kg (ORG 9426) versus equally potent doses of vecuronium and atracurium under similar experimental conditions. PATIENTS AND METHODS: Sixty patients were divided into three groups of ...
Mirakhur R K - - 1994
The safety of neuromuscular relaxants can be assessed according to their cardiovascular and autonomic effects, their liability to release histamine, their tendency to cause anaphylactic/anaphylactoid reactions, their effect on cholinesterase, on intra-ocular and intracranial pressure, their tendency to cumulation and their reversibility. Any adverse effects of metabolites are also potential ...
Cortiñas J - - 1994
Ibebunjo C - - 1994
The purpose of the study was to compare the response of the cricoarytenoideus dorsalis muscle (CD) to neuromuscular blocking drugs with those of the thyroarytenoideus (TA), diaphragm (DI) and ulnaris lateralis (UL) muscles. Evoked electromyographic response to indirect supramaximal stimulation at 1 Hz was monitored in ten adult goats under ...
Whalley D G - - 1994
We have determined the cumulative dose-response relationship for vecuronium from the evoked compound electromyogram of the hypothenar muscles in eight patients who were receiving carbamazepine. The ED50, ED90 and ED95 were 29, 52 and 64 micrograms kg-1, respectively, and were significantly different (P < 0.05) from those of a control ...
Nitschmann P - - 1994
In a double-blind study, cardiovascular parameters (cardiac output, heart rate, systolic and diastolic arterial pressure, pulmonary and systemic vascular resistances) were measured invasively in two groups of patients receiving 3 x ED90 of rocuronium or vecuronium. Measurements were made at 2, 5 and 7 min after administration and 10 and ...
Appadu B L - - 1994
Interaction of the steroidal neuromuscular blocking drugs pancuronium, pipecuronium, rocuronium and vecuronium with cardiac muscarinic receptors in rat hearts was investigated in vitro by a tritiated N-methyl hyoscine binding assay. We showed an interaction with cardiac muscarinic receptors with a rank order of potency pancuronium > vecuronium > pipecuronium > ...
Nishiyama M - - 1994
Thirty-seven patients (ASA I or II) undergoing elective abdominal surgery were randomly allocated to four groups, which were anesthetized with nitrous oxide 67%, oxygen 33% and sevoflurane 0%, 1%, 2% and 3% respectively. We administered clinically used doses of vecuronium for abdominal surgery and studied the duration (the time from ...
Hunter J M - - 1994
The use of neuromuscular blocking drugs during anaesthesia for patients with chronic renal failure is discussed. The disadvantages of the older non-depolarizing agents, such as tubocurarine, alcuronium, and pancuronium are outlined, as are the significant benefits of the use of atracurium or vecuronium in these patients. Preliminary reports on the ...
Bevan D R - - 1994
Four neuromuscular blocking drugs, doxacurium, mivacurium, pipecuronium, and rocuronium have been or are about to be introduced into clinical practice. The purpose of this MiniReview is to describe their pharmacology, to consider their place in clinical anaesthetic practice, and to examine whether the needs of the clinician have been met. ...
Norel X - - 1994
Vecuronium (100 microM) but not pancuronium (100 microM) increased the sensitivity of human isolated bronchial preparations (HBP) to exogenous acetylcholine (ACh). The pD2 values obtained from concentration-dependent contractions were: control, 4.59 +/- 0.29 vecuronium, 5.86 +/- 0.31. Vecuronium or pancuronium (100 microM) significantly decreased (50%) the neostigmine contractions in HBP. ...
Pirttikangas C O - - 1994
This study was set up to evaluate the effects of propofol infusion anaesthesia on immunological function in minor surgery. Twenty-seven patients (median age 51 years, ASA 1-2) scheduled for minor breast surgery were randomly assigned to two groups. Anaesthesia was induced in group 1 with propofol 2.5 mg.kg-1 and maintained ...
Robertson E N - - 1994
The aim of this study was to compare, in 30 patients, the pharmacodynamics of equipotent intubating doses of rocuronium and vecuronium and to compare their effects on heart rate, arterial pressure and intra-ocular pressure under steady state propofol anaesthesia. Baseline readings of heart rate and arterial pressure, using a Dinamap, ...
Marshall R J - - 1994
In various animal species anaesthetized with a-chloralose (cats and pigs) or pentobarbitone (Beagle dogs and Rhesus monkeys), rocuronium has been shown to be a readily reversible, non-depolarizing neuromuscular blocking agent with a similar duration of action as vecuronium but a 6-10 fold lower potency. The outstanding features of its action ...
Waldvogel H H - - 1994
End-expiratory capnometrical and capnographical data correspond well with blood carbon dioxide content. Carbon dioxide insufflation for laparoscopy results in a big increase in CO2 uptake as well as in respiratory deterioration due to positioning and increased intra-abdominal pressure. We observed 226 female patients during laparoscopy under general anaesthesia (midazolam-alfentanil-atracurium or ...
Storella R J - - 1993
BACKGROUND: The agonist actions of succinylcholine (SCh) have recently come under study because of their involvement in the clinical problem of masseter muscle rigidity, and their possible involvement in malignant hyperthermia. The authors investigated factors affecting SCh-induced contractures in an animal preparation. METHODS: Rats were anesthetized with either halothane (1-2%) ...
Kalman S H - - 1993
The dose-response relationship for vecuronium during anesthesia with the azeotropic mixture of halothane and diethyl ether (HE) (66 ml of halothane mixed with 34 ml of ether in the same bottle)/oxygen was compared with halothane/nitrous oxide/oxygen anesthesia. The HE is not explosive and has preserved many of the advantageous properties ...
Sugahara S - - 1993
Juvenile hyaline fibromatosis (JHF) is a rare disease of autosomal recessive heredity characterized by multiple subcutaneous nodules, hypertrophy of the gingiva, and flexural contracture of the joints including those of the cervical vertebrae and the mandibula. It has been pointed out that the clinical features render tracheal intubation profoundly difficult. ...
Norman J - - 1993
A 19-year-old epileptic patient taking carbamazepine was anaesthetised for a sigmoid colectomy. Such patients are reported to show a resistance to the actions of competitive neuromuscular blocking drugs, and a conventional dose of vecuronium (0.1 mg.kg-1) produced relaxation for only 18 min. Subsequently she received vecuronium 6.7 mg.h-1 which kept ...
Haines M - - 1993
The speed of onset (T1 = 95% twitch depression) and the duration of action (T1 = 25% control) of equipotent doses of atracurium 0.5 mg/kg and vecuronium 0.1 mg/kg were compared in 21 ASA physical status I and II adult patients. Train-of-four (TOF) ratios (height of T4/T1) were also compared ...
Abballe C - - 1993
A study carried out on 44 patients undergoing laparoscopic cholecystectomy was started in order to evaluate if nitrous oxide is or not contraindicated. The patients were divided in two groups of 22 subjects receiving or not nitrous oxide in the anaesthetic mixture. All the patients received the same preanaesthetic medication ...
Klinge E - - 1993
Inhibition of relaxation of strips of the bovine retractor penis muscle induced by a standard dose of nicotine (30 microM) was used for quantitative assessment of the ganglion-blocking activity of eight neuromuscular blocking agents that are in clinical use. The order of potency of the drugs studied was (+)-tubocurarine >> ...
Hogan Q H - - 1993
BACKGROUND: The mechanisms producing hemodynamic changes during epidural anesthesia are incompletely understood. This study examines the sympathetic block and splanchnic venodilatation that result from extensive thoracolumbar epidural anesthesia in rabbits using direct measurements of sympathetic efferent nerve activity (SENA) and mesenteric vein diameter (VD). METHODS: Epidural catheters were inserted in ...
Mahajan R P - - 1993
We questioned whether the side effects outweighed the advantages of priming doses of nondepolarizing neuromuscular relaxants in awake patients. We have assessed lung function and clinical evidence of muscle weakness in 10 elderly patients, eight women and two men, aged 67-78 yr, ASA grade I or II, before and 3 ...
Chung P C PC Department of Anesthesia, Chang Gung Memorial Hospital, - - 1993
As high dose intravenous labetalol was always used in performing deliberate hypotensive anesthesia and it was reported that small dose of intravenous labetalol would decrease the hyperglycemic response under surgical stress, high dose intravenous labetalol may theoretically causes more pronounced reduction in plasma glucose. 14 female cervical cancer patients (ASA ...
Houweling P L - - 1993
Sixty ASA Grade II-III patients, without clinical symptoms of ventricular dysfunction and scheduled for elective bifemoral grafting for abdominal aneurysms, were allocated randomly to three equal groups to receive 150 micrograms sufentanil intravenously, epidurally or intrathecally. All patients received midazolam, vecuronium and nitrous oxide. Except for right ventricular stroke work ...
Khuenl-Brady K S - - 1993
Rocuronium bromide (Org 9426) is a new, non-depolarising steroidal muscle relaxant that is currently undergoing extensive clinical trials worldwide. Since it is expected to be introduced into clinical practice in the near future, the purpose of this review is to give a summary of the currently available information on this ...
Vieira Z E - - 1993
Butorphanol and nalbuphine, narcotic agonist-antagonists were shown to cause no increase in biliary pressure in contrast to morphine in dogs or men. A non-invasive, ultrasonographic technique confirmed that morphine caused constriction of the common bile duct while placebo caused no effect. To prove the lack of constrictive effect of butorphanol ...
Min J C - - 1993
The duration of recovery from neuromuscular block after a 3 x ED90 dose of atracurium or vecuronium is similar in spite of a three-fold difference in their elimination half-lives. We have investigated simultaneous spontaneous recovery from equipotent doses of atracurium and vecuronium in the isolated forearms of volunteers in order ...
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