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Reid K H - - 2001
Cardiac arrest and resuscitation were used to induce brain damage and susceptibility to sound-triggered seizures in Sprague-Dawley rats. Glucose preloading was used to vary seizure susceptibility. Because loop diuretics can block these seizures, we investigated changes in KCC2, a potassium-chloride cotransporter, in the inferior colliculus - the origin of the ...
Relevancy Score: Relevancy Score: 258
Wu Wenyu W Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000 - - 2014
A novel metal-organic framework (MOF) was fabricated by spontaneous K(+) -induced supramolecular self-assembly with the embedded tripodal ligand units. When the 3D ligand was loaded onto Fe3 O4 @mSiO2 core-shell nanoparticles, it could effectively separate K(+) ions from a mixture of Na(+) , K(+) , Mg(2+) , and Ca(2+) ions ...
Relevancy Score: Relevancy Score: 258
Hulter H N - - 1980
In dogs dietary K+ restriction (16 days) results in diminished urinary net acid excretion (NAE) and systemic hyperchloremic metabolic acidosis (sigma delta NAE, -200 meq; delta[HCO3-]p, -2.9 +/- 0.3 meq/liter, P less than 0.05). Urinary aldosterone (aldo) excretion decreased by 34 +/- 3% (P less than 0.001) and metabolic clearance ...
Relevancy Score: Relevancy Score: 258
Ballmaier D - - 1995
The oxidative DNA damage induced by the renal carcinogen potassium bromate (KBrO3) in cultured mammalian cells and in a cell-free system was characterized by means of various repair endonucleases. Under cell-free conditions, no modifications were induced by KBrO3 alone, but extensive DNA damage was observed in the presence of glutathione ...
Relevancy Score: Relevancy Score: 258
Gámez P - - 2005
OBJECTIVE: Lung preservation quality is a crucial factor in the success of a lung transplant. In October 2000 we stopped using Euro-Collins (EC) lung preservation solution and began using a low potassium dextran solution (Perfadex [PER]). The objective of the present study was to assess outcome with the 2 solutions. ...
Relevancy Score: Relevancy Score: 258
Lee Y S - - 1996
It has been suggested that 8-hydroxyguanine (oh8Gua), a DNA adduct formed by active oxygens, impairs the maintenance of genetic integrity, oh8Gua glycosylase removes oh8Gua residues as a free base from DNA strands. In E. coli, it has been demonstrated that oh8Gua glycosylase is induced in response to oxidative stress, but ...
Relevancy Score: Relevancy Score: 258
Malek Reza S - - 2005
PURPOSE: We present long-term observations on photoselective vaporization of the prostate in a prospectively studied cohort of men with obstructive benign prostatic hyperplasia. MATERIALS AND METHODS: Obstructive benign prostatic hyperplasia in 94 men was treated with transurethral near contact vaporization with potassium-titanyl-phosphate laser with the patient under general or spinal ...
Relevancy Score: Relevancy Score: 258
Rahman A - - 1999
Nitric oxide (NO) is a short-lived, readily diffusible intracellular messenger molecule associated with multiple organ-specific regulatory functions. Endogenous stimulation or exogenous administration of NO have been shown to inhibit production of reactive oxygen species (ROS) and expression of oxidant-mediated molecular or tissue injury. Potassium bromate (KBrO3) is one such potent ...
Relevancy Score: Relevancy Score: 258
Takenaka K - - 1984
To study the relationship between the electron transfer rate and the net or local charge of protein, chemically modified cytochrome f, in which positively charged amino groups are replaced with negatively charged carboxyl groups, has been prepared by using an arylating reagent 4-chloro-3,5-dinitrobenzoic acid. Four distinct species of chemically modified ...
Relevancy Score: Relevancy Score: 258
McKinney K L - - 1982
The immunogenicity of antigenic fractions obtained by the extraction of Pasteurella multocida strain X-73 (serotype 1) with potassium thiocyanate (KSCN) was determined in chickens and mice. The initial KSCN extract was centrifuged at 105 000 X g, and the antigens were separated into a particulate fraction (40p) and a soluble ...
Relevancy Score: Relevancy Score: 258
Suga Shin-Ichi - - 2002
BACKGROUND: Chronic potassium (K+) deficiency, one of the well-known causes of renal tubulointerstitial injury, is associated with an alteration in vasoactive mediators including persistent generation of renal cortical angiotensin (Ang) II despite the suppression of plasma Ang II, and suppression of urinary nitrite/nitrate excretion. We tested the hypothesis that K+-deficiency-induced ...
Relevancy Score: Relevancy Score: 258
Burns K D - - 1998
Dietary potassium (K+) deficiency is associated with blood pressure elevation and impaired urinary sodium excretion. Since angiotensin II is a potent stimulator of tubular sodium transport, we studied the effect of low [K+] on expression of kidney AT1 angiotensin receptors. In rabbits fed a K+-deficient diet for 14 days, plasma ...
Relevancy Score: Relevancy Score: 258
Moshelion Menachem - - 2002
In a search for potassium channels involved in light- and clock-regulated leaf movements, we cloned four putative K channel genes from the leaf-moving organs, pulvini, of the legume Samanea saman. The S. saman SPOCK1 is homologous to KCO1, an Arabidopsis two-pore-domain K channel, the S. saman SPORK1 is similar to ...
Relevancy Score: Relevancy Score: 258
Moinzadeh Alireza - - 2005
PURPOSE: Laparoscopic partial nephrectomy (LPN) with hilar clamping represents the various challenges associated with warm ischemia. We tested the feasibility, and acute and chronic outcomes of LPN using a potassium-titanyl-phosphate (KTP) laser without vascular hilar clamping in the survival calf model. MATERIALS AND METHODS: Six Jersey calves weighing 76 to ...
Relevancy Score: Relevancy Score: 258
Chang Shaohua - - 2010
Large-conductance voltage- and calcium-activated potassium (BK) channels have been shown to play a role in detrusor overactivity (DO). The goal of this study was to determine whether bladder outlet obstruction-induced DO is associated with downregulation of BK channels and whether BK channels affect myosin light chain 20 (MLC(20)) phosphorylation in ...
Relevancy Score: Relevancy Score: 258
Herrington James - - 2005
Voltage-gated potassium (Kv) currents of human pancreatic islet cells were studied by whole-cell patch clamp recording. On average, 75% of the cells tested were identified as beta-cells by single cell, post-recording RT-PCR for insulin mRNA. In most cells, the dominant Kv current was a delayed rectifier. The delayed rectifier activated ...
Relevancy Score: Relevancy Score: 258
Sharma Deepak - - 2013
To compare the efficacy of a new potassium oxalate (KO)-containing mouthrinse [Listerine® Advanced Defence Sensitive (LADS)] in reducing dentine permeability and occluding open dentinal tubules versus other desensitising products. The permeability of acid-etched dentine disks was measured by hydraulic conductance; dentine surfaces were examined by scanning electron microscopy and energy-dispersive ...
Relevancy Score: Relevancy Score: 258
Sharma Deepak - - 2013
The study aimed to determine the efficacy in relieving dentinal sensitivity of 4 weeks' treatment with an alcohol-free mouthrinse comprising 1.4% potassium oxalate (KO) (Listerine® Advanced Defence Sensitive; LADS), compared with negative and positive controls. Subjects were randomised to one of three treatments: LADS mouthrinse - twice-daily toothbrushing with Crest® ...
Relevancy Score: Relevancy Score: 258
Gelernter Joel - - 2013
We report a genome-wide association study (GWAS) of two populations, African-American and European-American (AA, EA) for opioid dependence (OD) in three sets of subjects, to identify pathways, genes, and alleles important in OD risk. The design employed three phases (on the basis of separate sample collections). Phase 1 included our ...
Relevancy Score: Relevancy Score: 258
Crecelius Anne R - - 2012
Circulating ATP possesses unique vasomotor properties in humans and has been hypothesized to play a role in vascular control under a variety of physiological conditions. However, the primary downstream signalling mechanisms underlying ATP-mediated vasodilatation remain unclear. The purpose of the present experiment was to determine whether ATP-mediated vasodilatation is independent ...
Relevancy Score: Relevancy Score: 258
Lumb G D - - 1985
A 3-month dose range finding study in preparation for a 2-yr carcinogenicity study of potassium prorenoate (SC-23992), a steroid with an antihypertensive profile, is reported. The drug was administered by gavage once daily at doses of 10, 30, and 100 mg/kg/day to Charles River CD rats. Treatment was terminated at ...
Relevancy Score: Relevancy Score: 258
Raffaelli Giacomo G Neuroscience Program, International School for Advanced Studies (SISSA), Via Beirut 2-4, 34014 Trieste, - - 2004
Large conductance calcium- and voltage-activated potassium channels (BK channels) activate in response to calcium influx during action potentials and contribute to the spike repolarization and fast afterhyperpolarization. BK channels targeted to active zones in presynaptic nerve terminals have been shown to limit calcium entry and transmitter release by reducing the ...
Relevancy Score: Relevancy Score: 258
Shimizu S S Division of Molecular Pharmacology, Tottori University School of Medicine, Yonago, - - 2014
There is increasing evidence that the effects of administered ATP sensitive potassium (KATP ) channel openers or blockers during ischaemia are still controversial in many organs/tissues. Testicular torsion detorsion which causes ischaemia-reperfusion (IR) injury, cannot be predicted, thus an effective drug should be administered during or after the ischaemia. The ...
Relevancy Score: Relevancy Score: 258
Silvester Debbie S - - 2010
A theoretical treatment of potentiometric data is applied to calculate coextraction constants (K(IA)) for three potassium salts from water into a liquid nitrobenzene phase. The experiment involves treating nitrobenzene as a membrane and contacting it with two aqueous solutions of different ion activities. In the presence of either a cation ...
Relevancy Score: Relevancy Score: 257
Schmalhofer William A - - 2010
The voltage-gated potassium channel, human Ether-à-go-go related gene (hERG), represents the molecular component of IKr, one of the potassium currents involved in cardiac action potential repolarization. Inhibition of IKr increases the duration of the ventricular action potential, reflected as a prolongation of the QT interval in the electrocardiogram, and increases ...
Relevancy Score: Relevancy Score: 257
Shim J-K - - 2012
BACKGROUND: /st>The aim of this randomized and controlled trial was to investigate the effect of a glucose-insulin-potassium (GIK) solution on myocardial protection in acute coronary syndrome (ACS) patients undergoing urgent multivessel off-pump coronary artery bypass (OPCAB) surgery. METHODS: /st>Sixty-six patients were randomly allocated either to receive 0.3 ml kg(-1) h(-2) ...
Relevancy Score: Relevancy Score: 257
Epron Daniel - - 2011
Understanding the underlying mechanisms that account for the impact of potassium (K) fertilization and its replacement by sodium (Na) on tree growth is key to improving the management of forest plantations that are expanding over weathered tropical soils with low amounts of exchangeable bases. A complete randomized block design was ...
Relevancy Score: Relevancy Score: 257
Sakhaee Khashayar - - 2011
BACKGROUND: Calcium supplementation is commonly recommended for patients after Roux-en-Y gastric bypass to avert bone loss. To test the hypothesis that effervescent (liquid) potassium-calcium-citrate (PCC) might be more bioavailable than a tablet formulation of calcium citrate (Citracal Petite), the present study compared a single dose response of the 2 compounds. ...
Relevancy Score: Relevancy Score: 257
Toldi Gergely - - 2012
OBJECTIVE: The transient increase of the cytoplasmic free calcium level plays a key role in the process of lymphocyte activation. Kv1.3 and IKCa1 potassium channels are important regulators of the maintenance of calcium influx during lymphocyte activation and present a possible target for selective immunomodulation. DESIGN: Case-control study. SUBJECTS AND ...
Relevancy Score: Relevancy Score: 257
Mengel K - - 1977
The composition of phloem sap has been investigated in Ricinus communis var. gibsonii, grown for 2 weeks on nutrient solution of low and high potassium content (K(1) and K(2)). Diagonal cuts were made in the bark of the stem resulting in the exudation of clear droplets which mainly consisted of ...
Relevancy Score: Relevancy Score: 257
Scott J F - - 2001
Insulin is neuroprotective in animal stroke models but its effects in acute stroke in humans are unknown. The Glucose Insulin in Stroke Trial (GIST-UK) is a randomised controlled trial investigating the benefits of maintaining euglycaemia in hyperglycaemic patients with acute stroke. Data are reported from a GIST-UK substudy which sought ...
Relevancy Score: Relevancy Score: 257
Huang Zhi - - 2012
To determine the best conditions for Bacillus globisporus Q12 and Rhizobium sp. Q32 to produce organic acids and extracellular polysaccharides, respectively, and further elucidate the weathering mechanism of the two potassium-bearing mineral-solubilizing bacteria. Different contents (0-1.2 g/L) of (NH4)2SO4 were added to media to analyze the ability of the strains ...
Relevancy Score: Relevancy Score: 257
Kashiwabara Kosuke - - 2011
SUMMARY AT A GLANCE: When pleural adenosine deaminase (pADA) levels are high, measurements of pleural potassium (pK) are useful for distinguishing parapneumonic effusions from tubercular pleuritis, without performing pleural fluid differential cell counts. When pK levels exceed 5.0 mEq/L, high pADA levels do not indicate the presence of tuberculous pleuritis. ...
Relevancy Score: Relevancy Score: 257
Jacobson Ingemar - - 2013
OBJECTIVE: To examine the electrophysiological, hemodynamic, and antiarrhythmic effects of the novel antiarrhythmic agent AZ13395438. METHODS: The ion channel-blocking potency of AZ13395438 was assessed in Chinese hamster ovary cells stably expressing various human cardiac ion channels and in human atrial myocytes. The in vivo electrophysiological, hemodynamic, and antiarrhythmic effects of ...
Relevancy Score: Relevancy Score: 257
Lobarinas Edward - - 2011
Currently, there are no effective pharmacological therapies for chronic tinnitus despite a number of efforts from clinical studies and more recently, studies in animals using compounds to enhance endogenous inhibition or reduce central hyperactivity. The purpose of the current study was to evaluate the therapeutic efficacy of a novel anxiolytic ...
Relevancy Score: Relevancy Score: 257
Menéndez Sofía T - - 2012
Evidence indicates that human ether à-go-go-related gene 1 (HERG1) voltage-gated potassium channels could represent new valuable membrane therapeutic targets and diagnostic/prognostic biomarkers in various cancers. This study is the first to investigate the expression pattern of HERG1 potassium channel subunit in both primary tumors and precancerous lesions to establish its ...
Relevancy Score: Relevancy Score: 257
Cheng Hongfei - - 2012
The thermal decomposition and dehydroxylation process of coal-bearing strata kaolinite-potassium acetate intercalation complex (CSKK) has been studied using X-ray diffraction (XRD), infrared spectroscopy (IR), thermal analysis, mass spectrometric analysis and infrared emission spectroscopy. The XRD results showed that the potassium acetate (KAc) have been successfully intercalated into coal-bearing strata kaolinite ...
Relevancy Score: Relevancy Score: 257
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