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Liu Zhi-Liang - - 2012
γ-Aminobutyric acid (GABA) is the principle inhibitory neurotransmitter in adult mammalian brain. GABA receptors B subtype (GABA(B)Rs) are abundantly expressed at presynaptic and postsynaptic neuronal structures in the rat ventrolateral periaqueductal gray (PAG), an area related to pain regulation. Activation of GABA(B)Rs by baclofen, a selective agonist, induces presynaptic inhibition ...
Relevancy Score: Relevancy Score: 259
Gomes A P - - 2011
We investigated the effect of sodium reduction by partial substitution of sodium chloride (NaCl) with potassium chloride (KCl) on the manufacture of Minas fresh cheese during 21 d of refrigerated storage. Four treatments of low-sodium Minas fresh cheese were manufactured, with partial replacement of NaCl by KCl at 0, 25, ...
Relevancy Score: Relevancy Score: 259
Wang David T - - 2011
The potassium channel selectivity filter both discriminates between K(+) and sodium ions and contributes to gating of ion flow. Static structures of conducting (open) and nonconducting (inactivated) conformations of this filter are known; however, the sequence of protein rearrangements that connect these two states is not. We show that closure ...
Relevancy Score: Relevancy Score: 259
Hacohen Yael - - 2012
In childhood, central nervous system (CNS) presentations associated with antibodies to voltage-gated potassium channel (VGKC) complex include limbic encephalitis, status epilepticus, epileptic encephalopathy, and autistic regression. We report the cases of two individuals (a 6-year-old male and an 11-year-old female) who presented with an acute-onset explosive seizure disorder with positive ...
Relevancy Score: Relevancy Score: 259
Fujimiya H - - 1994
An antiallergic drug, pemirolast potassium (TBX) at concentrations between 0.01 and 10 micrograms/ml inhibited antigen (Ag)-stimulated degranulation in RBL-2H3 cells, which have the properties of mucosal mast cells. At the same concentrations, the drug suppressed both the formation of inositol 1,4,5-trisphosphate and the mobilization of Ca2+, indicating the prevention of ...
Relevancy Score: Relevancy Score: 259
Zhao Fang - - 2007
To explore the role of mechanosensitive potassium channel TREK-1, Western blot analysis was used to investigate the expression changes of TREK-1 in left ventricle in acute mechanically stretched heart. Forty Wistar rats were randomly divided into 8 groups (n=5 in each group), subject to single Langendorff perfusion for 0, 30, ...
Relevancy Score: Relevancy Score: 259
Athamneh N A - - 2012
A complex of low molecular weight chitosan (LMWC) with oleic acid and diclofenac potassium (DP) was prepared and dispersed in high concentrations of polysorbate 20, 60 and 80 in water to form a solution which releases its components slowly. The formed complex was characterized using different analytical methods. The size ...
Relevancy Score: Relevancy Score: 259
Chen Liu - - 2011
MiRP1 (MinK related protein 1) is a membrane protein in the KCNE family. It can associate with and modulate various voltage gated potassium channels. Mutations in human MiRP1 have been found to cause many congenital and acquired long QT syndromes, which are potentially life-threatening cardiac arrhythmias. Here, human MiRP1 was ...
Relevancy Score: Relevancy Score: 259
Kazemekaite Maryte - - 2008
Anti-inflammatory effects of three potassium salts of N,N-disubstituted 4-aminoazobenzenesulfonic acids were investigated and compared to that of acetylsalicylic acid (ASA) in rats with adjuvant arthritis (AA). Prophylactic oral administration of all compounds in a dose of 150 mg/kg ameliorated AA symptoms in animals. The most pronounced anti-inflammatory activity at the ...
Relevancy Score: Relevancy Score: 259
Lombardo Giuseppe M - - 2012
The vast literature concerning caffeic acid and its derivatives lacks any reference to the solid state structures of its inorganic salts as these crystals are quite difficult grow. Most of the already published works deal with computational studies of these compounds as well as investigations of their behaviour in solution. ...
Relevancy Score: Relevancy Score: 259
Colombo T - - 1982
1-p-(3,3-dimethyl-1-triazeno) benzoic acid potassium salt (DM-COOK) was tested on M 5076/73A (M5) mouse sarcoma at a dose of 40 or 50 mg/kg/day (Days 6--14) after im transplant of 7 x 10(5) cells, with or without surgical removal of the primary tumor on Day 14. Treatment at either dose level resulted ...
Relevancy Score: Relevancy Score: 259
Wong Carson - - 2007
BACKGROUND AND PURPOSE: We describe a safe and reproducible technique for potassium-titanyl-phosphate (KTP) and lithium triboride (LBO) laser photoselective vaporization prostatectomy (PVP). TECHNIQUE: With the patient under anesthesia in the dorsal lithotomy position, cystoscopy is performed. Using a high-power KTP/LBO laser system, a groove is created along the lateral-median lobe ...
Relevancy Score: Relevancy Score: 259
Deepa S - - 2005
Single crystal EPR study of VO(II)-doped magnesium potassium phosphate hexahydrate has been carried out at room temperature. Single crystal rotations in the three orthogonal planes indicate that the paramagnetic impurity has entered the lattice in place of magnesium ions by replacing the equatorial and axial coordinated water molecules. The spin ...
Relevancy Score: Relevancy Score: 259
Chon Jung-Whan - - 2013
The presence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) in raw poultry is one of the most common factors that interfere with the isolation of Campylobacter by cefoperazone-based selective agar. The performance of modified charcoal-cefoperazone-deoxycholate agar (mCCDA) was improved by addition of an ESBL inhibitor, potassium clavulanate (0.5mg/L). The ...
Relevancy Score: Relevancy Score: 259
KamiƄski A - - 1989
Potassium penicillin G was administered intravenously 4 times daily in doses of 6 million u for 10 days to 49 patients, 36 with central nervous system syphilis and 13 with latent seroresistant syphilis. Forty six patients were followed up after treatment. In 16 patients with central nervous system syphilis treated ...
Relevancy Score: Relevancy Score: 259
Isaev N K - - 2000
In cerebellar granule cells in culture, lowering of extracellular [K(+)] results in apoptotic death (D'Mello, S.R., Galli, C., Ciotti, T. and Calissano, P., Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP, Proc. Natl. Acad. Sci. USA, 90 (1993) ...
Relevancy Score: Relevancy Score: 258
Garber Eric A E - - 2004
Water samples were collected between 1999 and 2000 from wetlands in Minnesota that contained malformed frogs. The water samples were analyzed for 14 minerals/ions and screened for the presence of biologically active compounds using Xenopus laevis. Results indicated that water from two sites, CWB and ROI2, induced severe retardation with ...
Relevancy Score: Relevancy Score: 258
Pradeep A R - - 2010
A considerable number of agents are effective in the treatment of dentin hypersensitivity. This 6-week randomized clinical trial compares a dentifrice containing calcium sodium phosphosilicate to potassium nitrate and to a placebo. A total of 110 subjects (58 males and 52 females; aged 20 to 60 years) were entered into ...
Relevancy Score: Relevancy Score: 258
Harvey R D - - 1989
The conductance of the inward-rectifying K+ current (IK1) in isolated cat ventricular myocytes is decreased by reducing the extracellular Na+ concentration. Using a whole-cell patch-clamp technique, possible mechanisms underlying this Na+ dependence were investigated. These included (a) block of inward K+ current by the Na+ substitute, (b) changes in membrane ...
Relevancy Score: Relevancy Score: 258
Hinton Arthur A - - 2006
The antimicrobial activity of solutions of potassium hydroxide (KOH) and mixtures of KOH and lauric acid against microorganisms associated with poultry processing was determined. In vitro tests were performed by enumerating viable microorganisms recovered from bacterial cultures suspended in peptone water (control) and in solutions of 0.1% KOH or mixtures ...
Relevancy Score: Relevancy Score: 258
Schmidlin O - - 1999
In 16 African Americans (blacks, 14 men, 2 women) with average admission mean arterial pressure (MAP, mm Hg) 99.9+/-3.5 (mean+/-SEM), we investigated whether NaCl-induced renal vasoconstriction attends salt sensitivity and, if so, whether supplemental KHCO3 ameliorates both conditions. Throughout a 3-week period under controlled metabolic conditions, all subjects ate diets ...
Relevancy Score: Relevancy Score: 258
Frassetto Lynda - - 2005
Potassium bicarbonate (KBC) potently reduces urine calcium excretion in adult humans, including patients with hypertension or calcium urolithiasis, and postmenopausal women. In the latter, who have substantial risk of calcium deficiency, it remains unknown whether the observed short-term urine calcium-lowering effect of KBC persists over years. We studied 170 postmenopausal ...
Relevancy Score: Relevancy Score: 258
Xian Tao - - 2006
OBJECTIVE: The biophysical properties and the regulation of the two-pore-domain potassium channel TREK-1 were studied in rat cardiomyocytes. METHODS: RT-PCR, immunohistochemistry and patch-clamp recording were performed in isolated rat ventricular cardiomyocytes. In some whole-cell-clamp experiments the myocytes were mechanically stretched using a glass stylus. RESULTS: We found strong expression of ...
Relevancy Score: Relevancy Score: 258
Larsson Britt - - 2007
BACKGROUND: Exposure to aluminium compounds, such as fluorides in gaseous and particulate form, places people who work in potrooms at risk for respiratory symptoms. Workers in potrooms, however, also are exposed to a number of other air contaminants. In this study, we present the first report of a dose-response relationship ...
Relevancy Score: Relevancy Score: 258
Castro Pablo F - - 2003
OBJECTIVE: To evaluate the effects of glucose-insulin-potassium (GIK) therapy on infarct size and left ventricular function when used as an adjuvant therapy to primary angioplasty. DESIGN: Prospective, randomized, double-blind, placebo-controlled study. SETTING: Cardiac intensive care unit at a university hospital. PATIENTS: Thirty-seven patients with acute myocardial infarction for whom primary ...
Relevancy Score: Relevancy Score: 258
Long Chao-Liang - - 2008
BACKGROUND AND OBJECTIVES: It has been demonstrated that hyperuricemia induces reno-cardiovascular damage resulting in hypertension and renal injury because of vascular endothelial dysfunction. The pathogenesis of hyperuricemia, endothelial dysfunction, hypertension, and renal injury is progressive, and develops into a vicious cycle. It is reasonable to suggest that an antihypertensive drug ...
Relevancy Score: Relevancy Score: 258
Grünberg W - - 2011
Hyperkalemia is a common complication in neonatal diarrheic dairy calves and is corrected by administration of glucose or sodium bicarbonate. Although the hypokalemic effect of glucose is well established in other species, controversial results are reported for sodium bicarbonate. Our objective was to study the effect and mechanism of action ...
Relevancy Score: Relevancy Score: 258
Liu Yang - - 2012
BACKGROUND: We investigated the myocardial protective effect of a moderate-potassium cold blood cardioplegic solution (K(+), 10 mmol/L) in pediatric cardiac surgery. METHODS: Sixty-eight pediatric patients with congenital heart disease and undergoing open heart surgery with cardiopulmonary bypass were randomly allocated to the high potassium (HP [K(+), 20 mmol/L, n = ...
Relevancy Score: Relevancy Score: 258
Mustapha Mirna M Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109-5618, - - 2009
The absence of thyroid hormone (TH) during late gestation and early infancy can cause irreparable deafness in both humans and rodents. A variety of rodent models have been used in an effort to identify the underlying molecular mechanism. Here, we characterize a mouse model of secondary hypothyroidism, pituitary transcription factor ...
Relevancy Score: Relevancy Score: 258
Hoover E L - - 1981
Efforts to improve myocardial preservation during aortocoronary bypass procedures have led to the perfusion of saphenous vein segments with potassium cardioplegic (KCP) solutions after completion of the distal anastomosis. Recent reports show that the procurement of veins leads to varying degrees of damage, particularly to the endothelial surface, as a ...
Relevancy Score: Relevancy Score: 258
Georgiev Danko - - 2014
In schizophrenia, alterations in markers of cortical GABA neurotransmission are prominent in parvalbumin-containing neurons. Parvalbumin neurons selectively express KCNS3, the gene encoding the Kv9.3 potassium channel α-subunit. Kv9.3 subunits are present in voltage-gated potassium channels that contribute to the precise detection of coincident excitatory synaptic inputs to parvalbumin neurons. This ...
Relevancy Score: Relevancy Score: 258
Charlton Karen E - - 2005
OBJECTIVES: We investigated whether habitual intakes of sodium (Na), potassium, magnesium, and calcium differ across South African ethnic groups, assessed the proportion of Na intake, which is discretionary, and identified which food sources were the major contributors to Na intake. METHODS: This was a cross-sectional study of 325 black, white, ...
Relevancy Score: Relevancy Score: 258
Qayyum M S - - 1994
The purpose of this study was to determine whether changes in arterial plasma potassium concentration [K+]a affect expired ventilation (VE) in euoxia, hypoxia and hyperoxia during rest and light exercise in humans. Three periods of ventilatory measurements were undertaken in eight healthy subjects at rest and in seven other subjects ...
Relevancy Score: Relevancy Score: 258
Ferguson T B TB - - 1986
A major objective of cardioplegic arrest for protection of the heart during cardiac operations is total electromechanical quiescence. Recent studies from our laboratory in which we used multiple bipolar intracardiac and unipolar intramural electrodes have detected the presence of electrical activity in the lower atrial septum, the atrioventricular node-His bundle ...
Relevancy Score: Relevancy Score: 258
Punske Bonnie B BB Nora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City, UT 84112-5000, USA. - - 2004
Diabetes is associated with high rates of cardiovascular disease and sudden death. Therefore, dissecting specific mechanisms, such as the effects of impaired insulin signaling on cardiac electrophysiology may lead to better diagnosis and treatment. Lack of insulin receptors in mouse myocytes has been shown to reduce repolarizing potassium currents and ...
Relevancy Score: Relevancy Score: 258
Carr Richard D - - 2003
A novel potassium channel opener compound, NN414, selective for the SUR1/Kir6.2 subtype of the ATP-sensitive potassium channel, was used to examine the effect of reducing beta-cell workload in the male Vancouver diabetic fatty (VDF) Zucker rat model of mild type 2 diabetes. Two chronic dosing protocols of NN414 of 3 ...
Relevancy Score: Relevancy Score: 258
Pitt Bertram B University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA. - - 2008
Aldosterone blockade is recommended for patients with congestive heart failure after acute myocardial infarction complicated by left ventricular systolic dysfunction; however, the perceived risk of hyperkalemia may limit implementation of this therapeutic approach. This subanalysis examined the relationship between eplerenone, serum potassium (K(+)), and clinical outcomes in the Eplerenone Post-Acute ...
Relevancy Score: Relevancy Score: 258
Gulliksson H - - 2003
BACKGROUND AND OBJECTIVES: In a preliminary study, the presence of potassium and magnesium in a modified synthetic medium (PAS-III) was found to have a significant influence on platelet metabolism (using apheresis-derived, as well as buffy-coat-derived platelets) when compared with standard PAS-III. The differences included reduced glycolysis, as evidenced by lower ...
Relevancy Score: Relevancy Score: 258
Furness John B - - 2003
Recent functional evidence suggests that intermediate conductance calcium-activated potassium channels (IK channels) occur in neurons in the small intestine and in mucosal epithelial cells in the colon. This study was undertaken to investigate whether IK channel immunoreactivity occurs at these and at other sites in the gastrointestinal tract of the ...
Relevancy Score: Relevancy Score: 258
Kawano T - - 2009
ATP-sensitive potassium (K(ATP)) channels may be linked to mechanisms of pain after nerve injury, but remain under-investigated in primary afferents so far. We therefore characterized these channels in dorsal root ganglion (DRG) neurons, and tested whether they contribute to hyperalgesia after spinal nerve ligation (SNL). We compared K(ATP) channel properties ...
Relevancy Score: Relevancy Score: 258
Hein Travis W - - 2006
PURPOSE: Lactate, a key metabolite in the retinal tissue, has been implicated in regulating retinal blood flow to match retinal metabolic demand. However, the direct effect of lactate on retinal vascular tone and the possible underlying signaling mechanisms remain unknown. In the present study, the roles of endothelium-derived vasodilators, guanylyl ...
Relevancy Score: Relevancy Score: 258
Schweitzer Paul - - 2004
gamma-Hydroxybutyrate (GHB) is used for the treatment of alcoholism and to induce absence seizures in animals, but it has also recently emerged as a drug of abuse. In hippocampal neurons, GHB may activate its own putative receptor as well as GABA(B) receptors to affect synaptic transmission. We used voltage-clamp recordings ...
Relevancy Score: Relevancy Score: 258
Naqvi Haider Nawaz - - 2005
OBJECTIVE: Evaluation of fractional excretion of Sodium, Potassium and Magnesium as indicators of cyclosporine (CsA) toxicity in de-novo renal transplant recipients. METHODS: A prospective study was conducted on 59 live related renal allograft recipients. Fractional excretion(FE) of sodium (Na+), potassium (K+) and magnesium (Mg2+) were calculated on day 1, 3, ...
Relevancy Score: Relevancy Score: 258
Masuda N - - 1995
PURPOSE: The effect of a potassium channel opener, YM934, on the contractile response to excitatory neurotransmitters was investigated in isolated pig detrusor smooth muscle. MATERIALS AND METHODS: Electrical field stimulation (EFS; 5 second trains, 50 V, 0.8 msec. duration), alpha, beta-MeATP (3 x 10(-7) to 10(-5) M.) or carbachol (3 ...
Relevancy Score: Relevancy Score: 258
Chang Hao-hui - - 2006
OBJECTIVE: To investigate the changes of the potassium channels voltage gated potassium channel (Kv) 4.2, Kv4.3, and Kv interacting protein 1 (KChIP1) during the process of amygdala kindling epilepsy and possible role thereof. METHODS: Thirty-two SD rats were randomly divided into sham operation group (n = 12, receiving the implantation ...
Relevancy Score: Relevancy Score: 258
Li Nicole - - 2009
A potassium chloride-containing salt substitute lowers blood pressure levels, but its overall acceptability has been of concern due to its potential adverse effects on food taste. In a large-scale, blinded randomised trial evaluating the comparative effects of a salt substitute (65 % sodium chloride, 25 % potassium chloride and 10 ...
Relevancy Score: Relevancy Score: 258
Tassler H - - 1993
The objective of this open-label, randomized, multicenter study was to compare the efficacy and safety of fleroxacin, 400 mg administered orally once daily, and amoxicillin/clavulanate potassium (AMX/CP), 500 mg/125 mg administered orally three times daily, for 4-21 days to patients with skin and soft tissue infections (SSTIs). The specific diagnoses ...
Relevancy Score: Relevancy Score: 258
Zhang Y H - - 2001
The whole cell patch-clamp technique was used to examine the effects of protein kinase C (PKC) activation (via the phorbol ester, phorbol 12,13 dibutyrate, PDBu) on the modulation of potassium currents (I(K)) in cultured capsaicin-sensitive neurons isolated from dorsal root ganglia from embryonic rat pups and grown in culture. PDBu, ...
Relevancy Score: Relevancy Score: 258
Knight G M - - 2006
BACKGROUND: Diamine silver fluoride (Ag(NH3)2F), referred to as AgF, has been shown to provide a pronounced antimicrobial action against caries. The clinical application of this material has been limited by the staining associated with both teeth and tooth coloured restorative materials. The application of potassium iodide (KI) after AgF eliminates ...
Relevancy Score: Relevancy Score: 258
Trotter Linda - - 2002
A stress-activated protein kinase pathway comprising mitogen-activated protein kinase kinases (MKKs), c-Jun N-terminal kinase (JNK) and the transcription factor c-Jun is implicated in neuronal apoptosis. Using an immune-complex kinase assay, we measured the activation of MKK4 and MKK7 in low potassium (LK)-induced apoptosis of rat cerebellar granule neurons (CGN). MKK7, ...
Relevancy Score: Relevancy Score: 258
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