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Lajos Giuliane J - - 2014
Cluster-based studies in health research are increasing. An important characteristic of such studies is the presence of intracluster correlation, typically quantified by the intracluster correlation coefficient (ICC), that indicate the proportion of data variability that is explained by the way of clustering. The purpose of this manuscript was to evaluate ...
Di Santo Rachael R Centre for Gene Regulation & Expression, College of Life Sciences, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH, - - 2014
Elongator is a conserved, multi-protein complex discovered in Saccharomyces cerevisiae, loss of which confers a range of pleiotropic phenotypes. Elongator in higher eukaryotes is required for normal growth and development and a mutation in the largest subunit of human Elongator (Elp1) causes Familial Dysautonomia, a severe recessive neuropathy. Elongator promotes ...
Buhling Kai J KJ aDepartment of Gynecological Endocrinology bClinic for Gynecology, University Medical Center Hamburg-Eppendorf, Hamburg, - - 2014
To describe the beneficial effects of micronutrient supplementation on male fertility. Several micronutrients have beneficial effects on sperm quality, as well on male fertility (e.g. pregnancy rate). A deliberate use of micronutrients might be helpful for infertile patients. Healthcare providers should be aware that supplements contain the studied dose. Male ...
Nahar Papreen P Department of Anthropology, Durham University, UK, Institute of Health and Society, Newcastle University, UK. papreen.nahar@durham.ac.uk, papreen21@yahoo.com, - - 2014
In a context where motherhood is an integral part of a woman's stereotype, being childless is a devastating experience. We explore how these so-called deviant women manage this situation. The objective of this article is to contribute to the debate regarding infertile women's agency, resilience, and resistance. This article is ...
Liu Yufei Y Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Human Sperm Bank, Shanghai, People's Republic of - - 2014
To evaluate the potential clinical application of Raman spectroscopy (RS) as a tool that may identify spermatogenesis within human seminiferous tubules. RS scanning of human testicular tissue at different maturational stages; immunohistochemistry study and metabolomic analysis of nonobstructive azoospermic/obstructive azoospermic testes. State-owned hospital. Fifty-two patients with clinical indications of nonobstructive ...
Braidy C C Service de gynécologie obstétrique, hôpital Bicêtre, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, - - 2014
Fertiloscopy is a recent technique designed to explore the tubo-ovarian axis in unexplained infertility. It is a simple outpatient technique, allowing to perform operative procedures, but its position relative to laparoscopy is yet to be defined. A thorough and extensive bibliographical search was undertaken to fully embrace the question, challenging ...
Ciarmela Pasquapina P Department of Experimental and Clinical Medicine, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60020 Ancona, Italy; Department of Information Engineering, Polytechnic University of Marche, Ancona, Italy. Electronic address: - - 2014
Uterine leiomyomas, commonly called fibroids, are the leading indication for hysterectomy in the United States. Incidence increases with age from menarche to perimenopause. Regardless of their generally benign neoplastic character, uterine fibroids are responsible for significant morbidity in a large proportion of women of reproductive age. As uterine leiomyomas generally ...
Liu Zhen - - 2014
CDK4 is a protein kinase in the CDK family important for G1/S phase cell cycle progression. However, the roles and molecular mechanisms of CDK4 triggering nasopharynx carcinogenesis are still unclear. Lentiviral-vector mediated shRNA was used to suppress CDK4 expression and examine its molecular mechanisms. Using immunohistochemistry, we analyzed CDK4 protein ...
Chen Dan-Na DN Central South University of China, - - 2014
Mutations in the G-protein coupled prokineticin receptor 2 (PKR2) are known to cause Kallmann syndrome (KS) and idiopathic hypogonadotropic hypogonadism (IHH) manifesting with delayed puberty and infertility. Some of the mutant receptors are not routed to the cell surface, instead they are trapped in the cellular secretory pathway. The cell-permeant ...
Hörbst Viola V CEAF, Center for African Studies, ISCSP, Higher Institute for Social and Political, Sciences University of Lisbon, Max-Planck-Institute for the Study of Religous and Ethnic Diversity. - - 2014
Asking why some diseases gain global attention whereas others are neglected, we present two case studies that demonstrate the unequal treatment and financing options available for HIV/AIDS versus infertility treatments. We track three key phenomena central to understanding the unequal public attention given to certain ailments: peace and security, subordination ...
Asl Zare Mohammad M Department of Urology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR - - 2014
Complete androgen insensitivity syndrome (previously called testicular feminization) is specified by a 46 XY karyotype and negative sex chromatin, bilateral undescended testes, female genitalia appearance, and lack of mullerian derivatives. A 28-year-old woman with complete (severe) androgen resistance underwent prophylactic laparoscopic bilateral gonadectomy because of the eventually increased risk of ...
Tomao Federica F aDepartment of Gynaecology and Obstetrics, University of Rome 'Sapienza', Rome bDepartment of Medico-Surgical Sciences and Biotechnologies, University of Rome 'Sapienza', Latina, Italy *Federica Tomao and Giuseppe Lo Russo contributed equally to this - - 2014
Female infertility is today a very common, expanding problem and therefore restoring fertility strategies are increasing in the last few years. An association between ovarian stimulation and breast cancer risk has been hypothesized, but the question has not yet been clarified. In the last 2 years, many important studies have ...
Zare-Abdollahi D D Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, - - 2014
Nuclear receptor subfamily 5 group A member 1 (NR5A1) encodes a nuclear receptor that regulates transcription of multiple genes involved in adrenal and gonadal development, steroidogenesis and the reproductive axis. Human mutations in NR5A1were initially found in two 46, XY female patients suffering from severe gonadal dysgenesis and primary adrenal ...
Torrealday Saioa S Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Womack Army Medical Center, Fort Bragg, North Carolina, - - 2014
With the recent advancements in reproductive medicine, many infertile couples now have the opportunity to conceive their own biological children. Although some medication protocols, such as clomiphene citrate, have been utilized for decades, other treatment modalities have evolved over the recent years. It therefore becomes imperative to assess the outcomes ...
de Mateo Sara S Center for Epigenetics and Metabolism School of Medicine, Department of Biological Chemistry University of California, - - 2014
The spermatogenic process relays in highly regulated gene expression mechanisms at the transcriptional and post-transcriptional levels to generate the male gamete that is needed for the perpetuation of the species. Small non-coding RNA pathways have been determined to participate in the post-transcriptional regulatory processes of germ cells. The most important ...
Polat Mehtap M Anatolia IVF and Women Health Center, Ankara, - - 2014
This study is to assess whether transient intrauterine fluid accumulation (IUFA) first noted during controlled ovarian hyperstimulation that does not persist on the day of embryo transfer not due to any identifiable pelvic pathology has any detrimental effect on in vitro fertilization (IVF) outcome. From a database of 16,900 cycles, ...
Chen L L Reproductive and Genetic Medical Center, Peking University First Hospital, Beijing,100034, - - 2014
To investigate the effects of big and bit Y chromosome configurations on male fertility and to evaluate the relevant clinical significance. The relevant cases were divided into A and B groups. Group A included male infertile cases. Group B included cases whose wives had adverse pregnancy history or the abnormal ...
Cecconi Sandra S Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy. Electronic address: - - 2014
The role of the endocannabinoid system (ECS) in mammalian reproduction is a rather active field of research, due to its potential exploitation to combat human infertility. Available data shows that the aberrant endocannabinoid signaling negatively affects embryo development, implantation and pregnancy. Although many efforts have been devoted to a better ...
Catak Zekiye Z Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical School, Firat University, 23119 Elazig, - - 2014
Although, the exact mechanisms underlying the development of the metabolic syndrome (MetS) are not still completely understood, obesity, circulated peptide hormone levels and their interaction with genetic factors are considered largely responsible. The purpose of this study is to explore how the levels of ghrelin, obestatin (OBS) and NUCB2/nesfatin-1 (NES)/NUCB2 ...
Pineau Charles C IRSET, Inserm U1085, Campus de Beaulieu, Rennes, F-35042, France; Proteomics Core Facility Biogenouest, Campus de Beaulieu, Rennes, F-35042, France. Electronic address: - - 2014
The strikingly complex structural organization of the mammalian testis in vivo creates particular difficulties for studies of its organization, function and regulation. These difficulties are particularly pronounced for investigations of the molecular communication networks within the seminiferous tubules that govern spermatogenesis. The use of classical molecular and cell biology approaches ...
Tobler Kyle J KJ Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Falls Concourse, 10751 Falls Road, Suite 280, Lutherville, MD, 21093, USA, - - 2014
To identify common and varying practice patterns used by in vitro fertilization (IVF) providers from a broadly distributed, worldwide survey. Specific information regarding clinical IVF practices involving the oocyte maturation triggering, oocyte retrieval and embryo transfer was elicited. This is an internet-based questionnaire study of IVF practices throughout the world. ...
Ravel Célia C Service de biologie de la reproduction, hôpital Sud, 35000 Rennes, - - 2014
DAX-1 stands for Dosage sensitive sex-reversal, Adrenal hypoplasia congenital (AHC), on the X chromosome. DAX-1 mutations usually cause primary adrenal insufficiency or congenital adrenal hypoplasia in early childhood and hypogonadotropic hypogonadism (MIM # 300200). DAX-1 protein is necessary to maintain normal spermatogenesis. In humans, male fertility has been studied in ...
Ott Johannes J Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria, - - 2014
We evaluated perioperative androstenedione levels in laparoscopic ovarian drilling (LOD) for polycystic ovary syndrome (PCOS) and whether an intraoperative androstenedione change was predictive for spontaneous ovulation. In a prospective study, 21 anovulatory women with clomiphene citrate-resistant PCOS who underwent LOD and eight female controls who underwent diagnostic laparoscopy for infertility ...
Cui Yuqian Y Center for Reproductive Medicine, Provincial Hospital Affiliated with Shandong University; National Research Center for Assisted Reproductive Technology and Reproductive Genetics; Key Laboratory for Reproductive Endocrinology of the Ministry of Education; and Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of - - 2014
To determine the serum antimüllerian hormone (AMH) reference values in Chinese women with and without polycystic ovary syndrome (PCOS), and the associations of AMH with clinical or biochemical characteristics. Retrospective study. Academic institutions. Totals of 1,896 infertile control women and 304 women with PCOS. None. Serum basal AMH levels and ...
Zhang Jie J Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, People's Republic of - - 2014
To identify the differential urinary metabolic pattern of oligozoospermic infertile men and to determine the potential biomarkers indicative of infertility. Observational study. University hospital. Totals of 158 fertile volunteers and 135 oligozoospermic infertile men. None. Urinary metabolic profiles were acquired with the use of liquid chromatography/mass spectrometry. Potential oligozoospermic biomarkers ...
Chen Baoying - - 2014
From previous reviews, there still have been controversies over the effect of metformin (MET) on reproductive function in PCOS patients. The reasons for the inconsistent findings especially lie in the transparency and accuracy of randomized controlled trials (RCTs) reports. However, we could find no data about the quality of RCTs ...
Steiner Anne Z AZ Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: - - 2014
To determine the impact of sexual intercourse around the time of implantation on the probability of achieving a pregnancy. Time-to-pregnancy cohort using day-specific probability of pregnancy modeling to account for intercourse during the fertile window. Community cohort. Women trying to conceive naturally, ages 30-44, without known infertility. None. Positive pregnancy ...
Chang Eun Mi EM Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, CHA University, Seoul 135-081, Republic of - - 2014
Context: Vitamin D maintains calcium and phosphorous homeostasis and promotes bone mineralization; however, its non-skeletal functions are increasingly being recognized. Recent evidence supports a role for vitamin D in reproductive potential but few studies have investigated the potential effects of vitamin D on reproductive hormone biosynthesis and ovarian reserve. Objective: ...
Chiu Philip C N PC Department of Obstetrics and Gynaecology; Centre of Reproduction, Development and Growth, LKS Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, - - 2014
Mammalian oocytes are surrounded by an acellular zona pellucida (ZP). Fertilization begins when a capacitated spermatozoon binds to the ZP. Defective sperm-ZP interaction is a cause of male infertility and reduced fertilization rates in clinical assisted reproduction treatment. Despite the importance of spermatozoa-ZP binding, the mechanisms and regulation of the ...
Pathak Narendra N Nephrology Division, Massachusetts General Hospital, 149 13 Street, Charlestown, MA 02129 Department of Genetics, Harvard Medical School, Boston MA, 02115 Department of Pathology, Massachusetts General Hospital, 149 13 Street, Charlestown, MA - - 2014
Glutamylation is a functionally important tubulin posttranslational modification enriched on stable microtubules of neuronal axons, mitotic spindles, centrioles and cilia. In vertebrates, balanced activities of tubulin glutamyl ligase and cytoplasmic carboxypeptidase deglutamylase enzymes maintain organelle and cell type specific tubulin glutamylation patterns. Tubulin glutamylation in cilia is regulated via restricted ...
Fauque Patricia P Laboratoire de Biologie de la Reproduction, Hôpital de Dijon, Université de Bourgogne, Dijon, France. Electronic address: - - 2014
To determine the impact of the time interval from the end of sperm preparation (TSP) to intrauterine insemination (IUI) on the outcome. Prospective multicentre cohort study. Seven French centers (assisted reproduction group in northeastern France, four academic centers, and three clinics). Eight hundred sixty-two IUI cycles (709 patients) managed by ...
Milone Marco M Marco Milone, Mario Musella, Paola Maietta, Francesco Milone, Department of Advanced Biomedical Science, University of Naples "Federico II", 80131 Naples, - - 2014
Varicocele has been implicated as a cause in 35%-50% of patients with primary infertility and up to 81% of men with secondary infertility. Although a large number of reports have shown improvement in the semen parameters after correction of varicocele, other studies have suggested no benefit. We report the first ...
Krausz Csilla C Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini, Florence, - - 2014
Genetic disorders can be identified in about 15% of cases of male infertility. With the widespread application of assisted reproductive technology, infertile patients are now given the possibility of having their biological children; however, a genetic risk exists for assisted reproductive technology-born offspring, implying the necessity for future parents to ...
Hansen Michèle M Telethon Kids Institute, University of Western Australia, Perth, - - 2014
Pooled odds ratios from meta-analyses of infants born following assisted reproductive technologies (ART) compared with non-ART singletons show increases in low birth weight, preterm birth, small for gestational age, and birth defects. Although there have been small reductions in recent data, odds associated with these outcomes are still higher for ...
Van Voorhis Brad J BJ Department of Obstetrics and Gynecology, University of Iowa Hospital and Clinics, Iowa City, - - 2014
Gonzalez-Garcia Jose Raul - - 2014
Egg activation at fertilization in mammals is initiated by prolonged Ca(2+) oscillations that trigger the completion of meiosis and formation of pronuclei. A late fall in MAPK activity is essential for pronuclear formation, but the precise timing and mechanism of decline are unknown. Here, we have measured the dynamics of ...
Rooney Kristin L KL Domar Center for Mind/Body Health, Boston IVF, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, - - 2014
The impact of lifestyle behaviors on fertility is poorly understood, as is the impact of specific behaviors on the advanced reproductive technologies. It is vital for healthcare professionals to understand which lifestyle behaviors can have the greatest negative impact in an effort to improve patient recommendations. The purpose of this ...
Shi Qing-Qing QQ College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China; Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, Yangzhou 225009, China. Electronic address: - - 2014
Differentiation of germ cells from embryonic stem cells in vitro could have great application for treating infertility and provide an excellent model for uncovering molecular mechanisms of germline generation. In this study, we aim to screen the suitable inducers that may prove the efficiency of driving chicken embryonic stem cells ...
Bianchi Enrica E Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, - - 2014
Fertilization occurs when sperm and egg recognize each other and fuse to form a new, genetically distinct organism. The molecular basis of sperm-egg recognition is unknown, but is likely to require interactions between receptor proteins displayed on their surface. Izumo1 is an essential sperm cell-surface protein, but its receptor on ...
Ferlin Alberto A Department of Medicine, Centre for Human Reproduction Pathology, University of Padova, Padova, - - 2014
The purpose of this review is to highlight the most important advances in the field of genetics of male infertility, with particular attention to primary articles dealing with the identification of new genetic and epigenetic markers that could be translated into clinical practice in the near future. Copy number variations ...
Pourdanesh Fereydoun F Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 8916733754, - - 2014
In this study, a new nanocomposite, which contained high density polyethylene (HDPE), tricalcium phosphate (Ca3(PO4)2) nanoparticles (TCP NPs), hydroxyapatite nanoparticles (HA NPs), and magnesium oxide nanoparticles (MgO NPs) was prepared. As in vitro experiment, human osteoblasts (HOB) cells were exposed to pristine HDPE and its nanocomposite for a period of ...
McGee W K WK Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon; - - 2014
Many patients with hyperandrogenemia are overweight or obese, which exacerbates morbidities associated with polycystic ovary syndrome (PCOS). To examine the ability of testosterone (T) to generate PCOS-like symptoms, monkeys received T or cholesterol (control) implants (n = 6/group) beginning prepubertally. As previously reported, T-treated animals had increased neuroendocrine drive to ...
Hallamaa Marianne M Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, - - 2014
Human epididymal secretory protein 4 (HE4) is a biomarker for ovarian cancer. The effect of follicle stimulating hormone (FSH) stimulation during in vitro fertilization (IVF) on HE4 was evaluated in order to see whether substantial hormonal stimulation of the ovaries affects the serum levels of this marker. Findings were compared ...
Skeldon Sean C SC Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, - - 2014
Bladder cancer is the fourth most common cancer among men in the United States, with a 3-fold higher incidence than women. Globally, tobacco smoking remains significantly more common in men, contributing to half of all cases of bladder cancer. To prevent bladder cancer, urologists should promote smoking cessation to patients ...
Pfadenhauer Lisa Maria - - 2014
The toxic heavy metal lead continues to be a leading environmental risk factor, with the number of attributable deaths having doubled between 1990 and 2010. Although major sources of lead exposure, in particular lead in petrol, have been significantly reduced in recent decades, lead is still used in a wide ...
Godia Pamela M - - 2014
Addressing the Sexual and Reproductive Health (SRH) needs of young people remains a big challenge. This study explored experiences and perceptions of young people in Kenya aged 10-24 with regard to their SRH needs and whether these are met by the available healthcare services. 18 focus group discussions and 39 ...
Polisi Addisu - - 2014
In many areas of the world where HIV prevalence is high, rates of unintended pregnancy have also been shown to be high. Of all pregnancies worldwide in 2008, 41% were reported as unintended and approximately 50% of these ended in abortion. To address these problems family planning is the best ...
Paulson Richard J RJ Division of Reproductive Endocrinology and Infertility, University of Southern California, Los Angeles, - - 2014
Kim Ju Yeong JY Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of - - 2014
To determine whether intracytoplasmic sperm injection (ICSI) could prevent total fertilization failure (TFF) and enhance the embryo quality in patients with non-male factor infertility. A total of 296 in vitro fertilization (IVF) cycles performed in patients with non-male factor infertility between April 2009 and March 2013 were included in this ...
Lee Susan K - - 2014
Although the challenges of working with culturally and linguistically diverse groups can lead to the exclusion of some communities from research studies, cost effective strategies to encourage access and promote cross-cultural linkages between researchers and ethnic minority participants are essential to ensure their views are heard and their health needs ...
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