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Jiang Hanwei H CAS-Institute of Physics, Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei 230027, - - 2014
Reciprocal translocation is one of the most common structural chromosomal rearrangements in human beings; it is widely recognized to be associated with male infertility. This association is mainly based on the abnormal chromosome behavior of the translocated chromosomes and sex chromosomes during meiosis prophase I in reciprocal translocation carriers. However, ...
Hao Jianxiu J State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 100101; Graduate School of the Chinese Academy of Sciences, Beijing 100049, - - 2014
The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in mammalian fertilization. However, the regulatory mechanisms controlling acrosome biogenesis and acrosome exocytosis during fertilization are largely unknown. Equatorin (Eqtn) is a membrane protein that is specifically localized to the ...
Cheng Pan P Department of Genetics, College of Agriculture and Biology, Dali University, Dali 671003, China; College of Basic Medicine, Dali University, Dali 671000, - - 2014
As an important methyltransferase, DNMT1 plays a key role in DNA methylation that is essential for normal spermatogenesis, which suggests that it may be involved in male infertility with spermatogenesis impairment. To explore the relationship between DNMT1 and spermatogenesis impairment, polymorphic distributions of single-nucleotide polymorphisms (SNP) rs16999593, rs2228612 and rs2228611 ...
Sun Wei W Reproductive Medical Center, the Second Hospital affiliated to Shandong University of Traditional Chinese Medicine, Jingba Road, Jinan, 250001, People's Republic of - - 2014
The aim of this study was to determine whether altered expression and distribution of calcium- and integrin-binding protein-1 (CIB1) is involved in the pathogenesis of patients with oligoasthenozoospermia. Sperm samples were obtained from 25 infertile Chinese men who had failed to achieve conception after a period of 1-2 y and ...
Asero P P Sezione di Endocrinologia, Andrologia e Medicina Interna, Dipartimento di Scienze Mediche e Pediatriche, Università di Catania, Policlinico "G. Rodolico," Bldg 4, Rm 2C18, Via S. Sofia 78, 95123, Catania, - - 2014
Genetic causes can be directly responsible for various clinical conditions of male infertility and spermatogenic impairment. With the increased use of assisted reproduction technologies our understanding of genetic basis of male infertility has large implications not only for understanding the causes of infertility but also in determining the prognosis and ...
Duale N N Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, - - 2014
An increased global prevalence of obesity coincides with an apparent decline in male sperm quality and a possible association between these pathologies has been suggested. In this study, we examined the effects of obesity on sperm chromatin integrity using two mouse models of obesity. In one group of mice, obesity ...
Comptour Aurélie A INSERM U1016, Institut Cochin, 75014, Paris, France; CNRS UMR8104, 75014, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, 75014, Paris, - - 2014
In mammals, X- and Y-encoded genes are transcriptionally shut down during male meiosis, but the expression of many of them is (re)activated, after meiosis, in spermatids. Postmeiotic XY gene expression is timely regulated by active epigenetic marks, which are de novo incorporated in the sex chromatin of spermatids, and by ...
Alabiso G - - 2014
A panel of 29 experts in the field of endometriosis express their opinion on management options regarding a 35 years old patient, currently not desiring pregnancy, with moderate pelvic pain, and with an ultrasonographic diagnosis of bilateral endometriomas. Many questions that this paradigmatic patient may pose to the clinician are ...
Kokilavani Palanivel P Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli 620 024, Tamilnadu, - - 2014
Quinalphos (QP) is speculated to cause endocrine disruption through the generation of reactive oxygen species (ROS) by oxidative stress (OS). Exposure of QP decreased testosterone level considerably which resulted in reduced viable sperms in mice. The QP induced toxicity is initiated by the formation of free radicals as it is ...
Mardešič Tonko T Institut Pronatal, Prague, Czech Republic. Electronic address: - - 2014
To evaluate whether a short follicular phase of ovarian stimulation compromises the chance of pregnancy, subjects from a double-blind, randomized trial treated with a single dose of corifollitropin alfa (n=756) or daily recombinant FSH (n=750) were categorized as early responders if three follicles ⩾17mm were reached and human chorionic gonadotrophin ...
Bodri Daniel D Kobe Motomachi Yume Clinic, Kobe, Japan. Electronic address: - - 2014
A 3-year, retrospective, single-centre cohort study was conducted in a private infertility centre to determine cumulative live birth rates (LBR) per scheduled oocyte retrieval following minimal ovarian stimulation/natural-cycle IVF in unselected infertile patients. A total of 727 consecutive infertile patients were analysed who underwent 2876 (median 4) cycles with scheduled ...
Ryan Mandy M Health Economics Research Unit, University of Aberdeen, UK. Electronic address: - - 2014
Healthcare policy leaders internationally recognise that people's experiences of healthcare delivery are important, and invest significant resources to monitor and improve them. However, the value of particular aspects of experiences of healthcare delivery - relative to each other and to other healthcare outcomes - is unclear. This paper considers how ...
Hawkins Leah K LK Department of Obstetrics and Gynecology, Northwestern University, 250 E. Superior, # 5-2177, Chicago, IL, 60611, USA, - - 2014
To assess how patients perceive various lifestyle behaviors impact IVF success. Cross-sectional study of heterosexual, English-speaking couples (n = 138) who completed web-based surveys during IVF treatment cycle. Perceived impact of lifestyle choices assessed by multivariable logistic regression and p-value tests for linear trend (Pt). During the IVF cycle, most patients consider ...
Araujo-Lopes Roberta R Departamento de Fisiologia e Biofísica (R.A.-L., N.S.S.A., R.M.M., A.M.R., R.E.S.), Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil; Centre for Neuroendocrinology and Department of Anatomy (J.R.C., I.C.K., D.R.G.), University of Otago, Dunedin, 9054, New Zealand; and Departamento de Fisiologia (C.R.F.), Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14049-900, São Paulo, - - 2014
Prolactin (PRL) is known to suppress LH secretion. Kisspeptin neurons regulate LH secretion and express PRL receptors. We investigated whether PRL acts on kisspeptin neurons to suppress LH secretion in lactating (Lac) and virgin rats. Lac rats displayed high PRL secretion and reduced plasma LH and kisspeptin immunoreactivity in the ...
Sabouhi S S Department of Biology, Faculty of Sciences, University of Guilan, Rasht, - - 2014
Infertility is the failure of a couple to engender after endeavouring at least one full year of unprotected intercourse. It has been reported that reactive oxygen species contributed to pathogenesis of various disease. To inactivate ROS cells biosynthesise several antioxidant enzymes, one of them is catalase which contributes H2 O2 ...
Johnson Matrika D MD Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University Hospitals Case Medical Center , Cleveland, OH , USA - - 2014
Abstract The object of this retrospective cohort study was to determine if hCG levels correlate with ovarian hyperstimulation syndrome (OHSS) risk after adjustment for other risk factors during in vitro fertilization (IVF). We measured serum hCG approximately 12 h after hCG trigger in women undergoing 406 cycles of controlled ovarian hyperstimulation ...
Balmori C C IVI Madrid, Rey Juan Carlos University, Madrid, - - 2014
In this report, we describe for the first time a pregnancy using sperm retrieved from an azoospermic man with kidney transplant due to type I primary hyperoxaluria. It is the first case that we were able to find in the literature for both male infertility and hystopathologic findings.
Ucar V B VB Department of Medical Genetics, Selçuk University Medical School, Konya, - - 2014
Varicocele is one of the main reasons for male infertility the exact aetiology of which remains unclear. Methylenetetrahydrofolate reductase (MTHFR) is important for DNA synthesis and methylation, which has a key role during spermatogenesis. Numerous literature suggests that the MTHFR polymorphism may be genetic risk factors for male infertility. In ...
Bord Ilia I Department of Obstetrics and Gynecology, Barzilai Medical Center , Ashkelon , Israel - - 2014
Abstract Aims: To examine whether misoprostol treatment for first trimester missed abortion affects future fertility. Patients and methods: In a historical prospective approach, we analyzed our database for patients treated with misoprostol. All eligible patients underwent an interview according to a questionnaire, which includes their demographic characteristics, obstetric, gynecologic and ...
Lopes Ione Maria Ribeiro Soares IM 1Departamento Materno Infantil, Centro de Ciências da Saúde, Universidade Federal do Piauí, UFPI, Teresina, - - 2014
Literature data indicate that the infertility in women with polycystic ovary syndrome (PCOS) is not only attributed to anovulation but also to endometrial dysfunction. Endometrial biopsies were performed in the proliferative and secretory phases of women with normal cycle and in women with PCOS before and after oral treatment with ...
Lee Yong-An YA Department of Animal Science and Technology, Chung-Ang University, Ansung, Gyeonggi-Do, South - - 2014
To study the influence of sugars and establish a serum-free freezing method for the cryopreservation of spermatogonial stem cells (SSCs). Animal study. University laboratory. C57BL/6-TgEGFP, C57BL/6 mice. Germ cells enriched from testis cells were frozen using standard freezing medium containing sugars, including monosaccharides, disaccharides, and trisaccharides at 50, 100, and ...
Yuen Ryan K C RK Program in Genetics and Genome Biology, Centre for Applied Genomics, Hospital for Sick Children, Toronto, Ontario, - - 2014
To develop a novel clinical test using microarray technology as a high-resolution alternative to current methods for detection of known and novel microdeletions on the Y chromosome. Custom Agilent 8x15K array comparative genomic hybridization (aCGH) with 10,162 probes on an average probe spacing of 2.5 kb across the euchromatic region ...
Luyckx Valérie V Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, - - 2014
To create an artificial ovary to provide an alternative way of restoring fertility in patients who cannot benefit from transplantation of cryopreserved ovarian tissue due to the threat of reintroducing malignant cells. In vivo experimental study. Gynecology research unit in a university hospital. Six-week-old female NMRI mice. Autografting of isolated preantral ...
Steward Ryan G RG Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North - - 2014
To investigate the association between oocyte number and the rates of ovarian hyperstimulation syndrome (OHSS) and live birth (LB) in fresh autologous in vitro fertilization (IVF) cycles. Retrospective cohort study. An academic reproductive medicine practice. We analyzed data from 256,381 IVF cycles using the 2008-2010 Society for Assisted Reproductive Technology national ...
Xing Jinyi J College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an, Shandong Province, The People's Republic of China ; College of Life Science, Linyi University, Linyi, Shandong Province, The People's Republic of - - 2014
Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is an infectious disease characterized by severe reproductive deficiency in pregnant sows, typical respiratory symptoms in piglets, and high mortality rate of piglets. In this study, we employed an Affymetrix microarray chip to compare the gene expression profiles of ...
Calhoun Kathryn C KC Reproductive Medicine Group, Laboratory of Reproductive & Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America ; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States of - - 2014
Bisphenol A (BPA) exposure results in numerous developmental and functional abnormalities in reproductive organs in rodent models, but limited data are available regarding BPA effects in the primate uterus. To determine if maternal oral BPA exposure affects fetal uterine development in a non-human primate model, pregnant rhesus macaques carrying female ...
Yamagata Yoshiaki Y Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, - - 2014
The objective of this study was to characterize the genome-wide DNA methylation profiles of isolated endometrial stromal cells obtained from eutopic endometria with (euESCa) and without endometriosis (euESCb) and ovarian endometrial cysts (choESC). Three samples were analyzed in each group. The infinium methylation array identified more hypermethylated and hypomethylated CpGs ...
Lin I-Ying IY Genomics Research Center, Academia Sinica, Taipei 115, Taiwan ; Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, - - 2014
The mechanisms of transcriptional regulation underlying human primordial germ cell (PGC) differentiation are largely unknown. The transcriptional repressor Prdm1/Blimp-1 is known to play a critical role in controlling germ cell specification in mice. Here, we show that PRDM1 is expressed in developing human gonads and contributes to the determination of ...
Stewart Colin L CL Institute of Medical Biology; Immunos; - - 2014
Pairing of homologous chromosome is a unique event in meiosis that is essential for both haploidization of the genome and genetic recombination. Rapid chromosome movements during meiotic prophase are a key feature of the pairing process. This is usually telomere-led, and in metazoans is dependent upon microtubules and dynein. Chromosome ...
Ostrowski L E LE Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center, University of North Carolina, Chapel Hill, NC, - - 2014
Primary ciliary dyskinesia (PCD) is a genetically heterogenous autosomal recessive disease in which mutations disrupt ciliary function, leading to impaired mucociliary clearance and life-long lung disease. Mouse tracheal cells with a targeted deletion in the axonemal dynein intermediate chain 1 (Dnaic1) gene differentiate normally in culture but lack ciliary activity. ...
Hoyer Patricia B PB The University of Arizona, College of Medicine, Department of Physiology , 1501 N. Campbell Ave, Tucson AZ 85724 , USA +1 520 626 6688 ; +1 520 626 2382 ; - - 2014
Introduction: Damage caused by xenobiotic compounds to the ovaries is a subject of concern because of their critical role in reproduction. Female mammals are born with a finite number of germ cells (oocytes) encased in primordial follicles. Xenobiotic-induced damage to primordial follicles can result in early ovarian failure (premature menopause). ...
Kosawang Chatchai - - 2014
Clonostachys rosea strain IK726 is a mycoparasitic fungus capable of controlling mycotoxin-producing Fusarium species, including F. graminearum and F. culmorum, known to produce Zearalenone (ZEA) and Deoxynivalenol (DON). DON is a type B trichothecene known to interfere with protein synthesis in eukaryotes. ZEA is a estrogenic-mimicing mycotoxin that exhibits antifungal ...
Huang Helong H Department of Cell and Developmental Biology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, - - 2014
Male germ cells with aberrant DNA damage are the weighted factor contributing to male infertility. Mounting evidence shows that DNA damage in male germ cells impairs spermatogenesis and lowers fecundity. MicroRNAs (miRNAs) regulating expression of multiple genes play a significant role in spermatogenesis. Our previous results have shown that microRNA-383 ...
Ali Aus Tariq AT Department of Chemical Pathology, Stellenbosch Medical School, Tygerberg Hospital, Cape Town, South - - 2014
Endometrial cancer is the most common malignancy of women in developed countries, and its incidence is 10 times higher than in developing countries. Endometrial cancer is most common in the sixth and the seventh decades of life; thus, postmenopausal women have a higher risk of developing the disease compared with ...
Malunga Lovemore Nkhata - - 2014
Undernutrition during childhood is a common disorder in the developing countries, however most research has focussed much on its treatment rather than its prevention. We investigated the potential of using chickpeas in infant follow-on formula production against the requirements of WHO/FAO on complementary foods and EU regulations on follow-on formula. ...
Zuure Freke R - - 2014
Effective screening programs are urgently needed to provide undiagnosed hepatitis C virus (HCV)-infected individuals with therapy. This systematic review of characteristics and outcomes of screening programs for HCV focuses on strategies to identify HCV risk groups hidden in the general population. We conducted a comprehensive search of MEDLINE and EMBASE ...
Boon Mieke - - 2014
Primary ciliary dyskinesia (PCD) is a rare disorder with variable disease progression. To date, mutations in more than 20 different genes have been found. At present, PCD subtypes are described according to the ultrastructural defect on transmission electron microscopy (TEM) of the motile cilia. PCD with normal ultrastructure (NU) is ...
Grazi Richard V RV Division of Reproductive Endocrinology and Infertility, Maimonides Medical Center, Brooklyn, NY, 11219, USA, - - 2014
Infertility counseling is a specialized field that will continue to grow in coming years as the impact of infertility and its treatment is documented more and more in terms of emotional, physical, social and life consequences. Counselors should anticipate issues that may arise in the future and assist couples in ...
Inoue Satoshi S The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G - - 2014
The generation of viable sperm proceeds through a series of coordinated steps, including germ cell self-renewal, meiotic recombination, and terminal differentiation into functional spermatozoa. The p53 family of transcription factors, including p53, p63, and p73, are critical for many physiological processes, including female fertility, but little is known about their ...
Luo Haiqing H Center of Oncology, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, - - 2014
Epidemiological studies have evaluated the association between 3801T>C polymorphism of CYP1A1 gene and the risk for idiopathic male infertility, but the results are inconclusive. We aimed to derive a more precise estimation of the relationship by conducting a meta-analysis of case-control studies. This study conformed to Preferred Reporting Items for ...
Abergel A A Service de chirurgie gynécologique, hôpital Jeanne-de-Flandre, CHRU de Lille, avenue Eugène-Avinée, 59037 Lille cedex, France. Electronic address: - - 2014
To evaluate fertiloscopy's results and to redefine its place in the management of female infertility. Retrospective study including 262 cases of fertiloscopy and 260 patients with primary or secondary idiopathic infertility. Analysis of infertility assessment's findings (hysterosalpingography), perioperative data (operating technique, laparoscopic conversion, failures and complications). Comparison of hysterosalpingography's findings and peroperative ...
Cook Rebecca J RJ Faculty of Law, Faculty of Medicine, Joint Centre for Bioethics, University of Toronto, Toronto, - - 2014
Stigmatization marks individuals for disgrace, shame, and even disgust-spoiling or tarnishing their social identities. It can be imposed accidentally by thoughtlessness or insensitivity; incidentally to another purpose; or deliberately to deter or punish conduct considered harmful to actors themselves, others, society, or moral values. Stigma has permeated attitudes toward recipients ...
Mira Nuno P NP 1 IBB-Institute for Biotechnology and Bioengineering, Center for Biological and Chemical Engineering, Instituto Superior Técnico, Department of Bioengineering, Universidade de Lisboa, Avenida Rovisco Pais, Lisbon 1049-001, - - 2014
In this work, it is described the sequencing and annotation of the genome of the yeast strain ISA1307, isolated from a sparkling wine continuous production plant. This strain, formerly considered of the Zygosaccharomyces bailii species, has been used to study Z. bailii physiology, in particular, its extreme tolerance to acetic ...
Rivas Bryan B Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, 33199, - - 2014
As a dual function protein, β-catenin affects both cell adhesion and mediates canonical Wnt/β-catenin cell signaling. β-Catenin is prominently expressed in somatic Sertoli cells in the testis and postmeiotic germ cells, suggesting an additional role in spermatogenesis. It was reported previously that Cre/loxP-mediated conditional inactivation of the β-catenin gene (Ctnnb1) ...
Kim Tae-Hee TH Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, - - 2014
We read your review on the relation between endometriosis and ovarian cancer (1). Endometriosis is characterized by inflammation and invasion of endometrial cells into other tissues and organs. It is a serious condition associated with complications such as infertility, dysmenorrhea, and dyspareunia in females of reproductive age, and the pathophysiology ...
Faure Celine C UFR SMBH, Université Paris 13, Sorbonne Paris Cité, UREN (Unité de Recherche en Epidémiologie Nutritionnelle), Inserm (U557), Inra (U1125), Cnam, Bobigny, France ; - - 2014
The aim of this study was to investigate in a case-control study the associations between idiopathic infertility and antioxidant gene polymorphisms. 110 infertile subjects (58 women and 52 men) with a history of idiopathic infertility and 69 fertile subjects (35 women and 34 men) with no history of infertility were ...
Abuelghar Wessam M WM Obstetrics and Gynecology Department, Faculty of Medicine, Ain-shams University, Cairo, - - 2014
To evaluate the role of different clinical, biochemical and sonographic factors as predictors of spontaneous ovulation after laparoscopic ovarian drilling (LOD) in women with clomiphene citrate resistant polycystic ovarian disease (CCR-PCOD). This prospective study recruited 251 infertile women with CCR-PCOD. Several clinical, biochemical and sonographic criteria were tested as possible ...
Durruthy Jens Durruthy JD Institute for Stem Cell Biology and Regenerative Medicine, Center for Reproductive and Stem Cell Biology, Department of Genetics and Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, - - 2014
Studies of human germ cell development are limited in large part by inaccessibility of germ cells during development. Moreover, although several studies have reported differentiation of mouse and human germ cells from pluripotent stem cells in vitro, differentiation of human germ cells from pluripotent stem cells in vivo has not ...
Fraga L R LR Post-Graduation Program in Genetics and Molecular Biology, Departament of Genetics, Biosciences Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Caixa Postal 15031 - Agencia Campus UFRGS, Porto Alegre, RS, 91501-970, Brazil, - - 2014
The p53 protein is known for performing essential functions in the maintenance of genomic stability in somatic cells and prevention of tumor formation. Studies of the p53 signaling pathway have suggested associations between some polymorphisms and infertility, post-in vitro fertilization implantation failure and recurrent abortions. The TP53 Pro72Arg polymorphism has ...
Gizzo Salvatore S Department of Woman and Child Health, University of Padua, Padua, Italy, - - 2014
To compare qualitative and quantitative ovarian response in idiopathic infertile women treated with low-dose-aspirin (LDA) during in-vitro-fertilization (IVF) cycles (pl) versus untreated ones. We conducted an observational-cohort-study on normo-responders patients aged between 25 and 45 years referred to Assisted-Reproductive Unit - University of Padua - in order to evaluate the ovarian ...
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