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Tomao Federica F aDepartment of Gynaecology and Obstetrics, University of Rome 'Sapienza', Rome bDepartment of Medico-Surgical Sciences and Biotechnologies, University of Rome 'Sapienza', Latina, Italy *Federica Tomao and Giuseppe Lo Russo contributed equally to this - - 2014
Female infertility is today a very common, expanding problem and therefore restoring fertility strategies are increasing in the last few years. An association between ovarian stimulation and breast cancer risk has been hypothesized, but the question has not yet been clarified. In the last 2 years, many important studies have ...
Zare-Abdollahi D D Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, - - 2014
Nuclear receptor subfamily 5 group A member 1 (NR5A1) encodes a nuclear receptor that regulates transcription of multiple genes involved in adrenal and gonadal development, steroidogenesis and the reproductive axis. Human mutations in NR5A1were initially found in two 46, XY female patients suffering from severe gonadal dysgenesis and primary adrenal ...
Torrealday Saioa S Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Womack Army Medical Center, Fort Bragg, North Carolina, - - 2014
With the recent advancements in reproductive medicine, many infertile couples now have the opportunity to conceive their own biological children. Although some medication protocols, such as clomiphene citrate, have been utilized for decades, other treatment modalities have evolved over the recent years. It therefore becomes imperative to assess the outcomes ...
Polat Mehtap M Anatolia IVF and Women Health Center, Ankara, - - 2014
This study is to assess whether transient intrauterine fluid accumulation (IUFA) first noted during controlled ovarian hyperstimulation that does not persist on the day of embryo transfer not due to any identifiable pelvic pathology has any detrimental effect on in vitro fertilization (IVF) outcome. From a database of 16,900 cycles, ...
de Mateo Sara S Center for Epigenetics and Metabolism School of Medicine, Department of Biological Chemistry University of California, - - 2014
The spermatogenic process relays in highly regulated gene expression mechanisms at the transcriptional and post-transcriptional levels to generate the male gamete that is needed for the perpetuation of the species. Small non-coding RNA pathways have been determined to participate in the post-transcriptional regulatory processes of germ cells. The most important ...
Chen L L Reproductive and Genetic Medical Center, Peking University First Hospital, Beijing,100034, - - 2014
To investigate the effects of big and bit Y chromosome configurations on male fertility and to evaluate the relevant clinical significance. The relevant cases were divided into A and B groups. Group A included male infertile cases. Group B included cases whose wives had adverse pregnancy history or the abnormal ...
Pineau Charles C IRSET, Inserm U1085, Campus de Beaulieu, Rennes, F-35042, France; Proteomics Core Facility Biogenouest, Campus de Beaulieu, Rennes, F-35042, France. Electronic address: - - 2014
The strikingly complex structural organization of the mammalian testis in vivo creates particular difficulties for studies of its organization, function and regulation. These difficulties are particularly pronounced for investigations of the molecular communication networks within the seminiferous tubules that govern spermatogenesis. The use of classical molecular and cell biology approaches ...
Ravel Célia C Service de biologie de la reproduction, hôpital Sud, 35000 Rennes, - - 2014
DAX-1 stands for Dosage sensitive sex-reversal, Adrenal hypoplasia congenital (AHC), on the X chromosome. DAX-1 mutations usually cause primary adrenal insufficiency or congenital adrenal hypoplasia in early childhood and hypogonadotropic hypogonadism (MIM # 300200). DAX-1 protein is necessary to maintain normal spermatogenesis. In humans, male fertility has been studied in ...
Tobler Kyle J KJ Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Falls Concourse, 10751 Falls Road, Suite 280, Lutherville, MD, 21093, USA, - - 2014
To identify common and varying practice patterns used by in vitro fertilization (IVF) providers from a broadly distributed, worldwide survey. Specific information regarding clinical IVF practices involving the oocyte maturation triggering, oocyte retrieval and embryo transfer was elicited. This is an internet-based questionnaire study of IVF practices throughout the world. ...
Catak Zekiye Z Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical School, Firat University, 23119 Elazig, - - 2014
Although, the exact mechanisms underlying the development of the metabolic syndrome (MetS) are not still completely understood, obesity, circulated peptide hormone levels and their interaction with genetic factors are considered largely responsible. The purpose of this study is to explore how the levels of ghrelin, obestatin (OBS) and NUCB2/nesfatin-1 (NES)/NUCB2 ...
Cecconi Sandra S Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy. Electronic address: - - 2014
The role of the endocannabinoid system (ECS) in mammalian reproduction is a rather active field of research, due to its potential exploitation to combat human infertility. Available data shows that the aberrant endocannabinoid signaling negatively affects embryo development, implantation and pregnancy. Although many efforts have been devoted to a better ...
Ott Johannes J Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria, - - 2014
We evaluated perioperative androstenedione levels in laparoscopic ovarian drilling (LOD) for polycystic ovary syndrome (PCOS) and whether an intraoperative androstenedione change was predictive for spontaneous ovulation. In a prospective study, 21 anovulatory women with clomiphene citrate-resistant PCOS who underwent LOD and eight female controls who underwent diagnostic laparoscopy for infertility ...
Cui Yuqian Y Center for Reproductive Medicine, Provincial Hospital Affiliated with Shandong University; National Research Center for Assisted Reproductive Technology and Reproductive Genetics; Key Laboratory for Reproductive Endocrinology of the Ministry of Education; and Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of - - 2014
To determine the serum antimüllerian hormone (AMH) reference values in Chinese women with and without polycystic ovary syndrome (PCOS), and the associations of AMH with clinical or biochemical characteristics. Retrospective study. Academic institutions. Totals of 1,896 infertile control women and 304 women with PCOS. None. Serum basal AMH levels and ...
Steiner Anne Z AZ Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: - - 2014
To determine the impact of sexual intercourse around the time of implantation on the probability of achieving a pregnancy. Time-to-pregnancy cohort using day-specific probability of pregnancy modeling to account for intercourse during the fertile window. Community cohort. Women trying to conceive naturally, ages 30-44, without known infertility. None. Positive pregnancy ...
Zhang Jie J Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, People's Republic of - - 2014
To identify the differential urinary metabolic pattern of oligozoospermic infertile men and to determine the potential biomarkers indicative of infertility. Observational study. University hospital. Totals of 158 fertile volunteers and 135 oligozoospermic infertile men. None. Urinary metabolic profiles were acquired with the use of liquid chromatography/mass spectrometry. Potential oligozoospermic biomarkers ...
Chiu Philip C N PC Department of Obstetrics and Gynaecology; Centre of Reproduction, Development and Growth, LKS Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, - - 2014
Mammalian oocytes are surrounded by an acellular zona pellucida (ZP). Fertilization begins when a capacitated spermatozoon binds to the ZP. Defective sperm-ZP interaction is a cause of male infertility and reduced fertilization rates in clinical assisted reproduction treatment. Despite the importance of spermatozoa-ZP binding, the mechanisms and regulation of the ...
Chang Eun Mi EM Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, CHA University, Seoul 135-081, Republic of - - 2014
Context: Vitamin D maintains calcium and phosphorous homeostasis and promotes bone mineralization; however, its non-skeletal functions are increasingly being recognized. Recent evidence supports a role for vitamin D in reproductive potential but few studies have investigated the potential effects of vitamin D on reproductive hormone biosynthesis and ovarian reserve. Objective: ...
Chen Baoying - - 2014
From previous reviews, there still have been controversies over the effect of metformin (MET) on reproductive function in PCOS patients. The reasons for the inconsistent findings especially lie in the transparency and accuracy of randomized controlled trials (RCTs) reports. However, we could find no data about the quality of RCTs ...
Pathak Narendra N Nephrology Division, Massachusetts General Hospital, 149 13 Street, Charlestown, MA 02129 Department of Genetics, Harvard Medical School, Boston MA, 02115 Department of Pathology, Massachusetts General Hospital, 149 13 Street, Charlestown, MA - - 2014
Glutamylation is a functionally important tubulin posttranslational modification enriched on stable microtubules of neuronal axons, mitotic spindles, centrioles and cilia. In vertebrates, balanced activities of tubulin glutamyl ligase and cytoplasmic carboxypeptidase deglutamylase enzymes maintain organelle and cell type specific tubulin glutamylation patterns. Tubulin glutamylation in cilia is regulated via restricted ...
Krausz Csilla C Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini, Florence, - - 2014
Genetic disorders can be identified in about 15% of cases of male infertility. With the widespread application of assisted reproductive technology, infertile patients are now given the possibility of having their biological children; however, a genetic risk exists for assisted reproductive technology-born offspring, implying the necessity for future parents to ...
Fauque Patricia P Laboratoire de Biologie de la Reproduction, Hôpital de Dijon, Université de Bourgogne, Dijon, France. Electronic address: - - 2014
To determine the impact of the time interval from the end of sperm preparation (TSP) to intrauterine insemination (IUI) on the outcome. Prospective multicentre cohort study. Seven French centers (assisted reproduction group in northeastern France, four academic centers, and three clinics). Eight hundred sixty-two IUI cycles (709 patients) managed by ...
Hansen Michèle M Telethon Kids Institute, University of Western Australia, Perth, - - 2014
Pooled odds ratios from meta-analyses of infants born following assisted reproductive technologies (ART) compared with non-ART singletons show increases in low birth weight, preterm birth, small for gestational age, and birth defects. Although there have been small reductions in recent data, odds associated with these outcomes are still higher for ...
Rooney Kristin L KL Domar Center for Mind/Body Health, Boston IVF, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, - - 2014
The impact of lifestyle behaviors on fertility is poorly understood, as is the impact of specific behaviors on the advanced reproductive technologies. It is vital for healthcare professionals to understand which lifestyle behaviors can have the greatest negative impact in an effort to improve patient recommendations. The purpose of this ...
Milone Marco M Marco Milone, Mario Musella, Paola Maietta, Francesco Milone, Department of Advanced Biomedical Science, University of Naples "Federico II", 80131 Naples, - - 2014
Varicocele has been implicated as a cause in 35%-50% of patients with primary infertility and up to 81% of men with secondary infertility. Although a large number of reports have shown improvement in the semen parameters after correction of varicocele, other studies have suggested no benefit. We report the first ...
Shi Qing-Qing QQ College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China; Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, Yangzhou 225009, China. Electronic address: - - 2014
Differentiation of germ cells from embryonic stem cells in vitro could have great application for treating infertility and provide an excellent model for uncovering molecular mechanisms of germline generation. In this study, we aim to screen the suitable inducers that may prove the efficiency of driving chicken embryonic stem cells ...
Van Voorhis Brad J BJ Department of Obstetrics and Gynecology, University of Iowa Hospital and Clinics, Iowa City, - - 2014
Gonzalez-Garcia Jose Raul - - 2014
Egg activation at fertilization in mammals is initiated by prolonged Ca(2+) oscillations that trigger the completion of meiosis and formation of pronuclei. A late fall in MAPK activity is essential for pronuclear formation, but the precise timing and mechanism of decline are unknown. Here, we have measured the dynamics of ...
Bianchi Enrica E Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, - - 2014
Fertilization occurs when sperm and egg recognize each other and fuse to form a new, genetically distinct organism. The molecular basis of sperm-egg recognition is unknown, but is likely to require interactions between receptor proteins displayed on their surface. Izumo1 is an essential sperm cell-surface protein, but its receptor on ...
Hallamaa Marianne M Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, - - 2014
Human epididymal secretory protein 4 (HE4) is a biomarker for ovarian cancer. The effect of follicle stimulating hormone (FSH) stimulation during in vitro fertilization (IVF) on HE4 was evaluated in order to see whether substantial hormonal stimulation of the ovaries affects the serum levels of this marker. Findings were compared ...
Skeldon Sean C SC Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, - - 2014
Bladder cancer is the fourth most common cancer among men in the United States, with a 3-fold higher incidence than women. Globally, tobacco smoking remains significantly more common in men, contributing to half of all cases of bladder cancer. To prevent bladder cancer, urologists should promote smoking cessation to patients ...
Ferlin Alberto A Department of Medicine, Centre for Human Reproduction Pathology, University of Padova, Padova, - - 2014
The purpose of this review is to highlight the most important advances in the field of genetics of male infertility, with particular attention to primary articles dealing with the identification of new genetic and epigenetic markers that could be translated into clinical practice in the near future. Copy number variations ...
Godia Pamela M - - 2014
Addressing the Sexual and Reproductive Health (SRH) needs of young people remains a big challenge. This study explored experiences and perceptions of young people in Kenya aged 10-24 with regard to their SRH needs and whether these are met by the available healthcare services. 18 focus group discussions and 39 ...
Pourdanesh Fereydoun F Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran 8916733754, - - 2014
In this study, a new nanocomposite, which contained high density polyethylene (HDPE), tricalcium phosphate (Ca3(PO4)2) nanoparticles (TCP NPs), hydroxyapatite nanoparticles (HA NPs), and magnesium oxide nanoparticles (MgO NPs) was prepared. As in vitro experiment, human osteoblasts (HOB) cells were exposed to pristine HDPE and its nanocomposite for a period of ...
Pfadenhauer Lisa Maria - - 2014
The toxic heavy metal lead continues to be a leading environmental risk factor, with the number of attributable deaths having doubled between 1990 and 2010. Although major sources of lead exposure, in particular lead in petrol, have been significantly reduced in recent decades, lead is still used in a wide ...
McGee W K WK Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon; - - 2014
Many patients with hyperandrogenemia are overweight or obese, which exacerbates morbidities associated with polycystic ovary syndrome (PCOS). To examine the ability of testosterone (T) to generate PCOS-like symptoms, monkeys received T or cholesterol (control) implants (n = 6/group) beginning prepubertally. As previously reported, T-treated animals had increased neuroendocrine drive to ...
Polisi Addisu - - 2014
In many areas of the world where HIV prevalence is high, rates of unintended pregnancy have also been shown to be high. Of all pregnancies worldwide in 2008, 41% were reported as unintended and approximately 50% of these ended in abortion. To address these problems family planning is the best ...
Kim Ju Yeong JY Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of - - 2014
To determine whether intracytoplasmic sperm injection (ICSI) could prevent total fertilization failure (TFF) and enhance the embryo quality in patients with non-male factor infertility. A total of 296 in vitro fertilization (IVF) cycles performed in patients with non-male factor infertility between April 2009 and March 2013 were included in this ...
Paulson Richard J RJ Division of Reproductive Endocrinology and Infertility, University of Southern California, Los Angeles, - - 2014
Eghbali Maryam M Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Poursina Ave, 16 Azar St. Keshavarz BLVD, Tehran, Iran, - - 2014
Non-obstructive azoospermia (NOA) is one the many causes of male infertility (10 %) resulting from testicular failure. Multiple testicular biopsies fail to find mature sperm in at least 50 % of cases Therefore; hunting for sensitive and specific biomarkers of spermatogenesis that could better determine the fertility status in NOA can lead ...
Qian Xiaojing X The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave, New York, New York 10065; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, - - 2014
The transport of germ cells across the seminiferous epithelium is composed of a series of cellular events during the epithelial cycle essential to the completion of spermatogenesis. Without the timely transport of spermatids during spermiogenesis, spermatozoa that are transformed from step 19 spermatids in the rat testis fail to reach ...
Bertone-Johnson Elizabeth R - - 2014
Moderate to severe premenstrual syndrome (PMS) affects 8-20 percent of premenopausal women. Previous studies suggest that high dietary vitamin D intake may reduce risk. However, vitamin D status is influenced by both dietary vitamin D intake and sunlight exposure and the association of vitamin D status with PMS remains unclear. ...
Lee Susan K - - 2014
Although the challenges of working with culturally and linguistically diverse groups can lead to the exclusion of some communities from research studies, cost effective strategies to encourage access and promote cross-cultural linkages between researchers and ethnic minority participants are essential to ensure their views are heard and their health needs ...
Fishel Simon S CARE Fertility Group, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham NG8 6PZ, United Kingdom. Electronic address: - - 2014
Thrombophilia and impaired placental vasculature are a major cause of adverse pregnancy outcome. In 2007, a new hereditary factor for obstetric complications and recurrent pregnancy loss (RPL) was identified as a sequence variation in the core promoter of the annexin A5 gene, ANXA5, called the M2 haplotype. M2 carriership has ...
Hadjkacem Loukil L L Unité Cibles pour le Diagnostic et la Thérapie, Centre de Biotechnologie de Sfax, Sfax, - - 2014
Obesity is associated with significant disturbance in the hormonal milieu that can affect the reproductive system. Male infertility affects approximately 6% of reproductive-aged men. It has been suggested that overweight men or men with obese body mass index (BMI) experience prolonged time to pregnancy, although the influence of male BMI ...
Al-Kindi Adila - - 2014
The rare autosomal genetic disorder, Spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL), is reported to be caused by missense or splice site mutations in the human discoidin domain receptor 2 (DDR2) gene. Previously our group has established that trafficking defects and loss of ligand binding are the underlying ...
Liu Wen W University of - - 2014
In Aspergillus nidulans, after extensive mutagenesis, a collection of mutants was obtained and four suppressor loci were identified genetically that could suppress mutations in putative chain termination mutations in different genes. Suppressor mutations in suaB and suaD have a similar restricted spectrum of suppression and suaB111 was previously shown to ...
Liu Yunqiang Y Department of Medical Genetics and Division of Human Morbid Genomics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China. - - 2014
Male infertility is one of the major diseases that affect human health and social life, and is influenced by many genetic and environmental factors. Epigenetic modification on DNA strands in response to environmental factors plays an important role in the process of spermatogenesis. Abnormalities of epigenetic regulation may affect both ...
Dai Li L Center for Reproduction and Genetics, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu 215002, P. R. China. - - 2014
Failure of spermatogenesis is the main clinical manifestation of male infertility. Multiple factors including genetic factors may affect spermatogenesis. Azoopermia factor (AZF) is closely involved in spermatogenesis. This paper reviews recent progress made in the study of AZF and its role in spermatogenesis and male infertility.
Ramasamy Ranjith R Baylor College of Medicine, Houston, - - 2014
Pilatz Adrian A Department of Urology, Pediatric Urology and Andrology, Justus-Liebig-University, Giessen, Germany. Electronic address: - - 2014
To use a proteomic approach to evaluate possible postinflammatory alterations in the protein composition of motile sperm in patients 3 months after acute epididymitis. Prospective case-control study. University medical school research laboratory. Eight patients 3 months after acute unilateral epididymitis and 10 healthy controls. None. Proteome analysis of sperm samples ...
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