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Pranjić Nurka - - 2002
The aim of this study was to made assessment of health effects in 37 workers exposed to gasoline, and its constituents at gasoline stations between 1985 and 1996. Thirty-seven persons who had been exposed to gasoline for more than five years were examined. The evaluation included a medical / occupational ...
Relevancy Score: Relevancy Score: 173
Mihalache Cornelia - - 2004
The objective of this article is to present a series of 12 cases with the chronic lead poisoning produced after a short but intensive professional exposure (in average 12-14 hours per day, 41.6 days) at mineral dust and oxides containing lead (technical revision of a oven and of a furnace ...
Relevancy Score: Relevancy Score: 173
Kojima S S Institute of Environmental Toxicology, Ibaraki, - - 1999
In order to clarify age-related changes in hematological values of normal rats after birth, blood samples from neonatal F344 rats of both sexes were examined periodically during the period from 0 to 40 days postpartum. The erythrocyte count (RBC) increased with time after birth as a function of age. In ...
Relevancy Score: Relevancy Score: 173
Bianchi Paola - - 2003
Pyrimidine 5'-nucleotidase deficiency is a rare autosomal recessive disorder characterized by haemolytic anaemia, marked basophilic stippling and accumulation of pyrimidine nucleotides within the erythrocytes. The gene encoding for this enzyme (P5'N-1) has been cloned recently, and seven mutations have so far been identified in 11 unrelated families. We describe the ...
Relevancy Score: Relevancy Score: 173
Sözen M - - 2004
A boy presented at age 4 years with severe congenital hemolytic anemia characterized by highly elevated reticulocyte count (30-50%) and prominent basophilic stippling. Hb had been 4 g/dL at age 7 months. The patient was on a monthly transfusion regimen up to the age of 7 years, when he underwent ...
Relevancy Score: Relevancy Score: 173
Renschler Janelle S - - 2009
A 13-year-old domestic shorthair cat was presented for evaluation of pollakiuria. Laboratory abnormalities included mild hypercholesterolemia, moderate hypertriglyceridemia, and a mild increase in the Na:K ratio (43, reference interval 32-41). Abdominal ultrasonography revealed urinary calculi and a soft tissue mass between the right caudate liver lobe and the right kidney. ...
Relevancy Score: Relevancy Score: 173
Paglia D E - - 1977
Pyrimidine nucleotides, detectable in normal erythrocytes only in trace quantities if at all, were found to comprise 7-80% of the intracellular nucleotide pools in nine subjects with severe lead over-burden. Blood lead concentrations ranged from approximately equal to 200- to 400-microgram/dl packed cells, and the greatest accumulations of pyrimidine-containing nucleotides ...
Relevancy Score: Relevancy Score: 173
Marinaki A M - - 2001
Pyrimidine 5' nucleotidase (P5'N-1) deficiency is an autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. It is implicated in the anemia of lead poisoning and is possibly associated with learning difficulties. Recently, a protein with ...
Relevancy Score: Relevancy Score: 173
Balta Gunay - - 2003
Pyrimidine 5' nucleotidase-I (P5N-I) deficiency is a rare autosomal recessive disorder associated with hemolytic anemia, marked basophilic stippling, and accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. Recently, the structure and location of the P5N-I gene have been published. This paper presents the results of a study characterizing ...
Relevancy Score: Relevancy Score: 173
Pootrakul P - - 1981
Twenty-two patients with mild haemolytic anaemia and haemoglobin (Hb) Constant Spring (CS) of around 6% were studied because they were suspected of having homozygous Hb CS. Family studies revealed Hb CS trait in both parents of eight patients, supporting that they were homozygous for Hb CS. The other patients were ...
Relevancy Score: Relevancy Score: 173
Falke H E - - 1990
The effect of chronic subcutaneous administration of lead acetate was studied in female rabbits. The low-dose group (15 animals) received three times a week 0.10-0.20 microgram/kg body weight and the high-dose group (15 animals) 0.80-1.20 micrograms/kg. The control group received the vehicle only. Concentrations of lead in blood in the ...
Relevancy Score: Relevancy Score: 173
Mecklenburg Lars - - 2004
Nude mice have a mutation in the transcription factor Foxn1(nu), resulting in downregulation of hair keratins. Although hair follicles develop normally, the hair fibers become structurally weak, curl, and break off at the surface. Nails in nude mice are deformed, based on alterations of the onychocyte differentiation process. Elemental microanalysis ...
Relevancy Score: Relevancy Score: 173
Katoh M - - 1992
Hematological and serum biochemical values of dams and offspring of Sprague-Dawley rats were measured during late gestation, lactation and postweaning. In dams, slightly low erythrocytic parameters, high platelets and high frequency of neutrophils were seen after parturition although WBC showed no marked changes. On Day 20 of gestation, glucose and ...
Relevancy Score: Relevancy Score: 173
Wickramasinghe S N - - 1991
A hitherto undescribed form of congenital dyserythropoietic anaemia is reported. The patient was severely anaemic and hydropic at birth and is now 8 years old. She has a moderate normochromic normocytic anaemia. HbF level of 50%, reticulocyte count of 5-12% and hyperbilirubinaemia. Bone marrow smears showed intense normoblastic erythroid hyperplasia ...
Relevancy Score: Relevancy Score: 173
Vance M V - - 1990
To our knowledge, acute inorganic lead poisoning from single ingestions of lead compounds has been only rarely reported. During a 14-month period, we were contacted regarding eight instances of acute ingestions of liquid lead-based ceramic glazes by mentally impaired residents of nursing homes or psychiatric facilities participating in ceramic arts ...
Relevancy Score: Relevancy Score: 173
Martin C J - - 2004
BACKGROUND: Zinc protoporphyrin (ZPP) has been used both as a screening and diagnostic test for overexposure to lead for nearly 30 years, although limitations for both purposes are recognized. METHODS: We present longitudinal findings for ZPP and whole-blood lead in a man with two episodes of acute lead intoxication and ...
Relevancy Score: Relevancy Score: 173
Dos Santos Andrey A Hemocentro e Instituto Nacional de Ciência e Tecnologia do Sangue, Universidade de Campinas, São Paulo, - - 2014
Pyrimidine-5'-nucleotidase type I (P5'NI) deficiency is an autosomal recessive condition that causes nonspherocytic hemolytic anemia, characterized by marked basophilic stippling and pyrimidine nucleotide accumulation in erythrocytes. We herein present two African descendant patients, father and daughter, with P5'N deficiency, both born from first cousins. Investigation of the promoter polymorphism of ...
Relevancy Score: Relevancy Score: 164
Riess Matthias L - - 2007
We report a case of acute lead poisoning in an adult female who had last been exposed to lead 7 years ago. She presented with abdominal pain, knee pain, and neurological symptoms, hypertension, chronic kidney disease, and anemia with basophilic stippling and lead gum lines. Compared to during her recent ...
Relevancy Score: Relevancy Score: 164
Shannon Michael - - 2003
BACKGROUND: Lead freely crosses the placenta. Consequently, gestational lead poisoning is not only harmful to the woman but also to the developing fetus, invariably producing congenital lead poisoning. The scope and consequences of severe lead poisoning in pregnancy (blood lead level > or =45 microg/dL) have not been well characterized. ...
Relevancy Score: Relevancy Score: 157
Doll K - - 1989
Among the cattle admitted to the II. Medizinische Tierklinik of the University of Munich during the years 1982-86, 38 calves of up to 6 weeks of age had a dystrophy (n=5), pre-cirrhosis (n=21) or cirrhosis (n=12) of the liver. Similar hepatic lesions were found in three 1- to 7-day-old calves ...
Relevancy Score: Relevancy Score: 157
Lane Laura V - - 2012
A 6-year-old spayed Labrador Retriever Mix dog was evaluated for a 2-week history of progressive generalized weakness and reluctance to stand. Physical examination revealed severe weakness with obtunded mentation, head tilt, bilateral nystagmus, and decreased vision. CBC findings included mild nonregenerative anemia, marked thrombocytopenia, and a few atypical mononuclear cells ...
Relevancy Score: Relevancy Score: 157
Aixála M T - - 2001
Hereditary spherocytosis (HS) is a congenital and hemolytic anemia characterized by the presence of microspherocytes on the peripheral blood film and negative Coombs test. Although HS is a heterogeneous syndrome in terms of clinical severity, inherents and underlying molecular defects (deficiency of membrane skeleton proteins), typical HS has a dominant ...
Relevancy Score: Relevancy Score: 157
Maguire A - - 2001
Two brothers with X-linked ataxia (XLA) were found to have hypochromic red cells and increased erythrocyte protoporphyrin despite normal iron stores. The mother was unaffected by ataxia and had normal iron stores but showed evidence of some red cell hypochromia with heavy basophilic stippling that stained positive for iron. Bone ...
Relevancy Score: Relevancy Score: 157
Autenrieth T - - 1998
HISTORY AND ADMISSION FINDINGS: A 24-year-old woman, an administrative employee, was admitted with colicky abdominal pain and constipation, as well as breathing-related chest pain of recent onset with cough and sometimes blood-streaked sputum. She had previously been unsuccessfully treated for gastritis and adnexitis. On physical examination revealed diffuse, ill-defined abdominal ...
Relevancy Score: Relevancy Score: 157
Piao Fengyuan - - 2003
In order to expand our knowledge of zinc toxicity and to assess further the toxicities of zinc systematically, we observed the toxic effects of zinc on the functions of various tissues and organs in rats. The rats were randomly divided into four groups (14 in each group), viz. one normal ...
Relevancy Score: Relevancy Score: 157
Rheinboldt Matthew M ER division, Department of Radiology, Henry Ford Hospital, Detroit, MI, USA, - - 2014
We report an unusual case of systemic lead poisoning, i.e., plumbism, following a remote gunshot injury to the right femur. Plumbism is a rare side-effect of penetrating projectiles and has been shown to be directly related to the degree of ballistic fragmentation, as well as to the impact location, with ...
Relevancy Score: Relevancy Score: 157
Nassiri Seyed Mahdi - - 2011
BACKGROUND: Immune-mediated hemolytic anemia (IMHA) occurs in cattle; however, there are few reported cases. OBJECTIVE: The aim of this study was to investigate the prevalence of IMHA in cattle with anemia, describe the associated clinical and laboratory findings, including osmotic fragility, and identify potential causative infectious agents or drugs. METHODS: ...
Relevancy Score: Relevancy Score: 157
Sanderson B J - - 1993
The level of clastogenic damage in mice following in vivo adult and transplacental exposure to benzidine, heliotrine, monocrotaline and urethane was compared using the micronucleus (MN) assays of polychromatic erythrocytes (PCE) found in mouse adult bone marrow and foetal liver. Saline was used as a negative control. Swiss-albino mice (gestation ...
Relevancy Score: Relevancy Score: 157
Jongnarangsin K - - 1999
Abdominal pain is a common complaint with diverse etiologies. We describe an unusual case of recurrent abdominal pain in an adult due to lead poisoning, a condition usually associated with childhood. A previously healthy 42-yr-old man presented with 2 days of severe crampy abdominal pain and a 1-month history of ...
Relevancy Score: Relevancy Score: 157
Ukaejiofo E O - - 2009
OBJECTIVE: To determine blood levels of lead and its effects on haematological parameters among occupational lead handlers in Enugu, Enugu State, Nigeria. In developing countries, rapid industrialisation has lead to an alarming demand for lead. Furthermore, the burden of lead toxicity is greatly underestimated. Hence, the need to assess the ...
Relevancy Score: Relevancy Score: 157
Balali-Mood M - - 2010
Occupational lead poisoning is a health problem in Iran. It has not previously been studied in traditional tile makers. To determine the prevalence of lead poisoning and its complications in traditional tile workers in Mashhad, Northwest of Iran. We visited workers in two traditional tile factories and collected data by ...
Relevancy Score: Relevancy Score: 157
Weide R - - 2003
HISTORY AND CLINICAL FINDINGS: A 39-year-old woman with a history of slowly progressive muscular dystrophia was transferred to us for further evaluations of a hypochromic, microcytic anaemia. The patient complained about progressive muscle weakness, loss of appetite and constipation, sleep disorders as well as muscle and back pain. Clinical examination ...
Relevancy Score: Relevancy Score: 157
Fonte Rodolfo - - 2007
We describe a 47-year-old patient with chronic anaemia with basophilic stippling of erythrocytes, recurrent abdominal colics, discoloration of gums, sensitive polyneuropathy to the four limbs, hyperuricaemia, hepatosteatosis with raised transaminases, and a long ignored history of lead exposure in a battery recycling plant. The diagnosis of poisoning was confirmed by ...
Relevancy Score: Relevancy Score: 157
Valentine W N - - 1980
The maturing reticulocyte degrades ribosomal RNA to constituent ribonucleoside phosphates. Guanosine ribonucleotides are retained only in small amounts and pyrimidine ribonucleotides only in trace quantities. In the mature erythrocyte more than 97% of total nucleotides are the interconvertible adenosine mono-, di-, and triphosphates. High energy ATP fuels most of the ...
Relevancy Score: Relevancy Score: 157
Roscoe D E - - 1975
Three groups of rabbits (A, B, and C; 6 rabbits/group) were fed a lead supplement of 25, 50, and 100 mg of Pb/kg of live weight/day for 87 days to compare the efficacies of 3 diagnostic tests--whole blood lead concentration, urinary delta-aminolevulinic acid (UALA), and fluorescent erythrocyte test (FET)--and to ...
Relevancy Score: Relevancy Score: 157
Kales Stefanos N SN Department of Medicine, Cambridge Health Alliance, Cambridge, MA 02139, USA. - - 2007
Millions worldwide use Ayurvedic (traditional Indian) medicines. These medications are increasingly associated with lead poisoning, often accompanied by anemia. We compared the relative hematopoietic toxicity of Ayurvedic lead poisoning with a common form of occupational lead poisoning. We retrospectively studied 66 adult lead intoxications: 43 published Ayurvedic cases identified in ...
Relevancy Score: Relevancy Score: 156
LAMBRECHTS A - - 1946
Relevancy Score: Relevancy Score: 154
BASTENIER H - - 1948
Relevancy Score: Relevancy Score: 135
Kim Y R - - 1998
After the neonatal period, the presence of nucleated red blood cells (NRBC) in peripheral blood is indicative of pathology. Despite the clinical utility of such measurements, automated NRBC counting has hitherto not been available on routine automated blood cell counting analysers. To address this, an automated method for the analysis ...
Relevancy Score: Relevancy Score: 134
Mehta Ashish - - 2002
Monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA), a vicinal thiol chelator, is gaining recognition recently as a better chelator than meso 2,3-dimercaptosuccinic acid (DMSA) in decreasing heavy metal burden in tissues because of its lipophilic character. There is, however, little information available on the toxicological properties of this chelator after repeated administration in ...
Relevancy Score: Relevancy Score: 134
Domingo-Claros Alicia - - 2002
BACKGROUND AND OBJECTIVES: The terms acute erythroleukemia and AML-M6 are defined in the FAB classification as proliferations of dysplastic erythroid elements mixed with blasts of myeloid origin, but pure erythroid leukemias are not included. The recent WHO classification has a category of acute myeloid leukemia not otherwise categorized, which includes ...
Relevancy Score: Relevancy Score: 134
Kachur Anatoly N - - 2003
The Rudnaya River valley in the Russian Far East contains a rich reserve of lead, zinc and boron and has been mined for nearly 100 years. Environmental contamination related to the area's mines and lead smelter was studied for over 30 years during the Soviet era, by members of the ...
Relevancy Score: Relevancy Score: 134
Chang Se Heon - - 2013
Relevancy Score: Relevancy Score: 132
Marinaki, A. M.
Pyrimidine 5' nucleotidase (P5'N-1) deficiency is an autosomal recessive condition causing hemolytic anemia characterized by marked basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. It is implicated in the anemia of lead poisoning and is possibly associated with learning difficulties. Recently, a protein with ...
Relevancy Score: Relevancy Score: 122
Alessio L - - 1999
In preparing this paper we considered the articles published in La Medicina del Lavoro from 1901, its first year of publication. This scientific journal was founded in Milan, when an animated debate arose in Italy on the necessity of treating and, above all, preventing occupational diseases. In the same city, ...
Relevancy Score: Relevancy Score: 110
Rao Janapareddy Vijaya Bhaskara JV Department of Neurology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, - - 2014
Lead poisoning is a common occupational health hazard in developing countries. We report the varied clinical presentation, diagnostic and management issues in two adult patients with lead encephalopathy. Both patients worked in a battery manufacturing unit. Both patients presented with seizures and one patient also complained of abdominal colic and ...
Relevancy Score: Relevancy Score: 93
ขนิษฐ บูรณศิริ
Workers in dry-cell battery plant were exposed to manganese and some lead. Health status of 147 workers were studied by history taking, physical, hematological and biochemical examination. These workers were 95% female, 18-60 years of age. Abnormal physical findings were pale conjunctive, exaggerated reflex response, high blood pressure and skin ...
Relevancy Score: Relevancy Score: 91
Rolston David D K - - 2011
Lead-containing cooking utensils, sometimes used in South Indian homes, and indigenous medications, widely used in India and increasingly in developed countries, may be responsible for lead intoxication in adults. We report chronic lead poisoning in five adult patients. Not all patients had abdominal colic, while dramatic weight loss, depression and ...
Relevancy Score: Relevancy Score: 90
Kim Hyunah H College of Pharmacy, Sookmyung Women's University, Seoul, - - 2014
This study was performed to review studies carried out in Korea reporting toxic reactions to traditional Chinese medicines (TCMs) as a result of heavy metal contamination. PubMed (1966-August 2013) and International Pharmaceutical Abstracts (1965-August 2013) were searched using the medical subject heading terms of "Medicine, Chinese Traditional," "Medicine, Korean Traditional," ...
Relevancy Score: Relevancy Score: 82
Kang Jung Hyun - - 2013
Relevancy Score: Relevancy Score: 81
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