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Yang Liang L Department of Pharmacology, Nankai University School of Medicine, Tianjin, - - 2014
Extensive data have shown that exercise training can provide cardio-protection against pathological cardiac hypertrophy. However, how long the heart can retain cardio-protective phenotype after the cessation of exercise is currently unknown. In this study, we investigated the time course of the loss of cardio-protection after cessation of exercise and the ...
Röckmann Heike H Department of Dermatology/Allergology, University Medical Center Utrecht, Heidelberglaan 100, G 02,124, 3584 Utrecht, CX, The Netherlands. - - 2014
Limited data are available on the frequency of IgE mediated food sensitization and food allergy (FA) in adults with atopic dermatitis (AD). We investigated the pattern of food sensitization in adults with AD in relation to AD severity using multiplexed allergen microarray. 211 adult patients referred between January 2010-July 2011 ...
Yahya Ali I AI General surgery department, Zliten Teaching Hospital and Edwaw District Hospital, Zliten, - - 2014
Hepatic hydatid disease is very common in Libya. In Zliten hospital, we operated 400 patients with hepatic hydatid cysts over period of 20 years. All patients were symptomatic. Their ages varied from 3 to 85 years including 215 female and 185 male patients. Their symptoms varied from abdominal pain to abdominal mass ...
Linard Ana Thaise Sousa AT Health Academic Unit, Education and Health Center, Federal University of Campina Grande, Cuité campus, Cuité, Paraíba State, - - 2014
The present study aims to investigate the clinical-epidemiological characteristics of bee sting cases recorded between 2007 and 2012 in the city of Campina Grande, Paraíba state, Brazil. Data were collected from the database of the Injury Notification Information System of the Brazilian Ministry of Health. A total of 459 bee ...
Bergmann Karl-Christian KC Allergy Centre Charité, Universitätsmedizin, Berlin, - - 2014
From its very beginning, the 20th century represented the period of the main breakthrough for allergology as a clinical and scientific entity. The first years of this period were extraordinarily exciting because of the discovery of the anaphylactic reaction in 1902 and its clinical diagnosis as 'local anaphylaxis', 'serum sickness' ...
Theakston R David G RD Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, University of Liverpool, Liverpool L3 5QA, UK. - - 2014
In many cases of envenoming following snake bite, the snake responsible for the accident remains unidentified; this frequently results in difficulty deciding which antivenom to administer to the systemically-envenomed victim, especially when only monospecific antivenoms are available. Normally the specific diagnosis of snake bite can be conveniently made using clinical ...
Alavi Shiva S Associate Professor, Torabinejad Dental Research Center, Department of Orthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, - - 2014
The amount and consistency of the applied forces to the tooth are important factors in tooth movements; therefore, the aim of this study was to compare the initial force and the force loss of three brands of elastics in 24 hours. In this in-vitro study sixty non-latex elastics (3/16 medium) ...
Capelle Heloise H Oncopharma, Hôpital Nord, AP-HM, Marseille, - - 2014
Pemetrexed is approved to treat non-small cell lung cancer and has an overall favorable toxicity profile. We describe a 58-year-old man who developped an anaphylactic shock within few minutes from the beginning of pemetrexed perfusion. Pemetrexed was discontinued and the patient's symptoms gradually resolved with administration of symptomatic treatment. Serum ...
Simons F Estelle R FE Department of Pediatrics & Child Health and Department of Immunology, Faculty of Medicine, University of Manitoba, Room FE125, 820 Sherbrook Street, Winnipeg, Manitoba, Canada, R3A - - 2014
ICON: Anaphylaxis provides a unique perspective on the principal evidence-based anaphylaxis guidelines developed and published independently from 2010 through 2014 by four allergy/immunology organizations. These guidelines concur with regard to the clinical features that indicate a likely diagnosis of anaphylaxis -- a life-threatening generalized or systemic allergic or hypersensitivity reaction. ...
Andreucci Michele M 0000-0002-7974-3792 Nephrology Unit, Department of "Health Sciences", Campus "Salvatore Venuta", "Magna Graecia" University, Loc. Germaneto, 88100 Catanzaro, - - 2014
Radiocontrast media (RCM) are medical drugs used to improve the visibility of internal organs and structures in X-ray based imaging techniques. They may have side effects ranging from itching to a life-threatening emergency, known as contrast-induced nephropathy (CIN). We define CIN as acute renal failure occurring within 24-72 hrs of ...
Nayak Sushrusha S Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, Florida, United States of America; Department of Medicine, Center for Infection Medicine, Karolinska Institute, Stockholm, - - 2014
Enzyme replacement therapy (ERT) with recombinant human acid-α-glucosidase (rhGAA) is the only FDA approved therapy for Pompe disease. Without ERT, severely affected individuals (early onset) succumb to the disease within 2 years of life. A spectrum of disease severity and progression exists depending upon the type of mutation in the ...
Li Xiaohong X Department of Allergy, First Affiliated Hospital of Anhui Medical University, No. 210, Jixi Road, Anhui Province, Hefei 230022, - - 2014
The house dust mites are major sources of indoor allergens for humans, which induce asthma, rhinitis, dermatitis, and other allergic diseases. Der f 25 is a triosephosphate isomerase, representing the major allergen identified in Dermatophagoides farinae. The objective of this study was to predict the B and T cell epitopes ...
Kim Min-Hye MH Department of Internal Medicine, Division of Allergy and Clinical Immunology, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Republic of Korea; Seoul National University Hospital Regional Pharmacovigilance Center, Seoul, Republic of Korea; Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of - - 2014
Anaphylaxis is the most severe form of radiocontrast media (RCM) induced hypersensitivity and can be life-threatening if profound hypotension is combined. With increased use of iodine based RCM, related hypersensitivity is rapidly growing. However, the clinical characteristics and risk factors of RCM induced anaphylaxis accompanied by hypotension (anaphylactic shock) are ...
Farahani Rahim R Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, - - 2014
Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. During the process of airway inflammation, complex interactions of innate and adaptive immune ...
Zehri Aqib H AH Neurosurgery Research Laboratory, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, - - 2014
The clinical application of fluorescent contrast agents (fluorescein, indocyanine green, and aminolevulinic acid) with intraoperative microscopy has led to advances in intraoperative brain tumor imaging. Their properties, mechanism of action, history of use, and safety are analyzed in this report along with a review of current laser scanning confocal endomicroscopy ...
Gillis Caitlin C Laboratoire Anticorps en Thérapie et Pathologie, Département d'Immunologie, Institut Pasteur , Paris , France ; U760, INSERM , Paris , - - 2014
The biological activities of human IgG antibodies predominantly rely on a family of receptors for the Fc portion of IgG, FcγRs: FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, FcRL5, FcRn, and TRIM21. All FcγRs bind IgG at the cell surface, except FcRn and TRIM21 that bind IgG once internalized. The affinity ...
Huq A K M Moyeenul AK Centre for Drug and Herbal Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, - - 2014
Persicaria hydropiper (L.) Delarbre, belonging to Polygonaceae family, is a common weed found in most of the temperate countries including Bangladesh, China, Malaysia, and Japan. The plant is also referred to as "marsh pepper" or "smart weed." It appears to be a useful herb with evidence-based medicinal properties. The present ...
Lu Winston I WI Savon Pharmacy, El Paso, TX, USA ; Foundation Hospital, El Paso, TX, - - 2014
Many Americans, not completely satisfied with traditional western medicine, have turned to alternative and complementary medicine which explains the increasing popularity of the herbal products and the Chinese herbal medicine. The lack of government regulations and the increasing advertisements by the manufactures have created an impression to the common public ...
Gómez-Rincón Carlota C 0000-0003-3982-2282 Facultad de Ciencias de la Salud, Universidad San Jorge, Campus Universitario Villanueva de Gállego, Autovia A-23 Zaragoza, Huesca, Km 299, 50.830 Villanueva de Gállego, Zaragoza, - - 2014
Nematicidal activity of Melaleuca alternifolia essential oil, commonly known as tea tree oil (TTO), was assayed in vitro against L3 larvae of Anisakis simplex. The results showed a mortality of 100% for concentrations between 7 and 10  μ L/mL after 48 h of incubation, obtaining an LD50 value of 4.53  μ ...
Shahidi Bonjar Leyla L Department of Pharmacology, College of Pharmacy, Kerman University of Medical Sciences, International Campus, Kerman, - - 2014
The prospective removal of snake venoms from the blood of snake-bitten patients is discussed here. Opportune neutralization of killer antigens from the blood of poisoned victims is a vital treatment step. Delays may lead to death, or cripple the patient permanently. The present procedure describes the elimination of venom antigens ...
Varban Oliver O University of Michigan Health Systems, 2210 Taubman Center, 1500 E Medical Center Drive, SPC 5343, Ann Arbor, MI 48109-5343, United States. Electronic address: - - 2014
Splenic cyst during pregnancy is rare and may result in spontaneous rupture during the third trimester, which increases perinatal morality. We present a 27-year-old healthy Caucasian female who presented at 18 weeks gestation with left flank pain, early satiety and weight loss. Imaging studies demonstrated a large complex multiloculated splenic ...
George Melissa R MR Department of Pathology, Penn State Milton S Hershey Medical Center, Hershey, PA, - - 2014
Hemophagocytic lymphohistiocytosis (HLH) covers a wide array of related life-threatening conditions featuring ineffective immunity characterized by an uncontrolled hyperinflammatory response. HLH is often triggered by infection. Familial forms result from genetic defects in natural killer cells and cytotoxic T-cells, typically affecting perforin and intracellular vesicles. HLH is likely under-recognized, which ...
Wang Shou Zhen SZ Surgical Intensive Care Unit, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, - - 2014
Daptomycin, a cyclic lipopeptide that exhibits rapid, concentration-dependent bactericidal activity in vitro against a broad spectrum of Gram-positive pathogens, has now, since 2003, been approved in more than 70 countries and regions to treat skin and soft-tissue infections (SSTIs). The purpose of this meta-analysis was to compare the safety and ...
Stone Shelley F SF Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research and the University of Western Australia, Perth, Australia; Department of Emergency Medicine, Royal Perth Hospital, Perth, - - 2014
Systemic spread of immune activation and mediator release is required for the development of anaphylaxis in humans. We hypothesized that peripheral blood leukocyte (PBL) activation plays a key role. To characterize PBL genomic responses during acute anaphylaxis. PBL samples were collected at three timepoints from six patients presenting to the ...
Ryniak Stan S Department of Anaesthesia & Intensive Care, Karolinska Institutet, Danderyds University Hospital, Danderyd, 182 88 Stockholm, - - 2014
A 16-year-old woman with craniofacial injury developed severe acute respiratory failure under the primary reconstructive surgical procedure requiring several units of blood and plasma. A transfusion related acute lung injury (TRALI) was suspected and supportive treatment was initiated. Because of the severity of symptoms, acute extracorporeal membrane oxygenation (ECMO) was ...
Palmieri Arianna A Department of Philosophy, Sociology, Pedagogy and Applied Psychology (FISPPA), University of Padova Padova, - - 2014
The nature of near-death-experiences (NDEs) is largely unknown but recent evidence suggests the intriguing possibility that NDEs may refer to actually "perceived," and stored, experiences (although not necessarily in relation to the external physical world). We adopted an integrated approach involving a hypnosis-based clinical protocol to improve recall and decrease ...
Järvinen Kirsi M KM Division of Allergy and Immunology, Department of Medicine, Albany Medical College, Albany, NY, - - 2014
Anaphylaxis is an increasingly prevalent problem in westernized countries. Therefore, it is of utmost importance that the increasing numbers of patients at risk for anaphylaxis receive proper education on the etiology and risk factors as well as appropriate treatment of anaphylaxis with epinephrine. The physician's role is crucial in order ...
Leoni Maria Chiara MC Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Ambulatorio di Immuno-Pneumo-Allergologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, University Hospital of Pavia, Pavia, - - 2014
Villegas-Bastida Albino A Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre "Siglo XXI," Mexican Social Security Institute (IMSS), 06720 Mexico City, DF, Mexico ; Universidad Autónoma Benito Juarez de Oaxaca (UABJO), 68120 Oaxaca de Juárez, OAX, Mexico ; National School of Medicine and Homeopathy, National Polytechnic Institute, 07320 Mexico City, DF, - - 2014
Electrical vagus nerve (VN) stimulation during sepsis attenuates tumor necrosis factor (TNF) production through the cholinergic anti-inflammatory pathway, which depends on the integrity of the VN and catecholamine production. To characterize the effect of electroacupuncture at ST36 (EA-ST36) on serum TNF, IL-6, nitrite, and HMGB1 levels and survival rates, based ...
Lorkowska-Zawicka Barbara B Chair of Pharmacology, Jagiellonian University Medical College, 16 Grzegórzecka Str., Cracow 31-531, Poland. - - 2014
This study was performed to evaluate the ability of N-(2-hydroxypropyl)-3-tri methylammonium chitosan chloride (HTCC), the cationically modified chitosan, to form biologically inactive complexes with unfractionated heparin and thereby blocking its anticoagulant activity. Experiments were carried out in rats in vivo and in vitro using the activated partial thromboplastin time (APTT) ...
Abate-Daga Daniel D Surgery Branch; Center for Cancer Research; National Cancer Institute; Bethesda, MD - - 2014
Pancreatic cancer remains largely an incurable disease necessitating the development of novel therapeutic approaches. Adoptive immunotherapy using chimeric antigen receptor (CAR)-transduced T cells represents an alternative treatment with curative potential. We present an overview of the engineering of novel CARs targeting prostate stem cell antigen (PSCA), implications for the development ...
Baird Fiona J FJ Centre for Biodiscovery & Molecular Development of Therapeutics, Centre for Biosecurity in Tropical Infectious Diseases, Australian Institute of Tropical Health & Medicine, James Cook University Townsville, QLD, Australia ; Molecular Immunology Group, School of Pharmacy and Molecular Biology, James Cook University Townsville, QLD, - - 2014
Traditional prophylactic vaccination to prevent illness is the primary objective of many research activities worldwide. The golden age of vaccination began with an approach called variolation in ancient China and the evolution of vaccines still continues today with modern developments such as the production of Gardasil(TM) against HPV and cervical ...
Råmunddal Truls T Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, - - 2014
Evidence for the current guidelines for the treatment of patients with chronic total occlusions (CTO) in coronary arteries is limited. In this study we identified all CTO patients registered in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) and studied the prevalence, patient characteristics and treatment decisions for CTO in ...
Sharma Jagdish N - - 2014
Bradykinin and related kinins may act on two types of receptors designated as B1 and B2. It seems that the B2 receptors are most commonly found in various vascular and non-vascular smooth muscles, whereas B1 receptors are formed in vitro during trauma, and injury, and are found in bone tissues. ...
Mazuc Elsa E IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France; INSERM, U896, Montpellier, France; Université Montpellier1, Montpellier, France; ICM, Institut régional du Cancer Montpellier, Montpellier, - - 2014
The high specificity of antibodies for their antigen allows a fine discrimination of target conformations and post-translational modifications, making antibodies the first choice tool to interrogate the proteome. We describe here an approach based on a large-scale intracellular expression and selection of antibody fragments in eukaryotic cells, so-called intrabodies, and ...
Hardy Margaret C MC 0000-0001-5033-4322 Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, - - 2014
Envenomation and poisoning by terrestrial animals (both vertebrate and invertebrate) are a significant economic problem and health risk for domestic animals in Australia. Australian snakes are some of the most venomous animals in the world and bees, wasps, ants, paralysis ticks, and cane toads are also present as part of ...
Knipping Karen K Nutricia Research B.V., Utrecht, The Netherlands; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The - - 2014
Cow's milk-derived whey hydrolysates are nutritional substitutes for allergic infants. Safety or residual allergenicity assessment of these whey hydrolysates is crucial. Currently, rat basophilic leukemia RBL-2H3 cells expressing the human IgE receptor α-chain (huFcεRIα-RBL-2H3), sensitized with serum IgE from cow's milk allergic children, are being employed to assess in vitro ...
Wu Xinmin X Peking University First Hospital, No 8 Xishiku St, Beijing 100034, - - 2014
This study compared efficacy and safety of the selective relaxant binding agent sugammadex (2 mg/kg) with neostigmine (50 μg/kg) for neuromuscular blockade (NMB) reversal in Chinese and Caucasian subjects. This was a randomized, active-controlled, multicenter, safety-assessor-blinded study (NCT00825812) in American Society of Anesthesiologists Class 1-3 subjects undergoing surgery with propofol anesthesia. Rocuronium ...
Golik Magdalena M Centre of Endoscopy, Jan Biziel's University Hospital No 2 with Clinic for Intestinal Diseases, Bydgoszcz, - - 2014
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, present a major challenge for present-day gastroenterology due to their increasing incidence, chronic nature, risk of permanent worsening of quality of life of patients, and the costs of conservative and invasive treatment. Basic and advanced nursing care are important parts ...
Lonjaret Laurent L Department of Anesthesiology and Intensive Care, Clinique des eaux claires, Baie-Mahault, - - 2014
Perioperative blood pressure management is a key factor of patient care for anesthetists, as perioperative hemodynamic instability is associated with cardiovascular complications. Hypertension is an independent predictive factor of cardiac adverse events in noncardiac surgery. Intraoperative hypotension is one of the most encountered factors associated with death related to anesthesia. ...
Blank Ulrich U INSERM UMRS 1149 , Paris , France ; CNRS ERL8252 , Paris , France ; Université Paris Diderot, Sorbonne Paris Cité, Laboratoire d'excellence INFLAMEX , Paris , - - 2014
Upon activation mast cells (MCs) secrete numerous inflammatory compounds stored in their cytoplasmic secretory granules by a process called anaphylactic degranulation, which is responsible for type I hypersensitivity responses. Prestored mediators include histamine and MC proteases but also some cytokines and growth factors making them available within minutes for a ...
Nakamura Shigeru S Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku, Tokyo 160-8582, - - 2014
Fasting is a rigorous type of dietary restriction that is associate with a number of health benefits. During fasting, ketone bodies significantly increase in blood and become major body fuels, thereby sparing glucose. In the present study, we investigated effects of fasting on hypersensitivity. In addition, we also investigated the ...
- - 2014
Histamine that belongs to one of the most important mediators involved in the regulation of the body's vital functions plays a great role in the pathogenesis of different diseases. Histamine is released during inflammatory and allergic reactions, anaphylactic and anaphylactoid shock, pseudoallergic reactions, and others. Acting through histamine receptors, it ...
Madani George G Little Fireface Project, Cisurupan, Cipaganti, Garut, Java - - 2014
Asian slow lorises (Nycticebus spp.) are one of few known venomous mammals, yet until now only one published case report has documented the impact of their venomous bite on humans. We describe the reaction of a patient to the bite of a subadult Nycticebus kayan, which occurred in the Mulu ...
Zhang Tiemin T Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, - - 2014
Cystic echinococcosis (CE) caused by the larval stage of Echinococcus granulosus sensu lato (s.l.) is one of the most important zoonotic parasitic diseases worldwide and 10 genotypes (G1-G10) have been reported. In China, almost all the epidemiological and genotyping studies of E. granulosus s.l. are from the west and northwest ...
Takazawa Tomonori T Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511 - - 2014
Sugammadex has a unique mechanism of action and is widely used because of its safety and efficacy. A few recent reports have described allergic reactions to clinical doses of sugammadex. We hereby describe another series of cases of possible anaphylaxis to sugammadex. We present three suspected cases of sugammadex-induced anaphylactic ...
Puchalski Adam R AR Division of Endocrinology, Diabetes and Hypertension David Geffen School of Medicine at UCLA 24-130 Warren Hall, 900 Veteran Avenue, Los Angeles, California, 90095 - - 2014
Radioiodine ((131)I) is a critical component in the treatment of differentiated thyroid cancer. We recently saw a patient with thyroid cancer who was hesitant to take (131)I treatment because he had previously encountered an allergic reaction to administration of iodine-containing radiocontrast agent for computed tomography (CT) scanning. We were able ...
Cerný A - - 2014
Amniotic fluid embolism is a rare but mortal pregnancy complication. Presentations may vary from subtle clinical events to sudden cardiac arrest or death. Amniotic fluid embolism is one of the most common cause of maternal mortality in developed countries. Basic principle is amniotic fluid and its particles gaining access to ...
Yamaki Kouya K Department of Pharmacology, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Kobe, Hyogo, 658-8558, Japan, - - 2013
Administration of the influenza vaccination to patients with an egg allergy is major health concern. Contaminating egg antigens occasionally induce severe anaphylactic shock in these patients following administration of the vaccination; therefore, the development of a safer vaccination is needed. In the present study, we investigated whether a mixture of ...
Maloney Jennifer J Merck & Co, Inc, Whitehouse Station, New Jersey. Electronic address: - - 2014
In North America, few studies have evaluated sublingual immunotherapy for allergic rhinitis with or without conjunctivitis (AR/C); pediatric data are sparse. The authors report findings from the largest published immunotherapy trial yet conducted in adults and children. To evaluate grass sublingual immunotherapy tablet (MK-7243) treatment in subjects with AR/C. North ...
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