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Assefa Netsanet Gizaw NG Department of Chemistry/Norstruct, UiT The Arctic University of Norway, 9037 Tromsø, - - 2014
Uracil-DNA N-glycosylase from Atlantic cod (cUNG) shows cold-adapted features such as high catalytic efficiency, a low temperature optimum for activity and reduced thermal stability compared with its mesophilic homologue human UNG (hUNG). In order to understand the role of the enzyme-substrate interaction related to the cold-adapted properties, the structure of ...
Whittingham Jean L JL Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, - - 2014
Rhodococcus equi is a multi-host pathogen that infects a range of animals as well as immune-compromised humans. Equine and porcine isolates harbour a virulence plasmid encoding a homologous family of virulence-associated proteins associated with the capacity of R. equi to divert the normal processes of endosomal maturation, enabling bacterial survival ...
Tan Jingquan J Schools of Medicine and Biochemistry and Immunology, Trinity College, Dublin, - - 2014
The exopolysaccharide alginate is an important component of biofilms produced by Pseudomonas aeruginosa, a major pathogen that contributes to the demise of cystic fibrosis patients. Alginate exits the cell via the outer membrane porin AlgE. X-ray structures of several AlgE crystal forms are reported here. Whilst all share a common ...
Arpino James A J JA School of Biosciences, Cardiff University, Park Place, Cardiff CF10 3AT, - - 2014
Single-amino-acid deletions are a common part of the natural evolutionary landscape but are rarely sampled during protein engineering owing to limited and prejudiced molecular understanding of mutations that shorten the protein backbone. Single-amino-acid deletion variants of enhanced green fluorescent protein (EGFP) have been identified by directed evolution with the beneficial ...
Choi Seong-Min SM Department of Neurology, Chonnam National University Medical School, Gwangju, - - 2014
Excessive accumulation of β-amyloid peptide (Aβ) is one of the major mechanisms responsible for neuronal death in Alzheimer's disease. Flavonoids, primarily antioxidants, are a group of polyphenolic compounds synthesized in plant cells. The present study aimed to identify flavonoid compounds that could inhibit Aβ-induced neuronal death by examining the effects ...
Burden Daniel K DK a Chemistry Division , Naval Research Laboratory , Washington , DC , - - 2014
The radial growth and advancement of the adhesive interface to the substratum of many species of acorn barnacles occurs underwater and beneath an opaque, calcified shell. Here, the time-dependent growth processes involving various autofluorescent materials within the interface of live barnacles are imaged for the first time using 3D time-lapse ...
Drevinskas Tomas - - 2014
A capacitance-to-digital converter integrated circuit was implemented in an automated CE device as a single chip detector. In this paper, design and hardware issues related to the fabrication and application of a miniature detector for contactless measurement of complex impedance are discussed. The capacitance-to-digital converter integrated circuit was used as ...
Liu Y J YJ The Third Hospital of Hebei Medical University, Shijiazhuang, - - 2014
Our objective was to observe the biodegradable and osteogenic properties of magnesium scaffolding under in vivo conditions. Twelve 6-month-old male New Zealand white rabbits were randomly divided into two groups. The chosen operation site was the femoral condyle on the right side. The experimental group was implanted with porous magnesium ...
de Picoli Souza K K Faculdade de Ciências Biológicas e Ambientais, Universidade Federal da Grande Dourados, Dourados, MS, - - 2014
Myoglobin acts as an oxygen store and a reactive oxygen species acceptor in muscles. We examined myoglobin mRNA in rat cardiac ventricle and skeletal muscles during the first 42 days of life and the impact of transient neonatal hypo- and hyperthyroidism on the myoglobin gene expression pattern. Cardiac ventricle and ...
McConoughey Stephen J SJ Department of Orthopedics, The Ohio State University, Columbus, OH, - - 2014
ABSTRACT  As the number of total joint arthroplasty and internal fixation procedures continues to rise, the threat of infection following surgery has significant clinical implications. These infections may have highly morbid consequences to patients, who often endure additional surgeries and lengthy exposures to systemic antibiotics, neither of which are guaranteed ...
Nagasirisha Mandipati M Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, - - 2014
Rostellularia diffusa is an unexplored medicinal plant used as brain tonic in traditional medicine system. This study was designed to investigate the antioxidant and anti-stress potential of R. diffusa by experimental animal models. The extracts of R. diffusa were subjected to preliminary phytochemical screening and high performance thin layer chromatography ...
Kondeva-Burdina Magdalena M Laboratory for Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Sofia, - - 2014
Astragalus hamosus L. (Fabaceae) is used in herbal medicine as emollient, demulcent, phrodisiac, diuretic, laxative, and good for inflammation, ulcers, and leukoderma. It is useful in treating irritation of the mucous membranes, nervous affections, and catarrh. Rhamnocitrin 4-β-D-galactopyranoside (RGP), isolated from A. hamosus, was investigated for its possible protective effect ...
Ooh Keng-Fei KF Department of Chemical Science, Universiti Tunku Abdul Rahman, 31900 Kampar, - - 2014
The phytochemistry and bioactivity of wetland macrophytes are underexplored. Plants are known as the natural sources of phytochemical beneficial to health. The objective of this study is to analyze the phytochemical profiles and bioactivities of 10 extracts prepared from different plant parts of wetland macrophytes Hanguana malayana, Ludwigia adscendens and ...
Oh You-Chang YC Korean Medicine-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Jeonmin dong, Yuseong, Daejeon, 305-811, - - 2014
Hwangryunhaedoktang (HR) has been traditionally used in oriental medicine as a drug for the treatment of melena, hemoptysis, and apoplexy. We investigated whether HR and lactobacilli-fermented HRs have an inhibitory effect on the production of proinflammatory mediators in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The investigation was focused on whether ...
Oh You-Chang YC Korean Medicine-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Daejeon 305-811, South - - 2014
Artemisiae annuae herba (AAH) has been traditionally used as a drug for the treatment of malaria, heat stroke, bacterial infection, and fever in East-Asia. Although AAH has been used for the treatment of inflammation-related symptoms, the underlying mechanism of antiinflammatory activity of AAH is still unknown. We investigated whether AAH ...
Kaewpiboon Chutima C Department of Biology, Faculty of Science, Thaksin University, Phatthalung 93110, - - 2014
Cancer cells have the ability to develop resistance to chemotherapy drugs, which then leads to a reduced effectiveness and success of the treatment. Multidrug resistance (MDR) involves the resistance in the same cell/tissue to a diverse range of drugs of different structures. One of the characteristics of MDR is an ...
Upadhyay Aadesh A Division of Pharmaceutical Technology, Defence Research Laboratory, DRDO, Tezpur, Assam, India ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, - - 2014
Euphorbia hirta L. (Euphorbiaceae) is a traditional herbal medicine used for treatment of various diseases. E. hirta was investigated for in vitro/in vivo wound healing activity using human dermal fibroblast cell line and Wistar rats. Petroleum ether, chloroform, methanol and water successive extracts of E. hirta leaves were evaluated for ...
Sant'Anna Ricardo R Universidade Federal do Rio de Janeiro, - - 2014
Protein aggregation into β-sheet enriched amyloid fibrils is associated with an increasing number of human disorders. The adoption of such amyloid conformations seems to constitute a generic property of polypeptide chains. Therefore, during evolution, proteins have adopted negative design strategies to diminish their intrinsic propensity to aggregate, including enrichment of ...
Mostardeiro Clarice Pinheiro CP Department of Physiology, Graduate Program in Pharmacology, Federal University of Santa Maria, Santa Maria, - - 2014
Pavonia xanthogloea is traditionally used as an antimicrobial and anti-tumour medicine in Southern Brazilian region. However, investigations about this species are still incipient. The study postulated that P. xanthologea specie present some phenolic compound and present some biological properties as anti-oxidant and cytoprotective effect against oxidative stress. The content of ...
Choi Sung-Ho SH Department of Pharmacology and Toxicology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of - - 2014
Atractylodis Rhizoma Alba (ARA) has been used in Korean folk medicine for constipation, dizziness, and anticancer agent. In the present study, we performed to test whether the methanolic extract of ARA has antioxidant and antiosteoclastogenesis activity in RAW 264.7 macrophage cells. Antioxidant capacities were tested by measuring free radical scavenging ...
Sudha A A Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, - - 2014
Anisomeles malabarica R. Br. (Lamiaceae) is extensively used in traditional medicine in major parts of India for several medicinal purposes, including their use in rheumatism. The air-dried leaves of A. malabarica were extracted with ethanol, defatted with n-hexane and then successively partitioned into chloroform and n-butanol fractions. Bioassay-guided fractionation and ...
Yang Min Hye MH College of Pharmacy, Pusan National University, Busan, - - 2014
During the process of hepatic fibrosis, the activation of hepatic stellate cells (HSCs) is responsible for the increased formation and reduced degradation of extracellular matrix in the liver. By employing the hepatic stellate cell line, HSC-T6, it was found that the methanol extract of Limonium tetragonum, a halophyte living in ...
Fawzy Ghada Ahmed GA Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia ; Faculty of Pharmacy, Cairo University, Cairo, - - 2014
Previous investigation of the methanol extract of Plicosepalus curviflorus leaves led to the isolation of two new flavane gallates (1, 2), together with other compounds including quercetin (3). The stems of P. curviflorus are used traditionally for the treatment of cancer in Yemen. The aim of this study was to ...
Gawden-Bone Christian - - 2014
The dynamic properties of podosomes, their ability to degrade the underlying matrix and their modulation by TLR-signalling in dendritic cells (DC) suggests they may have an important role in migration. Integrins are thought to participate in podosome formation and dynamics but the multiplicity of integrins in podosomes has made this ...
Purushothaman Arun Kallur AK Centre for Advanced Research in Indian System of Medicine, SASTRA University, Thanjavur, Tamil Nadu, - - 2014
Jatropha tanjorensis (Euphorbiaceae) an exotic traditional plant unique to Thanjavur district of Southern India also commonly called as Catholic vegetable. It has been used traditionally in decoctions for treating various ailments and as a health tonic. The objective of the present work is to study a comprehensive characterization of methanolic ...
Goswami Sumanta Kumar SK Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh main gate, Hosur Main Road, Bangalore, Karnataka, - - 2014
Diabetes induced sexual dysfunction is a leading cause of male sexual disorder and an early indicator of cardiovascular complication. Reactive oxygen species generated in body during diabetes is a main causative factor for erectile dysfunction, a sexual dysfunction. Adjuvant antioxidant therapy along with phosphodiesterases type 5 enzyme inhibitor (PDE5i) is ...
Apaya Maria Karmella L MK Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, - - 2014
Antigonon leptopus Hook. and Arn., Polygonaceae (cadena de amor), is a herbal remedy for pain and gout-like symptoms in the Philippines. The methanol extract of A. leptopus have shown strong inhibitory action against xanthine oxidase. To isolate and identify the compound responsible for the xanthine oxidase inhibitory action. A bioassay-guided ...
Han Hye-Yeon HY Department of Oral Pathology, School of Dentistry, Institute of Translational Dental Sciences, Gyeongnam, - - 2014
The fruit of Kochia scoparia Scharder is widely used as a medicinal ingredient for the treatment of dysuria and skin diseases in China, Japan and Korea. Especially, K. scoparia had been used for breast masses and chest and flank pain. To investigate the anti-cancer effect of K. scoparia on breast ...
Gayosso-De-Lucio Juan J University of the State of Hidalgo, N. Abasolo 600, Colonia Centro, CP 42,000 Pachuca, Hidalgo, - - 2014
One of the major components of some geraniums is geraniin, described by its discoverer as crystallizable tannin, well known as an excellent antioxidant, and also found in fruits such as pomegranate. Recently, natural antioxidants have attracted great attention from consumers over the world due to their lower toxicity than synthetics. ...
Kim Aeyung A Korean Medicine-Based Herbal Drug Development Center Group, Korea Institute of Oriental Medicine, 483 Expo-ro, Yuseong-gu, Daejeon 305-811, Republic of - - 2014
Recently, our research group developed MA128, a novel herbal medicine, and demonstrated that MA128 is effective for the treatment of asthma and atopic dermatitis (AD). In particular, postinflammatory hyper-pigmentation in AD mice was improved with MA128 treatment. Thus, in this study, we determined the effect of MA128 on melanogenesis and ...
Shah Jay J Private Practitioner, Vapi, Gujarat, India - - 2014
The aim of the study was to evaluate and compare sorption, solubility and microhardness of heat cure polymethylmethacrylate (PMMA) denture base resin and flexible (thermoplastic polyamide nylon) denture base resin. Sorption, solubility and microhardness were assessed to determine compliance with ADA Specification no. 12. RESULTs were assessed using statistical and ...
Liu Qiang Q Department of Neurology, Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Jinan, Shandong Province, China ; Department of Neurology, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning Province, - - 2014
It is difficult to control the degree of ischemic postconditioning in the brain and other ischemia-sensitive organs. Remote ischemic postconditioning could protect some ischemia-sensitive organs through measures on terminal organs. In this study, a focal cerebral ischemia-reperfusion injury model was established using three cycles of remote ischemic postconditioning, each cycle ...
Wang Shaoxia S Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, - - 2014
Danhong injection (DHI), a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is widely used in China for treating acute ischemic stroke. In the present study, we explored the neuroprotective efficacy of DHI in a rat model of temporary middle cerebral artery occlusion, and ...
Zhang Wangxin W Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, China ; Department of Medical Psychology, Taishan Medical University, Taian, Shandong Province, - - 2014
Ganoderma lucidum is a traditional Chinese medicine, which has been shown to have both anti-oxidative and anti-inflammatory effects, and noticeably decreases both the infarct area and neuronal apoptosis of the ischemic cortex. This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum (by intragastric administration) ...
Sun Y X YX National Reference Laboratory of Veterinary Drug Residues (SCAU), College of Veterinary Medicine, South China Agricultural University, Guangzhou, - - 2014
T-2 toxin, one of the most toxic trichothecene mycotoxins, causes economic losses in animal production. Little information is available on the toxicokinetic parameters of T-2 toxin and its major metabolites (i.e., HT-2 toxin and T-2 triol) in broiler chickens. In this study, toxicokinetics of T-2 toxin and its major metabolites ...
Schug Kevin Albert - - 2014
Analytical performance characteristics of a new vacuum ultraviolet (VUV) detector for gas chromatography (GC) are reported. GC-VUV was applied to hydrocarbons, fixed gases, polyaromatic hydrocarbons, fatty acids, pesticides, drugs, and estrogens. Applications were chosen to feature the sensitivity and universal detection capabilities of the VUV detector, especially for cases where ...
Wang Zhijiang Z School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China. - - 2014
A chemoselective route to induce Fe3O4@ZnO core-shell nanoparticles decorating carbon nanotubes to form MWCNT/Fe3O4@ZnO heterotrimers has been developed. Charges are redistributed in the heterotrimers through C-O-Zn, C-O-Fe and Fe-O-Zn bondings, giving rise to multiple electronic phases. The generated significant interfacial polarization and synergetic interaction between dielectric and magnetic absorbers result ...
Lv Meng-Meng MM The First Clinical School of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, - - 2014
Acquired drug resistance is a major obstacle to chemotherapy of cancers. In this study, we aim to investigate the role of exosomes in drug-resistance transfer between breast cancer cells and detect the probable mechanism. A docetaxel-resistant variant of MCF-7 cell line (MCF-7/DOC) was established and then compared with the drug-sensitive ...
Wondimu Taddese T Division of Medical Sciences, Northern Ontario School of Medicine, Lakehead University, 955 Oliver Road, Thunder Bay, ON P7B5E1, Canada. Department of Chemistry, Johannesburg, South - - 2014
The discovery that hydrogen sulphide (H2S) acts as a gasotransmitter when present at very low concentrations (sub-parts per billion (ppbv)) has resulted in the need to quickly quantify trace amounts of the gas in complex biological samples. Selected ion flow tube mass spectrometry (SIFT-MS) is capable of real-time quantification of ...
Hwang Seung Rim SR Chosun University, College of Pharmacy , Gwangju 501-759 , Republic of - - 2014
Introduction: Various macromolecules including polypeptides, proteins, genes and polysaccharides have been drawing attention for their therapeutic potential. The passage through intestinal epithelium is the major barrier for the oral delivery of macromolecules, by either paracellular or transcellular pathways. However, most macromolecules are poorly absorbed in oral route due to their ...
Oliveira Silvana R SR Spectrometry, Sample Preparation and Mechanization Group - GEPAM and National Institute of Science and Technology for Bioanalytics - INCTBio, Institute of Chemistry, Department of Analytical Chemistry, University of Campinas - Unicamp, PO Box 6154, 13083-970, Campinas, SP, Brazil. - - 2014
A tracer experiment is carried out with transgenic T (variety M 7211 RR) and non-transgenic NT (variety MSOY 8200) soybean plants to evaluate if genetic modification can influence the uptake and translocation of Fe. A chelate of EDTA with enriched stable (57)Fe is applied to the plants cultivated in vermiculite ...
Huang Tian T Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, P. R. China. - - 2014
The interfacial rheological property is closely related to the stabilities of foams and emulsions, yet there have been limited studies on the interaction between proteins with ionic liquid-type imidazolium surfactants at the decane-water interface as well as in the bulk. Herein, we investigated the interfacial and bulk properties of pepsin ...
Biedrzycki Adam A Department of Surgical, University of Wisconsin-Madison, Madison, - - 2014
To compare the in vitro biomechanical properties of a novel subcuticular stapling device to current methods of abdominal skin closure for equine abdominal surgery. In vitro randomized, matched design. Equine ventral median abdominal skin specimens (n = 24 horses). Subcuticular absorbable staples (SAS), metallic staples (MS), polyglyconate suture (PG), and nylon monofilament ...
Manninen V M VM Department of Chemistry and Bioengineering, Tampere University of Technology, P.O. Box 541, FI-33101, Tampere, Finland. - - 2014
In this work, two p-cyanophenyl end-capped oligothiophenes, and , were compared as dopants in the P3HT:PC60BM bulk heterojunction (BHJ) layer of inverted organic solar cells. Inclusion of significantly increased the average efficiency of the solar cells, while the increase using doping in the cell efficiency was minor. In the BHJ ...
Suseem S R SR Pharmaceutical Chemistry Division, School of Advanced Sciences, VIT University, Vellore-14, - - 2014
To evaluate the ethyl acetate, methanol and aqueous extracts of dried fruiting bodies of Pleurotus eous for its anti-platelet activity on human volunteer's blood. And also to analyze the free radical scavenging property of the extracts of P.eous by using various in vitro models. Anti-platelet activity of dried fruiting bodies ...
Dwivedi Krishna K KK Caisson Laboratories, Inc., 1740 Research Park Way, North Logan, UT 84341, USA Crop Improvement Division, Indian Grassland and Fodder Research Institute, Jhansi (UP) 284003, India Plants, Soils and Climate Department, Utah State University, Logan, UT 84322-4820, - - 2014
During seed fill in cereals, nutrients are symplasmically unloaded to vascular parenchyma in ovules, but thereafter nutrient transport is less certain. In Zea mays, two mechanisms of nutrient passage through the chalaza and nucellus have been hypothesized, apoplasmic and symplasmic. In a recent study, nutrients first passed non-selectively to the ...
Jami Mohammad-Saeid - - 2014
Parkinson's disease (PD) is the second most common neurodegenerative movement disorder, caused by preferential dopaminergic neuronal cell death in the substantia nigra, a process also influenced by oxidative stress. L-3,4-dihydroxyphenylalanine (L-DOPA) represents the main treatment route for motor symptoms associated with PD however, its exact mode of action remains unclear. ...
Hewlett Susie E - - 2014
Feather pecking and cannibalism are major concerns in poultry farming, both in terms of animal welfare and farm economics. Genetic selection and introduction of (aspects of) maternal care have been suggested as potential interventions to reduce feather pecking in laying hens. Altered brain development has been proposed to reflect welfare ...
Johnson Zachary Lee ZL Department of Biochemistry, Duke University Medical Center, Durham, United - - 2014
Concentrative nucleoside transporters (CNTs) are responsible for cellular entry of nucleosides, which serve as precursors to nucleic acids and act as signaling molecules. CNTs also play a crucial role in the uptake of nucleoside-derived drugs, including anticancer and antiviral agents. Understanding how CNTs recognize and import their substrates could not ...
Kim Hyuk H Aesthetic Research Team, Amore Pacific Corporation Research and Development Center, Yongin, - - 2014
Recent advances in hyaluronic acid (HA) fillers and radiofrequency (RF) devices have been made in the context of skin rejuvenation and cosmetic surgery. Moreover, combination regimens with both techniques are currently being developed. The present study was designed to examine the clinical and histologic effects of a new needle that ...
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