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Pongkorpsakol Pawin P Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand; Research Center of Transport Protein for Medical Innovation, Faculty of Science, Mahidol University, Bangkok, - - 2014
Cyclic AMP-activated intestinal Cl- secretion plays an important role in pathogenesis of cholera. This study aimed to investigate the effect of diclofenac on cAMP-activated Cl- secretion, its underlying mechanisms, and possible application in the treatment of cholera. Diclofenac inhibited cAMP-activated Cl- secretion in human intestinal epithelial (T84) cells with IC50 ...
Tenge Victoria R VR Department of Microbiology, University of Washington, Seattle, Washington, United States of - - 2014
Human α-defensins are potent anti-microbial peptides with the ability to neutralize bacterial and viral targets. Single alanine mutagenesis has been used to identify determinants of anti-bacterial activity and binding to bacterial proteins such as anthrax lethal factor. Similar analyses of α-defensin interactions with non-enveloped viruses are limited. We used a ...
Han Young Woo YW College of Veterinary Medicine and Bio-Safety Research Institute, College of Natural Science, Chonbuk National University, Jeonju, Republic of - - 2014
Japanese encephalitis (JE) is major emerging neurologic disease caused by JE virus. To date, the impact of TLR molecules on JE progression has not been addressed. Here, we determined whether each TLR modulates JE, using several TLR-deficient mouse strains (TLR2, TLR3, TLR4, TLR7, TLR9). Surprisingly, among the tested TLR-deficient mice ...
Bielig Harald H Institute for Medical Microbiology, Immunology and Hygiene, Cologne, - - 2014
NOD1 is an intracellular pathogen recognition receptor that contributes to anti-bacterial innate immune responses, adaptive immunity and tissue homeostasis. NOD1-induced signaling relies on actin remodeling, however, the details of the connection of NOD1 and the actin cytoskeleton remained elusive. Here, we identified in a druggable-genome wide siRNA screen the cofilin ...
Bhatnagar Sushma S Department of Anesthesiology, All India Institute of Medical Sciences, New Delhi, - - 2014
To compare the efficacy and safety of oral transmucosal fentanyl citrate (OTFC) and oral morphine in Indian patients with breakthrough episodes of cancer pain. In this randomized, open label, active controlled, clinical study, total 186 patients who regularly experienced 1-4 episodes of breakthrough cancer pain (BTCP) daily, over the persistent ...
Esfahanizade Katayoun K Dept. of Pediatric Dentistry, Islamic Azad University, Dental Branch, Tehran, - - 2014
Epidermolysis bullosa (EB) is a group of rare inherited skin and mucous membrane disorders in which blister formation may arise spontaneously or following a minor friction. Various patterns of inheritance are explicated for the disease. The disease has a profound effect on oral mucosa and may result in high prevalence ...
Khurana M P S - - 2014
The study was conducted to evaluate the accumulation pattern of cadmium (Cd) and its tolerance in different crops grown on sewage irrigated soils with differentCd levels. Growth, yield, uptake and tolerance of maize, raya, berseem and spinach were assessed to different levels of Cd ranging from 0-40 mg kg(-1) soil. ...
Duracinsky Martin - - 2014
Facial lipoatrophy is a frequently reported condition associated with use of antiretroviral (ARV) drugs. Poly-L-lactic acid (PLLA) acid has been used to correct facial lipoatrophy in people with HIV since 2004 both in Europe and the United States. The objective of this study was to establish, in real life conditions ...
Song Hyunkeun - - 2014
Along with de novo resistance, continued exposure to trastuzumab, an anti-human epidermal growth factor receptor 2 (HER2/neu) antibody, can lead to acquired resistance. In this study, we characterize a new anti-HER2/neu antibody resistant and metastatic mouse breast carcinoma cell line, TUBO-P2J. This cell line was developed during in vivo experiments ...
Diggle Christine P CP School of Medicine, University of Leeds, Leeds, United - - 2014
Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis. In humans, defects specifically affecting motile cilia lead to chronic airway infections, infertility and laterality defects in the genetically heterogeneous disorder Primary Ciliary Dyskinesia (PCD). Using the comparatively simple Drosophila ...
Singh Anirudh K AK Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of - - 2014
Bacterial cell-surface proteins play integral roles in host-pathogen interactions. These proteins are often architecturally and functionally sophisticated and yet few studies of such proteins involved in host-pathogen interactions have defined the domains or modules required for specific functions. Streptococcus pneumoniae (pneumococcus), an opportunistic pathogen that is a leading cause of ...
Qvarnström Anna - - 2014
Young adults are at risk for HIV/STIs because they generally have an active sex life with multiple sexual partners; moreover, they use condoms to a lesser extent. Travelling increases sexually risky behaviour, and among both women and men, sexual contacts abroad are common. Better knowledge of how young adults experience ...
Brown Armand O AO Dept. of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of - - 2014
Hospitalization of the elderly for invasive pneumococcal disease is frequently accompanied by the occurrence of an adverse cardiac event; these are primarily new or worsened heart failure and cardiac arrhythmia. Herein, we describe previously unrecognized microscopic lesions (microlesions) formed within the myocardium of mice, rhesus macaques, and humans during bacteremic ...
Ducroux Aurélie A Unité des Hépacivirus et Immunité Innée, Institut Pasteur, Paris, France; UMR CNRS 3569, Paris, - - 2014
Hepatitis B virus infection (HBV) is a major risk factor for the development of hepatocellular carcinoma. HBV replicates from a covalently closed circular DNA (cccDNA) that remains as an episome within the nucleus of infected cells and serves as a template for the transcription of HBV RNAs. The regulatory protein ...
Waisberg Michael M Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America; Department of Pathology, University of Virginia, Charlottesville, Virginia, United States of - - 2014
Invasion of mosquito salivary glands (SGs) by Plasmodium falciparum sporozoites is an essential step in the malaria life cycle. How infection modulates gene expression, and affects hematophagy remains unclear. Using Affimetrix chip microarray, we found that at least 43 genes are differentially expressed in the glands of Plasmodium falciparum-infected Anopheles ...
Kumar Nitesh N School of Life Sciences, Jawaharlal Nehru University, New Delhi, - - 2014
Entamoeba histolytica is a protist parasite that is the causative agent of amoebiasis, and is a highly motile organism. The motility is essential for its survival and pathogenesis, and a dynamic actin cytoskeleton is required for this process. EhCoactosin, an actin-binding protein of the ADF/cofilin family, participates in actin dynamics, ...
Cronemberger-Andrade André A Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, - - 2014
Extracellular vesicles (EVs) are structures with phospholipid bilayer membranes and 100-1000 nm diameters. These vesicles are released from cells upon activation of surface receptors and/or apoptosis. The production of EVs by dendritic cells, mast cells, macrophages, and B and T lymphocytes has been extensively reported in the literature. EVs may ...
Berry Andrea A AA Center for Vaccine Development, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, United States of - - 2014
Enteroaggregative Escherichia coli (EAEC) is a leading cause of acute and persistent diarrhea worldwide. A recently emerged Shiga-toxin-producing strain of EAEC resulted in significant mortality and morbidity due to progressive development of hemolytic-uremic syndrome. The attachment of EAEC to the human intestinal mucosa is mediated by aggregative adherence fimbria (AAF). ...
Khan Asis A Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of - - 2014
Previous studies have stressed the genetic divergence and high pathogenicity of strains of T. gondii from French Guiana. Although strains from coastal, human adapted environments (so called anthropized) resemble those found in other regions of the Caribbean, strains collected from inland jungle environment are genetically quite diverse. To better understand ...
Akabane Shiori S Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa-shi, Chiba, - - 2014
Release factors (RFs) govern the termination phase of protein synthesis. Human mitochondria harbor four different members of the class 1 RF family: RF1Lmt/mtRF1a, RF1mt, C12orf65 and ICT1. The homolog of the essential ICT1 factor is widely distributed in bacteria and organelles and has the peculiar feature in human mitochondria to ...
Kinoshita Naoki N Department of Radiology, University of Fukui - - 2014
The uncertainty of the beam quality conversion factor (kQ,Q0) of standard dosimetry of absorbed dose to water in external beam radiotherapy 12 (JSMP12) is determined by combining the uncertainty of each beam quality conversion factor calculated for each type of ionization chamber. However, there is no guarantee that ionization chambers ...
Matsumoto Yoshitsugu Y Division of Radiology, Department of Medical Technology, Kyushu University - - 2014
In postoperative radiotherapy for seminoma, control of the testicular absorbed dose is important, since exposure of the testis can lead to temporary or permanent infertility. In this case, instead of using a dog-leg-shaped field, treatment using a field focused near the aorta was provided in several disease stages of seminoma. ...
Weenink Don D Rural Sociology Group, Wageningen - - 2014
Inspired by phenomenological and interactionist studies of youth violence, this article offers an empirical evaluation of Collins's micro-sociological theory of violence. The main question is whether situations of extreme violence have distinct situational dynamics. Based on analyses of 159 interactions taken from judicial case files, situations of extreme youth violence, ...
Giewekemeyer Klaus K European XFEL GmbH, Hamburg, - - 2014
Coherent (X-ray) diffractive imaging (CDI) is an increasingly popular form of X-ray microscopy, mainly due to its potential to produce high-resolution images and the lack of an objective lens between the sample and its corresponding imaging detector. One challenge, however, is that very high dynamic range diffraction data must be ...
de Jonge Martin D MD Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168, - - 2014
X-ray nanoprobes require coherent illumination to achieve optic-limited resolution, and so will benefit directly from diffraction-limited storage rings. Here, the example of high-resolution X-ray fluorescence tomography is focused on as one of the most voracious demanders of coherent photons, since the detected signal is only a small fraction of the ...
Es Haghi M M Liver and Gastrointestinal Diseases Research Center, Tabriz, - - 2014
Oxidative damage is implicated in the pathogenesis of kidney injury. Cornus mas is used for in renal aliments traditionally in Iran. The present study was aimed to investigate the antioxidant activity of C. mas fruit extract (CMFE) on carbon tetrachloride (CCl4) treated oxidative stress in Wistar albino rats. Forty two ...
Del Valle Paulo Roberto PR Departamento de Radiologia e Oncologia , Faculdade de Medicina , Universidade de São Paulo , São Paulo, SP , Brazil - - 2014
Cancer-associated fibroblasts (CAF) influence tumor development at primary as well as in metastatic sites, but there have been no direct comparisons of the transcriptional profiles of stromal cells from different tumor sites. In this study, we used customized cDNA microarrays to compare the gene expression profile of stromal cells from ...
Liu Li-Jia LJ School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, - - 2014
To study the absorption properties and mechanism of two important components, trolline and veratric acid, from the flowers of Trollius chinensis, in order to better understand the contribution of these two compounds to the effectiveness of these flowers. The human Caco-2 cell monolayer model was employed to study the transport ...
Schoenardie Elizandra Roselaine ER Post-Graduate Program in Parasitology, Department of Microbiology and Parasitology, Universidade Federal de Pelotas ? UFPEL, Capão do Leão, RS, - - 2014
Toxocariasis is a zoonotic disease in that IgM titers can remain high for long periods making difficult to determine the stage of the disease. The aim of this study is to investigate the applicability of indirect ELISA, associated with urea, to discriminate between the acute and chronic toxocariasis. IgG avidity ...
Leen J Brian JB Los Gatos Research, 67 E. Evelyn Avenue, Suite 3, Mountain View, California 94041, - - 2014
Non-mode-matched cavity-enhanced absorption spectrometry (e.g., cavity ringdown spectroscopy and integrated cavity output spectroscopy) is commonly used for the ultrasensitive detection of trace gases. These techniques are attractive for their simplicity and robustness, but their performance may be limited by the reflection of light from the front mirror and the resulting ...
Lambert P K PK Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, - - 2014
We have developed two techniques for time-resolved x-ray diffraction from bulk polycrystalline materials during dynamic loading. In the first technique, we synchronize a fast detector with loading of samples at strain rates of ∼10(3)-10(4) s(-1) in a compression Kolsky bar (split Hopkinson pressure bar) apparatus to obtain in situ diffraction ...
Kaalund Søren - - 2014
Background : Playing soccer on artificial turf can provoke pain in young players. Using shock-absorbing insoles (SAIs) can result in decreased pain perception. We sought to investigate the pain and comfort intensity experienced during the switch from natural grass to third-generation artificial turf and with the use of SAIs on ...
Lee Kyung Min KM Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, - - 2014
The objective of this article is to evaluate clinical outcomes of combined orbital floor and medial wall fracture repair using a three-dimensional pre-bent titanium implant in an East Asian population. Clinical and radiologic data were analyzed for 11 patients with concomitant orbital floor and medial wall fractures. A combined transcaruncular ...
Cornejo Isabel I Centro de Estudios Científicos (CECs), Valdivia, - - 2014
Parasitic sea lice represent a major sanitary threat to marine salmonid aquaculture, an industry accounting for 7% of world fish production. Caligus rogercresseyi is the principal sea louse species infesting farmed salmon and trout in the southern hemisphere. Most effective control of Caligus has been obtained with macrocyclic lactones (MLs) ...
Sezgin Billur B Department of Plastic, Reconstructive and Aesthetic Surgery, Erzurum Regional Training and Research Hospital, Erzurum, - - 2014
Disulfiram implantation is a widely used treatment alternative for alcohol abuse, yet reports on the surgical aspect of disulfiram implantation with respect to patient and drug-related treatment efficacy and wound complications are very limited. We present our clinical experiences with disulfiram implantation and discuss the surgical outcomes obtained with different ...
Bosio Christopher F CF Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, - - 2014
Arthropod-borne pathogens are transmitted into a unique intradermal microenvironment that includes the saliva of their vectors. Immunomodulatory factors in the saliva can enhance infectivity; however, in some cases the immune response that develops to saliva from prior uninfected bites can inhibit infectivity. Most rodent reservoirs of Yersinia pestis experience fleabites ...
Rocha Letícia B LB Laboratório de Bacteriologia, Instituto Butantan, São Paulo, São Paulo, - - 2014
Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC/EHEC) are human intestinal pathogens responsible for diarrhea in both developing and industrialized countries. In research laboratories, EPEC and EHEC are defined on the basis of their pathogenic features; nevertheless, their identification in routine laboratories is expensive and laborious. Therefore, the aim of the present ...
Ruiz-Linares Andrés A Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London, United - - 2014
The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social stratification. We estimated individual ancestry proportions in a sample of 7,342 subjects ascertained in five countries ...
Lim Efrem S - - 2014
STL polyomavirus (STLPyV) was recently identified in human specimens. To determine seropositivity for STLPyV, we developed an ELISA and screened patient samples from 2 US cities (Denver, Colorado [500]; St. Louis, Missouri [419]). Overall seropositivity was 68%-70%. The age-stratified data suggest that STLPyV infection is widespread and commonly acquired during ...
Sundby Johanne J a Institute of Health and Society , University of Oslo , Oslo , - - 2014
Global trends influence strategies for health-care delivery in low- and middle-income countries. A drive towards uniformity in the design and delivery of healthcare interventions, rather than solid local adaptations, has come to dominate global health policies. This study is a participatory longitudinal study of how one country in West Africa, ...
Albino Frank P FP Department of Plastic Surgery, Georgetown University Hospital, Washington, DC, - - 2014
Knee disarticulations (KD) are most commonly employed following trauma or tumor resection but represent less than 2% of all lower extremity amputations performed in the United States annually. KDs provide enhanced proprioception, a long lever arm, preservation of adductor muscle insertion, decreased metabolic cost of ambulation, and an end weight-bearing ...
Gonzalez-Leal Iris J IJ Institute for Molecular Infection Biology, University of Würzburg, Würzburg, - - 2014
Resistance and susceptibility to Leishmania major infection in the murine model is determined by the capacity of the host to mount either a protective Th1 response or a Th2 response associated with disease progression. Previous reports involving the use of cysteine cathepsin inhibitors indicated that cathepsins B (Ctsb) and L ...
Dasdag S - - 2014
Oral tissues are important parts of body that absorbs radiation emitted from mobile phones which is the most popular technological equipment in the world. Because of the limited studies in this field, we aimed to investigate the effect of Radio Frequency (RF) radiation emitted from 900 MHz mobile phones on ...
Yorifuji Takashi T Department of Obstetrics and Gynecology, Juntendo University, Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address: - - 2014
To determine the sustained effects of emergency cerclage using slowly absorbable monofilament sutures, changes in cervical length after cerclage were evaluated in six cases. A delayed absorbable monofilament suture (1 PDS-Plus; Ethicon, Inc., Somerville, NJ, USA) has been used for emergency cerclage after 20 weeks of gestation at Juntendo University ...
Capranzano Piera - - 2014
Currently, one of the most relevant innovations in interventional cardiology is the advent of bioresorbable vascular scaffolds (BVS). Among the BVS developed so far, the AbsorbTM BVS 1.1 (Abbott®) is one of the two devices that achieved the CE mark for the use in clinical practice. A reasonable amount of ...
Hong Young-Seoub YS Heavy Metal Exposure Environmental Health Center, Dong-A University, Busan, Korea ; Department of Preventive Medicine, Dong-A University College of Medicine, Busan, - - 2014
Arsenic is a unique element with distinct physical characteristics and toxicity whose importance in public health is well recognized. The toxicity of arsenic varies across its different forms. While the carcinogenicity of arsenic has been confirmed, the mechanisms behind the diseases occurring after acute or chronic exposure to arsenic are ...
Mathew Joan J Department of Conservative Dentistry and Endodontics, Rajas Dental College, Tirunelveli District, Tamil Nadu, - - 2014
Several disinfection techniques have been recently introduced with the main objective of improving root canal disinfection in the inaccessible areas of the root canal system. This in vitro study was done to evaluate the antimicrobial effect and viability of Enterococcus faecalis biofilms using conventional irrigation, EndoActivator (Dentsply, Tulsa Dental, USA), ...
Durgashivaprasad Ega E Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, - - 2014
1,3,4-oxadiazole ring is a versatile moiety with a wide range of pharmacological properties. The present work deals with the synthesis and evaluation of the anti-inflammatory activity of two novel 2,5-disubstituted-1,3,4-oxadiazoles (OSD and OPD). Carrageenan-induced rat hind paw edema was employed as an acute model of inflammation. For evaluating sub-acute anti-inflammatory ...
Surajudeen Yaqub A YA Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, - - 2014
Reports have clearly indicated the role of oxidative stress in the pathogenesis of organophosphate pesticides (Op) toxicity. However, there is dearth of information on which group of the farm workers is more at risk of Op-induced oxidative stress. This study determined serum levels of malondialdehyde (MDA), catalase (CAT), glutathione peroxidase ...
de Souza André Mattos Brito AM Faculty of Pharmacy, Dentistry and Nursing, Post Graduate Program in Dentistry, Department of Restorative Dentistry, Federal University of Ceara, - - 2014
Non-carious cervical lesions are usually associated with dentin hypersensitivity. The use of oxalic acid in restorations of these lesions could be beneficial in relieving pain. To evaluate the use of oxalic acid in restorations of non-carious cervical lesions. A randomized clinical trial. One operator placed 90 restorations in 20 volunteers ...
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