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Houshyani Benyamin - - 2014
Molecular characterization is an essential step of risk/safety assessment of genetically modified (GM) crops. Holistic approaches for molecular characterization using omics platforms can be used to confirm the intended impact of the genetic engineering, but can also reveal the unintended changes at the omics level as a first assessment of ...
Ma Zhiwei - - 2014
The periodontitis is one of the most prevalent diseases with alveolar resorption in adult people and is the main cause of the tooth loss. To investigate the possibility for protecting the loss of alveolar bone in periodontal diseases, a RNAi-based therapeutic strategy is applied for silencing RANK signaling using thermosensitive ...
Plaza David Fernando - - 2014
It is well known that mushrooms produce defense proteins and secondary metabolites against predators and competitors; however, less is known about the correlation between the tissue-specific expression and the target organism (antagonist) specificity of these molecules. In addition, conserved transcriptional circuitries involved in developing sexual organs in fungi are not ...
Osterman Janina - - 2014
The species Neorhizobium galegae comprises two symbiovars that induce nodules on Galega plants. Strains of both symbiovars, orientalis and officinalis, induce nodules on the same plant species, but fix nitrogen only in their own host species. The mechanism behind this strict host specificity is not yet known. In this study, ...
Li Qihong - - 2014
The aim of this study was to analyze stress distribution in a normal articular disc during the jaw opening movement. A two-dimensional finite element model of the articular disc was developed based on sagittal MRI slices from a healthy subject. Disc deformation was simulated using the contours of the disc ...
Foo Jhi Biau - - 2014
Dillenia suffruticosa root dichloromethane extract (DCM-DS) has been reported to exhibit strong cytotoxicity towards breast cancer cells. The present study was designed to investigate the cell cycle profile, mode of cell death and signalling pathways of DCM-DS-treated human caspase-3 deficient MCF-7 breast cancer cells. Dillenia suffruticosa root was extracted by ...
Ryu Jina J Department of Food and Life Science, Pukyong National University, Busan 608-737, Republic of - - 2014
The significant increase in life expectancy is closely related to the growing interest in the impact of aging on the function and appearance of the skin. Skin aging is influenced by several factors, and solar ultraviolet (UV) irradiation is considered one of the most important causes of skin photoaging. The aim ...
Spinler Jennifer K JK Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, 1102 Bates Ave., Houston, Texas, USADepartment of Pathology & Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA - - 2014
The vertebrate gut symbiont Lactobacillus reuteri has diversified into separate clades reflecting host origin. Strains show evidence of host adaptation, but how host-microbe co-evolution influences microbial-derived effects on hosts is poorly understood. Emphasizing human-derived strains of L. reuteri, we combined comparative genomic analyses with functional assays to examine variations in ...
Ghosh Arnab A Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, - - 2014
Conserved ribosomal proteins frequently harbor additional segments in eukaryotes not found in bacteria, which could facilitate eukaryotic-specific reactions in the initiation phase of protein synthesis. Here we provide evidence showing that truncation of the N-terminal domain (NTD) of yeast Rps5 (absent in bacterial ortholog S7) impairs translation initiation, cell growth ...
Delijewski Marcin M Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Silesia, Jagiellońska 4, 41-200, Sosnowiec, - - 2014
Nicotine is a compound of tobacco plants and is responsible for addictive properties of tobacco which is used by about one billion of smokers all over the world. Recently, nicotine has drawn even more attention due to its presumed neuroprotective and antioxidant features as far as common use in various ...
Shuai Peng P College of Biological Sciences and Technology, National Engineering Laboratory of Tree Breeding, Beijing Forestry University, mailbox 69, No. 35 Qinghua East Road, Haidian District, Beijing 100083, P.R. - - 2014
Protein-coding genes are considered to be a dominant component of the eukaryotic transcriptome; however, many studies have shown that intergenic, non-coding transcripts also play an important role. Long intergenic non-coding RNAs (lincRNAs) were found to play a vital role in human and Arabidopsis. However, lincRNAs and their regulatory roles remain ...
Wu Rongmei R The New Zealand Institute for Plant & Food Research Limited (Plant & Food Research) Mt Albert, Private Bag 92169, Auckland 1142, New - - 2014
SVP-like MADS domain transcription factors have been shown to regulate flowering time and both inflorescence and flower development in annual plants, while having effects on growth cessation and terminal bud formation in perennial species. Previously, four SVP genes were described in woody perennial vine kiwifruit (Actinidia spp.), with possible distinct ...
Glaser Adam K AK Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, - - 2014
Recent studies have proposed that light emitted by the Cherenkov effect may be used for a number of radiation therapy dosimetry applications. There is a correlation between the captured light and expected dose under certain conditions, yet discrepancies have also been observed and a complete examination of the theoretical differences ...
Mahmood Khalid K School of Advanced Materials Science & Engineering, Sungkyunkwan University , Suwon 440-746, Republic of - - 2014
The realization of arrays of high-aspect-ratio nitrogen-doped ZnO (NZO) nanorod is critical to the development of high-quality nanostructure-based optoelectronic and electronic devices. In this study, we used a solution-based method to grow arrays of vertically aligned high-aspect-ratio NZO nanorods on ZnO seed layer covered fluorine-doped tin oxide substrates. We investigated ...
Cen Yao - - 2014
Phospholipase D (PLD) is a critical component of intracellular signal transduction and has been implicated in many important biological processes. It has been observed that there are abnormalities in PLD expression in many human cancers, and PLD is thus recognized as a potential diagnostic biomarker as well as target for ...
Cheal Sarah M SM Radiology, Memorial Sloan-Kettering Cancer - - 2014
Bispecific antibodies (BsAb) have proven to be useful targeting vectors for pretargeted radioimmunotherapy (PRIT). We sought to overcome key PRIT limitations such as high renal radiation exposure and immunogenicity (e.g. of streptavidin-antibody fusions), to advance clinical translation of this PRIT strategy for diasialoganglioside GD2-positive (GD2(+)) tumors. For this purpose, a ...
Mostafa Nesrine Z NZ University of Alberta, Dentistry, Edmonton, Alberta, Canada ; - - 2014
Background: Absorbable collagen sponge (ACS) loaded with bone morphogenetic protein-2 (BMP-2) is approved for selected clinical applications, however burst release limits its widespread use. Therefore, nanofiber (NF) based scaffold with ACS backbone was developed to sustain release of loaded BMP-2 to improve the outcomes of bone grafting in a rodent ...
Schultz Aaron G AG University of - - 2014
Inorganic phosphate (Pi) is an essential nutrient for all organisms, but in seawater Pi is a limiting nutrient. This study investigated the primary mechanisms of Pi uptake in Pacific hagfish (Eptatretus stoutii) using ex vivo physiological, and molecular techniques. Hagfish were observed to have the capacity to absorb Pi from ...
Nakatani Shimpei S Thoraxcenter, Department of Cardiology, Erasmus - - 2014
Background:Quantitative light intensity analysis of the strut core by optical coherence tomography (OCT) may enable assessment of changes in the light reflectivity of the bioresorbable polymeric scaffold from polymer to provisional matrix and connective tissues, with full disappearance and integration of the scaffold into the vessel wall. The aim of ...
Zhou Gang G Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, - - 2014
Burn wound dressings have played significant roles in daily clinical practice. An "ideal" burn wound dressing is non-adhesion, absorbency and antimicrobial activity. However, such a dressing is currently not available. A novel composite hydrogel was based on poly (vinyl alcohol) (PVA) containing lysine (Lys) and vanillin (V) using freezing-thawing method. ...
Pandie Shaheen - - 2014
Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. The utility of the new quantitative PCR test (Xpert MTB/RIF) for the diagnosis of TBP is unknown. This study ...
Shanmugam Vijayalakshmi - - 2014
The outcome of patients with metastatic colorectal carcinoma (mCRC) following first line therapy is poor, with median survival of less than one year. The purpose of this study was to identify candidate therapeutically targetable somatic events in mCRC patient samples by whole genome sequencing (WGS), so as to obtain targeted ...
Govender Kaymarlin - - 2014
Recent studies have questioned whether orphanhood is primarily associated with key dimensions of psycho-social wellbeing in children living in circumstances of material deprivation and high prevalence of HIV and AIDS. This study uses cross-sectional data from a longitudinal study conducted between 2004-2007 to examine the psychosocial well-being of orphans and ...
Doderer-Lang Cécile - - 2014
Malaria Is A Life-Threatening Pathology In Africa. Plasmodium Falciparum And Plasmodium Vivax Attract The Most Focus Because Of Their High Prevalence And Mortality. Knowledge About The Prevalence Of The Cryptic Pathogens Plasmodium Ovale And Plasmodium Malariae Is Limited. Thanks To Recombinant Tools, Their Seroprevalence Was Measured For The First Time, ...
Nacul Luis - - 2014
Our aim, having previously investigated through a qualitative study involving extensive discussions with experts and patients the issues involved in establishing and maintaining a disease specific brain and tissue bank for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), was to develop a protocol for a UK ME/CFS repository of high quality human ...
Uzan Jennifer - - 2014
Colouterine fistula is a very rare condition; most cases described in the literature are secondary to complications of diverticulitis in elderly patients. We report the case of a 34-year-old African woman who presented with a colouterine fistula secondary to polymyomectomy, which was diagnosed in the setting of severe endometritis. She ...
Adachi-Hayama Masayo - - 2014
Glioma is the most common primary malignant central nervous system tumor in adult, and is usually not curable due to its invasive nature. Establishment of serum biomarkers for glioma would be beneficial both for early diagnosis and adequate therapeutic intervention. Filamins are an actin cross-linker and FLNC, normally restricted in ...
French Rebecca S - - 2014
Men who have sex with men (MSM) are at increased risk of HIV infection in both high- and low-income settings. Mass media campaigns have been used as a means of communicating HIV health promotion messages to large audiences of MSM. There is no consensus on which designs are most appropriate ...
Nakabayashi Makoto M Biomass Refinery Research Center, National Institute of Advanced Industrial Science, 3-11-32 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, - - 2014
One of the β-glucosidases from Pyrococcus furiosus (BGLPf) is found to be a hyperthermophilic tetrameric enzyme that can degrade cellooligosaccharides. Recently, the crystal structures of the tetrameric and dimeric forms were solved. Here, a new monomeric form of BGLPf was constructed by removing the C-terminal region of the enzyme and ...
Kataoka Misumi M Biomass Refinery Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 3-11-32 Kagamiyama, Higashi-hiroshima, Hiroshima 739-0046, - - 2014
The hyperthermophilic glycoside hydrolase family endocellulase 12 from the archaeon Pyrococcus furiosus (EGPf; Gene ID PF0854; EC 3.2.1.4) catalyzes the hydrolytic cleavage of the β-1,4-glucosidic linkage in β-glucan in lignocellulose biomass. A crystal of EGPf was previously prepared at pH 9.0 and its structure was determined at an atomic resolution ...
Kovačič M M University of Ljubljana, Faculty of Electrical Engineering, Tržaška 25, Si-1000 Ljubljana, - - 2014
The detection of biomolecules based on fluorescence measurements is a powerful diagnostic tool for the acquisition of genetic, proteomic and cellular information. One key performance limiting factor remains the integrated optical filter, which is designed to reject strong excitation light while transmitting weak emission (fluorescent) light to the photodetector. Conventional ...
Tirino Pasquale P Institute for Polymers, Composites and Biomaterials, CNR, Via Campi Flegrei 34, 80078 Pozzuoli (Naples), Italy. Electronic address: - - 2014
In this work, a well-defined hydrogel was developed by coupling chitosan with PEO through "click chemistry". Azide functionalities were introduced onto chitosan, through mesylation of C-6 hydroxyl groups, and reacted with a di-alkyne PEO by a regioselective Cu(I)-catalyzed cycloaddition. This synthetic approach allowed us to obtain a hydrogel with a ...
Bai Li-Ping LP State Key Laboratory of Quality Research in Chinese Medicine, and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, - - 2014
A comparative study on human telomeric DNA G-quadruplex binding of meso-5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin (TMPyP4) between its two salt forms, i.e., tetratosylate and tetrachloride, was conducted by using ESI-TOF-MS, UV-melting measurement, and molecular modeling methods. Besides cation TMPyP4, the tosyl anion was found to bind to human telomeric DNA G-quadruplex with multiple binding ...
Patanwala Imran I From the Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (IP, MH, and DEJ); the Institute of Food Research, Norwich Research Park, Norwich, United Kingdom (MJK, MP, JRD, AJAW, and PMF); the Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom (DAB); and the Department of Radiology, Freeman Hospital, Newcastle upon Tyne, United Kingdom (JR and - - 2014
Current thinking, which is based mainly on rodent studies, is that physiologic doses of folic acid (pterylmonoglutamic acid), such as dietary vitamin folates, are biotransformed in the intestinal mucosa and transferred to the portal vein as the natural circulating plasma folate, 5-methyltetrahydrofolic acid (5-MTHF) before entering the liver and the ...
Hęś Marzanna M Department of Food Service and Catering, Poznań University of Life Sciences, 60-637, Poznań, - - 2014
In recent years, there has been an ever-increasing interest in the research of polyphenols obtained from dietary sources, and their antioxidative properties. The purpose of this study was to determine the effect of boiling buckwheat and barley groats on the antioxidant properties and dietary fiber composition. Antioxidative properties were investigated ...
Shin Ryoung R RIKEN Center for Sustainable Resource Science, Yokohama 230-0045, - - 2014
Potassium is a macronutrient that is crucial for healthy plant growth. Potassium availability, however, is often limited in agricultural fields and thus crop yields and quality are reduced. Therefore, improving the efficiency of potassium uptake and transport, as well as its utilization, in plants is important for agricultural sustainability. This ...
Li Yiming - - 2014
We describe the characterization of degradation products responsible for color change in near UV-visible light-irradiated and heat-stressed monoclonal antibody (mAb) drug product in liquid formulation. The treated samples were characterized using reversed phase HPLC and size exclusion HPLC with absorption spectroscopy. Both methods showed color change was due to chromophores ...
Choi Jae Moon JM Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap 2-dong, Songpa-gu, Seoul, 138-736, Korea, - - 2014
Roitman Pablo P Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel, - - 2014
Many patients with post-traumatic stress disorder (PTSD) achieve but partial remission with current treatments. Patients with unremitted PTSD show high rates of substance abuse. Marijuana is often used as compassion add-on therapy for treatment-resistant PTSD. This open-label study evaluates the tolerance and safety of orally absorbable Δ(9)-tetrahydrocannabinol (THC) for chronic ...
Song Yan Y Key Laboratory of Applied Chemistry and Nanotechnology at Universities of Jilin Province, Changchun University of Science and Technology, Changchun 130022, P. R. China. - - 2014
A core-shell hybrid nanostructure was prepared by combining NaYF4 doped with the lanthanide dopant Tb(3+) as shell layer materials and noble metal nanoparticles (Au and Ag) as cores. For the core-shell system, the luminescence resonance energy transfer (LRET) was demonstrated, in which noble metal nanoparticles as fluorescence quenchers can absorb ...
Hilal M A MA Analytical Chemistry and Control Department, Hot Laboratories and Waste Management Center (HLWMC), Atomic Energy Authority, Post Office No. 13759, Cairo, - - 2014
In this study, a potential radiation hazard from TENORM sludge wastes generated during exploration and extraction processes of oil and gas was evaluated. The activity concentration of natural radionuclides (238)U, (226)Ra and (232)Th were determined in TENORM sludge waste. It was found that sludge waste from oil and gas industry ...
Thorne David - - 2014
Tobacco smoke toxicity has traditionally been assessed using the particulate fraction under submerged culture conditions which omits the vapour phase elements from any subsequent analysis. Therefore, methodologies that assess the full interactions and complexities of tobacco smoke are required. Here we describe the adaption of a modified BALB/c 3T3 neutral ...
Qu Yiqing - - 2014
Purpose: Although the EGF receptor tyrosine kinase inhibitors (EGFR-TKI) gefitinib have shown dramatic effects against EGFR mutant lung cancer, patients become resistant by various mechanisms, including gatekeeper EGFR-T790M mutation, MET amplification, and KRAS mutation, thereafter relapsing. AZD6244 is a potent, selective, and orally available MEK1/2 inhibitor. In this study, we ...
Myles Ian A - - 2014
While numerous changes in human lifestyle constitute modern life, our diet has been gaining attention as a potential contributor to the increase in immune-mediated diseases. The Western diet is characterized by an over consumption and reduced variety of refined sugars, salt, and saturated fat. Herein our objective is to detail ...
Decorte Inge - - 2014
Oral fluid collected by means of ropes has the potential to replace serum for monitoring and surveillance of important swine pathogens. Until now, the most commonly used method to collect oral fluid is by hanging a cotton rope in a pen. However, concerns about the influence of rope material on ...
Mello Marcia Bc - - 2014
Due to students' initial inexperience, slides are frequently broken and blood smears are damaged in microscopy training, leading to the need for their constant replacement. To minimize this problem a method of preparing blood smears on transparent acetate sheets was developed with the goal of implementing appropriate and more readily ...
Fujita Naoyuki - - 2014
Vascular endothelial growth factor (VEGF) plays a major role in angiogenesis. One of the functions of VEGF is to regulate neovascularization in clear cell renal cell carcinoma (CCRCC). The objective of our study was to examine whether before nephrectomy serum levels of VEGF or expression of VEGF using immunohistochemistry (IHC) ...
Vakondios Nikos N Department of Environmental Engineering, Technical University of Crete, 73100 Chania, Crete, - - 2014
This work developed a method, based on the Lowry method and Frølund modification, for the simultaneous determination of proteins and humic matter in wastewater effluent samples at low concentrations. The method was based on simultaneous spectrophotometric measurements of proteins and humic matter at 750 nm in the absence and presence of ...
Sun Jiangwen - - 2014
Accurate classification of patients with a complex disease into subtypes has important implications formedicine and healthcare. Using more homogeneous disease subtypes in genetic association analysiswill facilitate the detection of new genetic variants that are not detectible using the non-differentiateddisease phenotype. Subtype differentiation can also improve diagnostic classification, which canin turn ...
Sultan Muhammad Tauseef - - 2014
Nigella sativa fixed (NSFO) and essential (NSEO) oils have been used to treat diabetes mellitus and its complications. Present study was undertaken to explore and validate these folkloric uses. Sprague dawley rats having streptozotocin (STZ) induced diabetes mellitus were used to assess the role of NSFO and NSEO in the ...
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