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Yazdankhah Siamak P - - 2006
Triclosan is a widely used biocide that is considered as an effective antimicrobial agent against different microorganisms. It is included in many contemporary consumer and personal health-care products, like oral and dermal products, but also in household items, including plastics and textiles. At bactericidal concentrations, triclosan appears to act upon ...
Relevancy Score: Relevancy Score: 505
Kjaerheim V - - 1995
Previous studies indicate that triclosan reduces the pain and other symptoms after chemically-induced inflammation in the oral mucosa and skin when sodium lauryl sulfate (SLS) is used as an irritant. The aim of the present study was to examine whether triclosan has an effect on the inflammation in human skin ...
Relevancy Score: Relevancy Score: 505
Krishnakumar B - - 2011
The effect of antimicrobial chemical, triclosan (TCS) on protozoa present in aerobic and anaerobic bioreactors for wastewater treatment is reported in this study. Bioreactor sludge ciliated protozoa such as Spirostomum, Cyclidium and Colpoda and flagellated protozoa Mastigella were exposed to TCS at 1 mg/L level in batch cultures. The response ...
Relevancy Score: Relevancy Score: 504
Foran C M - - 2000
Triclosan is an antibacterial agent commonly used in industry and often detected in waste-water effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e.g. DES, bisphenol A). Japanese medaka fry (Oryzias latipes) were exposed for 14 days ...
Relevancy Score: Relevancy Score: 504
Jang Hyeung-Jin - - 2008
For the first time, a genome-wide transcriptional analysis was performed to elucidate the cellular response of Staphylococcus aureus to triclosan. Our results indicate that the effects of triclosan are widespread on metabolism, affecting many vital cellular processes. Triclosan downregulated the transcription of genes involved in virulence factor and energy metabolism ...
Relevancy Score: Relevancy Score: 504
Guillén Jaime - - 2004
Triclosan is a hydrophobic antibacterial agent used in dermatological preparations and oral hygiene products. Although the molecular mechanism of action of this molecule has been attributed to inhibition of fatty acid biosynthesis, earlier work in our laboratories strongly suggested that the antibacterial action of Triclosan is mediated at least partly ...
Relevancy Score: Relevancy Score: 504
Wiƛniewska Katarzyna - - 2006
Susceptibility to triclosan in Staphylococcus aureus was determined. The study was carried out on 200 strains, including 100 resistant (MRSA) and 100 susceptibile (MSSA) to methicillin. The examined strains were isolated from varied clinical samples and patients in 18 medical centers, in majority from hospitals in the region of Gdansk. ...
Relevancy Score: Relevancy Score: 503
Lu Huihui - - 2009
A spectrophotometric method for the determination of triclosan in personal care products was proposed. It was based on the reaction of sodium nitrite with p-sulfanilic acid in an acidic medium to form diazonium ion, with which triclosan further formed an azo compound in an alkaline medium. The resulting yellow colored ...
Relevancy Score: Relevancy Score: 503
Roujeinikova A - - 1999
Molecular genetic studies with strains of Escherichia coli resistant to triclosan, an ingredient of many anti-bacterial household goods, have suggested that this compound works by acting as an inhibitor of enoyl reductase (ENR) and thereby blocking lipid biosynthesis. We present structural analyses correlated with inhibition data, on the complexes of ...
Relevancy Score: Relevancy Score: 503
Schweizer H P - - 2001
Triclosan is the active ingredient in a multitude of health care and consumer products with germicidal properties, which have flooded the market in recent years in response to the public's fear of communicable bacteria. Although originally thought to kill bacteria by attacking multiple cellular targets, triclosan was recently shown to ...
Relevancy Score: Relevancy Score: 503
Bertelsen R J RJ Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, N-0403 Oslo, Norway. - - 2013
Exposure to the synthetic antimicrobial chemical, triclosan, used in personal care products, has been hypothesized to lead to allergic disease. We investigated whether triclosan exposure was associated with allergic sensitization and symptoms in 10-year-old Norwegian children. Urinary concentrations of triclosan were measured in one first morning void from 623 children, ...
Relevancy Score: Relevancy Score: 503
McNamara Patrick J - - 2013
Triclosan is an antimicrobial agent that is discharged to soils with land-applied wastewater biosolids, is persistent under anaerobic conditions, and yet its impact on anaerobic microbial communities in soils is largely unknown. We hypothesized that triclosan enriches for Dehalococcoides-like Chloroflexi because these bacteria respire organochlorides and are likely less sensitive, ...
Relevancy Score: Relevancy Score: 500
Lankester Joanna - - 2013
Triclosan-a ubiquitous chemical in toothpastes, soaps, and household cleaning supplies-has the potential to alter both gut microbiota and endocrine function and thereby affect body weight. We investigated the relationship between triclosan and body mass index (BMI) using National Health and Nutrition Examination Surveys (NHANES) from 2003-2008. BMI and spot urinary ...
Relevancy Score: Relevancy Score: 500
Wu Jianlin - - 2009
Triclosan has been widely used as a disinfectant in human health care products. Although this particular chemical is less toxic, its biotransformation products might have toxicity to human. Therefore, understanding the pharmacokinetics and metabolism of triclosan in animal and human body is important. Plasma samples from SD rats collected after ...
Relevancy Score: Relevancy Score: 500
Kawanai Takuya - - 2011
The effects of triclosan, an environmental pollutant from household items and health care products, on membrane potential and intracellular Ca(2+) concentrations of rat thymocytes were examined by a flow cytometry with fluorescent probes, di-BA-C(4) and fluo-3-AM, because triclosan is often found in humans and wild animals. Triclosan at a concentration ...
Relevancy Score: Relevancy Score: 500
Ren Yan-Ze YZ Institute of Technical Chemistry and Environmental Chemistry, Friedrich-Schiller-University Jena, Lessingstr.12, 07743 Jena, - - 2014
The sonoelectrochemical degradation of triclosan in aqueous solutions with high-frequency ultrasound (850kHz) and various electrodes was investigated. Diamond coated niobium electrode showed the best results and was used as standard electrode, leading to effective degradation and positive synergistic effect. The influence of different parameters on the degradation degree and energy ...
Relevancy Score: Relevancy Score: 500
Srinivasan Shashank - - 2013
To compare the delivery and retention of triclosan in dental plaque, and to compare the antibacterial efficacy of a newly developed toothpaste to a marketed calcium carbonate toothpaste. Two clinical delivery/retention studies were carried out to determine the concentration of triclosan in plaque 10 minutes, and two and four hours ...
Relevancy Score: Relevancy Score: 500
Wallet Ma - - 2013
Periodontal diseases are a class of pathologies wherein oral microbes induce harmful immune responses in a susceptible host. Therefore, an agent that can both reduce microbial burden and lessen pathogenesis of localized inflammation would have beneficial effects in periodontal disease; 2,4,4-trichloro-2-hydroxydiphenyl-ether [triclosan] is currently used in oral care products owing ...
Relevancy Score: Relevancy Score: 499
Yang Bin - - 2010
The oxidation of triclosan by commercial grade aqueous ferrate (Fe(VI)) was investigated and the reaction kinetics as a function of pH (7.0-10.0) were experimentally determined. Intermediate products of the oxidation process were characterized using both GC-MS and RRLC-MS/MS techniques. Changes in toxicity during the oxidation process of triclosan using Fe(VI) ...
Relevancy Score: Relevancy Score: 499
Sheridan A - - 2013
Triclosan is a biocidal active agent commonly used in domestic and industrial formulations. Currently, there is limited understanding of the mechanisms involved in triclosan tolerance in E. coli O157. The aim of this study was to identify the differences between a triclosan susceptible E. coli O157:H19 isolate (minimum inhibitory concentration; ...
Relevancy Score: Relevancy Score: 499
Copitch Justin L - - 2010
Previous laboratory studies have implicated triclosan as a possible selective force driving resistance to multiple antibiotics and have identified a number of triclosan resistance mechanisms in Salmonella enterica. The aim of this work was to determine the prevalence of decreased susceptibility to triclosan in a panel of human and animal ...
Relevancy Score: Relevancy Score: 498
Gilbert R J - - 1987
An antiplaque toothpaste containing 0.2% (w/w) triclosan significantly inhibited overnight plaque growth in 12 human volunteers. After use of a 1 g quantity of the toothpaste containing 0.2% (w/w) [3H]-triclosan, 36.3 +/- 1.4% of the triclosan was retained. The mean concentration (+/- s.d.) achieved in saliva 5 min after toothpaste ...
Relevancy Score: Relevancy Score: 498
Qiao Xianliang X Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Linggong Road 2, Dalian 116024, PR China. Electronic address: - - 2014
Triclosan has received extensive attention as it has been frequently detected in the aquatic environment. Photolysis was found to be a major pathway governing the fate of triclosan in the aquatic environment. However, the effects of surfactants that usually coexist with triclosan, on the photodegradation of triclosan, are largely unknown. ...
Relevancy Score: Relevancy Score: 498
Farré Marinella - - 2008
In this work, the contributions of triclosan and its metabolite methyl triclosan to the overall acute toxicity of wastewater were studied using Vibrio fischeri. The protocol used in this paper involved various steps. First, the aquatic toxicities of triclosan and methyl triclosan were determined for standard substances, and the 50% ...
Relevancy Score: Relevancy Score: 497
Uhl S - - 1993
Relevancy Score: Relevancy Score: 495
Engelhaupt Erika - - 2007
Relevancy Score: Relevancy Score: 495
Hundt K - - 2000
We investigated the ability of Trametes versicolor and Pycnoporous cinnabarinus to metabolize triclosan. T. versicolor produced three metabolites, 2-O-(2,4,4'-trichlorodiphenyl ether)-beta-D-xylopyranoside, 2-O-(2,4,4'-trichlorodiphenyl ether)-beta-D-glucopyranoside, and 2,4-dichlorophenol. P. cinnabarinus converted triclosan to 2,4, 4'-trichloro-2'-methoxydiphenyl ether and the glucoside conjugate known from T. versicolor. The conjugates showed a distinctly lower cytotoxic and microbicidal activity ...
Relevancy Score: Relevancy Score: 495
Queckenberg Christian - - 2010
We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% +/- 2.1% of the dose (mean +/- standard deviation). The amount absorbed suggests that daily application of a standard adult ...
Relevancy Score: Relevancy Score: 495
Darouiche Rabih O - - 2009
OBJECTIVES: The objectives of this study were to examine: (i) synergy of the combination of triclosan and DispersinB (DspB); (ii) in vitro efficacy and durability of triclosan + DspB-coated vascular catheters; and (iii) in vivo efficacy of triclosan + DspB-coated catheters compared with chlorhexidine-silver sulfadiazine (CH-SS)-coated and uncoated (control) vascular ...
Relevancy Score: Relevancy Score: 495
Gee R H - - 2008
As a consequence of its widespread use as an antimicrobial agent in consumer goods, triclosan has become distributed ubiquitously across the ecosystem, and recent reports that it can cause endocrine disruption in aquatic species has increased concern. It is reported here that triclosan possesses intrinsic oestrogenic and androgenic activity in ...
Relevancy Score: Relevancy Score: 495
Morrall Donna - - 2004
Triclosan (TCS) is an anti-microbial agent used in down-the-drain consumer products. Following sewage treatment some of the triclosan will enter receiving waters. This study was designed to determine the die-away rate of triclosan released into a river as part of the sewage treatment plant effluent matrix. The study was conducted ...
Relevancy Score: Relevancy Score: 494
Rodríguez-Cruz Isabel M - - 2012
The aim of this study was to evaluate the passive and iontophoretic permeation of triclosan in human skin using a triclosan solution and triclosan-loaded cationic nanospheres in order to determine which of the two strategies is more effective in allowing the deposition of triclosan within the skin. Triclosan-loaded nanospheres were ...
Relevancy Score: Relevancy Score: 494
Chuanchuen Rungtip - - 2012
Global gene transcription was assessed by microarray experiments following treatment of a triclosan-susceptible Δ(mexAB-oprM) Pseudomonas aeruginosa strain with subinhibitory concentrations of triclosan. Expression patterns of selected genes were verified by quantitative real-time PCR analysis. The results showed that triclosan exposure had a profound effect on gene expression, affecting 44% of ...
Relevancy Score: Relevancy Score: 493
Babich H - - 1997
Triclosan and sodium lauryl sulfate (SLS) are antimicrobial agents used, both singularly and in combination, in dentifrices and mouth-rinses. Studies by Waaler et al. (Scand. J. Dent. Res. 101 (1993) 192-195) with human volunteers showed that the adverse side-effects induced by SLS in mouth-rinses, i.e. desquamation of oral epithelium and ...
Relevancy Score: Relevancy Score: 492
McBain Andrew J - - 2004
OBJECTIVES: To investigate the effect of triclosan exposure on the antimicrobial susceptibilities of numerically important dental bacteria. METHODS: A gradient plate technique was used to expose Fusobacterium nucleatum, Lactobacillus rhamnosus, Neisseria subflava, Porphyromonas gingivalis, Actinomyces naeslundii, Prevotella nigrescens, Streptococcus oralis, Streptococcus sanguis, Streptococcus mutans and Veillonella dispar repeatedly to escalating, ...
Relevancy Score: Relevancy Score: 492
Winitthana Thidarat T Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, - - 2014
Alteration of cancer cell toward mesenchymal phenotype has been shown to potentiate tumor aggressiveness by increasing cancer cell metastasis. Herein, we report the effect of triclosan, a widely used antibacterial agent found in many daily products, in enhancing the epithelial-to-mesenchymal transition (EMT) in aggressive anoikis resistant human H460 lung cancer ...
Relevancy Score: Relevancy Score: 492
Tamura Ikumi - - 2011
Triclosan is used as an antibacterial agent in household items and personal care products. Since this compound is found in maternal milk of humans and bodies of wild animals, there is growing concern among some consumer groups and scientific community that triclosan is adverse for humans and wild animals. In ...
Relevancy Score: Relevancy Score: 491
Bagley D M - - 2000
PURPOSE: To demonstrate through clinical pharmacokinetic studies that triclosan does not accumulate in blood or plasma in human subjects who regularly use triclosan-containing dentifrice. MATERIALS AND METHODS: Three clinical pharmacokinetic studies were conducted to assess the blood or plasma levels of triclosan following toothbrushing with dentifrice formulations containing triclosan. In ...
Relevancy Score: Relevancy Score: 491
Møretrø Trond - - 2006
Antibacterial surfaces are increasingly used in the food industry. In the present study, the antibacterial effect of a triclosan-containing industrial floor was assessed. A poultry processing plant, which had a floor that contained triclosan, was visited, and the floor was sampled for bacteria. A high bacterial diversity was found on ...
Relevancy Score: Relevancy Score: 490
Tsai Shih-Wei - - 2008
Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) is a widely used antibacterial agent. However, it was concerned recently that triclosan might act as an antibiotic and will cause resistant bacterial strains. Furthermore, possible formation of toxic chloroform was also reported when the triclosan contained in household dishwashing soaps reacted with the chlorinated water. To ...
Relevancy Score: Relevancy Score: 490
Gaffar A - - 1990
A dentifrice containing triclosan/PVM/MA, Colgate Gum Protection Formula Toothpaste (GPF), was found to be highly effective against oral bacteria with minimal inhibitory concentration ranging from 0.3 to 5.35 micrograms/ml. A variety of in vitro model systems simulating oral environment were used to compare dentifrices containing triclosan/PVM/MA versus the dentifrices containing ...
Relevancy Score: Relevancy Score: 489
Dóri F - - 1999
The purpose of this work was to assess the in vitro antibacterial effectiveness of three dentifrices containing antimicrobial agents and to test the in vivo anti plaque and anti gingivitis effect of a toothpaste containing triclosan (CAOLA). The in vitro tests showed a marked antibacterial effect of both triclosan and ...
Relevancy Score: Relevancy Score: 488
Jenkins S - - 1993
Triclosan is used in toothpastes and mouthrinses as a plaque inhibitory agent. The concentrations used and therefore the dose of triclosan varies between products and there is, as with most plaque inhibitory agents, little information on the dose response of this agent. The purpose of this investigation was to measure ...
Relevancy Score: Relevancy Score: 488
Escalada M Gomez - - 2005
AIMS: To investigate the inhibitory and lethal effects of triclosan against several micro-organisms at different stages of their phase of population growth. METHODS AND RESULTS: Triclosan minimum inhibitory concentrations against several test organisms were determined in broth and agar using standard protocols. The bisphenol effect on bacterial population growth kinetics ...
Relevancy Score: Relevancy Score: 488
Imazato S - - 1995
It has been shown that composite incorporating the antibacterial agent Triclosan (Irgasan DP 300, which is sparingly soluble in water, inhibited in vitro plaque formation by Streptococcus mutans, although the release of the agent was much less than the minimum inhibitory concentration for the bacterium. In this study, the inhibitory ...
Relevancy Score: Relevancy Score: 488
Fuchsman Phyllis - - 2010
Triclosan is an antimicrobial compound found in many consumer products including soaps and personal care products. Most triclosan is disposed of down household drains, whereupon it is conveyed to wastewater treatment plants. Although a high percentage of triclosan biodegrades during wastewater treatment, most of the remainder is adsorbed to sludge, ...
Relevancy Score: Relevancy Score: 488
Yu Byung Jo - - 2010
OBJECTIVES: To gain further insight into the defence mechanisms against triclosan in a mutant derived from an Escherichia coli strain carrying the triclosan-resistant target enzyme, FabI(G93V). METHODS: An E. coli imp4231 FabI(G93V) strain was constructed by replacing intact fabI with a linear DNA cassette, fabI(G93V)-CmR, that contains a single mutation, ...
Relevancy Score: Relevancy Score: 488
Sanches-Silva Ana - - 2005
A reverse-phase high-performance liquid chromatographic (RP-HPLC) method coupled with an ultraviolet detector was developed to determine triclosan which had migrated into foodstuffs from packaging materials. The method includes extraction with hexane, followed by evaporation to dryness and residue re-dissolution in ACN 90%. Chromatographic separation was performed with a Kromasil 100 ...
Relevancy Score: Relevancy Score: 487
Rölla G - - 1993
Polydimethylsiloxan (silicone oil) adsorbs to solid surfaces and to teeth because of its low surface tension, forming a thin, resistant layer. Triclosan is a lipid-soluble, antibacterial substance which is added to toothpastes and mouthwashes to inhibit plaque. Triclosan can be dissolved in silicone oil, conferring an antibacterial property on the ...
Relevancy Score: Relevancy Score: 487
Otero Elver E Química de Plantas Colombianas, Instituto de Química, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, A.A 1226 Medellín, Colombia. - - 2014
Twelve hybrids derived from triclosan were obtained via Williamson etherification of O-triclosan alkyl bromide plus chalcone and O-coumarin or O-chromone alkyl bromide plus triclosan, respectively. Structures of the products were elucidated by spectroscopic analysis. The synthesized compounds were evaluated for antileishmanial activity against L. (V) panamensis amastigotes. Cytotoxic activity was ...
Relevancy Score: Relevancy Score: 486
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