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Roberts L - - 2000
This study examines histomorphometric features in chorionic villi obtained by chorionic villus sampling (CVS) at 11-14 weeks of gestation from 124 ongoing pregnancies (38 with trisomy 21, 14 with trisomy 18, 11 with trisomy 13 and 61 chromosomally normal controls). In the trisomy 21 group there was an inverse relationship ...
Relevancy Score: Relevancy Score: 229
Vives i Corrons J L - - 2000
In 1972, Valentine et al described, under the name of 'non-spherocytic haemolytic anaemia, high red cell ATP and ribose phosphate pyrophosphokinase (RPK; EC 2.7.6.1) deficiency', an obscure congenital haemolytic anaemia with the characteristic feature of red blood cell basophilic stippling. The activity of Embden-Meyerhof pathway and hexose monophosphate shunt were ...
Relevancy Score: Relevancy Score: 223
Lumeij J T - - 1986
The diagnosis and treatment of a case of lead poisoning in a cynomolgus monkey (Macaca fascicularis) are described. The clinical signs were jaundice and amaurosis. Clinicopathological findings suggested cholestasis. A tentative diagnosis of lead poisoning was made when basophilic stippling of erythrocytes was observed in a peripheral blood smear. The ...
Relevancy Score: Relevancy Score: 220
Rosa R - - 1977
A new case of a defect in red cell pyrimidine 5'-nucleotide (P5N) activity was found in a large family from Guadeloupe in the West Indies. The propositus presented a characteristic hemolytic anemia with red cell basophilic stippling, an increased GSH level, and a shift of the peak in absorbance of ...
Relevancy Score: Relevancy Score: 220
Masuda M - - 1996
Abnormalities in erythrocyte nucleotide metabolism are associated with hereditary nonspherocytic hemolytic anemia. Deficiency of adenylate kinase and pyrimidine 5'-nucleotidase and hyperactivity of adenosine deaminase shorten the red cell lifespan. Deficiency of adenylate kinase has been reported in four different families. Although in one family, total absence of this enzymatic activity ...
Relevancy Score: Relevancy Score: 220
Sherazi Syed Furqan Haider - - 2012
AML-M6 has a peak incidence in the seventh decade with slight male preponderance, and can also present at a younger age. The usual features are anaemia, thrombocytopenia, malaise, fatigue, easy bruising, epistaxis and petechiae. Splenomegaly may occur in 20-40 % of the cases but massive splenomegaly is rare presentation and ...
Relevancy Score: Relevancy Score: 220
Williams J H - - 1990
A case of lead poisoning caused by ingestion of a lead roof-washer is described in a one-year-old, spayed Fox Terrier bitch, presented with nervous signs, and basophilic stippling of red blood cells. Blood concentrations of lead were in the low toxic range. Radiography of the abdomen revealed radio-dense objects in ...
Relevancy Score: Relevancy Score: 220
Lassen E D - - 1979
Thirty pigs, weighing 17 to 24 kg, were exposed to lead or sodium acetate orally or intraperitoneally (IP) 6 days each week for 13 weeks. These pigs were extremely tolerant of lead. Only mild clinical signs of lead toxicosis were observed in orally lead-exposed pigs despite blood lead concentrations of ...
Relevancy Score: Relevancy Score: 220
Muller Halima H Service de Médecine Interne, Hôpital de la Tour, Geneva, - - 2013
A 42-year-old man from Bhutan was admitted to the emergency department with a 5-day history of abdominal pain, nausea and vomiting. Enhanced abdominal CT scan was found negative, however laboratory tests showed hemolytic anemia and basophilic stippling which are often seen in lead and heavy metal poisoning. Additional tests revealed ...
Relevancy Score: Relevancy Score: 220
Havelda C J - - 1980
To assess the usefulness of various routine and inexpensive tests widely used in the detection of an increased body lead load, the whole blood lead value, the 24-hour urinary excretion of lead, delta-aminolevulinic acid (DALA) and coproporphyrin, the presence of basophilic stippling and the whole blood osmotic fragility test were ...
Relevancy Score: Relevancy Score: 220
Pekrun A - - 1993
An 11-year-old girl had marked haemolytic anaemia since the first year of life. Physical examination revealed scleral and cutaneous icterus and slight splenomegaly. Haemoglobin concentration was reduced to 9.5 g/dl, while platelet count and bilirubin concentration were increased (350,000/microliter and 2.2 mg/dl, respectively). The erythrocytes showed marked basophilic stippling, its ...
Relevancy Score: Relevancy Score: 220
Uchida T A - - 1985
The intra-erythrocytic merozoite of Theileria sergenti was 2.2 to 2.4 micron long; several mitochondria and a large nucleus lay at the anterior and posterior part of the cell, respectively, and free ribosomes were evenly scattered in the cytoplasm. A micropore located at the antero-ventral side of the protozoon was framed ...
Relevancy Score: Relevancy Score: 220
Shiri Rahman - - 2007
Severe abdominal colic because of lead poisoning is an uncommon condition in adults. The diagnosis of lead toxicity is often delayed and abdominal pain is mistaken for acute abdomen. We describe three blood brothers who were involved in pottery glazing and suffered from repeated episodes of severe abdominal pain, nausea, ...
Relevancy Score: Relevancy Score: 220
Fischbein A - - 1982
A case of lead poisoning in a female art conservator is reported. The patient had experienced excessive lead exposure while restoring an antique Peruvian tapestry from the Chancay period (1000 to 1500 AD) using a powdered pigment (cinnabar), which had been recovered from the same tomb in which the tapestry ...
Relevancy Score: Relevancy Score: 220
Kanen B L J - - 2005
A 46-year-old man with multiple sclerosis had severe generalised pain for which treatment with paracetamol, ibuprofen, gabapentin and methyl-prednisolone had been unsuccessful. In addition normocytic anaemia without haemolysis and with a normal iron load was found. Due to bright red rectal blood loss and nausea, vomiting, weight loss, anorexia, abdominal ...
Relevancy Score: Relevancy Score: 220
Beris P - - 1980
A statistical analysis was done on the levels of Hb A2 and Hb F in 1 340 normal subjects and 356 subjects heterozygous for beta-thalassemia. This study revealed that both groups had a normal distribution of Hb A2 and a gaussologarithmic distribution of Hb F. The plotted curves show an ...
Relevancy Score: Relevancy Score: 220
Sears David A - - 2011
Understanding the process by which red cell precursors lose their nuclei developed in the late 19th and early 20th centuries led to the identification of nuclear remnants in circulating red cells in certain pathological states, particularly absence or decreased function of the spleen. William Howell, an American, and Justin Jolly, ...
Relevancy Score: Relevancy Score: 220
Mamom T - - 2004
A 7-year-old male castrated Yorkshire Terrier dog developed slowly progressive neurologic disturbances consisting of difficulties in moving the neck, lack of proprioception, and tetraparesis 4 months prior its death. Neurologic examination, computer tomography, and myelography resulted in the tentative diagnosis of intramedullary cervicothoracic spinal cord lesion. At necropsy, an intramedullary ...
Relevancy Score: Relevancy Score: 220
George J W - - 1981
Erythrocyte protoporphyrin was measured in calves by the free erythrocyte porphyrin (FEP) test. The FEP of 15 healthy calves was 142.8 +/- 32.4 micrograms/dl (mean +/- SD) of packed erythrocytes or 45.6 +/- 10.3 micrograms/dl of whole blood. Biweekly oral lead administration to 3 calves produced a continuous increase of ...
Relevancy Score: Relevancy Score: 220
Awad el Karim M A - - 1986
Health effects of occupational exposure to lead were investigated among 92 exposed workers in lead-acid battery factory and 40 nonexposed workers serving as a control group from an oil mill in Khartoum North industrial area. The two groups were closely similar in age, stature, body weight, and socioeconomic conditions. A ...
Relevancy Score: Relevancy Score: 212
Hwang Y F - - 1976
Clinical, biochemical, haematological and erythrokinetic studies were performed on 63 adult males with prolonged lead exposure. Their most common symptoms and findings were abdominal pain (62%), gingival lead lines (48%), headache and/or dizziness (33%), muscle cramps (32%), anaemia (19%), and fatigue (18%). Colicky abdominal pain (27%) and gingival lead lines ...
Relevancy Score: Relevancy Score: 212
Rosenfeld G - - 1976
Hematological studies were developed on two mares and twelve adults castrate sheeps of "Ideal" breed. The animals had been on a pasture formed with Brachiaria radicans Napper for one and two months respectively. This experiment was developed in winter time, so the leaves of the graminea had a yellow-green color. ...
Relevancy Score: Relevancy Score: 212
Kudo Y Y - - 1990
The diseases known as the Vinyl Chloride Monomer (VCM) Syndrome include hepatic angiosarcoma, acroosteolysis and Raynaud's phenomenon. These, however, are known to be clinically recognizable from several to over 10 years after the actual exposure to VCM. By fluorescence microscopy the authors examined smeared samples of peripheral blood obtained from ...
Relevancy Score: Relevancy Score: 212
Schröter C - - 1991
A 59-year-old potter presented with lead polyneuropathy after 37 years of occupational exposure. There was a 25-year history of normochromic normocytic anaemia with moderate basophilic stippling, mild renal failure, hyperuricaemia and abnormal porphyrins. Since 1964 three short psychotic episodes were noted. Cranial computed tomography showed extensive bilateral symmetrical calcification in ...
Relevancy Score: Relevancy Score: 212
Verheij Joanne - - 2009
We describe the case of a 40-year old Iranian man who was admitted to our hospital with severe abdominal pain, abnormal liver function tests and normocytic anemia. Suffering from multiple sclerosis, he was a regular user of opium for pain relief. Basophilic stippling of erythrocytes pointed towards the diagnosis of ...
Relevancy Score: Relevancy Score: 212
Hermann J - - 1984
We have studied the diagnostic efficiency of some biological tests in 59 consecutive patients whom we suspected to be poisoned by lead from drinking water. This diagnosis was confirmed in 30 patients in whom EDTA-promoted urinary excretion of lead was greater than 800 micrograms/24 hr. The measurement of delta-ALA (delta-aminolevulinic ...
Relevancy Score: Relevancy Score: 212
Valentine W N - - 1985
The human erythrocyte generates high-energy adenosine triphosphate by anaerobic glycolysis and cycles oxidized and reduced nicotinamide adenine dinucleotide phosphate by the aerobic pentose phosphate shunt pathway. Certain enzymopathies of the pentose phosphate shunt are associated with hemolysis resulting from oxidative denaturation of hemoglobin. Glucose-6-phosphate dehydrogenase deficiency, an X-chromosome-linked disorder, is ...
Relevancy Score: Relevancy Score: 203
Valentine W N - - 1974
A severe deficiency of a red cell pyrimidine 5'-nucleotidase was found to be associated with hereditary hemolytic anemia in four members of three kindreds. The syndrome was characterized by marked increases above normal in red cell basophilic stippling, total nucleotides, and GSH and by a fairly severe deficiency of ribosephosphate ...
Relevancy Score: Relevancy Score: 203
Paglia D E - - 1975
Similarities between lead-induced anemia and a new hereditary erythorenzymopathy involving pyrimidine-specific 5'-nucleotidase prompted studies of the effects of lead on this and other erythrocyte enzymes. In vitro incubations of normal mature erythrocytes demonstrated that significant inhibition of pyrimidine 5'-nucleotidase occurred in the presence of lead at concentrations that had minimal ...
Relevancy Score: Relevancy Score: 195
Cooper P H - - 1986
The microscopic appearance of eruptive xanthoma (EX) presents the potential for misinterpretation as granuloma annulare (GA). Both exhibit one or multiple lesions in the superficial reticular dermis. Both have a perivascular and interstitial inflammatory cell infiltrate. Extracellular lipid in EX separates and disrupts the reticular dermis, simulating necrobiosis. There are ...
Relevancy Score: Relevancy Score: 190
Yeruham I - - 2003
Infection with Babesia bovis was diagnosed in a 2-day-old female calf apparently transmitted in utero. The calf was born as the second calving to a cross-bred beef cow permanently on pasture. Diagnosis was based upon identification of B. bovis in peripheral blood smears and clinical signs which included fever, jaundice, ...
Relevancy Score: Relevancy Score: 181
Hochholzer Karina K MBBS, Emergency Medicine Registrar, Emergency Department, Westmead Hospital, Westmead, - - 2014
Case study A woman aged 34 years presented to hospital with a history of progressive shortness of breath, palpitations, decreased exercise tolerance and generalised arthralgia over the previous month. A full blood count revealed normochromic normocytic anaemia and a haemoglobin level of 66 g/L. The blood film showed basophilic stippling ...
Relevancy Score: Relevancy Score: 181
Johnson James G JG 3rd Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, - - 2014
A 2.5-year-old intact male Roborovski hamster (Phodopus roborovskii) was presented with a large subcutaneous mass overlying the abdomen, affecting the animal's ambulation and access to different compartments of the cage through narrow tubing. Ultrasound examination delineated a well-circumscribed mass in the subcutis of the caudoventral abdominal region. The mass was ...
Relevancy Score: Relevancy Score: 181
Egger M - - 2008
A 33-year-old previously healthy man was admitted to the hospital with a 6-day history of diffuse abdominal pain and constipation. He was afebrile, looked unwell with a pale skin and displayed an elevated blood pressure. He had no peritoneal sign, and bowel sounds were normal. Blood tests were remarkable for ...
Relevancy Score: Relevancy Score: 181
Mount M E - - 1984
Strychnine toxicosis is characterized by inducible tetanic seizures and metaldehyde poisoning by fine fasciculations progressing to generalized tremors and seizures. Intoxication with 1080 causes seizures, random running movements, vomiting, defecation, urination, acidosis and hyperglycemia. Intoxication with rodenticides causing coagulopathy is characterized by hemorrhage into body cavities but not necessarily external ...
Relevancy Score: Relevancy Score: 181
Huang Jin-Bo - - 2012
To explore the clinical significance of genetic detection and changes of red cell enzyme activities of pyrimidine 5' nucleotidase (P5'N), pyruvate kinase (PK) and glucose-6-phosphate dehydrogenase (G-6-PD) in patients with α-thalassaemia (α-thal). Three α-thal patients were further processed to gene detection by PCR-trans-dot blot and gap-PCR, and red cell enzymes ...
Relevancy Score: Relevancy Score: 181
Christopher M M - - 1992
In conclusion, many specialized tests for the evaluation of anemia and RBC abnormalities can readily be performed in-house or by commercial laboratories. Tests include RBC indices, examination of blood smears (for morphological changes, infectious agents, basophilic stippling, and polychromasia), reticulocyte counts, iron stains, serum iron determinations, Heinz body counts, and ...
Relevancy Score: Relevancy Score: 181
Dunbabin D W - - 1992
OBJECTIVE: To present a case of lead poisoning following ingestion of Indian herbal medicine. CLINICAL FEATURES: A 37-year-old man presented with a history of abdominal pain, anorexia and malaise. He had recently returned from a trip to India where he had been taking two different herbal tonics. Investigation revealed low-grade ...
Relevancy Score: Relevancy Score: 181
Polizopoulou Z S - - 1994
In a total number of 275 dogs of various ages, sex and breed, blood lead concentrations (BLC) and erythrocyte ALAD activity were measured. Sixty-six of the dogs were living in lead mining areas (Group A), 157 in urban areas (Group B) and 52 in rural areas (Group C) of Greece. ...
Relevancy Score: Relevancy Score: 181
Papanikolaou Nikolas C - - 2005
Lead is a metal which has been associated with human activities for the last 6000 years. In ancient civilizations, uses of lead included the manufacture of kitchen utensils, trays, and other decorative articles. However, lead is also toxic to humans, with the most deleterious effects on the hemopoietic, nervous, reproductive ...
Relevancy Score: Relevancy Score: 181
Hershko C - - 1984
Eleven patients from the West Bank village of Es-Sawiyeh were admitted with lead poisoning to two Jerusalem hospitals between November 1982 and January 1983. They all belonged to several households of a single large family. Colicky abdominal pains were present in five patients, weakness in four, behavioral changes ranging from ...
Relevancy Score: Relevancy Score: 181
López López R M - - 2001
BACKGROUND: A decrease in hemoglobin production is probably the main cause of anemia observed in patients poisoned by lead although hemolysis caused by the effects on membrane or by inhibition of other enzymes such as 5'-pyrimidine nucleotidase may also play a key role. The main lead exposure source comes from ...
Relevancy Score: Relevancy Score: 181
LeBlanc Casey J - - 2004
A 9-year-old intact male Miniature Schnauzer presented laterally recumbent, cachexic, and dehydrated with multiple firm bone masses and a bilaterally enlarged prostate. Fine-needle aspiration of a rib mass revealed numerous basophilic polygonal to fusiform cells predominantly found in small to large clusters. The cells exhibited cytologic criteria of malignancy and ...
Relevancy Score: Relevancy Score: 181
Akiyama M - - 1989
The morphology of mast cells in the skin lesion from a case of urticaria pigmentosa was observed using light and electron microscopy. Furthermore, the IgE deposition on mast cells in the lesion was studied with immunoelectron microscopy. Diaminobenzidine reaction and 4-chloro-naphthol reaction were used to detect endogenous peroxidase activity in ...
Relevancy Score: Relevancy Score: 181
Vayá A - - 1983
A total of 200 cases of thalassaemia trait, 102 of F thalassaemia and 98 of A2 thalassaemia were studied, evaluating haematometric, and morphological aspects of both groups. Significantly higher values were found in F thalassaemia for PCV, MCV and MCH, with 33.5% of women and 52% of men being found ...
Relevancy Score: Relevancy Score: 181
Aksu Tekin T Department of Hematology, Ankara Children's Hematology and Oncology Research Hospital , Ankara , - - 2014
Abstract Hb Adana (HBA1: c.179G > A) is a very rare, unstable form of α-globin variant that results from deficient synthesis of functional α chains. We present a 2-month-old boy with hypochromic microcytic anemia, and remarkable anisocytosis, target cells and basophilic stippling on his peripheral blood smear. α-Globin gene analysis of the ...
Relevancy Score: Relevancy Score: 181
Lorenzo A V - - 1978
An animal model for asymptomatic and overt lead toxicity is presented in which rabbit pups, 1 to 30 days of age, were fed a milk supplement containing Pb(NO3)2. Reduced body growth, increased mortality, hematologic abnormalities, kidney and liver histopathology, as well as encephalopathy, were observed in rabbits 2 to 30 ...
Relevancy Score: Relevancy Score: 181
Boes Katie - - 2009
An adult castrated male Golden Retriever of unknown age was presented with a history of weight loss and progressive left thoracic limb lameness. On physical examination, a solid mass was palpated on the left scapula that had areas of lysis on radiographs and an area of cortical bone loss on ...
Relevancy Score: Relevancy Score: 181
Lukaszewska Janina - - 2008
An 11-year-old female Dachshund was presented with depression, diarrhea, weight loss, and radiographic evidence of masses involving the liver, spleen, and cranial lobe of the right lung. Results of a CBC included severe nonregenerative anemia (HCT 14.2%, hemoglobin, 4.3 g/dL, reticulocytes 66,000/microL) with marked metarubricytosis (nucleated RBCs 6.39 x 10(3)/microL). ...
Relevancy Score: Relevancy Score: 173
Magni Giulio - - 2013
In mammals, cellular 5'-nucleotidase (5'-NT) activity (EC 3.1.3.5) encompasses a number of genetically and structurally distinct enzyme forms, either membrane-bound or soluble, mainly cytosolic, that are characterized by broad specificity towards nucleoside 5'-monophosphate substrates differing in base (purine/pyrimidine) and/or sugar (oxy/deoxy-ribose) moieties. In particular, among the cytosolic 5'-NTs active towards ...
Relevancy Score: Relevancy Score: 173
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