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Jandacek Ronald J RJ University of Cincinnati, Cincinnati, Ohio. Electronic address: - - 2014
Serum polychlorinated biphenyls (PCBs) in Anniston, AL, residents have been associated with hypertension and diabetes. There have been no systematic interventions to reduce PCB body burdens in Anniston or other populations. Our objective was to determine the efficacy of 15 g/day of dietary olestra to reduce PCBs in Anniston residents. ...
Karavetian Mirey M Department of Health Promotion, Maastricht University, 6200 MD Maastricht, - - 2014
THIS STUDY AIMS TO DETERMINE THE EFFECT OF A TRAINED DEDICATED DIETITIAN ON CLINICAL OUTCOMES AMONG LEBANESE HEMODIALYSIS (HD) PATIENTS: and thus demonstrate a viable developing country model. This paper describes the study protocol and baseline data. The study was a multicenter randomized controlled trial with parallel-group design involving 12 ...
Siebelt Michiel - - 2014
Articular cartilage needs sulphated-glycosaminoglycans (sGAG) to withstand high pressures while mechanically loaded. Chondrocyte sGAG synthesis is regulated by exposure to compressive forces. Moderate physical exercise is known to improve cartilage sGAG content and might protect against osteoarthritis (OA). This study investigated whether rat knee joints with sGAG depleted articular through ...
Huang Sheng-You SY Department of Physics and Astronomy, Department of Biochemistry, Dalton Cardiovascular Research Center, and Informatics Institute, University of Missouri, Columbia, MO 65211, - - 2014
Protein-RNA interactions play important roles in many biological processes. Given the high cost and technique difficulties in experimental methods, computationally predicting the binding complexes from individual protein and RNA structures is pressingly needed, in which a reliable scoring function is one of the critical components. Here, we have developed a ...
Proschel Christoph C Department for Biomedical Genetics, University of Rochester, Rochester, NY, - - 2014
In addition to dopaminergic neuron loss, it is clear that Parkinson disease includes other pathological changes, including loss of additional neuronal populations. As a means of addressing multiple pathological changes with a single therapeutically-relevant approach, we employed delayed transplantation of a unique class of astrocytes, GDAs(BMP), that are generated in ...
Jimenez Joaquin J JJ Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, 33136, USA, - - 2014
Male and female pattern hair loss are common, chronic dermatologic disorders with limited therapeutic options. In recent years, a number of commercial devices using low-level laser therapy have been promoted, but there have been little peer-reviewed data on their efficacy. To determine whether treatment with a low-level laser device, the ...
Zong L L Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, China, Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, - - 2014
Studies have shown that edaravone may prevent liver injury. This study aimed to investigate the effects of edaravone on the liver injury induced by D-galactosamine (GalN) and lipopolysaccharide (LPS) in female BALB/c mice. Edaravone was injected into mice 30 min before and 4 h after GalN/LPS injection. The survival rate ...
Glasgow Philip D PD Sports Institute Northern Ireland, University of Ulster, Jordanstown, Newtownabbey, Co. Antrim BT37 0QB, United - - 2014
Cold Water Immersion (CWI) is commonly used to manage delayed onset muscle soreness (DOMS) resulting from exercise. Scientific evidence for an optimal dose of CWI is lacking and athletes continue to use a range of a treatment protocols and water temperatures. To compare the effectiveness of four different water immersion ...
Alçada Joana J Department of Thoracic Medicine, University College London Hospitals, London, - - 2014
Mediastinal lymphadenopathy (MLN) in human immunodeficiency virus (HIV) infection has a wide spectrum of aetiologies with different prognoses and treatments. The decision to pursue a histopathological diagnosis represents a clinical challenge as patients present with non-specific symptoms. This study aimed to determine the aetiology and predictive factors of MLN in ...
Ramsay Pam - - 2014
Increasing numbers of patients are surviving critical illness, but survival may be associated with a constellation of physical and psychological sequelae that can cause ongoing disability and reduced health-related quality of life. Limited evidence currently exists to guide the optimum structure, timing, and content of rehabilitation programmes. There is a ...
Reme Silje Endresen SE 1Uni Health, Uni Research, Bergen, Norway 2Department of Environmental Health, Harvard School of Public Health, Boston, MA 3Department of Pain Management and Research, Oslo University Hospital, Oslo, - - 2014
Study Design. Cross-sectional study.Objective. To examine the sensitivity of two single-item questions compared to two longer questionnaires in screening for depression and anxiety in chronic low back pain (CLBP).Summary of Background Data. Psychosocial factors are frequently identified as risk factors for developing CLBP and as predictors for treatment, and questionnaires ...
Chan Stephen L SL State Key Laboratory in Oncology in South China, Sir YK Pao Center for Cancer, Department of Clinical Oncology and Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China - - 2014
There have been many clinical trials conducted to evaluate novel systemic regimens for unresectable pancreatic cancer. However, most of the trial results were negative, and gemcitabine monotherapy has remained the standard systemic treatment for years. A number of molecular targeted agents, including those against epidermal growth factor receptor and vascular ...
Reilly Timothy P TP Drug Safety Evaluation, Research and Development, Bristol-Myers Squibb, Princeton, NJ, USA, - - 2014
Dapagliflozin is a selective inhibitor of the sodium-glucose co-transporter 2 (SGLT2) that increases urinary glucose excretion to reduce hyperglycemia in the treatment of type 2 diabetes mellitus. A robust carcinogenicity risk assessment was undertaken to assess the chronic safety of dapagliflozin and SGLT2 inhibition. Genotoxicity potential of dapagliflozin and its ...
Grasser Erik K EK Laboratory of Integrative Cardiovascular and Metabolic Physiology, Division of Physiology, Department of Medicine, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland, - - 2014
Energy drinks are beverages containing vasoactive metabolites, usually a combination of caffeine, taurine, glucuronolactone and sugars. There are concerns about the safety of energy drinks with some countries banning their sales. We determined the acute effects of a popular energy drink, Red Bull, on cardiovascular and hemodynamic variables, cerebrovascular parameters ...
Subtelny Alexander O AO 1] Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [2] Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA [3] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [4] Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts 02139, USA - - 2014
Poly(A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but difficulties in globally measuring poly(A)-tail lengths have impeded greater understanding of poly(A)-tail function. Here we describe poly(A)-tail length profiling by sequencing (PAL-seq) and apply it to measure tail lengths of millions of individual RNAs isolated from yeasts, ...
Gibbs Ayana A AA Division of Clinical Medicine, Brighton and Sussex Medical School, Falmer, Brighton, United Kingdom Institute of Psychiatry, King's College London, King's Health Partners, London, United - - 2014
Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the prefrontal cortex (PFC). A common polymorphism in the COMT gene (COMT val158met) has pleiotropic effects on cognitive and emotional processing. The met allele has been associated with enhanced cognitive processing but impaired emotional processing relative to the val allele. We genotyped healthy, white men ...
Xu Xiaohan X Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Disease, Anzhenli Avenue, Chao Yang District, Beijing, 100029, - - 2014
Trimetazidine has been shown to improve angina pectoris and left ventricular (LV) function in diabetic patients with ischaemic cardiomyopathy. The objective of this study was to evaluate the effects of trimetazidine on recurrent angina pectoris and LV structure after drug-eluting stent (DES) implantation in elderly multivessel coronary heart disease (CHD) ...
Felden Lisa L Institute of Clinical Pharmacology, Goethe University, Theodor Stern Kai 7, 60590, Frankfurt am Main, - - 2014
Once daily doses of 100-400 mg lumiracoxib have been proposed to inhibit local prostaglandin synthesis longer than systemic prostaglandin synthesis due to local accumulation in inflamed, acidic tissue. Lower, less toxic doses, however, might still achieve the clinical goal and merit further contemplation. In a randomized, double-blind, placebo-controlled, three-way cross-over study, ...
Shin Kwang-Hee KH Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine & Hospital, 103 Daehak-ro, Jongno-gu, Seoul, 110-744, - - 2014
Introduction A pegylated recombinant human granulocyte colony-stimulating factor (G-CSF) is effective in reducing the severity and duration of neutropenia. This study was performed to investigate the pharmacokinetics (PK), pharmacodynamics (PD), and tolerability of GCPGC, a new formulation of pegylated G-CSF, in healthy volunteers and to compare them with those of ...
Kamalian Shervin S Department of Radiology, Massachusetts General Hospital, Harvard Medical School, GRB 2nd Floor-279, 55 Fruit Street, Boston, MA, 02114, - - 2014
Evaluation of the posterior fossa (PF) on 5-mm-thick helical CT images (current default) has improved diagnostic accuracy compared to 5-mm sequential CT images; however, 5-mm-thick images may not be ideal for PF pathology due to volume averaging of rapid changes in anatomy in the Z-direction. Therefore, we sought to determine ...
Bauer Isabelle I Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, - - 2014
The current study aimed to investigate the effects of eicosapentaenoic acid (EPA)-rich and docosahexaenoic acid (DHA)-rich supplementations on cognitive performance and functional brain activation. A double-blind, counterbalanced, crossover design, with a 30-day washout period between two supplementation periods (EPA-rich and DHA-rich) was employed. Functional magnetic resonance imaging scans were obtained ...
Fritz K L KL Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, 55108, - - 2014
Appaloosa horses are predisposed to equine recurrent uveitis (ERU), an immune-mediated disease characterized by recurring inflammation of the uveal tract in the eye, which is the leading cause of blindness in horses. Nine genetic markers from the ECA1 region responsible for the spotted coat color of Appaloosa horses, and 13 ...
Stacey Dawn D School of Nursing, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, - - 2014
Decision aids are intended to help people participate in decisions that involve weighing the benefits and harms of treatment options often with scientific uncertainty. To assess the effects of decision aids for people facing treatment or screening decisions. For this update, we searched from 2009 to June 2012 in MEDLINE; ...
Huang Xinfang X Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, - - 2014
Febuxostat, a novel non-purine selective inhibitor of xanthine oxidase, has been identified as a potential alternative to allopurinol in patients with hyperuricemia. The purpose of this study was to compare the urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol in Chinese gout patients with hyperuricemia. Gout patients (n = 512) ...
Buckinx F F Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium, - - 2014
We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement of motor capacity were observed. The objective of the present study was to evaluate the impact of 6-month training by ...
Szucs-Farkas Zsolt Z From the *University Institute of Diagnostic, Interventional and Paediatric Radiology, Inselspital, University Hospital Bern, Berne; †Institute of Radiology, Hospital Centre of Biel, Biel/Bienne, Switzerland; ‡Department of Anaesthesiology and Intensive Care, University of Debrecen, Health and Medical Science Centre, Debrecen, Hungary; §Department of Emergency Medicine, Inselspital, University Hospital Bern, Berne; ∥Department of Emergency Medicine, University Hospital Basel, Basel, Switzerland; ¶Department of Medicine, University of Debrecen, Health and Medical Science Centre, Debrecen, Hungary; and #Department of Radiology, University Hospital Basel, Basel, - - 2014
The objective of the study was to test the diagnostic performance of low-dose computed tomography pulmonary angiography (CTPA) at peak tube voltage of 80 kVp with both reduced radiation and reduced contrast material (CM) dose. In this single-center, single-blinded prospective randomized trial, 501 patients with body weights of less than ...
Yamaguchi Osamu O Division of Bioengineering and LUTD Research, Nihon University, School of Engineering, Koriyama, Japan. - - 2014
To evaluate the efficacy and safety of the β3 -adrenoceptor agonist, mirabegron, in a Japanese population with overactive bladder (OAB). This randomized, double-blind, placebo-controlled Phase III study enrolled adult patients experiencing OAB symptoms for ≥24 weeks. Patients with ≥8 micturitions/24 h and ≥1 urgency episode/24 h or ≥1 urgency incontinence ...
Viana R T RT Department of Physical Therapy, Universidade Federal de Pernambuco, Recife, Pernambuco, - - 2014
Upper limb (UL) impairment is the most common disabling deficit following a stroke. Previous studies have suggested that transcranial direct current stimulation (tDCS) enhances the effect of conventional therapies. This pilot double-blind randomized control trial aimed to determine whether or not tDCS, combined with Wii virtual reality therapy (VRT), would ...
Ingle John W JW University of Pittsburgh Voice Center, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, - - 2014
Steroids are used for the treatment of laryngitis in vocal performers and other individuals despite the absence of evidence demonstrating their impact on vocal fold inflammation. Our objective was to examine laryngeal secretion cytokine inflammatory profile changes associated with corticosteroid treatment in a human phonotrauma model. Prospective, individual, randomized, double-blinded, ...
Staevska M M Clinical Centre of Allergology, Medical University Sofia, - - 2014
Many physicians believe that the most effective way to treat chronic urticaria is to take a non-sedating second-generation H1 -antihistamine in the morning and a sedating first-generation H1 -antihistamine, usually hydroxyzine, at night to enhance sleep. But is this belief well founded? To test this belief by comparing the effectiveness ...
Li Zhen Z Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, - - 2014
Background and study aims: Gastric intestinal metaplasia (GIM) is associated with a risk for development of intestinal-type gastric cancer. This study aimed to compare the diagnostic yield of GIM from confocal laser endomicroscopy (CLE) and white light endoscopy (WLE). Patients and methods: In a prospective, double-blind, randomized study, patients were ...
Thomas E E Category Development Organisation, Reckitt Benckiser, Slough, - - 2014
The alginate-antacid, Gaviscon Double Action (Gaviscon DA; Reckitt Benckiser, Slough, UK) suppresses reflux after meals by creating a gel-like barrier that caps and displaces the acid pocket distal to the oesophago-gastric junction. The effect of Gaviscon DA on reflux and dyspepsia symptoms has not yet been demonstrated with a modern ...
Harro C C CC Grand Valley State University, Grand Rapids, MI, - - 2014
The purpose of this single-blinded, randomized controlled study was to examine and compare the immediate and retention effects of progressive speed-dependent treadmill training (SDTT) and rhythmic auditory-cued (RAC) training on balance function, fall incidence, and quality of life (QOL) in individuals with PD. Twenty participants (mean age 66.1 yrs) with ...
Cook James L JL Comparative Orthopaedic Laboratory, University of Missouri, Columbia, - - 2014
While magnetic resonance imaging (MRI) is often considered the "gold standard" diagnostic imaging modality for detection of meniscal abnormalities, it is associated with misdiagnosis in as high as 47% of cases, is costly, and is not readily available to a large number of patients. Ultrasonographic examination of the knee has ...
Palareti Gualtiero G Unit of Angiology and Blood Coagulation, University Hospital of Bologna, - - 2014
Thromboses limited to infra-popliteal leg deep veins (isolated distal deep vein thrombosis, IDDVT) are frequently diagnosed in subjects with suspected pulmonary embolism or DVT, and account for one-fourth to half of all diagnosed leg DVTs. Despite their frequency, the natural history of IDDVTs and their real risk of thromboembolic complications ...
Wei Xin X Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore, 168751, - - 2014
Purpose:Recently, three genetic susceptibility loci for primary angle closure glaucoma (PACG) were identified: COL11A1 rs3753841, PCMTD1-ST18 rs1015213, and PLEKHA7 rs11024102. The purpose of this study was to investigate whether these single nucleotide polymorphisms (SNPs) affect the phenotype of PACG patients. Methods:: A retrospective analysis was performed for 700 Singaporean Chinese ...
Phan Chau-Minh CM Centre for Contact Lens Research, School of Optometry and Vision Science , 200 University Avenue West, Waterloo, ON, N2L 3G1 , Canada +1 519 888 4567 Extn: 36547 ; - - 2014
Introduction: Fungal keratitis, a potentially blinding disease, has been difficult to treat due to the limited number of approved antifungal drugs and the taxing dosing regimen. Thus, the development of a contact lens (CL) as an antifungal drug delivery platform has the potential to improve the treatment of fungal keratitis. ...
O'Hara John P JP 1 Research Institute for Sport, Physical Activity and Leisure, Carnegie Faculty, Leeds Metropolitan University, Leeds, UK 2 Department of Sport, Health and Exercise Science, University of Hull, Hull, - - 2014
This study evaluated the effects of the pre-exercise (30 minutes) ingestion of galactose (Gal) or glucose (Glu) on endurance capacity as well as glycaemic and insulinaemic responses. Ten trained male cyclists completed three randomised high-intensity cycling endurance tests. Thirty minutes prior to each trial cyclists ingested 1 litre of either ...
Cimino Sebastiano S Department of Urology, University of Catania, Catania, - - 2014
Objective: The aim of this prospective single-blinded study was to analyze the stone-free (SF) rates between pneumatic lithotripsy (PL) and laser lithotripsy (LL) for the treatment of single and primary ureteral stones and to evaluate potentially predictive factors of a SF status. Material and Methods: From January 2010 to January ...
Newell Kelly A - - 2014
Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression. However, the status of mGluR5 in the pathophysiology of these disorders remains unknown. The majority of studies in the schizophrenia post-mortem brain indicate that total mGluR5 expression ...
Boogerd Emiel A - - 2014
Type 1 diabetes demands a complicated disease self-management by child and parents. The overwhelming task of combining every day parenting tasks with demands of taking care of a child with diabetes can have a profound impact on parents, often resulting in increased parenting stress. Tailored disease information, easy accessible communication ...
Rejeski W Jack - - 2014
PAD is a disabling, chronic condition of the lower extremities that affects approximately 8 million people in the United States. The purpose of this study was to determine whether an innovative home-based walking exercise program for patients with peripheral artery disease (PAD) improves self-efficacy for walking, desire for physical competence, ...
Muhindo Mary K - - 2014
Artemisinin-based combination therapy (ACT) is widely recommended as first-line therapy for uncomplicated Plasmodium falciparum malaria worldwide. Artemisinin resistance has now been reported in Southeast Asia with a clinical phenotype manifested by slow parasite clearance. Although there are no reliable reports of artemisinin resistance in Africa, there is a need to ...
Prymula Roman R University Hospital, Hradec Kralove, Czech - - 2014
Rates of varicella have decreased substantially in countries implementing routine varicella vaccination. Immunisation is possible with monovalent varicella vaccine or a combined measles-mumps-rubella-varicella vaccine (MMRV). We assessed protection against varicella in naive children administered one dose of varicella vaccine or two doses of MMRV. This study was done in ten ...
Lee Gino G Department of Cardiology; Cardiovascular Research Institute Basel - - 2014
Myocardial ischemia has been shown to be associated with increased levels of B-type natriuretic peptide (BNP). However, it remains unclear whether and how BNP levels could be used clinically in patients with suspected exercise-induced myocardial ischemia. We enrolled 274 consecutive patients with suspected exercise-induced myocardial ischemia referred for evaluation by ...
Aronson Boaz E - - 2014
GATA transcription factors are essential for self-renewal of the small intestinal epithelium. Gata4 is expressed in the proximal 85% of small intestine while Gata6 is expressed throughout the length of small intestine. Deletion of intestinal Gata4 and Gata6 results in an altered proliferation/differentiation phenotype, and an up-regulation of SAM pointed ...
Ogutu Bernhards R - - 2014
This open-label, randomized study evaluated efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) in treatment of uncomplicated falciparum malaria in children below five years of age, to build evidence on use of AL as first-line treatment and DP as second-line treatment in Kenya. A total of 454 children aged ...
Wong Donald - - 2014
CXCL12/CXCR4 transactivation of epidermal growth factor family receptors in lipid raft membrane microdomains on cell surface is thought to mediate tumor growth and subsequent development of metastatic disease. CTCE-9908 is a known inhibitor of CXCR4. Herein, we tested the efficacy of CTCE-9908 in inhibiting prostate cancer cell growth, invasion, and ...
Kobylecki Christopher C Centre for Clinical and Cognitive Neurosciences, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK; Department of Neurology, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Salford, UK. Electronic address: - - 2014
The antiepileptic drug topiramate reduces levodopa-induced dyskinesia without exacerbating parkinsonism in animal models. We report a randomized, double-blind, placebo-controlled crossover trial in patients with Parkinson's disease and levodopa-induced dyskinesia. Fifteen patients with Parkinson's disease and stable levodopa-induced dyskinesia were enrolled into the study, of whom 13 were randomized to topiramate ...
van Landingham Suzanne W - - 2014
Prior studies have shown age-related macular degeneration (AMD) to be associated with falls. The purpose of this study is to determine if age-related macular degeneration (AMD) and AMD-related vision loss are associated with fear of falling, an important and distinct outcome. Sixty-five persons with AMD with evidence of vision loss ...
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