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Huang Ting-Shuo TS The Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Keelung Branch, Keelung, - - 2014
Procalcitonin (PCT)-based algorithms have been used to guide antibiotic therapy in several clinical settings. However, evidence supporting PCT-based algorithms for secondary peritonitis after emergency surgery is scanty. In this study, we aimed to investigate whether a PCT-based algorithm could safely reduce antibiotic exposure in this population. From April 2012 to ...
Shi Xiaoshan - - 2014
ABSTRACT As with most life on Earth, the transition metal copper (Cu) is essential for the viability of the human pathogen Mycobacterium tuberculosis. However, infected hosts can also use Cu to control microbial growth. Several Cu-responsive pathways are present in M. tuberculosis, including the regulated in copper repressor (RicR) regulon, ...
Gou Wenlong W Instistute of Orthopaedics, Chinese PLA General Hospital, Haidian District, Beijing, P.R. - - 2014
Bisphosphonates (BPs) have been widely used in clinical treatment of bone diseases with increased bone resorption because of their strong affinity for bone and their inhibition of bone resorption. Recently, there has been growing interest in their improvement of bone formation. However, the effect of local controlled delivery of BPs ...
Liu Junle J Anesthesia and Operation Center, Chinese People's Liberation Army General Hospital and Medical School of Chinese People's Liberation Army, Beijing, People's Republic of - - 2014
Both peripheral nerve blocks with sedation or general anesthesia can be used for total knee replacement surgery. We compared these anesthetic techniques on the postoperative quality of recovery early in elderly patients. In our study, 213 patients who were ≥65 years old and undergoing total knee replacement were randomized to ...
Stoyanov Plamen P Faculty of Biology, Plovdiv University, Plovdiv, - - 2014
The polyphasic approach is the most progressive system that has been suggested for distinguishing and phylogenetically classifying Cyanoprokaryota (Cyanobacteria/Cyanophyta). Several oscillatorialean genera (Lyngbya, Phormidium, Plectonema, and Leptolyngbya) have problematic phylogenetic position and taxonomic state because of their heterogeneity and polyphyletic nature. To accurately resolve the phylogenetic relationship of some filamentous ...
Trück Johannes J Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United - - 2014
In a previous UK multi-center randomized study 278 children received three doses of 7-valent (PCV-7) or 13-valent (PCV-13) pneumococcal conjugate vaccine at 2, 4 and 12 months of age. At 13 months of age, most of these children had pneumococcal serotype-specific IgG concentrations ≥0.35 µg/ml and opsonophagocytic assay (OPA) titers ...
Chen Xiao-Li XL Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China; Department of Radiology, Sichuan Cancer Hospital and Institute & The Second People's Hospital of Sichuan Province, Chengdu, Sichuan, - - 2014
To determine whether right liver lobe volume (RV) and spleen size measured utilizing magnetic resonance (MR) imaging could identify the presence and severity of cirrhosis in patients with hepatitis B. Two hundred and five consecutive patients with clinically confirmed diagnosis of cirrhosis due to hepatitis B and 40 healthy control ...
Tsai Chung-Hung CH Department of Family Medicine, Tainan Municipal An-Nan Hospital-China Medical University, Tainan City, - - 2014
To evaluate whether metabolic syndrome is associated with gallstones, independent of hepatitis C infection or chronic kidney disease (CKD), in a non-diabetic population. A total of 8,188 Chinese adult participants that underwent a self-motivated health examination were recruited into the final analysis after excluding the subjects who had a history ...
Rogers Susannah K SK Department of Anthropology, University of Texas , Austin, TX , - - 2014
Epilepsy is a neurological seizure disorder that affects over 100 million people worldwide. Levetiracetam, either alone, as monotherapy, or as adjunctive treatment, is widely used to control certain types of seizures. Despite its increasing popularity as a relatively safe and effective anti-convulsive treatment option, its mechanism(s) of action are poorly ...
Fan Qiu-Hong QH Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, - - 2014
Gastric cancer including the cardia and non-cardia types is the second frequent cause of cancer-related deaths worldwide. A subset of non-cardia gastric cancer genetic susceptibility loci have been addressed among Asian through genome-wide association studies (GWASs). This study was to evaluate the effects of single nucleotide polymorphisms (SNPs) of long ...
Huang Hongxin H Clinical Research Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, - - 2014
The risk of fatal adverse events (FAEs) due to bevacizumab-based chemotherapy has not been well described; we carried out an updated meta-analysis regarding this issue. An electronic search of Medline, Embase and The Cochrane Central Register of Controlled Trials was conducted to investigate the effects of randomized controlled trials on ...
Zhong Zhi Z Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of - - 2014
An increase of ethanol metabolism and hepatic mitochondrial respiration occurs in vivo after a single binge of alcohol. Here, our aim was to determine how ethanol intake affects hepatic mitochondrial polarization status in vivo in relation to ethanol metabolism and steatosis. Hepatic mitochondrial polarization, permeability transition (MPT), and reduce pyridine ...
Zhou Qinming Q Institute of Neuroscience, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, - - 2014
To assess the influence of infant rearing on the behavior of depressed adult female Macaca fascicularis and the influence of depressed infant-rearing adult female Macaca fascicularis on their infants in a free enclosure environment. Here, 20 depressed subjects and then 20 healthy subjects were randomly selected from a total population ...
Walkowski Stevan S Osteopathic Manipulative Medicine Department, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, United States of - - 2014
It has been claimed that osteopathic manipulative treatment (OMT) is able to enhance the immune response of individuals. In particular, it has been reported that OMT has the capability to increase antibody titers, enhance the efficacy of vaccination, and upregulate the numbers of circulating leukocytes. Recently, it has been shown ...
Patel Nima N Department of Laboratory Oncology Research, Memorial University Medical Center (MUMC) and Mercer University School of Medicine (MUSM), Anderson Cancer Institute, Savannah, Georgia, United States of - - 2014
The results of prostate specific antigen (PSA) and digital rectal examination (DRE) screenings lead to both under and over treatment of prostate cancer (PCa). As such, there is an urgent need for the identification and evaluation of new markers for early diagnosis and disease prognosis. Studies have shown a link ...
Zhu Xiaoyan X Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha, - - 2014
The management of neuropathic pain is still a major challenge because of its unresponsiveness to most common treatments. Curcumin has been reported to play an active role in the treatment of various neurological disorders, such as neuropathic pain. Curcumin has long been recognized as a p300/CREB-binding protein (CBP) inhibitor of ...
Deloria Knoll Maria M From the *International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; †Biostatistics Consulting, Chicago, IL; ‡Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA; §Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA; ¶Institute of Child Health, University College London, London, United - - 2014
Despite the breadth of studies demonstrating benefits of pneumococcal conjugate vaccine (PCV), uncertainty remains regarding the optimal PCV dosing schedule in infants. We conducted a systematic literature review of PCV immunogenicity published from 1994 to 2010 (supplemented post hoc with studies from 2011). Studies included for analysis evaluated ≥2 doses ...
Whitney Cynthia G CG From the *Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, †Institute for Child Health, London, United Kingdom; and ‡International Vaccine Access Center, Johns Hopkins University School of Public Health, Baltimore, - - 2014
Since second generation pneumococcal conjugate vaccines (PCVs) targeting 10 and 13 serotypes became available in 2010, the number of national policy makers considering these vaccines has steadily increased. An important consideration for a national immunization program is the timing and number of doses-the schedule-that will best prevent disease in the ...
Antonio João Roberto JR São José do Rio Preto State School of Medicine, Hospital de Base, Dermatology Service, São José do Rio PretoSP, Brazil, Emeritus Professor, State School of Medicine, São José do Rio Preto (FAMERP) - Head of Dermatology and the Dermatology Service, Hospital de Base, São José do Rio Preto State School of Medicine (FAMERP) - São José do Rio Preto (SP), - - 2014
The scientific community and general public have been exposed to a series of achievements attributed to a new area of knowledge: Nanotechnology. Both abroad and in Brazil, funding agencies have launched programs aimed at encouraging this type of research. Indeed, for many who come into contact with this subject it ...
Cestari Tania Ferreira TF Rio Grande do Sul Federal University, Internal Medicine Department, Porto Alegre(RS), Brazil, PhD - Associate Professor at the Internal Medicine Department, at Rio Grande do Sul Federal University (UFRGS). Teaching Professor at the Child and Adolescent Health Sciences and the Surgical Post-Graduation Programs at Rio Grande do Sul Federal University (UFRGS). Chief of the Dermatology Department at Porto Alegre Clinics Hospital - Rio Grande do Sul Federal University (HCPA-UFRGS) - Porto Alegre (RS), - - 2014
Cutaneous hyperpigmentations are frequent complaints, motivating around 8.5% of all dermatological consultations in our country. They can be congenital, with different patterns of inheritance, or acquired in consequence of skin problems, systemic diseases or secondary to environmental factors. The vast majority of them are linked to alterations on the pigment ...
Rugani Rosa R Department of General Psychology, University of Padova Padova, - - 2014
In our previous research we reported a leftward-asymmetry in domestic chicks required to identify a target element, on the basis of its ordinal position, in a series of identical elements. Here we re-coded behavioral data collected in previous studies from chicks tested in a task involving a different kind of ...
Silva Diana D Immunoallergology Department, Centro Hospitalar de São João, Alameda Prof, Hernâni Monteiro, 4200-309 Porto, Portugal. - - 2014
The majority of drugs prescribed have not been tested in children and safety and efficacy of children's medicines are frequently supported by low quality of evidence. Therefore, a large percentage of prescriptions for children in the clinical daily practice are used off label. Despite the several recent legislation and regulatory ...
da Silva Larissa Bittencourt LB Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Aalborg University, Aalborg DK-9220, Denmark. - - 2014
The effect of botulinum neurotoxin type A (BoNTA) on glutamate-evoked temporalis muscle pain and vasomotor responses was investigated in healthy men and women over a 60 day time course. Subjects participated in a pre-BoNTA session where their responses to injection of glutamate (1 M, 0.2 mL) and saline (0.2 mL) ...
Alzoubi Kousi K Department of Physiology, University of Tuebingen, Gmelinstr. 5, D-72076 Tübingen, Germany. - - 2014
Background: Lumefantrine, a commonly used antimalarial drug, inhibits hemozoin formation in parasites. Several other antimalarial substances counteract parasitemia by triggering suicidal death or eryptosis of infected erythrocytes. Eryptosis is characterized by cell shrinkage and cell membrane scrambling leading to phosphatidylserine-exposure at the erythrocyte surface. Signaling involved in eryptosis include increase ...
Ihara Masafumi M Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center Hospital, Osaka, Japan ; Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, National Cerebral and Cardiovascular Center, Osaka, - - 2014
Combinatorial therapy directed at both vascular and neurodegenerative aspects of dementia may offer a promising strategy for treatment of dementia, which often has a multifactorial basis in the elderly. We investigated whether the phosphodiesterase III inhibitor cilostazol, which is often used in the prevention of stroke and peripheral artery disease, ...
Schreuder Henk W R HW Division of Women and Baby, Department of Reproductive Medicine and Gynaecology, University Medical Centre Utrecht, P.O. Box 85500, Room F05-126, 3508 GA Utrecht, The - - 2014
Objective. With the increase in robotic-assisted laparoscopic surgery there is a concomitant rising demand for training methods. The objective was to establish face and construct validity of a novel virtual reality simulator (dV-Trainer, Mimic Technologies, Seattle, WA) for the use in training of robot-assisted surgery. Methods. A comparative cohort study ...
Daikuhara Hiroyuki H Department of Internal Medicine, Sakaide City Hospital, Kagawa, - - 2014
This open-label controlled study compared the therapeutic efficacy of three representative angiotensin II receptor blockers (ARBs) in hypertensive patients with type 2 diabetes attending a hospital outpatient clinic. The primary measure in this study was morning home blood pressure (BP). Two studies were done concurrently to investigate the effects of ...
Krenk Lene L Section of Surgical Pathophysiology, Rigshospitalet, University of Copenhagen, Denmark ; Lundbeck Centre for Fast-Track Hip and Knee Arthroplasty, - - 2014
Previous studies have demonstrated pronounced reduction of REM sleep on the first nights following major surgery which may influence pain, analgesic use, and recovery. This placebo-controlled, randomized, double-blind study set out to evaluate the effect of zolpidem on sleep architecture in an elderly population undergoing fast-track total hip and knee ...
Grau Santiago S Hospital del Mar, Barcelona, - - 2014
Clinical efficacy of antibiotics may be affected by changes in the susceptibility of microorganisms to antimicrobial agents. The purpose of this study is to assess how these changes could affect the initial efficacy of ertapenem and ceftriaxone in the treatment of community-acquired pneumonia (CAP) in elderly patients and the potential ...
Cao Yaoqian Y Respiratory Department, Tianjin Medical University General Hospital, Tianjin 300052, People's Republic of - - 2014
The aim of this systematic review was to evaluate the efficacy and safety of thrombolytic treatment in patients with submassive pulmonary embolism (PE). An electronic search was carried out based on the databases from MEDLINE, Embase, Science Citation Index (SCI), and the Cochrane Library. We included prospective, randomized, and clinical ...
Hayashibe Mitsuhiro M INRIA DEMAR Project and LIRMM, University of Montpellier Montpellier, France ; Brain Science Institute-Toyota Collaboration Center, RIKEN Nagoya, - - 2014
A human motor system can improve its behavior toward optimal movement. The skeletal system has more degrees of freedom than the task dimensions, which incurs an ill-posed problem. The multijoint system involves complex interaction torques between joints. To produce optimal motion in terms of energy consumption, the so-called cost function ...
Spencer Frederick A FA Department of Medicine, Mcmaster University, Hamilton, Ontario, - - 2014
To provide a comprehensive comparison of patent foramen ovale (PFO) closure versus medical therapy in patients with cryptogenic stroke or transient ischaemic attack (TIA) and demonstrated PFO. Systematic review with complete case meta-analysis and sensitivity analyses. Data sources included MEDLINE and EMBASE from 1980 up to May 2013. All randomised ...
Ehinger Benedikt V BV Neurobiopsychology, Institute of Cognitive Science, University of Osnabrück Osnabrück, - - 2014
In everyday life, spatial navigation involving locomotion provides congruent visual, vestibular, and kinesthetic information that need to be integrated. Yet, previous studies on human brain activity during navigation focus on stationary setups, neglecting vestibular and kinesthetic feedback. The aim of our work is to uncover the influence of those sensory ...
D'Souza Susan S Sunovion Pharmaceuticals Inc., Marlborough, MA 01752, - - 2014
The aim of this study was to design and evaluate biodegradable PLGA microspheres for sustained delivery of Risperidone, with an eventual goal of avoiding combination therapy for the treatment of schizophrenia. Two PLGA copolymers (50 : 50 and 75 : 25) were used to prepare four microsphere formulations of Risperidone. The microspheres were characterized ...
Sousa Joana R JR Centro de Investigação em Ciências Veterinárias, Faculdade de Medicina Veterinária, Universidade Lusófona de Humanidades e Tecnologia, Campo Grande 376, 1749-024 Lisboa, - - 2014
The performance of the cerebral state index (CSI) in reflecting different levels of isoflurane anaesthesia was evaluated in ten cats subjected to four end-tidal isoflurane concentrations (EtIso), each maintained for 15 minutes (0.8%, 1.2%, 1.6%, or 2.0% EtIso). The CSI, hemodynamic data, ocular reflexes, and eye position were recorded for ...
Aubert Martine M Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, - - 2014
Following acute infection, herpes simplex virus (HSV) establishes latency in sensory neurons, from which it can reactivate and cause recurrent disease. Available antiviral therapies do not affect latent viral genomes; therefore, they do not prevent reactivation following therapy cessation. One possible curative approach involves the introduction of DNA double strand ...
Jaillette Emmanuelle - - 2014
Despite the increasing use of non-invasive ventilation and high-flow nasal-oxygen therapy, intubation is still performed in a large proportion of critically ill patients. The aim of this narrative review is to discuss recent data on long-term intubation-related complications, such as microaspiration, and tracheal ischemic lesions. These complications are common in ...
Xiao Li L 0000-0002-3105-4488 Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, - - 2014
This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P ...
Joseph Nitin N Department of Community Medicine, Kasturba Medical College, Manipal University, Mangalore, - - 2014
Skin diseases are a common problem among young adults. There is paucity of data about it among medical students. This study aimed to find out the pattern of skin disorders and to describe their association with various socio-demographic factors among medical students. This cross-sectional study was conducted in June 2011 ...
Kunisawa Takayuki T Surgical Operation Department, Asahikawa Medical University Hospital, Hokkaido, - - 2014
Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III. The objective of this study was to characterize the population pharmacokinetics of olprinone after a single continuous infusion in healthy male volunteers. We used 500 plasma concentration data points collected ...
Liu Ping P Key Laboratory of Traditional Chinese Medicine Resource and Compound Prescription of the Ministry of Education, Hubei University of Chinese Medicine, Wuhan 430065, - - 2014
Traditional Chinese medicine (TCM) is practiced in the Chinese health care system for more than 2,000 years. In recent years, herbal medicines, which are used to treat Alzheimer's disease (AD) in China based on TCM or modern pharmacological theories have attracted considerable attention. In this paper, we discuss etiology and ...
Lo Yu Tung YT Wellcome Laboratory of Neurobiology, University College London London, - - 2014
Psychophysical experiments show that two different visual attributes, color and motion, processed in different areas of the visual brain, are perceived at different times relative to each other (Moutoussis and Zeki, 1997a). Here we demonstrate psychophysically that two variants of the same attribute, motion, which have the same temporal structure ...
Dal Monte Olga O Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health Bethesda, MD, USA ; Department of Neuropsychology, University of Turin Turin, - - 2014
Human and non-human primates rely on the ability to perceive and interpret facial expressions to guide effective social interactions. The neuropeptide oxytocin (OT) has been shown to have a critical role in the perception of social cues, and in humans to increase the number of saccades to the eye region. ...
Rosenfeld Cheryl S CS Biomedical Sciences and Bond Life Sciences Center, University of Missouri; - - 2014
Spatial learning and memory of laboratory rodents is often assessed via navigational ability in mazes, most popular of which are the water and dry-land (Barnes) mazes. Improved performance over sessions or trials is thought to reflect learning and memory of the escape cage/platform location. Considered less stressful than water mazes, ...
Madan Christopher R CR Department of Psychology, University of Alberta Edmonton, AB, - - 2014
Hızlı Sayar Gökben G Uskudar University, Neuropsychiatry Istanbul Hospital, Istanbul, - - 2014
Propofol is often used as an anesthetic agent for electroconvulsive therapy (ECT). In recent studies, propofol was shown to possess significant seizure-shortening properties during ECT. "Valproate" is a mood stabilizer used mainly in the treatment of bipolar affective disorder. It is reported that valproate, being an anticonvulsant, raises the seizure ...
Li Y Y Department of Ophthalmology, Henry Ford Health System, 1 Ford Place 5D, Detroit, MI, United States ; Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi׳an, Shanxi, People׳s Republic of - - 2014
The effectiveness of current treatment for age related macular degeneration (AMD) by targeting one molecule is limited due to its multifactorial nature and heterogeneous pathologies. Treatment strategy to target multiple signaling pathways or pathological components in AMD pathogenesis is under investigation for better clinical outcome. Inhibition of the redox function ...
Changiz Tahereh T Department of Medical Education, Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, - - 2014
Standardized patient (SP) can serve as a valuable tool to measure the physician performance in actual clinical settings, but it has not been validated for obesity/overweight disorders. This study has been conducted to describe the process of creating reliable and valid SPs for evaluation of general-practitioners' management of obesity/overweight in ...
Raffone Antonino A Department of Psychology, 'Sapienza' University of Rome, , Via dei Marsi, 78, 00185 Rome, - - 2014
Despite the acknowledged relationship between consciousness and attention, theories of the two have mostly been developed separately. Moreover, these theories have independently attempted to explain phenomena in which both are likely to interact, such as the attentional blink (AB) and working memory (WM) consolidation. Here, we make an effort to ...
Fu Weijie - - 2014
There is still uncertainty concerning the beneficial effects of shoe collar height for ankle sprain prevention and very few data are available in the literature regarding the effect of high-top and low-top shoes on muscle responses during landing. The purpose of this study was to quantify the effect of high-top ...
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