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Brown Dorothy Cimino DC Veterinary Clinical Investigations Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, - - 2014
To determine whether the Canine Orthopedic Index (COI) can detect changes in dogs with osteoarthritis (OA) treated with either non-steroidal anti-inflammatory drugs (NSAID) or placebo. Double blind randomized placebo controlled trial. Dogs (n = 80) with OA. Owners completed the COI on Day 0. Dogs were administered either carprofen or placebo on ...
Doraiswamy P M PM Duke University Medical Center, Durham, NC, - - 2014
This study was designed to evaluate whether subjects with amyloid beta (Aβ) pathology, detected using florbetapir positron emission tomorgraphy (PET), demonstrated greater cognitive decline than subjects without Aβ pathology. Sixty-nine cognitively normal (CN) controls, 52 with recently diagnosed mild cognitive impairment (MCI) and 31 with probable Alzheimer's disease (AD) dementia ...
Wee Sung Wook - - 2014
To validate the association between accommodation and visual asthenopia by measuring objective accommodative amplitude with the Optical Quality Analysis System (OQAS(R), Visiometrics, Terrassa, Spain), and to investigate associations among accommodation, ocular surface instability, and visual asthenopia while viewing 3D displays. Fifteen normal adults without any ocular disease or surgical history ...
Myers Julie - - 2014
This meta-analysis assessed the efficacy of duloxetine versus other oral treatments used after failure of acetaminophen for management of patients with osteoarthritis. A systematic literature review of English language articles was performed in PUBMED, EMBASE, MedLine In-Process, Cochrane Library, and ClinicalTrials.gov between January 1985 and March 2013. Randomized controlled trials ...
Goh B-S BS Department of Otorhinolaryngology Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur, - - 2014
Objective: This study investigated improvements in quality of life associated with eight weeks of montelukast and/or intranasal steroid treatment for moderate to severe allergic rhinitis. Methods: A single-centre, prospective, randomised, double-blind, placebo-controlled study was carried out. Assessments were made using the Rhinoconjunctivitis Quality of Life Questionnaire and symptom scales. Results: ...
Kwoh C Kent CK University of Pittsburgh, Pittsburgh, PA; VA Pittsburgh Healthcare System; University of Arizona, Tucson, - - 2014
Objective To determine the short-term efficacy of oral glucosamine supplementation by evaluating structural lesions as assessed using 3T MRI Methods This was a randomized, double-blind placebo-controlled trial. Recruitment was via mass mailings and an arthritis registry in southwestern Pennsylvania. 201 participants with mild to moderate pain in one or both ...
Kim Soon-Ja - - 2014
We investigated whether inhibiting phosphorylated p70S6K (p-p70S6K) suppresses the proliferation and growth of noninvasive low-grade urothelial carcinoma (LG-URCa) in vitroand whether p-p70S6K can serve as a predictive biomarker for the recurrence of noninvasive LG-URCa of the bladder in patients. We constructed a tissue microarray (TMA) for 95 LG-URCa and 35 ...
Márquez Ana - - 2014
We aimed to elucidate the role of four polymorphisms identified in a genome-wide association study (GWAS) analyzing the response of patients with rheumatoid arthritis (RA) to treatment with tumor necrosis factor inhibitors (TNFi). These genetic variants were significantly associated in this large study done by Plant et al. However, none ...
Walter Uwe U Department of Neurology, University of Rostock, Rostock, Germany, - - 2014
In patients with Wilson's disease (WD) transcranial brain sonography typically reveals areas of increased echogenicity (hyperechogenicity) of the lenticular nucleus (LN). Correlation with T2-hypointensity on magnetic resonance images suggested that LN hyperechogenicity in WD is caused by trace metal accumulation. Accumulation of both, copper and iron, in the brain of ...
Matsumura Noboru - - 2014
The conventional measuring method for glenoid version is greatly influenced by the scapular body shape that varies widely between patients. We postulated that the glenoid vault version could be more useful than the conventional glenoid version in clinical cases.Objectives: The purposes of this study were to compare the values of ...
Brook Robert D RD Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, - - 2014
Fine particulate matter (PM) air pollution is associated with numerous adverse health effects including increased blood pressure (BP) and vascular dysfunction. However, the cardiovascular (CV) impacts of coarse PM exposure remain largely unknown. Since it substantially contributes to global air pollution (yet differs in characteristics from fine particles and is ...
Khaenam Prasong - - 2014
There are diverse molecules present in blood plasma that regulate immune functions and also present a potential source of disease biomarkers and therapeutic targets. Genome-wide profiling has become a powerful method for assessing immune responses on a systems scale, but technologies that can measure the plasma proteome still face considerable ...
Sagi H Claude HC 1Orthopaedic Trauma Service, Florida Orthopaedic Institute, Tampa, FL 2Harborview Medical Center, Seattle, - - 2014
1) To determine if indomethacin has a positive clinical effect for the prophylaxis of heterotopic ossification (HO) after acetabular fracture surgery. 2) To determine if indomethacin affects the union rate of acetabular fractures. Prospective randomized double-blinded trial. Level one regional trauma center. Skeletally mature patients operated for an acute acetabular ...
Cui Xiaodong X Medical Research Center, Weifang Medical University, Weifang, Shandong 261053, P.R. - - 2014
The activation of hepatic stellate cells (HSCs) is involved in the development of hepatic fibrosis. Previous studies have indicated that the acquisition of certain properties by activated HSCs is highly dependent on the reorganization of the actin cytoskeleton. However, direct evidence showing that the reorganization of the actin cytoskeleton is ...
Mobley David L DL Departments of Pharmaceutical Sciences and Chemistry, University of California, Irvine, 147 Bison Modular, Irvine, CA, 92697, USA, - - 2014
Here, we give an overview of the small molecule hydration portion of the SAMPL4 challenge, which focused on predicting hydration free energies for a series of 47 small molecules. These gas-to-water transfer free energies have in the past proven a valuable test of a variety of computational methods and force ...
Eisendrath Stuart J - - 2014
Major depressive disorder (MDD) is the leading cause of disability in the developed world, yet broadly effective treatments remain elusive. Up to 40% of patients with depression are unresponsive to at least two trials of antidepressant medication and thus have "treatment-resistant depression" (TRD). There is an urgent need for cost-effective, ...
Thomas R R 1] The Primrose Research Unit, Bedford Hospital, Bedford, UK [2] Department of Oncology, Addenbrooke's Cambridge University NHS Trust, Cambridge, UK [3] Department of Postgraduate Medicine, Cranfield University, Cranfield, - - 2014
Background:Polyphenol-rich foods such as pomegranate, green tea, broccoli and turmeric have demonstrated anti-neoplastic effects in laboratory models involving angiogenesis, apoptosis and proliferation. Although some have been investigated in small, phase II studies, this combination has never been evaluated within an adequately powered randomised controlled trial.Methods:In total, 199 men, average age ...
Kymionis George D GD *Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Crete, Greece; and †Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, - - 2014
To describe a new minimally invasive surgical technique for the symptomatic management of bullous keratopathy in blind eyes. Four patients with severe corneal edema due to endothelial decompensation and no visual function in the affected eye presented for the relief of their ocular symptoms (pain and tearing). Femtosecond laser technology ...
Lara Beatriz B Exercise Physiology Laboratory, Camilo José Cela University, C/Castillo de Alarcon, 49. Villafranca del Castillo, 28692, Madrid, - - 2014
There is little information about the effects of caffeine intake on female team-sport performance. The aim of this study was to investigate the effectiveness of a caffeine-containing energy drink to improve physical performance in female soccer players during a simulated game. A double-blind, placebo controlled and randomized experimental design was ...
Heinonen Ann-Marie - - 2014
Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functionally active BMPs, we expressed BMP7, ...
Aung Kyaw Lwin KL Clinical and Experimental Pharmacology Group, CRUK Manchester Institute, Manchester, United - - 2014
BRAF mutation testing from circulating free DNA (cfDNA) using the amplification refractory mutation testing system (ARMS) holds potential as a surrogate for tumor mutation testing. Robust assay validation is needed to establish the optimal clinical matrix for measurement and cfDNA-specific mutation calling criteria. Plasma- and serum-derived cfDNA samples from 221 ...
St John Jan A JA Atherosclerosis Research Unit, University of Southern California, Los Angeles, California; Department of Preventive Medicine, University of Southern California, Los Angeles, - - 2014
To determine effect of change in urine excretion of isoflavonoids on cognitive change. Post hoc analysis of isoflavonoid exposure (mean 2.7 years) during the randomized, placebo-controlled, double-blind Women's Isoflavone Soy Health trial. General community. Healthy postmenopausal women (N = 350). Twenty-five grams of isoflavone-rich soy protein (91 mg of aglycone ...
Wilson David M DM Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, - - 2014
(1) Describe arthroscopic BURP surgical technique, (2) assess association of visual control and surgeon experience to tenotomy completeness and regional iatrogenic tissue damage. Cadaveric study. Canine cadavers weighing >20 kg (n = 16; 32 elbows). Phase 1 = dissection/anatomic description/procedural refinement (n = 6). Phase 2 = technique description (n = 6). Phase 3 = association of surgeon experience and procedural visual control ...
Anandkumar Sudarshan S Department of Physiotherapy, International School of Physiotherapy, Coventry University, Gokula Education Foundation , Bangalore , - - 2014
Abstract Study design: Double blind pre-test post-test control group design. Objectives: To compare the isokinetic quadriceps torque, standardized stair-climbing task (SSCT) and pain during SSCT between subjects diagnosed with knee osteoarthritis pre and post kinesio tape (KT) application with and without tension. Background: Strength of the quadriceps and torque producing ...
Russo Leo L Shire Development LLC, Wayne, PA, USA, - - 2014
Well-designed pharmacoepidemiology studies address several limitations of postmarketing spontaneous reports in regard to signal evaluation. This study evaluated a signal of disproportionate reporting of acute pancreatitis cases observed in patients with ulcerative colitis (UC) treated with MMX Multi Matrix System® (MMX®) mesalazine and demonstrated how inherent limitations of postmarketing reports ...
Liang Yan Y Institute Of Medical Biology; Chinese Academy of Medicine Science; Peking Union Medical College; Kunming, PR - - 2014
Background: Mumps, a communicable, acute and previously well-controlled disease, has had recent and occasional resurgences in some areas. Methods: A randomized, double-blind, controlled and multistep phase I study of an F-genotype attenuated mumps vaccine produced in human diploid cells was conducted. A total of 300 subjects were enrolled and divided ...
Oelke Matthias M Department of Urology, Hannover Medical School, Hannover, - - 2014
● To assess treatment satisfaction with tadalafil or tamsulosin versus placebo in a 12-week, randomized, double-blind study of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH). ● Following a 4-week placebo lead-in period, men aged ≥45 years with IPSS ≥13 and Qmax ≥4 to ≤15 mL/s ...
Clarkson Benjamin D S BD Department of Pathology and Laboratory Medicine, 2 Department of Neurological Surgery, 3 Department of Cellular and Molecular Pathology, 4 Neuroscience Training Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI - - 2014
T lymphocytes are key contributors to the acute phase of cerebral ischemia reperfusion injury, but the relevant T cell-derived mediators of tissue injury remain unknown. Using a mouse model of transient focal brain ischemia, we report that IL-21 is highly up-regulated in the injured mouse brain after cerebral ischemia. IL-21-deficient ...
Torres-Guzman Ana M - - 2014
Clinical and pre-clinical studies have shown that supplementation with omega-3 polyunsaturated fatty acids (n-3 PUFAs) reduce joint destruction and inflammation present in rheumatoid arthritis (RA). However, effects of individual n-3 PUFAs on chronic arthritic pain have not been evaluated. Thus, the aim of this study was to examine whether purified ...
Jaakkola Kelly - - 2014
The ability to mentally represent the movement of hidden objects (i.e., invisible displacement) is of theoretical importance due to its generally accepted status as an indicator of the development of a powerful type of representational capacity in human children. Over the past few decades, the understanding of invisible displacement has ...
Del Campo Rosa R Department of Microbiology, Hospital Universitario Ramón y Cajal, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Spanish Network for the Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Spain. Electronic address: - - 2014
Although scientific knowledge about the benefits of probiotic use in cystis fibrosis (CF) is scarce, their expectative is promising. The aim of this work was to analyze the effect of a Lactobacillus reuteri probiotic preparation versus placebo in CF patients. A prospective, double blind, crossover and with placebo study was ...
Irimia P P Clinica Universitaria de Navarra, 31008 Pamplona, - - 2014
INTRODUCTION. OnabotulinumtoxinA (OnabotA) is indicated for headache prophylaxis in patients with chronic migraine. However, there is some controversy about what is the minimum effective dose for treating chronic migraine patients. AIM. To determine the optimal dose of OnabotA for the prophylactic treatment of patients with chronic migraine. DEVELOPMENT. We performed ...
Minutoli Letteria - - 2014
The apoptosis machinery is a promising target against benign prostatic hyperplasia (BPH). Inhibitors of apoptosis proteins (IAPs) modulate apoptosis by direct inhibition of caspases. Serenoa Repens (SeR) may be combined with other natural compounds such as Lycopene (Ly) and Selenium (Se) to maximize its therapeutic activity in BPH. We investigated ...
Goenka Ajit H AH From the Sections of Abdominal Imaging (A.H.G., B.R.H., W.K., M.E.B.) and Medical Physics (F.D.), Imaging Institute, and Department of Quantitative Health Sciences (N.A.O.), Cleveland Clinic Foundation, 9500 Euclid Ave, Mail Code L10, Cleveland, OH 44195; and Siemens Medical Solutions, Malvern, Pa - - 2014
Purpose To measure the effect of reduced radiation exposure on low-contrast low-attenuation liver lesion detection in an anthropomorphic abdominal phantom by using filtered back projection (FBP) and sinogram-affirmed iterative reconstruction. Materials and Methods Eighteen radiologists blinded to phantom and study design interpreted randomized image data sets that contained 36 spherical ...
Chieffo Raffaella R Scientific Institute Vita-Salute University San Raffaele; Neurological Dep.t; Experimental Neurophysiology Unit, INSPE - Institute of Experimental Neurology; Milan, - - 2014
To assess the efficacy of high frequency (20 Hz) brain stimulation on lower limb motor function in subjects with chronic (> 6 months) subcortical stroke in a double-blind, placebo-controlled crossover study. double-blind, placebo controlled, crossover study SETTING: University hospital. ten right-handed subjects affected by a first-ever subcortical stroke in the ...
Herbst Meghan K MK Department of Emergency Medicine, University of Connecticut, Hartford Hospital, Hartford, - - 2014
Hydronephrosis is readily visible on ultrasonography and is a strong predictor of ureteral stones, but ultrasonography is a user-dependent technology and the test characteristics of clinician-performed ultrasonography for hydronephrosis are incompletely characterized, as is the effect of ultrasound fellowship training on predictive accuracy. We seek to determine the test characteristics ...
McNeely Eileen - - 2014
Few studies have examined the broad health effects of occupational exposures in flight attendants apart from disease-specific morbidity and mortality studies. We describe the health status of flight attendants and compare it to the U.S. population. In addition, we explore whether the prevalence of major health conditions in flight attendants ...
Gaarder Mario M Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, - - 2014
The radiographers' role in ultrasound (US) has been debated due to the operator-dependent aspect of diagnostic US. With standardized cine-loop ultrasound (SCUS) a reliable diagnosis can be achieved by reading SCUS independently from performing the procedure. To study the correlation between sonographic findings when SCUS is performed and read by ...
Yang C C Wuhan University, Renmin Hospital, Department of Psychiatry, Wuhan, - - 2014
Studies have indicated that early-life or early-onset depression is associated with a 2- to 4-fold increased risk of developing Alzheimer's disease (AD). In AD, aggregation of an abnormally phosphorylated form of the tau protein may be a key pathological event. Tau is known to play a major role in promoting ...
Arjmandi Bahram H BH 1 Department of Nutrition, Food, and Exercise Sciences, College of Medicine, the Florida State University , Tallahassee, Florida, USA - - 2014
Abstract The extracts of Scutellaria baicalensis and Acacia catechu have been shown in previous studies to alleviate joint discomfort, reduce stiffness, and improve mobility by reducing the production of proinflammatory molecules over long periods of supplementation. The acute effects of intake of these extracts have not yet been investigated. Thus, ...
Goldstein Felicia C FC Department of Neurology, Emory University School of Medicine, Atlanta, GA, - - 2014
The validity of the Montreal Cognitive Assessment (MoCA) as a screen for mild cognitive impairment (MCI) and dementia was evaluated in African Americans attending an urban outpatient memory disorders clinic. Eighty one patients ≥50 years old were administered the MoCA and neuropsychological tests. Clinicians, blinded to the MoCA scores, reviewed ...
Brandão Leonardo R LR Division of Haematology-Oncology, The Hospital for Sick Children, 555 University Avenue, Black Wing, room 10412, Toronto, Ontario, Canada, - - 2014
The prevalence of children diagnosed with deep vein thrombosis or pulmonary embolism has been increasing in the last decade. The most common thrombosis risk factor in neonates, infants and children is the placement of a central venous catheter (CVC). To date, it is unknown if the practice of anticoagulation prophylaxis ...
Shin J H JH Obesity Clinical Trials Programme, Duke University Medical Center, Durham, NC, - - 2014
We evaluated weight changes in obese patients at 6-months after they ended participation in a 12-month randomised controlled trial in which they received daily placebo, zonisamide 200 mg or zonisamide 400 mg, in addition to lifestyle counselling. Of the originally randomised 225 patients, 218 completed month-12 when study interventions were discontinued. For ...
Jones Gareth T - - 2014
Distal upper limb pain (pain affecting the elbow, forearm, wrist, or hand) can be non-specific, or can arise from specific musculoskeletal disorders. It is clinically important and costly, the best approach to clinical management is unclear. Physiotherapy is the standard treatment and, while awaiting treatment, advice is often given to ...
Denzer Ulrike W UW Departments of *Interdisciplinary Endoscopy #Medical Biometry and Epidemiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany †Department of Gastroenterology, Institut Arnault Tzanck, St. Laurent du Var ‡Department of Gastroenterology, Centre Hospitalier Universitaire and University of Nice Sophia Antipolis, Nice, France §Keio University School of Medicine ¶The Jikei University School of Medicine, Tokyo ∥Showa University Northern Yokohama Hospital, Yokohama, - - 2014
Upper gastrointestinal endoscopy is mostly performed under sedation and has a low yield of relevant gastric lesions in patients without alarm symptoms. Simpler screening tests such as capsule endoscopy could be helpful, but gastric visualization is insufficient with the current passive capsules. A magnetically guided gastric capsule was prospectively evaluated ...
Herrera Sócrates - - 2014
Massive implementation of malaria diagnostics in low-resource countries is regarded as a pivotal strategy in control and elimination efforts. Although malaria rapid diagnostic tests (RDTs) are considered a viable alternative, there are still obstacles to the widespread implementation of this strategy, such as reporting constraints and lack of proper quality ...
Kim Jisun - - 2014
Neoadjuvant endocrine therapy with an aromatase inhibitor has shown efficacy comparable to that of neoadjuvant chemotherapy in patients with postmenopausal breast cancer. Preclinical and clinical studies have shown that the antidiabetic drug metformin has anti-tumor activity. This prospective, multicenter, phase II randomized, placebo controlled trial was designed to evaluate the ...
Hazama Shoichi - - 2014
To evaluate the safety of combination vaccine treatment of multiple peptides, phase I clinical trial was conducted for patients with advanced colorectal cancer using five novel HLA-A*2402-restricted peptides, three peptides derived from oncoantigens, ring finger protein 43 (RNF43), 34 kDa-translocase of the outer mitochondrial membrane (TOMM34), and insulin-like growth factor-II ...
Jain Varsha K - - 2014
An inactivated quadrivalent influenza vaccine (QIV) was recently licenced in the US as a thimerosal-free formulation presented in a pre-filled syringe. A multidose presentation is preferred in some settings due to reduced acquisition and cold storage costs. We assessed the immunogenicity and safety of a thimerosal-containing QIV formulated using a ...
He Weihua - - 2014
The spatial distributions of the Kα emission from foil targets irradiated with ultra-intensity laser pulses have been studied using the x-ray coded imaging technique. Due to the effect of hard x-ray background contamination, noise as well as imperfection of imaging system, it is hard to determine the PSF analytically or ...
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