Search Results
Results 11751 - 11800 of 328727

Current sort is by publication date. Click to sort by relevancy

< 231 232 233 234 235 236 237 238 239 240 241 >
Soelberg Kerstin K KK Endokrinologisk Afdeling M, Odense Universitetshospital, Søndre Boulevard 29, 5000 Odense C, Denmark. - - 2014
(99m)Tc-pertechnetate scintigraphy is much used in the evaluation of patients with nodular goitre. We investigated the ability of experienced observers to estimate the thyroid 24-h (131)I uptake (RAIU) and the thyroid volume by visual evaluation of the scintigram. Two endocrinologists and two nuclear medicine specialists visually evaluated thyroid scintigrams from ...
Halladin Natalie L NL Department of Surgery, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark. - - 2014
Ischaemia-reperfusion injury following acute myocardial infarctions (AMI) is an unavoidable consequence of the primary percutaneous coronary intervention (pPCI) procedure. A pivotal mechanism in ischaemia-reperfusion injury is the production of reactive oxygen species following reperfusion. The endogenous hormone, melatonin, works as an antioxidant and could potentially minimise the ischaemia-reperfusion injury. Given ...
Li Hua H Department of Ophthalmology, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China, - - 2014
This study examined the prevalence of primary open-angle glaucoma (POAG) among residents aged ≥50 years living in Yongchuan district of Chongqing. Stratified cluster sampling was employed in random selection to estimate the prevalence of glaucoma from April to June, 2005. Twenty-nine villages or neighborhood communities were randomly selected in urban ...
Ernst Nielsen René R Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aalborg University Hospital, Mølleparkvej 10, 9000 Aalborg, - - 2014
To assess the cognitive effects of sertindole and olanzapine in patients diagnosed with schizophrenia. Cognition was the primary outcome of the study. This was a 12-week double-blinded randomized clinical controlled trial. Participants were randomized to either 16-24 mg of sertindole or 10-20 mg of olanzapine. The study had a low ...
Furie Richard R North Shore-LIJ Health System, Great Neck, New - - 2014
To compare the efficacy and safety of intravenous (IV) abatacept, a selective T cell costimulation modulator, versus placebo for the treatment of active class III or IV lupus nephritis, when used on a background of mycophenolate mofetil and glucocorticoids. This was a 12-month, randomized, phase II/III, multicenter, international, double-blind study. ...
McIntyre Alexander A Penticton Regional Hospital, Penticton, British Columbia, - - 2014
Fibromyalgia and major depressive disorder (MDD) frequently co-occur. Quetiapine fumarate extended-release (quetiapine XR) has demonstrated efficacy in the treatment of MDD and has been shown to have analgesic properties in patients with depression. The primary objectives of this study were to evaluate the effects of quetiapine XR on depressive and ...
Chopra Arvind A Center for Rheumatic Diseases, Pune, - - 2014
To evaluate whether chloroquine (CQ) is more effective than meloxicam for treating early musculoskeletal pain and arthritis following acute chikungunya (CHIK) virus infection. During the 2006 CHIK epidemic, 509 rural community cases of acute CHIK virus infection were identified in the district of Sholapur in India. Seventy consenting adult patients ...
Li Ming-Hua MH From the Institute of Diagnostic and Interventional Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, 600 Yi Shan Rd, Shanghai 200233, - - 2014
Purpose To evaluate the diagnostic accuracy of three-dimensional (3D) time-of-flight (TOF) magnetic resonance (MR) angiography at 3.0 T in the detection of small cerebral aneurysms. Materials and Methods The institutional review board approved the study protocol, and patients or qualifying family members provided informed consent. A total of 403 consecutive ...
Portnoy Joel E JE Department of Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania; Voice and Swallowing Center, ENT and Allergy Associates, Lake Success, New - - 2014
Proton pump inhibitors (PPIs) are the mainstay of current medical management for laryngopharyngeal reflux (LPR) but may be insufficient in managing some patients' disease. This study was designed to investigate the effectiveness of superdose PPI therapy in the improvement of 24-hour pH impedance studies and stroboscopy findings in patients with ...
Shah Baiju R BR University of Toronto, Toronto, Ontario, Canada ; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada ; Sunnybrook Health Sciences Centre, Toronto, Ontario, - - 2014
Printed educational materials for clinician education are one of the most commonly used approaches for quality improvement. The objective of this pragmatic cluster randomized trial was to evaluate the effectiveness of an educational toolkit focusing on cardiovascular disease screening and risk reduction in people with diabetes. All 933,789 people aged ...
Low Nicola N Institute of Social and Preventive Medicine, University of Bern, Bern, - - 2014
This Essay from Nicola Low and colleagues discusses the importance of the nucleic acid amplification tests for rapid detection of N. gonorrhoeae and its resistance determinants, as well as the importance of ensuring their rational use, as priorities for controlling both gonorrhoea and antimicrobial resistance. Please see later in the ...
Charman Tony T Institute of Psychiatry, King's College London , London , - - 2014
Abstract Camarata's (2014) review summarizes the progress that has been made in the field of early identification and early intervention in autism spectrum disorders (ASD) over the past few decades, but also provides a salutary reminder that much still needs to be done. Whilst it is possible to prospectively identify ...
Ozis Salih Erpulat - - 2014
In this study we aimed to determine the need for 18F-flourodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the preoperative staging of rectal carcinoma in our large patient group according to level and location of tumor. Totally, 97 patients diagnosed with primary rectal adenocarcinoma between May 2009 and July 2011 ...
Shojaee Majid M Emergency Medicine Department, Shahid Beheshti University of Medical Sciences, Tehran, - - 2014
Objective: An accurate scoring system for intra-abdominal injury (IAI) based on clinical manifestation and examination may decrease unnecessary CT scans, save time, and reduce healthcare cost. This study is designed to provide a new scoring system for a better diagnosis of IAI after blunt trauma. Methods: This prospective observational study ...
Swanson Neil - - 2014
Imiquimod 3.75% and 2.5% creams were studied for the treatment of actinic keratosis (AK) of the full face or balding scalp, to determine comparable efficacy and tolerability to imiquimod 5% cream.<BR /> In two identical multicenter, randomized, double-blind, placebo controlled studies. Adult subjects with 5 to 20 visible lesions, or ...
Froehlich Tanya E TE *Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; †Department of Psychology, University of Cincinnati, Cincinnati, OH; ‡Department of Psychology, Virginia Commonwealth University, Richmond, - - 2014
Stimulant medications, such as methylphenidate (MPH), improve the academic performance of children with attention-deficit hyperactivity disorder (ADHD). However, the mechanism by which MPH exerts an effect on academic performance is unclear. We examined MPH effects on math performance and investigated possible mediation of MPH effects by changes in time on-task, ...
Alexis Andrew F - - 2014
Three multicenter, randomized, double blind, parallel-group, placebo controlled studies involving 3,855 subjects established the safety and efficacy of an adapalene benzoyl peroxide topical gel in the treatment of acne for all skin types. The data from these 3 studies were pooled and the subgroup of self-identified black subjects was analyzed ...
Bandelow Borwin B Department of Psychiatry and Psychotherapy, University of Göttingen , Göttingen , - - 2014
Abstract Objectives. To evaluate quetiapine XR in patients with anxious depression, as defined by HAM-A total and HAM-D anxiety/somatisation factor scores. Methods. Post hoc analyses of pooled data from two 6-week, double-blind, randomised, placebo-controlled studies of adjunctive quetiapine XR (150 or 300 mg/day) in patients with MDD and inadequate response ...
Berman Brian - - 2014
Cryosurgery is the most common treatment for actinic keratosis (AK) in the United States. Efficacy with cryosurgery is variable, and is a modality for treating individual, visible lesions while failing to treat subclinical lesions.<BR /> FIELD Study 1 (NCT01541553) is a phase 3, multicenter, randomized, double-blind study that evaluated the ...
Jetter Alexander - - 2014
Long-term pharmacokinetics after supplementation with vitamin D3 or calcifediol (the 25-hydroxyvitamin D3 metabolite) is not well studied. Additionally, it is unclear whether bolus doses of vitamin D3 or calcifediol lead to 25(OH)D3 plasma concentrations considered desirable for fracture prevention (30 ng/mL). We therefore investigated plasma pharmacokinetics of 25(OH)D3 during different ...
Smith Miranda M Texas Tech University Health Sciences Center School of Pharmacy, Abilene, - - 2014
Adults older than 65 years of age with vision impairment are more likely to have difficulty managing medications compared with people having normal vision. This patient population has difficulty reading medication information and may take the wrong medication or incorrect doses of medication, resulting in serious consequences, including overdose or ...
Tran Nicholas M NM Ph.D. program in Molecular Genetics and Genomics, Washington University in Saint Louis, Saint Louis, Missouri, United States of - - 2014
Cone-rod homeobox (CRX) protein is a "paired-like" homeodomain transcription factor that is essential for regulating rod and cone photoreceptor transcription. Mutations in human CRX are associated with the dominant retinopathies Retinitis Pigmentosa (RP), Cone-Rod Dystrophy (CoRD) and Leber Congenital Amaurosis (LCA), with variable severity. Heterozygous Crx Knock-Out (KO) mice ("+/-") ...
White-Grindley Erica E Stowers Institute for Medical Research, Kansas City, Missouri, United States of - - 2014
How learned experiences persist as memory for a long time is an important question. In Drosophila the persistence of memory is dependent upon amyloid-like oligomers of the Orb2 protein. However, it is not clear how the conversion of Orb2 to the amyloid-like oligomeric state is regulated. The Orb2 has two ...
Harries Priscilla - - 2014
Health and social care professionals are well positioned to identify and intervene in cases of elder financial abuse. An evidence-based educational intervention was developed to advance practitioners' decision-making in this domain. The objective was to test the effectiveness of a decision-training educational intervention on novices' ability to detect elder financial ...
Botelho Marco Antonio MA University Potiguar, Post-graduation Program in Biotechnology, Laboratory of Nanotechnology, NatalRN, Brazil, University Potiguar, Post-graduation Program in Biotechnology, Laboratory of Nanotechnology, Natal/RN, - - 2014
To determine the safety and efficacy of a transdermal nanostructured formulation of progesterone (10%) combined with estriol (0.1%) + estradiol (0.25%) for relieving postmenopausal symptoms. A total of 66 postmenopausal Brazilian women with climacteric symptoms of natural menopause received transdermal nanostructured formulations of progesterone and estrogens in the forearm daily ...
Gallagher Martin M The George Institute for Global Health, Sydney, Australia ; University of Sydney, Sydney, - - 2014
The incidence of acute kidney injury (AKI) is increasing globally and it is much more common than end-stage kidney disease. AKI is associated with high mortality and cost of hospitalisation. Studies of treatments to reduce this high mortality have used differing renal replacement therapy (RRT) modalities and have not shown ...
Pereira Daniele Freitas DF Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Reumatologia, São PauloSP, Brazil, Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Reumatologia, São Paulo/SP, - - 2014
This study compares the clinical, ultrasonography, radiography, and laboratory outcomes of painless and painful chronic synovitis in patients with established rheumatoid arthritis. This cross-sectional study involved 60 patients with rheumatoid arthritis and synovitis in the metacarpophalangeal joints; 30 of the patients did not experience pain, and 30 had experienced pain ...
Lavezzi Anna M - - 2014
It is well known that maternal smoking during pregnancy is very harmful to the fetus. Prenatal nicotine absorption, in particular, is associated with alterations in lung development and functions at birth and with respiratory disorders in infancy. Many of the pulmonary disorders are mediated by the interaction of nicotine with ...
Barry Emma - - 2014
The Timed Up and Go test (TUG) is a commonly used screening tool to assist clinicians to identify patients at risk of falling. The purpose of this systematic review and meta-analysis is to determine the overall predictive value of the TUG in community-dwelling older adults. A literature search was performed ...
Hahn Robert G RG Södertälje Hospital, Research Unit, Södertälje, Sweden, Södertälje Hospital, Research Unit, Södertälje, - - 2014
To evaluate whether the pathophysiology of shock syndromes can be better understood by comparing central hemodynamics with kinetic data on fluid and electrolyte shifts. We studied the dilutional hyponatremic shock that developed in response to overhydration with electrolyte-free irrigating fluid - the so-called 'transurethral resection syndrome' - by comparing cardiac ...
Costa Altair da Silva AD Jr Federal University of São Paulo, Paulista School of Medicine, Department of Thoracic Surgery, São PauloSP, Brazil, Federal University of São Paulo, Paulista School of Medicine, Department of Thoracic Surgery, São Paulo/SP, - - 2014
Hyperhidrosis is a common disease, and thoracoscopic sympathectomy improves its symptoms in up to 95% of cases. Unfortunately, after surgery, plantar hyperhidrosis may remain in 50% of patients, and compensatory sweating may be observed in 70%. This clinical scenario remains a challenge. Our objective was to evaluate the effectiveness of ...
Chinigarzadeh Asma A University of Malaya, Faculty of Medicine, Department of Physiology, Kuala Lumpur, Malaysia, University of Malaya, Faculty of Medicine, Department of Physiology, Kuala - - 2014
High genistein doses have been reported to induce fluid accumulation in the uteri of ovariectomised rats, although the mechanism underlying this effect remains unknown. Because genistein binds to the oestrogen receptor and the cystic fibrosis transmembrane regulator mediates uterine fluid secretion, we hypothesised that this genistein effect involves both the ...
Torres Rogil Jose de Almeida RJ Pontificia Universidade Católica do Paraná, CuritibaPR, Brazil, Pontificia Universidade Católica do Paraná, Curitiba/PR, - - 2014
To evaluate the effect of blocking the angiotensin II AT-1 receptor by the systemic administration of candesartan on the expression of intercellular adhesion molecule-1 in the sclera and choroid of hypercholesterolemic rabbits. New Zealand rabbits were divided into 3 groups, as follows: GI, which was fed a rabbit standard diet; ...
Araujo Luiz Felipe Lopes LF Federal University of Rio Grande do Sul, Postgraduate Program in Pulmonary Sciences, Porto AlegreRS, Brazil, Federal University of Rio Grande do Sul (UFRGS), Postgraduate Program in Pulmonary Sciences, Porto Alegre/RS, - - 2014
Most lung transplants are obtained from brain-dead donors. The physiopathology of brain death involves hemodynamics, the sympathetic nervous system, and inflammatory mechanisms. Administering methylprednisolone 60 min after inducing brain death in rats has been shown to modulate pulmonary inflammatory activity. Our objective was to evaluate the effects of methylprednisolone on ...
Ilic Dragan D Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, - - 2014
The principles of evidence-based medicine (EBM) provide clinicians with the ability to identify, source, appraise and integrate research evidence into medical decision making. Despite the mantra of EBM encouraging the use of evidence to inform practice, there appears little evidence available on how best to teach EBM to medical trainees. ...
Kremmer S S Augenklinik, Evangelisches Krankenhaus, - - 2014
One of the most common sensory impairments of elderly people is hearing loss. Glaucoma is one of the leading causes of blindness worldwide. Hearing and vision loss typically increase with older age. There is scientific evidence that the coincidence of hearing and vision loss is more frequent than expected by ...
Foltynie Thomas T Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK. Electronic address: - - 2014
There is an increasing number of approaches to try and relieve the motor symptoms of Parkinson's disease (PD) that focus predominantly on strategies of dopaminergic replacement or deep brain stimulation. There remains, however, a major need to slow down or reverse the relentless progression of the disease to prevent the evolution ...
Ma Xiaoyan X Peking University Sixth Hospital, Peking University Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, - - 2014
Obsessive-compulsive disorder (OCD) is a highly prevalent and devastating psychiatric condition. Repetitive transcranial magnetic stimulation (rTMS) is a potential and non-invasive treatment for OCD. Diverse efficacies of rTMS have been reported in different locations or frequencies of the stimulation. The main objective of this study was to assess the treatment ...
Rotman-Pikielny Pnina P a Department of Medicine E , Meir Medical Center , Kfar Saba , - - 2014
Aims: DBCare® (Ace Continental Exports Inc., London, UK) is a traditional Indian herbal food supplement marketed as an antidiabetes remedy. This study evaluated the efficacy and safety of DBCare in patients with inadequately controlled type 2 diabetes mellitus (T2DM) despite oral hypoglycemic treatment. Methods: A 12-week randomized double-blind placebo-controlled trial ...
Xu Bo B Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, Beijing, - - 2014
The intention of the PEPCAD China ISR (A Prospective, Multicenter, Randomized Trial of Paclitaxel-Coated versus Paclitaxel-Eluting Stent for the Treatment of Drug-Eluting Stent In-Stent Restenosis) was to demonstrate the efficacy of paclitaxel-coated balloon (PCB) angioplasty in a non-European patient population with coronary drug-eluting stent in-stent restenosis (DES-ISR). The treatment of ...
Holmes Chris E CE Department of Medicine, University of Vermont, Burlington, VT, - - 2014
Treatment options for established post-thrombotic syndrome (PTS) are limited. Complex lymphedema therapy (CLT), a non-invasive treatment that improves lymphatic flow, may have the potential to improve PTS. We conducted a single-center, investigator-blind, randomized controlled trial of 31 patients with a clinically established diagnosis of PTS and compared the efficacy of ...
Chamling Xitiz X Department of Pediatrics, University of Iowa Interdisciplinary program of genetics, Iowa City, Iowa, United States of - - 2014
Bardet-Biedl syndrome (BBS) is a well-known ciliopathy with mutations reported in 18 different genes. Most of the protein products of the BBS genes localize at or near the primary cilium and the centrosome. Near the centrosome, BBS proteins interact with centriolar satellite proteins, and the BBSome (a complex of seven ...
Jebran Ahmad Fawad AF Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, - - 2014
Anthroponotic cutaneous leishmaniasis (CL) due to Leishmania (L.) tropica infection is a chronic, frequently disfiguring skin disease with limited therapeutic options. In endemic countries healing of ulcerative lesions is often delayed by bacterial and/or fungal infections. Here, we studied a novel therapeutic concept to prevent superinfections, accelerate wound closure, and ...
Martin Coralie C UMR 7245 MCAM MNHN CNRS, Muséum National d'Histoire Naturelle, Paris, - - 2014
Vernet Nadège N MRC National Institute for Medical Research, London NW7 1AA, - - 2014
Outbred XY(Sry-) female mice that lack Sry due to the 11 kb deletion Sry(dl1Rlb) have very limited fertility. However, five lines of outbred XY(d) females with Y chromosome deletions Y(Del(Y)1Ct)-Y(Del(Y)5Ct) that deplete the Rbmy gene cluster and repress Sry transcription were found to be of good fertility. Here we tested ...
Cao Lilly - - 2014
Little objective evidence exists regarding what makes a good lecture. Our purpose was to determine qualities of radiology review course lectures that are associated with positive audience evaluation. 57 presentations from the Ottawa Resident Review Course (2012) were analyzed by a PGY4 radiology resident blinded to the result of audience ...
Ahmad Shaad M SM Laboratory of Developmental Systems Biology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, - - 2014
The Drosophila heart is composed of two distinct cell types, the contractile cardial cells (CCs) and the surrounding non-muscle pericardial cells (PCs), development of which is regulated by a network of conserved signaling molecules and transcription factors (TFs). Here, we used machine learning with array-based chromatin immunoprecipitation (ChIP) data and ...
Cooper Vaughn S VS Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire, United States of - - 2014
Examples of ecological specialization abound in nature but the evolutionary and genetic causes of tradeoffs across environments are typically unknown. Natural selection itself may favor traits that improve fitness in one environment but reduce fitness elsewhere. Furthermore, an absence of selection on unused traits renders them susceptible to mutational erosion ...
Liu Yang Y Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People's Republic of - - 2014
C-type lectins are a family of proteins with carbohydrate-binding activity. Several C-type lectins in mammals or arthropods are employed as receptors or attachment factors to facilitate flavivirus invasion. We previously identified a C-type lectin in Aedes aegypti, designated as mosquito galactose specific C-type lectin-1 (mosGCTL-1), facilitating the attachment of West ...
Hijazi Omar M OM Department of Cardiac Sciences, King Abdulaziz Medical City, National Guard Health Affairs, PO Box 22490, Riyadh 11426, Kingdom of Saudi Arabia. Fax. +966 (11) 8011111 Ext. 16560. E-mail: - - 2014
To compare sedation outcomes for chloral hydrate (CH) and midazolam (MD) as sedative agents for diagnostic procedures in children. A prospective, randomized, double-blinded study conducted between July 2005 and October 2006, at the Pediatric Day Care Unit (DCU), King Abdulaziz Medical City, Riyadh, Saudi Arabia. After meeting the inclusion criteria ...
< 231 232 233 234 235 236 237 238 239 240 241 >
Recent Searches