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Montgomery Bruce B Department of Medicine, University of Washington, Seattle, Washington, - - 2014
Glucocorticoids have been used in the treatment of prostate cancer to slow disease progression, improve pain control and offset side effects of chemo- and hormonal therapy. However, they may also have the potential to drive prostate cancer growth via mutated androgen receptors or glucocorticoid receptors (GRs). In this review we ...
Jeon Hye-Seon HS Dept. of Physical Therapy, College of Health Science, and Dept. of Ergonomic Therapy, The Graduate School of Health and Environment, Yonsei University, Republic of Korea. Electronic address: - - 2014
to compare the effects of pulsed electromagnetic field (PEMF) therapy and sham treatment on DOMS-related variables in elbow flexors at 24, 48 and 72 h after delayed onset muscle soreness (DOMS) induction exercise. randomized, double-blind, placebo-controlled study. Yonsei University laboratory. In total, 30 healthy male college students. Muscle soreness, peak torque, ...
Vrijheid Martine M Centre for Research in Environmental Epidemiology (CREAL); Universitat Pompeu Fabra (UPF); and CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, - - 2014
Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure-health effect relationships. The "exposome" concept encompasses the totality of exposures from conception onwards, complementing the genome. The Human Early-Life Exposome (HELIX) project is a new ...
Hesketh P J PJ Thoracic Oncology, Lahey Hospital & Medical Center, Burlington, - - 2014
NEPA is a novel oral fixed-dose combination of netupitant (NETU), a new highly selective NK1 receptor antagonist (RA) and palonosetron (PALO), a pharmacologically and clinically distinct 5-HT3 RA. This study was designed to determine the appropriate clinical dose of NETU to combine with PALO for evaluation in the Phase 3 ...
Odawara Masato M The Third Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan, - - 2014
The objective of this study was to evaluate the efficacy and safety of vildagliptin, a potent dipeptidyl peptidase-4 inhibitor, as an add-on to metformin in Japanese patients with type 2 diabetes mellitus (T2DM). This multicenter, 12-week, randomized, double-blind, placebo-controlled, parallel-arm study compared vildagliptin 50 mg bid with placebo in T2DM patients ...
Batterham A M AM Teesside University, Health and Social Care Institute, Middlesbrough, - - 2014
/st>Evidence is limited for the effectiveness of interventions for survivors of critical illness after hospital discharge. We explored the effect of an 8-week hospital-based exercise-training programme on physical fitness and quality-of-life. /st>In a parallel-group minimized controlled trial, patients were recruited before hospital discharge or in the intensive care follow-up clinic ...
Boeckxstaens Guy G Department of Gastroenterology, Translational Research Center for Gastrointestinal Disorders (TARGID), University Hospital Leuven, KU Leuven, , Leuven, - - 2014
The worldwide incidence of GORD and its complications is increasing along with the exponentially increasing problem of obesity. Of particular concern is the relationship between central adiposity and GORD complications, including oesophageal adenocarcinoma. Driven by progressive insight into the epidemiology and pathophysiology of GORD, the earlier belief that increased gastroesophageal ...
Seino Yutaka Y Kansai Electric Power Hospital, Osaka, - - 2014
Abstract Objective: Luseogliflozin is a novel sodium glucose cotransporter 2 inhibitor for type 2 diabetes mellitus (T2DM) treatment. An exploratory Phase II study was conducted to assess the efficacy and safety of several doses of luseogliflozin in Japanese T2DM patients. Patients and methods: Japanese T2DM patients aged 20-74 years with ...
Lee Dong Hoon DH Department of Orthopaedic Surgery, Severance Hospital, College of Medicine, Yonsei University, 134 Sinchondong, CPO Box 8044, Seoul, Republic of Korea, - - 2014
During lower limb lengthening, poor bone regeneration is a devastating complication. Several local or systemic applications have been used to promote osteogenesis, and biologic stimulations are gaining attention, but their utility has not been proven in this setting. In patients undergoing bilateral tibial lengthening, we compared those receiving an osteotomy ...
Maijers M C MC Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, De Boelelaan 1117, PO Box 7057, 1007 MB, Amsterdam, The Netherlands, - - 2014
The recall of Poly Implant Prothèse (PIP) silicone breast implants in 2010 resulted in large numbers of asymptomatic women with implants who underwent magnetic resonance imaging (MRI) screening. This study's aim was to assess the accuracy and interobserver variability of MRI screening in the detection of rupture and extracapsular silicone ...
Matsui Kunihiko K Department of General Medicine, Yamaguchi University Hospital, Yamaguchi, - - 2014
The OlmeSartan Calcium Antagonists Randomized (OSCAR) study is a multicenter, prospective, randomized, open-label, blinded, end point study of elderly hypertensive Japanese patients that compared the efficacy of a high-dose angiotensin II receptor blocker (ARB) treatment to an ARB plus calcium channel blocker (CCB) combination. In this pre-specified subgroup analysis, we ...
Yang Bing B Neonatal Screening Center, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University , Nanjing , P. R. China - - 2014
Abstract 1. The aim of this study was to investigate the pharmacokinetics of thiamphenicol glycinate (TG) and thiamphenicol (TAP) after intravenous (i.v.) infusion of TG hydrochloride in healthy Chinese by evaluating the pharmacokinetic parameters, to provide clinical guidance in TG application. 2. In this double-blinded, phase I clinical trial, 24 healthy Chinese ...
Tommaselli Giovanni A GA Department of Neuroscience and Reproductive and Odontostomatologic Sciences, University of Naples "Federico II", Via S. Pansini, 5, 80131, Naples, Italy, - - 2014
To evaluate the effect of a protocol of local anesthesia and epinephrine associated with sedo-analgesia on post-TVT-O pain in comparison with infiltration of saline and epinephrine. Forty-two patients undergoing TVT-O were randomized into two groups to receive periurethral infiltration with epinephrine only (group A, n = 21) or with epinephrine plus 1 % ...
Muddana Hari S HS Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, MC 0736, La Jolla, CA, 92093-0736, - - 2014
Prospective validation of methods for computing binding affinities can help assess their predictive power and thus set reasonable expectations for their performance in drug design applications. Supramolecular host-guest systems are excellent model systems for testing such affinity prediction methods, because their small size and limited conformational flexibility, relative to proteins, ...
Fiorentino Francesco F Genoma Molecular Genetics Laboratory, Rome, Italy. Electronic address: - - 2014
To validate a next-generation sequencing (NGS)-based method for 24-chromosome aneuploidy screening and to investigate its applicability to preimplantation genetic screening (PGS). Retrospective blinded study. Reference laboratory. Karyotypically defined chromosomally abnormal single cells and whole-genome amplification (WGA) products, previously analyzed by array comparative genomic hybridization (array-CGH), selected from 68 clinical PGS ...
Yanik Gregory A GA Blood and Marrow Transplant Program, University of Michigan Medical Center, Ann Arbor, MI. Electronic address: - - 2014
Idiopathic Pneumonia Syndrome (IPS) is a diffuse, non-infectious lung injury that occurs acutely after allogeneic hematopoietic cell transplant (HCT). IPS related mortality has been historically high (>50%) despite treatment with systemic corticosteroids and supportive care measures. The role of TNF inhibition is examined in a randomized, double-blind, placebo controlled trial ...
Czarnetzki Christoph C From the Division of Anesthesiology, Geneva University Hospitals, Geneva, Switzerland (C.C., C.L., N.E., M.R.T.); Faculty of Medicine, University of Geneva, Geneva, Switzerland (M.R.T.); Department of Anesthesiology and Intensive Care, University of Debrecen, Debrecen, Hungary (E.T.); and Institute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland - - 2014
Magnesium enhances the effect of rocuronium. Sugammadex reverses rocuronium-induced neuromuscular block. The authors investigated whether magnesium decreased the efficacy of sugammadex for the reversal of rocuronium-induced neuromuscular block. Thirty-two male patients were randomized in a double-blinded manner to receive magnesium sulfate (MgSO4) 60 mg/kg or placebo intravenously before induction of ...
Frey Sharon E SE Saint Louis University Medical School, Department of Internal Medicine, United States. Electronic address: - - 2014
Reintroduction of Variola major as an agent of bioterrorism remains a concern. Time to seroconversion and plaque reduction neutralizing antibody titers (PRNT) of 1 or 2 standard doses (SD) were compared to a single high dose (HD) of modified vaccinia Ankara (MVA). Ninety subjects were randomized 1:1 to receive 1 ...
Leroux-Roels Geert G Center for Vaccinology, Ghent University and Ghent University Hospital, Ghent, Belgium. Electronic address: - - 2014
New vaccines containing highly conserved Streptococcus pneumoniae proteins such as pneumolysin toxoid (dPly) and histidine-triad protein D (PhtD) are being developed to provide broader protection against pneumococcal disease. This study evaluated the safety, reactogenicity and immunogenicity of different pneumococcal protein-containing formulations in adults. In a phase I double-blind study (www.clinicaltrials.gov: ...
Cazabat Laure L Endocrinology, Ambroise Pare Universitary hospital, Assistance publique hôpitaux de Paris, 9 Avenue Charles de Gaulle, Boulogne-Billancourt, - - 2014
Silent corticotroph adenomas (SCAs) present as non-functional pituitary tumours in routine preoperative evaluation. The objective of this study was to evaluate the diagnostic accuracy of MRI T2-weighted sequences for detecting the corticotroph subtype preoperatively. The preoperative T2-weighted MRI sequences were retrospectively evaluated in patients with SCA and two control groups: ...
Spear Scott L SL Department of Plastic Surgery, Georgetown University Hospital, Washington, - - 2014
Background:The current standard for breast augmentation involves placement of an implant. As an alternative, surgeons have been exploring breast augmentation with autologous tissue in the form of injectable fat.Objectives:The authors explore the efficacy and safety of lipoaugmentation of the breast, with specific interest in volume changes, fat retention, overall aesthetic ...
Dababneh Luma L Cleveland Clinic, Respiratory Institute, Cleveland, Ohio, United States ; - - 2014
Rationale: Pulmonary arterial hypertension (PAH) is a pulmonary vasculopathy that leads to failure of the right ventricle and premature death. Objectives: To determine whether the sublingual microcirculation is affected in pulmonary arterial hypertension patients compared to healthy age- and gender matched controls. Methods: Using the CapiScope Handheld Video Capillaroscope we ...
Goudakos John K JK First Department of Otorhinolaryngology-Head and Neck Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, - - 2014
IMPORTANCE The management of patients with unilateral acute vestibular neuritis (VN) has not been established to date. OBJECTIVE To compare the use of vestibular exercises vs corticosteroid therapy in the recovery of patients with acute VN. DESIGN, SETTING, AND PARTICIPANTS Prospective, single-blind, randomized clinical trial at a primary referral center. ...
Camponovo C C Department of Anaesthesiology, Regional Hospital, Lugano, - - 2014
This prospective, observer-blinded, randomised, multicentre study aimed at determining the non-inferiority of 50 mg of plain 1% 2-chloroprocaine vs. 10 mg of 0.5% plain bupivacaine in terms of sensory block onset time at T10 after spinal injection. The study hypothesis was that the difference in onset times of sensory block to T10 ...
Carle Michelle V MV Retina-Vitreous Associates Medical Group, Los Angeles, - - 2014
IMPORTANCE Dermal injection of cosmetic fillers can lead to irreversible blindness when injected in the forehead, and this possible adverse effect is not typically mentioned to patients. OBSERVATIONS Vision loss from central retinal artery occlusion occurring, after cosmetic facial enhancement, was irreversible in 3 patients. However, 1 patient had a ...
Pohl Oliver O 1PregLem SA, Product and Clinical Development, Chemin du Pré-Fleuri 3, Geneva, - - 2014
The combination of a progestin such as norethindrone acetate (NETA) reducing the ovarian estrogen production with a steroid sulfatase (STS) inhibitor (STS-I) decreasing the local estrogen production could result in a new treatment option for endometriosis. The study reported was a randomized, double-blind, and placebo-controlled study to investigate the pharmacodynamics, ...
Orme Lisa M LM Children's Cancer Centre, The Royal Children's Hospital, Parkville, Victoria, - - 2014
Febrile neutropenia (FN) is a frequent, serious complication of intensive pediatric chemotherapy regimens. The aim of this trial was to compare quality of life (QOL) between inpatient and outpatient intravenous antibiotic management of children and adolescents with low risk febrile neutropenia (LRFN). In this randomised non-blinded trial, patients between 1 ...
Li Kaijun K Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, - - 2014
Optic neuritis is a common disease in young adults, inducing apoptosis of retinal ganglion cells, which leads to varying degree of visual function damages, even blindness. As the standard treatment, methylprednisolone pulse therapy can only promote the recovery of visual acuity but not prevent retinal ganglion cell degeneration. It cannot ...
Rathkopf Dana E DE Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA. Electronic address: - - 2014
Abiraterone acetate (an androgen biosynthesis inhibitor) plus prednisone is approved for treating patients with metastatic castration-resistant prostate cancer (mCRPC). Study COU-AA-302 evaluated abiraterone acetate plus prednisone versus prednisone alone in mildly symptomatic or asymptomatic patients with progressive mCRPC without prior chemotherapy. Report the prespecified third interim analysis (IA) of efficacy ...
Shin Joon-Ho - - 2014
Virtual reality (VR) is not commonly used in clinical rehabilitation, and commercial VR gaming systems may have mixed effects in patients with stroke. Therefore, we developed RehabMaster TM, a task-specific interactive game-based VR system for post-stroke rehabilitation of the upper extremities, and assessed its usability and clinical efficacy. A participatory ...
Page Andrew - - 2014
Suicide in young adults remains an important public health issue in Australia. The attributable risks associated with broader socioeconomic factors, compared to more proximal psychiatric disorders, have not been considered previously in individual-level studies of young adults. This study compared the relative contributions of psychiatric disorder and socio-economic disadvantage associated ...
Browne Lorcan - - 2014
A series of imidazol-1-ylethyl)indazole sodium channel ligands were developed and optimized for sodium channel inhibition and in vitro neuroprotective activity. The molecules exhibited displacement of the radiolabelled sodium channel ligand and selectivity for blockade of the inactivated state of cloned neuronal Nav channels. A metabolically stable analogue 6 (CFM6104) was ...
Cui Yiwen - - 2014
Non-cell-autonomous motor neuronal death is suggested in a mutant Cu/Zn superoxide dismutase 1 (mSOD1)-mediated amyotrophic lateral sclerosis (ALS) model, in which glial cells play significant roles in disease progression. Connexins (Cxs) form homotypic or heterotypic gap junctions (GJs) and allow direct intercellular communications among nervous tissue cells. The role of ...
Kingston Dawn - - 2014
Stress, depression, and anxiety affect 15 to 25% of pregnant women. However, fewer than 20% of prenatal care providers assess and treat mental health problems and fewer than 20% of pregnant women seek mental healthcare. For those who seek treatment, the lack of health system integration and existing barriers frequently ...
Wilson Jacob M JM Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL, 33606, USA, - - 2014
Studies utilizing beta-hydroxy-beta-methylbutyrate (HMB) supplementation in trained populations are limited. No long-term studies utilizing HMB free acid (HMB-FA) have been conducted. Therefore, we investigated the effects of 12 weeks of HMB-FA supplementation on skeletal muscle hypertrophy, body composition, strength, and power in trained individuals. We also determined the effects of HMB-FA ...
Yuge Kentaro K Department of Gene Therapy and Regenerative Medicine, Graduate School of Medicine, Gifu University, Gifu 502-1194, - - 2014
Inflammatory bowel disease (IBD) severely affects the quality of life of patients. At present, there is no clinical solution for this condition; therefore, there is a need for innovative therapies for IBD. Hepatocyte growth factor (HGF) exerts various biological activities in various organs. However, a clinically applicable and effective HGF-based ...
Ko┼éaczkowski Marcin M Adamed Ltd, Pienków 149, 05-152, Czosnów, Poland, - - 2014
Many dementia patients exhibit behavioral and psychological symptoms (BPSD), including psychosis and depression. Although antipsychotics are frequently prescribed off-label, they can have marked side effects. In addition, comparative preclinical studies of their effects are surprisingly scarce, and strategies for discovery of novel pharmacotherapeutics are lacking. We therefore compared eight antipsychotics ...
Qu Ying Y Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. - - 2014
SOX11 is involved in gastrulation and in malignant diseases. The aim of this study was to investigate the role of SOX11 in gastric cancer and its expression pattern and clinical significance. SOX11 overexpression cell model was used to examine in vitro and in vivo the role of SOX11 in cell ...
Hua Jenna - - 2014
Given the rapid pace of urbanization and Westernization and the increasing prevalence of obesity, there is a need for research to better understand the influence of the built environment on overweight and obesity in world's developing regions. Culturally-specific food environment survey instruments are important tools for studying changing food availability ...
Babisch Wolfgang W Department of Environmental Hygiene, Federal Environment Agency, Berlin, - - 2014
Studies on the association between traffic noise and cardiovascular diseases rarely considered air pollution as a covariate in the analyses. Isolated systolic hypertension has not yet been in the focus of epidemiological noise research. The association between traffic noise (road and rail) and the prevalence of hypertension was assessed in ...
Troughton Richard W RW Department of Medicine, University of Otago Christchurch, Christchurch Hospital, PO Box 4345, Christchurch 8140, New - - 2014
Natriuretic peptide-guided (NP-guided) treatment of heart failure has been tested against standard clinically guided care in multiple studies, but findings have been limited by study size. We sought to perform an individual patient data meta-analysis to evaluate the effect of NP-guided treatment of heart failure on all-cause mortality. Eligible randomized ...
Taipale Heidi H aKuopio Research Centre of Geriatric Care bSchool of Pharmacy cResearch Centre for Comparative Effectiveness and Patient Safety (RECEPS), University of Eastern Finland dDepartment of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio eNational Institute for Health and Welfare, Helsinki, Finland fDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, - - 2014
The objective of this study was to investigate the prevalence of acetylcholinesterase inhibitor (AChEI) and memantine use, duration of treatment, concomitant use of these drugs, and factors associated with the discontinuation of AChEI therapy during 2006-2009. We utilized data from a nationwide sample of community-dwelling individuals with a clinically verified ...
Kersten Sander S Nutrition, Metabolism and Genomics Group, Wageningen University, Bomenweg 2, 6703HD Wageningen, The - - 2014
The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription factor that plays a major role in metabolic regulation. This review addresses the functional role of PPARα in intermediary metabolism and provides a detailed overview of metabolic genes targeted by PPARα, with a focus on liver. A distinction is made ...
Kappos Ludwig L Departments of Neurology and Biomedicine, University Hospital Basel, Basel, Switzerland. Electronic address: - - 2014
Depletion of B lymphocytes is associated with suppression of inflammatory activity in multiple sclerosis. We aimed to assess the safety and efficacy of atacicept, a recombinant fusion protein that suppresses B-cell function and antibody production. In this placebo-controlled, double-blind, 36-week, phase 2 trial (ATAMS) in Australia, Canada, Europe, and the ...
Krege J H JH Lilly USA, Indianapolis, IN, - - 2014
Postmenopausal women with severe osteoporosis may require treatment with the bone anabolic drug teriparatide. While changes in bone mineral density (BMD) are one measure of response, BMD changes often require a minimum of one year to observe measureable changes. Biochemical markers of bone turnover change within 1 to 3 months of ...
Kim Jae-Hun JH Departments of aRadiology bNeurology, Samsung Medical Center, Sungkyunkwan University School of Medicine cCenter for Molecular and Cellular Imaging, Samsung Biomedical Research Institute dSamsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul eDepartment of Applied Chemistry, Kyung Hee University, Gyeonggi-do fDepartment of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, - - 2014
In this study, we have shown the potential of a voxel-based analysis for imaging amyloid plaques and its utility in monitoring therapeutic response in Alzheimer's disease (AD) mice using manganese oxide nanoparticles conjugated with an antibody of Aβ1-40 peptide (HMON-abAβ40). T1-weighted MR brain images of a drug-treated AD group (n=7), ...
Harty Siobhán S Trinity College Institute of Neuroscience and School of Psychology, Trinity College Dublin, Dublin 2, Ireland, and Department of Clinical and Experimental Sciences, University of Brescia, and Istituti di Ricovero e Cura a Carattere Scientifico Centro San Giovanni di Dio Fatebenefratelli, Brescia, - - 2014
The ability to detect errors during cognitive performance is compromised in older age and in a range of clinical populations. This study was designed to assess the effects of transcranial direct current stimulation (tDCS) on error awareness in healthy older human adults. tDCS was applied over DLPFC while subjects performed ...
Doornberg Job N JN Department of Orthopaedic Surgery, Academic Medical Center & University of Amsterdam, Secretariaat G4-Noord, Meibergdreef 9, 1100 DD Amsterdam, The - - 2014
Elbow stiffness is a common complication after elbow trauma. The elbow capsule is often thickened, fibrotic, and contracted at the time of surgical release. The limited studies available suggest that the capsule is contracted because of fibroblast-to-myofibroblast differentiation. We hypothesize that myofibroblasts are absent in normal elbow capsules and in ...
Dodhia Sonam S Department of Psychiatry, University of Illinois at Chicago, Chicago, - - 2014
Generalized social anxiety disorder (GSAD) is characterized by aberrant patterns of amygdala-frontal connectivity to social signals of threat and at rest. The neuropeptide oxytocin (OXT) modulates anxiety, stress and social behaviors. Recent functional neuroimaging studies suggest these effects are mediated through OXT's effects on amygdala reactivity and/or amygdala-frontal connectivity. The ...
Kim B J BJ Department of Dermatology, Chung-Ang University College of Medicine, Seoul, - - 2014
Botulinum toxins have been widely used in cosmetic dermatology. Neurotoxin from the CBFC26 strain (NTC) is a recently developed botulinum toxin type A product manufactured through refined procedures. A double-blinded, randomized, multicentre-designed, phase III trial to investigate the non-inferiority of NTC to existing botulinum toxin A, onabotulinumtoxin A in the ...
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