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Yang Yanwei Y Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, - - 2014
Removable dentures are subject to plaque and/or staining problems. Denture hygiene habits and risk factors differ among countries and regions. The aims of this study were to assess hygiene habits and denture plaque and staining risk factors in Chinese removable denture wearers aged >40 years in Xi'an through multiple logistic ...
Hartling Lisa L Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, - - 2014
To quantify bias related to specific methodological characteristics in child-relevant randomized controlled trials (RCTs). Meta-epidemiological study. We identified systematic reviews containing a meta-analysis with 10-40 RCTs that were relevant to child health in the Cochrane Database of Systematic Reviews. Two reviewers independently assessed RCTs using items in the Cochrane Risk ...
Li Juan J Cancer Research Center, Medical College of Xiamen University, Xiamen, - - 2014
Phytogenic compounds with anti-oxidant and anti-inflammatory properties, such as ginsenoside metabolite compound K (CK) or berberine (BBR), are currently discussed as promising complementary agents in the prevention and treatment of cancer and inflammation. The latest study showed that ginsenoside Rb1 and its metabolites could inhibit TNBS-induced colitis injury. However, the ...
Xu Jiansong J Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United - - 2014
Functional magnetic resonance imaging (fMRI) studies indicate that the brain organizes its activity into multiple functional networks (FNs) during either resting condition or task-performance. However, the functions of these FNs are not fully understood yet. To investigate the operation of these FNs, spatial independent component analysis (sICA) was used to ...
Cohen Jarish N JN Department of Microbiology, Immunology, and Cancer Biology and Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, United States of - - 2014
Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase, and induce deletion of specific CD8 T cells via Programmed Death Ligand-1 (PD-L1). Here, we demonstrate that high-level expression of peripheral ...
Ozpinar Aysel A Department of Medical Biochemistry, School of Medicine, Acibadem University, Istanbul, - - 2014
Perchlorate, nitrate, and thiocyanate are competitive inhibitors of the sodium iodide symporter of the thyroid membrane. These inhibitors can decrease iodine uptake by the symporter into the thyroid gland and may disrupt thyroid function. This study assesses iodine status and exposure to iodide uptake inhibitors of non-pregnant and non-lactating adult ...
Kamin Dirk D Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany ; STED Microscopy of Synaptic Function, European Neuroscience Institute, Göttingen, - - 2014
Styryl (FM) dyes have been used for more than two decades to investigate exo- and endocytosis in conventional synapses. However, they are difficult to use in the inner hair cells of the auditory pathway (IHCs), as FM dyes appear to penetrate through mechanotransducer channels into the cytosol of IHCs, masking ...
Liu Binya B Department of Obstetrics and Gynecology, International Peace Maternity & Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, - - 2014
MicroRNAs play key roles in tumor proliferation and invasion. Here we show distinct expression of miR-222-3p between ERα-positive and ERα-negative endometrial carcinoma (EC) cell lines and primary tumors, and investigation of its relationship with ERα and other clinical parameters. In vitro, the function of miR-222-3p was examined in RL95-2 and ...
Astafurov Konstantin K Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, - - 2014
To determine whether short-term pressure elevation affects complement gene expression in the retina in vitro and in vivo. Muller cell (TR-MUL5) cultures and organotypic retinal cultures from adult mice and monkeys were subjected to either 24-h or 72-h of pressure at 0, 15, 30, and 45 mmHg above ambient. C57BL/6 ...
Qin Qin Q Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, - - 2014
Human telomeres, tandem repeats of TTAGGG nucleotides at the ends of chromosomes, are essential for maintaining genomic integrity and stability. Results of previous epidemiologic studies about the association of telomere length with risk of colorectal cancer (CRC) have been conflicting. A case-control study was conducted in a Han population in ...
Grenfell Rafaella Fortini Queiroz RF Schistosomiasis Laboratory, Rene Rachou Research Center, Oswaldo Cruz Foundation (Fiocruz), Belo Horizonte, Minas Gerais, Brazil ; Department of Infectious Diseases, College of Veterinary Medicine, and Center for Tropical and Emerging Global Diseases, University of Georgia (UGA), Athens, Georgia, United States of - - 2014
Current available methods for diagnosis of schistosomiasis mansoni lack sufficient sensitivity, which results in underreporting of infectious in areas of low endemicity. We developed three novel diagnostic methodologies for the direct detection of schistosome infection in serum samples. These three new methods were evaluated with positive patients from a low ...
van Vliet Maarten M Department of Haematology, Radboud University Medical Center, Nijmegen, The - - 2014
Long-term health-related quality of life (HRQoL) was determined for patients admitted to the haematology ward who needed intensive care treatment (H-IC+) and compared with those who did not (H-IC-) as well as with that for patients admitted to the general ICU (nH-IC+). A cross-sectional study was carried out median 18 ...
Hwang Sungjae S Department of Kinesiology, Temple University, Philadelphia, Pennsylvania, United States of - - 2014
We simultaneously perturbed visual, vestibular and proprioceptive modalities to understand how sensory feedback is re-weighted so that overall feedback remains suited to stabilizing upright stance. Ten healthy young subjects received an 80 Hz vibratory stimulus to their bilateral Achilles tendons (stimulus turns on-off at 0.28 Hz), a ±1 mA binaural ...
Huang Shao-Chang SC Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, - - 2014
Animal communication relies on conspicuous signals and compatible signal perception abilities. Good signal perception abilities are particularly important for polymorphic animals where mate choice can be a challenge. Behavioral studies suggest that polymorphic damselflies use their varying body colorations and/or color patterns as communication signal for mate choice and to ...
Des Jarlais Don C DC The Baron Edmond de Rothschild Chemical Dependency Institute, Beth Israel Medical Center, New York, New York, United States of - - 2014
To examine herpes simplex virus 2 (HSV-2)/HIV co-infection as a contributing factor in the increase in HIV infection among non-injecting heroin and cocaine users in New York City. Subjects were recruited from the Beth Israel Medical Center drug detoxification and methadone maintenance programs in New York City in 1995-1999 and ...
Hotez Peter J PJ Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine at Baylor College of Medicine, Houston, Texas, United States of America ; Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Houston, Texas, United States of America ; James A. Baker III Institute for Public Policy, Rice University, Houston, Texas, United States of - - 2014
Karkampouna Sofia S Department of Molecular Cell Biology, Cancer Genomics Centre and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The - - 2014
Dupuytren's disease (DD) is a benign fibroproliferative disease of the hand. It is characterized by the excessive production of extracellular matrix (ECM) proteins, which form a strong fibrous tissue between the handpalm and fingers, permanently disrupting the fine movement ability. The major contractile element in DD is the myofibroblast (MFB). ...
Williamson Victoria J VJ Hochschule Luzern - Musik, Lucerne University of Applied Sciences and Arts, Luzern, Switzerland ; Department of Music, University of Sheffield, Sheffield, United - - 2014
The vast majority of people experience involuntary musical imagery (INMI) or 'earworms'; perceptions of spontaneous, repetitive musical sound in the absence of an external source. The majority of INMI episodes are not bothersome, while some cause disruption ranging from distraction to anxiety and distress. To date, little is known about ...
Toosy Ahmed A Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, - - 2014
The range of symptoms which occur in multiple sclerosis (MS) can have disabling functional consequences for patients and lead to significant reductions in their quality of life. MS symptoms can also interact with each other, making their management challenging. Clinical trials aimed at identifying symptomatic therapies have generally been poorly ...
Ventres William - - 2014
Despite the historical and social significance of poverty, scholars from varied ideological and philosophical disciplines have often observed that its most notable feature is its invisibility. We suggest that poverty is not excluded from view, but rather from consciousness. This lack of consciousness is due to a subjective "poverty blindness" ...
Okoye Obiekwe - - 2014
Introduction. Pediatric ocular trauma is a significant worldwide problem of public health importance being a leading cause of non-congenital unilateral blindness. This study evaluated the proportion, type and causes of ocular injuries among children in a rural hospital of Nigeria. Methods. Children (&lt;16 years) presenting with ocular trauma at the ...
Conlon J Michael JM Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE. - - 2014
Skin secretions from frogs belonging to the genera Xenopus, Silurana, Hymenochirus, and Pseudhymenochirus in the family Pipidae are a rich source of host-defense peptides with varying degrees of antimicrobial activities and cytotoxicities to mammalian cells. Magainin, peptide glycine-leucine-amide (PGLa), caerulein-precursor fragment (CPF), and xenopsin-precursor fragment (XPF) peptides have been isolated ...
Chiu Chih-Min - - 2014
The human body plays host to a vast array of bacteria, found in oral cavities, skin, gastrointestinal tract and the vagina. Some bacteria are harmful while others are beneficial to the host. Despite the availability of many methods to identify bacteria, most of them are only applicable to specific and ...
Saito Tsunehiro T Department of Ophthalmology, Kyorin University School of Medicine, Japan. - - 2014
We compared therapeutic outcomes in two cases of juxtapapillary capillary hemangiomas associated with von Hippel-Lindau disease. Case 1 was a 47-year-old man whose left eye was blind due to proliferative vitreoretinopathy. Visual acuity of the right eye was 1.2. No exudative change was found, but the juxtapapillary retinal hemangioma was ...
Huellner Martin W MW Department of Radiology and Nuclear Medicine, Lucerne Cantonal Hospital, Spitalstrasse 1, Lucerne CH-6004, Switzerland. - - 2014
The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer. Fifty-four consecutive patients (median age 65 years, 15 females, 39 males) with suspected lung cancer were evaluated ...
Michailidis Lucia L Podiatry Department, Monash Health, Warrigal Road, Cheltenham, Victoria 3192, Australia. - - 2014
Foot ulceration has been reported as the leading cause of hospital admission and amputation in individuals with diabetes. Diabetes-related foot ulcers require multidisciplinary management and best practice care, including debridement, offloading, dressings, management of infection, modified footwear and management of extrinsic factors.Ulcer debridement is a commonly applied management approach involving ...
Rico-Blázquez Milagros M Unidad de Apoyo a la Investigación, Dirección Técnica de Docencia e Investigación, Gerencia Adjunta de Planificación y Calidad, Gerencia de Atención Primaria, C/ San Martín de Porres, 6 _ 5ª planta, 28035 Madrid, Spain. - - 2014
In Spain, family is the main source of care for dependent people. Numerous studies suggest that providing informal (unpaid) care during a prolonged period of time results in a morbidity-generating burden. Caregivers constitute a high-risk group that experiences elevated stress levels, which reduce their quality of life.Different strategies have been ...
Yilmazel Ucar Elif E Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Turkey. - - 2014
Pharmacologic therapies have an important role in the success of interventions for smoking cessation. This study aims to determine the efficacy of several pharmacologic treatments in patients who applied to a smoking cessation clinic. This retrospective study includes 422 patients who presented to our smoking cessation clinic between January 2010 ...
Dabisch Inna - - 2014
The German AMNOG healthcare reform includes a mandatory early-benefit-assessment (EBA) at launch. As per German social code, EBA is based on registration trials and includes evaluation of the patient-relevant effect of the new medicines compared to an appropriate comparator as defined by the Federal Joint Committee (G-BA). Current EBA decisions ...
Pournik Omid O Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran ; Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, IR - - 2014
Histopathologic assessment of liver tissue is an essential step in management and follow-up of non-alcoholic fatty liver disease (NAFLD) while inter- and intra-observer variations limit the accuracy of these assessments. The aim of this study was to assess the inter- and intra-observer reproducibility of histopathologic assessment of liver biopsies based ...
Cybula-Walczak Aneta A Department of Hepatology and Acquired Immunodeficiencies, Medical University of Warsaw, Warsaw, - - 2014
We report a case of a 52-year-old human immunodeficiency virus (HIV)-infected male patient receiving combined antiretroviral therapy (cART), who presented with acute ST-elevation myocardial infarction (STEMI). He was properly treated (e.g., prescribed anti-coagulation drugs: aspirin, clopidogrel, enoxaparin) and discharged. After 1.5 months, another STEMI related with in-stent thrombosis took place. ...
Glauber Harry S HS Department of Endocrinology, Northwest Permanente, Portland, Oregon, USA; ; Galil Center for Telemedicine, Medical Informatics and Personalized Medicine, RB Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, - - 2014
The world is facing an epidemic rise in diabetes mellitus (DM) incidence, which is challenging health funders, health systems, clinicians, and patients to understand and respond to a flood of research and knowledge. Evidence-based guidelines provide uniform management recommendations for "average" patients that rarely take into account individual variation in ...
Bailey Robert A RA 1000 US Route 202 South, Raritan, NJ 08869. E-mail: - - 2014
Objective: To evaluate attainment of diabetes-related quality measures with canagliflozin, a sodium glucose cotransporter 2 inhibitor, versus sitagliptin in patients with type 2 diabetes mellitus (T2DM). Study design: This post hoc analysis included data from a 52-week, randomized, double-blind, phase 3 study comparing canagliflozin 300 mg and sitagliptin 100 mg ...
Lee Joowon J Department of Pediatrics, Seoul National University Children's Hospital, Seoul, - - 2014
Acute giant coronary aneurysm after Kawasaki disease (KD) is a catastrophic complication that can be fatal and very difficult to manage. However, no fixed consensus has been reached for the management of super-giant coronary aneurysms in the acute setting. Here, we report the successful management of young children with super-giant ...
- - 2014
Patients with metastatic colorectal cancer who have exhausted their therapeutic options have a life expectancy of only a few months. Treatment is then based on tailored supportive care, without cytotoxic drugs. Regorafenib, an inhibitor of multiple protein kinases, has been authorised in the European Union for the treatment of patients ...
Mughal Tariq I TI Tufts University School of Medicine, Boston, MA, - - 2014
Myelofibrosis (MF) is a rare chronic BCR-ABL1 (breakpoint cluster region-Abelson murine leukemia viral oncogene homologue 1)-negative myeloproliferative neoplasm characterized by progressive bone marrow fibrosis, inefficient hematopoiesis, and shortened survival. The clinical manifestations of MF include splenomegaly, consequent to extramedullary hematopoiesis, cytopenias, and an array of potentially debilitating abdominal and constitutional ...
Tujii Tomoaki T Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Tohon Ehime, - - 2014
Pregabalin, a novel agent for treating partial epilepsy and peripheral neuropathic and central pain, was studied for its effect on driving performance in healthy volunteers. Sixteen healthy male volunteers who drove regularly were enrolled in a double-blind, parallel-group, placebo-controlled study assessing the effect of pregabalin on driving performance. Subjects received ...
Liu Boying - - 2014
Bjerkandera adusta (B. adusta) is one of the most important etiological fungi associated with chronic cough. However, precise details of the inflammatory response to exposure are not well understood yet. B. adusta was recently identified in Asian sand dust (ASD) aerosol. Therefore, in the present study the exacerbating effects of ...
Nichols Nicole L NL Department of Neuroscience, Cell Biology and Physiology, Wright State University Boonshoft School of Medicine, Dayton, Ohio, United States of - - 2014
NK1 receptors, which bind substance P, are present in the majority of brainstem regions that contain CO2/H(+)-sensitive neurons that play a role in central chemosensitivity. However, the effect of substance P on the chemosensitive response of neurons from these regions has not been studied. Hypoxia increases substance P release from ...
Alexandre Isabel - - 2014
Neonatal conjunctivitis or ophthalmia neonatorum (ON) is an acute bacterial conjunctivitis contracted by newborns during delivery. In non-industrialized countries, detection of the etiological agent is difficult due to the unavailability of modern diagnostic resources. Therefore, we analyzed the effectiveness of Gram and methylene blue staining techniques, which are simple microbiological ...
Sasaki Tsuyoshi T Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan ; Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, - - 2014
Tipepidine (3-[di-2-thienylmethylene]-1-methylpiperidine) has been used solely as a nonnarcotic antitussive in Japan since 1959. The safety of tipepidine in children and adults has already been established. It is reported that tipepidine inhibits G-protein-coupled inwardly rectifying potassium (GIRK)-channel currents. The inhibition of GIRK channels by tipepidine is expected to modulate the ...
Gross Andreas J AJ Department of Urology, Asklepios Hospital Barmbek, 22291 Hamburg, - - 2014
The natural course of untreated asymptomatic caliceal calculi has not been clearly defined, especially in terms of disease progression, and the indications for and outcomes of surgical intervention are not precise. Caliceal stones may remain asymptomatic but, in case of migration, ureteral calculi can cause acute ureteric colic with severe ...
Omer Muhammad Ovais MO Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, - - 2014
The Newcastle disease represents as one of the most infectious viral disease, which afflicts almost every species of the birds. The causative agent of the disease is a single-stranded RNA virus with rapid replication capability. This study was performed to evaluate the comparative anti-viral efficacy and toxicity of Glycyrrhiza glabra ...
Fatima Nishat N Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, - - 2014
Acute and chronic stress is a risk factor for the development and progression of coronary artery disease. Increased arterial stiffness is an independent marker for cardiovascular disease. Cold pressor test (CPT) is known to be associated with substantial activation of the autonomic nervous system. The aim of this study was ...
Mandal Pragnadyuti P Department of Pharmacology, Midnapore Medical College, Paschim Medinipur, West Bengal, - - 2014
Post-operative nausea and vomiting (PONV) frequently hampers implementation of ambulatory surgery in spite of so many costly antiemetic drugs and regimens. The study was carried out to compare the efficacy of ginger (Zingiber officinale) added to Ondansetron in preventing PONV after ambulatory surgery. It was a prospective, double blinded, and ...
Rahmat Adisa A AA Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, - - 2014
The chemoprevention of chemically-induced hepatotoxicity is a crucial means of minimizing susceptibility to hepatic carcinogenesis and plants remain a rich source of anti-hepatotoxicants with antioxidant properties. The protective role of defatted-methanol (MECF) and ethyl acetate fractions (EF), obtained from Leaves of Cnestis ferruginea in rats induced with carbon tetrachloride (CCl4) ...
Morgan Sherif S - - 2014
Serum protein acidic and rich in cysteine (SPARC) is a matricellular secreted glycoprotein that performs several cellular functions and has been implicated in tumorigenesis in a variety of tumor types. The chemotherapeutic agent nanoparticle albumin-encapsulated (NAB)-paclitaxel has been postulated to exploit SPARC expression to target neoplastic cells. SPARC's role, and ...
Schuhmann Christoph G CG Department of Cardiology, Medizinische Klinik I, Munich, - - 2014
Elevated levels of myeloperoxidase (MPO) have been found in patients in different stages of coronary artery disease (CAD). The aim of this study was to assess whether the MPO liberation is increased by stress inducible myocardial ischemia and could be used to improve the diagnostic accuracy of non-invasive evaluation for ...
Rhee Moo-Yong MY Cardiovascular Center, Dongguk University Ilsan Hospital, Goyang, - - 2014
Metabolic syndrome and high sodium intake are associated with frequent cardiovascular events. Few studies have estimated sodium intake in subjects with metabolic syndrome by 24-hour urine sodium excretion. We evaluated sodium intake in individuals with metabolic syndrome. Participants were recruited by random selection and through advertisement. Twenty four-hour urine collection, ...
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