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Däbritz Jan - - 2014
Hydrogen breath tests are noninvasive procedures frequently applied in the diagnostic workup of functional gastrointestinal disorders. Here, we review hydrogen breath test results and the occurrence of lactose, fructose and sorbitol malabsorption in pediatric patients; and determine the significance of the findings and the outcome of patients with carbohydrate malabsorption. ...
Banach Maciej M Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Zeromskiego 113, 90-549, Lodz, Poland, - - 2014
The year 2013 proved to be very exciting as far as landmark trials and new guidelines in the field of lipid disorders, blood pressure and kidney diseases. Among these are the International Atherosclerosis Society Global Recommendations for the Management of Dyslipidemia, European Society of Cardiology (ESC)/European Society of Hypertension Guidelines ...
Crack Peter J - - 2014
Lysophosphatidic acid (LPA) is a bioactive phospholipid with a potentially causative role in neurotrauma. Blocking LPA signaling with the LPA-directed monoclonal antibody B3/Lpathomab is neuroprotective in the mouse spinal cord following injury. Here we investigated the use of this agent in treatment of secondary brain damage consequent to traumatic brain ...
Qiu Shanhu - - 2014
While step counter use has become popular among type 2 diabetes (T2D) patients, its effectiveness in increasing physical activity (PA) and improving glycemic control has been poorly defined. The aim of this meta-analysis of randomized controlled trials (RCTs) was to evaluate the association of step counter use with PA and ...
Ciarapica Roberta - - 2014
Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma derived from myogenic precursors that is characterized by a good prognosis in patients with localized disease. Conversely, metastatic tumors often relapse, leading to a dismal outcome. The histone methyltransferase EZH2 epigenetically suppresses skeletal muscle differentiation by repressing the transcription of myogenic genes. ...
Madjunkova Svetlana S The Motherisk Program, Division of Clinical Pharmacology/Toxicology, Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Canada, - - 2014
Nausea and vomiting of pregnancy (NVP) affects up to 85 % of all pregnancies. Effective treatment can greatly improve a woman's quality of life, reduce the risk for maternal and fetal complications, and reduce healthcare costs. Unfortunately, many women receive either no pharmacological treatment or are recommended therapies for which fetal ...
Geho W Blair WB Diasome Pharmaceuticals, Inc, Cleveland, OH, USA - - 2014
The dose response of postprandial plasma glucose (PPG) to add-on, premeal oral hepatic-directed vesicle-insulin (HDV-I), an investigational lipid bio-nanoparticle hepatocyte-targeted insulin delivery system, was evaluated in a 3-test-meal/day model in type 2 diabetes patients. The single-blind, placebo-controlled, dose-escalating trial enrolled 6 patients with HbA1c 8.6 ± 2.0% (70.0 ± 21.9 ...
Buraczynska Monika M Laboratory for DNA Analysis and Molecular Diagnostics, Department of Nephrology, Medical University of Lublin, Dr K. Jaczewskiego 8, 20-954, Lublin, Poland, - - 2014
Variants of the transcription factor 7-like 2 gene (TCF7L2) have been associated with type 2 diabetes and cardiovascular disease in different populations. Here we investigated the potential association of the rs7903146 polymorphism in the TCF7L2 gene with clinical profile of end-stage renal disease (ESRD) patients. We examined a cohort of ...
Haneda Masataka M 1 Department of Transplant Immunology, Nagoya University School of Medicine, Nagoya, Japan. 2 Japanese Red Cross Aichi Blood Center, Seto, Japan. 3 Department of Surgery II, Nagoya University School of Medicine, Nagoya, Japan. 4 Address correspondence to: Takaaki Kobayashi, M.D., Department of Transplant Immunology, Nagoya University School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya 466-8550, - - 2014
Although more attention has been paid recently to B-cell immunity, assay for B-cell analysis has yet to be clinically applicable because, unlike T cell, a B-cell culture system has not been well established. We attempted to develop an in vitro culture system for the proliferation and differentiation of peripheral B ...
Egan Amy G AG From the Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD (A.G.E., B.T.H., T.B., C.R.); the European Medicines Agency, London (E.B.); Läkemedelsverket, Uppsala, Sweden (K.D.); and the Dutch Medicines Evaluation Board, Utrecht, the Netherlands - - 2014
Hasan Sibah S *Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK; - - 2014
In humans, a primate-specific variable-number tandem-repeat (VNTR) polymorphism (4 or 5 repeats 54 nt in length) in the circadian gene PER3 is associated with differences in sleep timing and homeostatic responses to sleep loss. We investigated the effects of this polymorphism on circadian rhythmicity and sleep homeostasis by introducing the ...
Arce Joan-Carles JC Reproductive Health, Ferring Pharmaceuticals A/S , Copenhagen , Denmark - - 2014
Abstract The aim was to compare ovarian response and clinical outcome of potential high-responders after stimulation with highly purified menotropin (HP-hMG) or recombinant follicle-stimulating hormone (rFSH) for in vitro fertilisation/intracytoplasmic sperm injection. Retrospective analysis was performed on data collected in two randomized controlled trials, one conducted following a long GnRH ...
Buckland Karen F KF Centre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, United Kingdom; Cellular Therapies, Great Ormond Street Hospital NHS foundation Trust, London, United Kingdom. Electronic address: - - 2014
The range of possible gene and cell therapy applications is expanding at an extremely rapid rate and advanced therapy medicinal products (ATMP) are currently the hottest topic in novel medicines, particularly for inherited diseases. Paediatric patients stand to gain enormously from these novel therapies as it now seems plausible to ...
Moran-Muñoz Rafael R Department of Veterinary Anesthesiology, Faculty of Veterinary Medicine, Universidad Autónoma del Estado de - - 2014
The aim of this study was to determine the effects of lidocaine (LIDO) and dexmedetomidine (DEX) or their combination (LIDO-DEX), administered by constant-rate infusion (CRI), on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Seven healthy mongrel dogs were used with a 2-week washout interval between treatments in this ...
Bianchi Diana W DW From the Mother Infant Research Institute, Tufts Medical Center and Tufts University School of Medicine, Boston (D.W.B.); Lyndhurst Clinical Research, Winston-Salem, NC (R.L.P.); the Group for Women, Norfolk, VA (J.W.); Long Island Jewish Medical Center, North Shore-LIJ Health Systems, New Hyde Park, NY (R.M.); West Coast OB/GYN, San Diego (C.S.), InClin, San Mateo (A.F.D.), and Illumina, Redwood City (D.I.C., P.L.D., K.W.J., K.O., R.P.R., A.J.S.) - all in California; and Colorado Permanente Medical Group, Denver - - 2014
In high-risk pregnant women, noninvasive prenatal testing with the use of massively parallel sequencing of maternal plasma cell-free DNA (cfDNA testing) accurately detects fetal autosomal aneuploidy. Its performance in low-risk women is unclear. At 21 centers in the United States, we collected blood samples from women with singleton pregnancies who ...
Bao Yu-Hua YH Pain Management Center, Shanghai Six People's Hospital, Shanghai Jiaotong University, No. 600 Yishan Road, Shanghai, 200233, People's Republic of - - 2014
In the present study, we investigated the anti-inflammatory mechanisms by which gabapentin enhances morphine anti-nociceptive effect in neuropathic pain in rats and the interaction between the anti-nociceptive effects of gabapentin on morphine and the interleukin (IL)-10-heme-oxygenase (HO)-1 signal pathway in a rat model of neuropathic pain. The neuropathic pain model ...
Tzabazis A Z AZ Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, - - 2014
The aim of this study was to test the efficacy of a single direct injection of viral vector encoding for encephalin to induce a widespread expression of the transgene and potential analgesic effect in trigeminal behavioral pain models in mice. After direct injection of herpes simplex virus type 1 based ...
Costa D J DJ Primary Care Department, University of Medicine, Montpellier I University, Montpellier, - - 2014
Background/objectives:An imbalance between Th1 and Th2 cells is involved in allergic rhinitis (AR) that may be improved by probiotics. To test the efficacy of the probiotic Lactobacillus paracasei subsp. paracasei LP-33, a double-blind, placebo-controlled, randomized trial was carried out in patients with AR to grass pollen treated with loratadine and ...
Ivey K L KL 1] School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, University of Western Australia, Perth, WA, Australia [2] Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA, - - 2014
Background/Objectives:Evidence from animal and in vitro models suggest a role of probiotic bacteria in improving glycaemic control and delaying the onset of type 2 diabetes. However, the evidence from controlled trials in humans is limited. The objective was to determine if the probiotic bacteria L. acidophilus La5 and B. animalis ...
Lee Hye Won HW Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, - - 2014
Endoscopic submucosal dissection (ESD) is the gold standard technique for en bloc resection of large superficial tumors in the upper and lower gastrointestinal tract. Little is known about the management of epigastric pain after ESD of gastric neoplasms. This study investigated the utility and safety of single-dose, perioperative, intravenous dexamethasone ...
Ansell James J Welsh Institute for Minimal Access Therapy (WIMAT), Cardiff, CF14 4UJ, Wales, UK, - - 2014
Ultravision™ is a new device that utilizes electrostatic precipitation to clear surgical smoke. The aim was to evaluate its performance during laparoscopic cholecystectomy. Patients undergoing laparoscopic cholecystectomy were randomized into "active (device on)" or "control (device off)." Three operating surgeons scored the percentage effective visibility and three reviewers scored the ...
Drollmann Anton - - 2014
Objectives: QVA149 is a dual bronchodilator, containing a fixed-dose combination of the long-acting β2-agonist indacaterol and long-acting muscarinic antagonist glycopyrronium, for the treatment of chronic obstructive pulmonary disease (COPD). Here we assess the potential of QVA149 (440/200 μg) at 4-fold the therapeutic dose for causing cardiac pharmacodynamic (PD) effects. Methods: ...
Mansergh Fiona C FC Ocular Genetics Unit, Smurfit Institute of Genetics, School of Genetics and Microbiology, Trinity College Dublin, Dublin, - - 2014
Primary mitochondrial disorders occur at a prevalence of one in 10 000; ∼50% of these demonstrate ocular pathology. Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial disorder. LHON results from retinal ganglion cell pathology, which leads to optic nerve degeneration and blindness. Over 95% of cases result from ...
Taylor-Brown F F Frances Taylor-Brown, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire, AL9 7TA, United Kingdom, Phone: +44 1707 666366, Fax: +44 1707 689384, E-mail: - - 2014
Objectives: To document the use of and to estimate the accuracy of magnetic resonance (MR) imaging for detection of late meniscal tears in dogs with cranial cruciate ligament injury treated with tibial tuberosity advancement (TTA). Methods: Medical records of dogs that had TTA followed by stifle MR imaging for suspected ...
Inoue Ken K Department of Molecular Gastroenterology and Hepatology, North Medical Center Kyoto Prefectural University of Medicine, Kyoto, - - 2014
Background and study aims: Colonoscopy is one of the most reliable methods for the detection of colorectal neoplasms. However, colonic peristalsis during colonoscopy results in some neoplastic lesions being hidden from view and commonly requires an intravenous or intramuscular injection of antispasmodic agents, which may sometimes causes unexpected adverse reactions. ...
Hsu Wen-Feng WF Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, - - 2014
Background and study aims: Carbon dioxide (CO2) insufflation during colonoscopy can significantly decrease abdominal pain and bloating after the procedure, but its impact on the frequency and duration of toilet use remains unknown. The aim of this study was to assess the impact of CO2 insufflation on toilet use after ...
Grosen Kasper K Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, - - 2014
To evaluate the effect of perioperative gabapentin treatment for the prevention of persistent post-thoracotomy pain and to establish whether gabapentin has a significant therapeutic impact on acute postoperative pain. Consecutive patients with pulmonary malignancies scheduled for anterior thoracotomy were enrolled in this randomized, double-blinded, placebo-controlled trial. Patients were given 1200 ...
Rodríguez-Santana Elizabeth E Fundalas, Foundation for Interdisciplinary Research and Development , Caracas, Venezuela - - 2014
Abstract Objective: The purpose of this study was to present preliminary evidence of the exclusion zone (EZ) and photobiomodulation (PBM) phenomena relating to ophthalmology. Background data: Water is the main media and fluid found in ocular tissues. Water is also an important photoacceptor and energy storage medium. Eyes are abundantly ...
Bordeleau Louise L Department of Oncology, Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, - - 2014
OBJECTIVEEpidemiologic studies linking insulin glargine and glucose-lowering therapies to cancers and n-3 fatty acids to cancer prevention have not been confirmed. We aim to assess the effect of insulin glargine and n-3 fatty acids on incident cancers within the context of the ORIGIN (Outcome Reduction with an Initial Glargine Intervention) ...
Zhang Yuanhui Y Graduate Program in Operations Research, North Carolina State University, Raleigh, - - 2014
OBJECTIVEWhile metformin is generally accepted as the first-line agent in treatment of type 2 diabetes, there are insufficient evidence and extensive debate about the best second-line agent. We aimed to assess the benefits and harms of four commonly used antihyperglycemia treatment regimens considering clinical effectiveness, quality of life, and cost.RESEARCH ...
Sax William W South Asia - - 2014
Ritual healing is very widespread in the Indian state of Uttarakhand, and is by far the most common option for those with serious behavioral disturbances. Although ritual healing thus accounts for a very large part of the actual health care system, the state and its regulatory agencies have, for the ...
Kim Yun-Hee YH Department of Anaesthesia and Pain Medicine, Ansan Hospital, Korea University College of Medicine, Ansan, Republic of - - 2014
To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine. Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0.5 mg/kg), 0.03 mg/kg cisatracurium or 0.15 mg/kg cisatracurium. All drugs were administered into the largest ...
Thibaut Aurore A From the Coma Science Group (A.T., M.-A.B., D.L., A.D., S.L.), Cyclotron Research Centre; and the Departments of Neurology (A.T., M.-A.B., A.D., S.L.) and General Intensive Care (D.L.), University Hospital of Liège, - - 2014
We assessed the effects of left dorsolateral prefrontal cortex transcranial direct current stimulation (DLPF-tDCS) on Coma Recovery Scale-Revised (CRS-R) scores in severely brain-damaged patients with disorders of consciousness. In a double-blind sham-controlled crossover design, anodal and sham tDCS were delivered in randomized order over the left DLPF cortex for 20 ...
Fechner Anita A Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University, Jena, - - 2014
Lupin kernel fiber beneficially modifies blood lipids because of its bile acid-binding capacity. The aim of this study was to evaluate the preventive effects of a lupin kernel fiber preparation on cardiovascular diseases and to clarify possible mechanisms. In a randomized, double-blind, controlled crossover trial, 60 moderately hypercholesterolemic adults (plasma ...
Soares Claudio N CN 1 Department of Psychiatry and Behavioural Neurosciences, McMaster University & St. Joseph's Healthcare, Hamilton, Ontario, - - 2014
The predictive value of early functional improvement for treatment success at week 8 was assessed in a pooled analysis in patients with major depressive disorder (MDD). Data were pooled from 7 double-blind studies in adult patients with MDD randomly assigned to desvenlafaxine 50 mg/d or placebo. Four levels of treatment ...
Beneck George J GJ 1Department of Physical Therapy California State University Long Beach, Long Beach, CA, - - 2014
Objective:The purpose of the study was to examine changes in quality of life measures in patients who have undergone an intensive exercise program following a single level microdiskectomy.Design:Randomized controlled trial with blinded examiners.Setting:The study was conducted in outpatient physical therapy clinics.Subjects:Ninety-eight participants (53 male, 45 female) who had undergone a ...
Slattery Katie May KM 1Sport & Exercise Discipline Group, Faculty of Health, University of Technology, Sydney, Australia; 2Human Exercise Performance Laboratory, School of Medical Science, University of Adelaide, Australia; 3Applied Sports Science and Exercise Testing Laboratory, School of Environmental and Life Sciences, University of Newcastle, - - 2014
This investigation examined the ergogenic effect of short-term oral N-acetylcysteine (NAC) supplementation and the associated changes in redox balance and inflammation during intense training. A double blind randomised placebo-controlled crossover design was used to assess 9 days of oral NAC supplementation (1200 mg/day) in 10 well-trained triathletes. For each supplement ...
Lam Hugh S HS Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Sha Tin, Hong - - 2014
Background: Infants receiving prolonged parenteral nutrition (PN) are at risk of PN-associated cholestasis (PNAC). This can progress to hepatic failure and death if PN cannot be discontinued. Fish oil-based parenteral lipid preparation (FOLP) has been shown to be beneficial in case studies. Objectives: (1) To evaluate whether FOLP could halt ...
Welsh Paul P Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, - - 2014
Are the new Ansh Labs Ultra-Sensitive anti-Müllerian hormone (AMH) and picoAMH ELISA assays suitable for clinical use and is the Ultra-Sensitive assay comparable to the Beckman Coulter AMH Gen II assay? The Ultra-Sensitive assay appears to have different calibration to the Gen II assay, but has performance characteristics generally suitable ...
Hruskova Zdenka Z Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University in Prague, Prague, Czech - - 2014
Histopathological lesions in renal biopsy (RB) at presentation of ANCA-associated vasculitis (AAV) have been described in depth but repeat protocolized renal biopsies are seldomly performed in AAV. In this study, we present a group of AAV patients with repeat protocolized biopsies, and we evaluate their clinical significance. A total of ...
Okamoto Yosuke - - 2014
It is well known that exposure to light, especially of short wavelength, enhances human alertness during the nighttime. However, more information is needed to elucidate the effects of light wavelength on alertness at other times of day. The present study investigated how two narrowband light spectra affected human alertness during ...
Zhang Yu-Fei - - 2014
Omega-3 fatty acids are known to prevent cardiac death. However, previous observational studies have suggested that omega-3 fatty acids are associated with cancer risk in adults. We conducted a meta-analysis based on randomized controlled trials to evaluate the effect of omega-3 fatty acids on the risk of cancer incidence, nonvascular ...
Djallé Djibrine - - 2014
Rapid diagnostic tests (RDTs) are the current complement to microscopy for ensuring prompt malaria treatment. We determined the performance of three candidate RDTs (ParacheckTM-Pf, SD Bioline malaria Ag-Pf and SD Bioline malaria Ag-Pf/pan) for rapid diagnosis of malaria in the Central African Republic. Blood samples from consecutive febrile patients who ...
Farias Charles C CC Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine; Miami, FL; Ophthalmic Biophysics Center and, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine; Miami, FL; Ocular Surface Center of Excellence, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine; Miami, - - 2014
To determine the clinical utility of intraocular video endoscopy examination for the evaluation of the retina and optic nerve in patients being considered for a Boston Type I Keratoprosthesis (KPro). Interventional case series study. Ten patients with a history of corneal blindness caused by failed penetrating keratoplasty (PK) and inability ...
Herschorn Sender S Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address: - - 2014
To determine clinical and demographic characteristics associated with antimuscarinic treatment response using a regression model. Adults with overactive bladder (OAB) symptoms for >3 months and ≥1 urgency urinary incontinence (UUI) episode and ≥8 micturitions per 24 hours at baseline were randomized to fesoterodine (8 mg), tolterodine extended-release (4 mg), or placebo in two 12-week, double-blind, head-to-head ...
Bennell Kim L - - 2014
Femoroacetabular impingement is a common cause of hip/groin symptoms and impaired functional performance in younger sporting populations and results from morphological abnormalities of the hip in which the proximal femur abuts against the acetabular rim. Many people with symptomatic femoroacetabular impingement undergo arthroscopic hip surgery to correct the bony abnormalities. ...
Saper Robert B - - 2014
Chronic low back pain causes substantial morbidity and cost to society while disproportionately impacting low-income and minority adults. Several randomized controlled trials show yoga is an effective treatment. However, the comparative effectiveness of yoga and physical therapy, a common mainstream treatment for chronic low back pain, is unknown. This is ...
Richert Laura - - 2014
Many candidate vaccine strategies against human immunodeficiency virus (HIV) infection are under study, but their clinical development is lengthy and iterative. To accelerate HIV vaccine development optimised trial designs are needed. We propose a randomised multi-arm phase I/II design for early stage development of several vaccine strategies, aiming at rapidly ...
Tsai Chon-Haw CH Department of Neurology, China Medical University Hospital, Taichung, Taiwan, China; Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung, Taiwan, China; School of Medicine, Medical College, China Medical University, Taichung, Taiwan, - - 2014
We have previously found that sarcosine, a glycine transporter I inhibitor, can improve the psychiatric symptoms of schizophrenia. In this study, we aimed to investigate whether the agent can also ameliorate neuropsychiatric symptoms of PD patients with dementia. An 8-week, double-blind, placebo-controlled trial was conducted in patients who had PD ...
Humbert P P Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC BT506), Department of Dermatology, University Hospital, Besançon, France; INSERM UMR, University of Franche-Comté, Besançon, - - 2014
Stringent control of proteolytic activity represents a major therapeutic approach for wound-bed preparation. We tested whether a protease-modulating polyacrylate- (PA-) containing hydrogel resulted in a more efficient wound-bed preparation of venous leg ulcers when compared to an amorphous hydrogel without known protease-modulating properties. Patients were randomized to the polyacrylate-based hydrogel ...
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