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Anagnostou Katherine K Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, - - 2014
Small studies suggest peanut oral immunotherapy (OIT) might be effective in the treatment of peanut allergy. We aimed to establish the efficacy of OIT for the desensitisation of children with allergy to peanuts. We did a randomised controlled crossover trial to compare the efficacy of active OIT (using characterised peanut ...
Ritchlin Christopher C Allergy, Immunology & Rheumatology Division, University of Rochester Medical Center, Rochester, New York, - - 2014
Assess ustekinumab efficacy (week 24/week 52) and safety (week 16/week 24/week 60) in patients with active psoriatic arthritis (PsA) despite treatment with conventional and/or biological anti-tumour necrosis factor (TNF) agents. In this phase 3, multicentre, placebo-controlled trial, 312 adults with active PsA were randomised (stratified by site, weight (≤100 kg/>100 ...
Li Yajuan - - 2014
Oxidative stress is implicated in tissue inflammation and plays an important role in the pathogenesis of immune-mediated nephritis. Using the anti-glomeruli basement membrane antibody-induced glomerulonephritis (anti-GBM-GN) mouse model, we found that increased expression of Glutathione S-transferase Mu 2 (GSTM2) was related to reduced renal damage caused by anti-GBM antibodies. Furthermore, ...
Wan Yue Y 1] Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA [2] Stem Cell and Development, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672 - - 2014
In parallel to the genetic code for protein synthesis, a second layer of information is embedded in all RNA transcripts in the form of RNA structure. RNA structure influences practically every step in the gene expression program. However, the nature of most RNA structures or effects of sequence variation on ...
Zheng Jin-Ping JP State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, - - 2014
Increased oxidative stress and inflammation has a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Drugs with antioxidant and anti-inflammatory properties, such as N-acetylcysteine, might provide a useful therapeutic approach for COPD. We aimed to assess whether N-acetylcysteine could reduce the rate of exacerbations in patients with COPD. ...
Morita Yukiko Y Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, - - 2014
To report a case of melanoma-associated retinopathy (MAR) in a Japanese patient found to have autoantibodies to transient receptor potential cation channel, subfamily M, member 1 (TRPM1). An 82-year-old man presented with blurred vision OS as well as night blindness and photopsia OU. Fundus photography, fluorescein angiography, and spectral domain-optical ...
Iyer Geetha G Medical Research Foundation, Sankara Nethralaya, 18 College Road, Chennai, 600006, Tamil Nadu, India, - - 2014
Stevens Johnson Syndrome (SJS) can lead to end stage corneal blindness. This study describes the comprehensive treatment measures and their outcomes in the management of ocular sequelae and complications of SJS. Four hundred sixty-four eyes of 232 patients of SJS who underwent surgical intervention (punctal cautery, mucus membrane grafting for ...
Cho H J HJ Eulji general hospital, Eulji University School of Medicine, Seoul, - - 2014
The efficacy and safety of treatment with alfuzosin 10 mg plus propiverine 10 or 20 mg in men with lower urinary tract symptoms (LUTS) and an overactive bladder were investigated. In this parallel-arm, prospective, multicentre, single-blind study, men who were ≥ 40 years old, had an International Prostate Symptom Score (IPSS) of ≥ 8, an ...
Murdoch Robert D - - 2014
Background: The transient receptor potential vanilloid 1 (TRPV1)-expressing sensory C-fibers may play a role in the development of nasal hyper-responsiveness and symptoms of non-allergic rhinitis (NAR). Objective: To evaluate the effects of a TRPV1-antagonist, SB-705498, on cold dry air (CDA)-induced symptoms in patients with NAR. Methods: This randomized, double-blind, placebo-controlled, ...
de Silva Samantha R SR Oxford Eye Hospital, Oxford, - - 2014
Age-related cataract is one of the leading causes of blindness worldwide. Therefore, it is important to establish the most effective surgical technique for cataract surgery. The aim of this review is to examine the effects of two types of cataract surgery for age-related cataract: phacoemulsification and extracapsular cataract extraction (ECCE). ...
Li Libo L Departments of Chemistry and Physics, Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, - - 2014
Here, we test a method, called semi-explicit assembly (SEA), that computes the solvation free energies of molecules in water in the SAMPL4 blind test challenge. SEA was developed with the intention of being as accurate as explicit-solvent models, but much faster to compute. It is accurate because it uses pre-simulations ...
Spiegel R R Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany, - - 2014
Prospective, placebo-controlled, double-blind, randomized studies on osteoporosis treatment with bisphosphonates in men are rare. This review focuses on a recent trial and compares the results with other studies. This review provides a summary of recent literature on fracture risk in men following treatment with zoledronic acid. According to a recent ...
Alvarez Herrero Lorenza L Department of Gastroenterology and Hepatology, St. Antonius Hospital, Nieuwegein, The - - 2014
Background and study aims: After radiofrequency ablation (RFA) of Barrett's esophagus, it may be difficult to determine whether complete eradication of intestinal metaplasia at the neosquamocolumnar junction (neo-SCJ) in the cardia has been achieved. It is claimed that narrow band imaging (NBI) may predict the presence of intestinal metaplasia, which ...
Marshall Randolph S RS From Columbia University Medical Center (R.S.M., Y.-K.C., M.A.P., K.S., R.M.L.), New York; St. Luke's Roosevelt Medical Center New York (J.R.F.), New York; NINDS (Y.-K.C.), Bethesda, MD; Washington University (C.P.D., T.O.V., R.L.G.), St. Louis, MO; University of Iowa (W.R.C.), Iowa City; and the University of North Carolina at Chapel Hill - - 2014
To determine whether extracranial-intracranial (EC-IC) bypass can improve cognition over 2 years compared to best medical therapy alone in patients with symptomatic internal carotid artery (ICA) occlusion and increased oxygen extraction fraction (OEF) on PET. Patients underwent (15)O PET and were randomized if OEF ratio was >1.13 on the occluded ...
Palena Luis Mariano LM Interventional Radiology Unit. Policlinico Abano Terme, Abano Terme, PD, - - 2014
Objectives. To assess and compare the intra-arterial injection-associated discomfort of iodinated contrast media (CM), and the impact on diagnostic efficacy, in diabetics with critical limb ischemia (CLI). Background. Arterial revascularization is a mainstay in patients with CLI. Previous diagnostic angiography is a crucial step that can be affected by CM ...
Rim Tyler H T TH Department of Ophthalmology, Institue of Vision Research, Yonsei University College of Medicine, Seoul, - - 2014
To describe the age, gender specific prevalence and risk factors of visual impairment and blindness in Korea. From 2008 to 2010, a total 14 924 randomly selected national representative participants of the Korea National Health and Nutrition Examination Survey underwent additional ophthalmologic examinations by the Korean Ophthalmologic Society. Best Corrected Distance ...
Ortega Francisco J FJ Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomédica de Girona, Girona, - - 2014
OBJECTIVEThis study sought to identify the profile of circulating microRNAs (miRNAs) in type 2 diabetes (T2D) and its response to changes in insulin sensitivity.RESEARCH DESIGN AND METHODSThe circulating miRNA profile was assessed in a pilot study of 12 men: 6 with normal glucose tolerance (NGT) and 6 T2D patients. The ...
Crilly Michael A MA Institute of Applied Health Sciences, Aberdeen University Medical School , Aberdeen , UK - - 2014
Objective: To estimate clinical agreement in relation to measuring aortic augmentation index (AIX-75) in pregnancy in a routine clinical setting. Methods: A hospital-based clinical agreement study of 20 women in which two trained nurses alternated in measuring arterial function (AIX standardized to a heart rate of 75 beats-per-minute, AIX-75) on ...
Cho Leslie L Department of Preventive Cardiology and Rehabilitation, Cleveland Clinic, Cleveland, - - 2014
Statins effectively lower low-density lipoprotein cholesterol (LDL-C), reducing cardiovascular morbidity and mortality. Most patients tolerate statins well, but approximately 10% to 20% experience side effects (primarily muscle-related) contributing to diminished compliance or discontinuation of statin therapy and subsequent increase in cardiovascular risk. Statin-intolerant patients require more effective therapies for lowering ...
Roh Go Un GU 1Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, South Korea 120-752 2Department of Anesthesiology and Pain Medicine, Choong-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul, South Korea 156-755 *These authors contributed - - 2014
Study Design. A prospective, randomized, and double-blind studyObjective. To compare the efficacy of ramosetron and palonosetron on preventing postoperative nausea and vomiting (PONV) associated with opioid-based intravenous patient-controlled analgesia (IV-PCAopioid) after lumbar spinal surgerySummary of Background Data. IV-PCAopioid, an effective method to control pain after lumbar spinal surgery, accompanies PONV. ...
Oliveira B H BH Department of Preventive and Community Dentistry, Faculty of Dentistry, Rio de Janeiro State University, Rio de Janeiro, - - 2014
Sound evidence on the effectiveness of fluoride varnishes (FV) to reduce caries incidence in preschool children is lacking. Objective: To assess whether the application of FV in preschool children at 6-month intervals decreases the incidence of caries and produces any adverse effects. Methods: A randomized, examiner- and patient-blind, placebo-controlled, parallel-group ...
Chen Der Cherng - - 2014
In our previous study, intracerebral implantation of peripheral blood stem cells (PBSC) improved functional outcome in rats with chronic cerebral infarction. Based on this findings, a randomized, single blind controlled study was conducted in 30 patients [PBSC group (n=15) and control group (n=15)] with middle cerebral artery infarction confirmed on ...
Requena Antonio - - 2014
Luteinizing hormone (LH) activity in human menopausal gonadotropin (hMG) preparations is derived from human chorionic gonadotropin (hCG) rather than LH. Therefore, we aimed to determine whether there are similarities in the endocrine and follicular profiles of serum and follicular fluid from controlled ovarian stimulation with the recombinant gonadotropins follicle-stimulating hormone ...
Yang Bo - - 2014
Matrix metalloproteinase-9 (MMP-9) is an important member of the matrix metalloproteinase family and is considered to be involved in the invasion and metastasis of cancer cells. This study analyzed the expression of MMP-9 in colon cancer patients and the relationship between this expression and clinicopathological features and survival. We immunohistochemically ...
Kira Jun-Ichi - - 2014
A 6-month phase 2 study of fingolimod demonstrated efficacy and safety in Japanese patients with relapsing-remitting multiple sclerosis (MS). Here we report a 6-month observational extension that evaluated efficacy and safety in patients who received fingolimod continuously for 12 months or who switched from placebo to fingolimod. Of 147 patients ...
Fan Longchang - - 2014
Voltage-gated potassium (Kv) channels are critical in controlling neuronal excitability and are involved in the induction of neuropathic pain. Therefore, Kv channels might be potential targets for prevention and/or treatment of this disorder. We reported here that a majority of dorsal root ganglion (DRG) neurons were positive for Kv channel ...
Castro Kaline Silva KS Preventive Dentistry and Pedodontics, Federal University of Paraiba, João Pessoa, PB, - - 2014
This parallel randomized clinical trial evaluated the efficacy of two treatments for removing fluorosis stains. Seventy individuals living in an area endemic for fluorosis, with at least four maxillary anterior teeth presenting fluorosis with a Thylstrup and Fejerskov index from 1 to 7, were randomized into two treatment groups (n= ...
Guihan Marylou M Spinal Cord Injury Quality Enhancement Research Initiative (SCI QUERI) & Edward Hines Jr. VA Hospital, Hines, Il 60141 and Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL. Electronic address: - - 2014
To compare a multi-component Motivational interviewing (MI)/Self-Management (SM) intervention to a multi-component education intervention to improve skin-protective behaviors and prevent skin worsening in Veterans with spinal cord injury (SCI) hospitalized for severe pressure ulcers. Single blinded, prospective, randomized controlled trial SETTING: 6 VA SCI Centers PARTICIPANTS: Veterans admitted for a ...
Castro A P AP Department of Pediatrics, Faculty of Medicine, University of Sao Paulo, Brazil. Electronic address: - - 2014
Cow's milk allergy diagnosis many times requires double-blind placebo-controlled food challenge (DBPCFC), which presents high accuracy but involves risks, specifically in infants and anaphylactic patients. The identification of the cut-off values for specific IgE to milk or its components would contribute to cow's milk allergy (CMA) diagnosis. The aim of ...
Qi Xiaole X Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin 150001, PR - - 2014
Infectious bursal disease (IBD) is a highly contagious immunosuppressive disease affecting all major poultry producing areas of the world. Infectious bursal disease virus (IBDV) is genetically prone to mutation so that vaccines have to be changed accordingly. However, the traditional method of vaccine development with blind passage could not fit ...
Cherney David Zi - - 2014
Individuals with type 1 diabetes mellitus are at high risk for the development of hypertension, contributing to cardiovascular complications. Hyperglycaemia-mediated neurohormonal activation increases arterial stiffness, and is an important contributing factor for hypertension. Since the sodium glucose cotransport-2 (SGLT2) inhibitor empagliflozin lowers blood pressure and HbA1c in type 1 diabetes ...
Assefa Yibeltal - - 2014
Patient retention, defined as continuous engagement of patients in care, is one of the crucial indicators for monitoring and evaluating the performance of antiretroviral treatment (ART) programs. It has been identified that suboptimal patient retention in care is one of the challenges of ART programs in many settings. ART programs ...
Vaidya Anil - - 2014
Asymptomatic Peripheral Arterial Disease (PAD) is associated with greater risk of acute cardiovascular events. This study aims to determine the cost-effectiveness of one time only PAD screening using Ankle Brachial Index (ABI) test and subsequent anti platelet preventive treatment (low dose aspirin or clopidogrel) in individuals at high risk for ...
Sato Yuzuri Tsurumaki - - 2014
Radical prostatectomy is used to treat patients with clinically localized prostate cancer, but there have been few reports of its use in locally advanced disease. We evaluated the long-term results of radical prostatectomy and immediate adjuvant androgen deprivation therapy in Japanese patients with pT3N0M0 prostate cancer. We retrospectively reviewed 128 ...
Morita Toyohisa - - 2014
Streptococcus agalactiae (Group B Streptococcus, GBS), a leading cause of sepsis and meningitis in infants, can be transmitted vertically from mother to infant during passage through the birth canal. Detection of GBS colonization in perinatal women is a major strategy for the prevention of postpartum neonatal disease. The U.S. Centers ...
Menezes Soraya Maria - - 2014
Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no disease-modifying therapies with long-term clinical benefits or validated biomarkers for clinical follow-up in HAM/TSP. Although CD80 and CD86 costimulatory molecules play prominent roles in immune regulation and ...
Niemann Axel A 1 Institute of Molecular Health Sciences, Cell Biology, Department of Biology, ETH Zurich, Swiss Federal Institute of Technology, Switzerland, ETH-Hönggerberg, 8093 Zürich, - - 2014
The ganglioside-induced differentiation-associated protein 1 (GDAP1) is a mitochondrial fission factor and mutations in GDAP1 cause Charcot-Marie-Tooth disease. We found that Gdap1 knockout mice (Gdap1(-/-)), mimicking genetic alterations of patients suffering from severe forms of Charcot-Marie-Tooth disease, develop an age-related, hypomyelinating peripheral neuropathy. Ablation of Gdap1 expression in Schwann cells ...
Duda Joan L - - 2014
The National Institute for Health and Clinical Excellence in the UK has recommended that the effectiveness of ongoing exercise referral schemes to promote physical activity should be examined in research trials. Recent empirical evidence in health care and physical activity promotion contexts provides a foundation for testing the feasibility and ...
Dias Paula Cristina Silveira PC Post Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, RN, - - 2014
Statins have multiple antiatherosclerotic effects, but can reduce blood plasma concentrations of minerals, including zinc. As zinc possesses antiinflammatory and antioxidant effects, low zinc status can promote injuries or inadequate tissue repair in endothelial cells. Metallothionein (MT) expression might modulate responses induced by statins in patients with atherosclerosis. However, research ...
Keller Sylvia S Friedrich Schiller University of Jena, Department of Nutritional Physiology, Dornburger Straße 24, D-07743 Jena, Germany. Electronic address: - - 2014
Reduced epidermal ceramide content may lead to an impaired skin barrier in atopic dermatitis. Plasma concentration of the ceramide precursor sphingomyelin increases after milk-fat consumption due to affected lipoprotein metabolism, although sphingomyelin, a main component of milk phospholipids, might also directly influence plasma sphingomyelin levels. The aim was to determine ...
Zhang Kejing K Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, - - 2014
The generation of functional retinal pigment epithelium (RPE) is of great therapeutic interest to the field of regenerative medicine and may provide possible cures for retinal degenerative diseases, including age-related macular degeneration (AMD). Although RPE cells can be produced from either embryonic stem cells or induced pluripotent stem cells, direct ...
Jandacek Ronald J RJ University of Cincinnati, Cincinnati, Ohio. Electronic address: - - 2014
Serum polychlorinated biphenyls (PCBs) in Anniston, AL, residents have been associated with hypertension and diabetes. There have been no systematic interventions to reduce PCB body burdens in Anniston or other populations. Our objective was to determine the efficacy of 15 g/day of dietary olestra to reduce PCBs in Anniston residents. ...
Karavetian Mirey M Department of Health Promotion, Maastricht University, 6200 MD Maastricht, - - 2014
THIS STUDY AIMS TO DETERMINE THE EFFECT OF A TRAINED DEDICATED DIETITIAN ON CLINICAL OUTCOMES AMONG LEBANESE HEMODIALYSIS (HD) PATIENTS: and thus demonstrate a viable developing country model. This paper describes the study protocol and baseline data. The study was a multicenter randomized controlled trial with parallel-group design involving 12 ...
Siebelt Michiel - - 2014
Articular cartilage needs sulphated-glycosaminoglycans (sGAG) to withstand high pressures while mechanically loaded. Chondrocyte sGAG synthesis is regulated by exposure to compressive forces. Moderate physical exercise is known to improve cartilage sGAG content and might protect against osteoarthritis (OA). This study investigated whether rat knee joints with sGAG depleted articular through ...
Huang Sheng-You SY Department of Physics and Astronomy, Department of Biochemistry, Dalton Cardiovascular Research Center, and Informatics Institute, University of Missouri, Columbia, MO 65211, - - 2014
Protein-RNA interactions play important roles in many biological processes. Given the high cost and technique difficulties in experimental methods, computationally predicting the binding complexes from individual protein and RNA structures is pressingly needed, in which a reliable scoring function is one of the critical components. Here, we have developed a ...
Proschel Christoph C Department for Biomedical Genetics, University of Rochester, Rochester, NY, - - 2014
In addition to dopaminergic neuron loss, it is clear that Parkinson disease includes other pathological changes, including loss of additional neuronal populations. As a means of addressing multiple pathological changes with a single therapeutically-relevant approach, we employed delayed transplantation of a unique class of astrocytes, GDAs(BMP), that are generated in ...
Jimenez Joaquin J JJ Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, 33136, USA, - - 2014
Male and female pattern hair loss are common, chronic dermatologic disorders with limited therapeutic options. In recent years, a number of commercial devices using low-level laser therapy have been promoted, but there have been little peer-reviewed data on their efficacy. To determine whether treatment with a low-level laser device, the ...
Zong L L Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, China, Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai, - - 2014
Studies have shown that edaravone may prevent liver injury. This study aimed to investigate the effects of edaravone on the liver injury induced by D-galactosamine (GalN) and lipopolysaccharide (LPS) in female BALB/c mice. Edaravone was injected into mice 30 min before and 4 h after GalN/LPS injection. The survival rate ...
Glasgow Philip D PD Sports Institute Northern Ireland, University of Ulster, Jordanstown, Newtownabbey, Co. Antrim BT37 0QB, United - - 2014
Cold Water Immersion (CWI) is commonly used to manage delayed onset muscle soreness (DOMS) resulting from exercise. Scientific evidence for an optimal dose of CWI is lacking and athletes continue to use a range of a treatment protocols and water temperatures. To compare the effectiveness of four different water immersion ...
Alçada Joana J Department of Thoracic Medicine, University College London Hospitals, London, - - 2014
Mediastinal lymphadenopathy (MLN) in human immunodeficiency virus (HIV) infection has a wide spectrum of aetiologies with different prognoses and treatments. The decision to pursue a histopathological diagnosis represents a clinical challenge as patients present with non-specific symptoms. This study aimed to determine the aetiology and predictive factors of MLN in ...
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