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Chiu S S 1] Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada [2] Department of Human Biology, Faculty of Medicine, University of Toronto, Toronto, ON, - - 2014
Background/Objectives:In the absence of consistent clinical evidence, there are concerns that fructose contributes to non-alcoholic fatty liver disease (NAFLD). To determine the effect of fructose on markers of NAFLD, we conducted a systematic review and meta-analysis of controlled feeding trials.Subjects/Methods:We searched MEDLINE, EMBASE, CINAHL and the Cochrane Library (through 3 ...
Iqbal Sohah N SN Cardiovascular Clinical Research Center, Department of Medicine, New York University School of Medicine, New York, - - 2014
In a prospective study, we previously identified plaque disruption (PD: plaque rupture or ulceration) in 38% of women with myocardial infarction (MI) without angiographically obstructive coronary artery disease (CAD), using intravascular ultrasound (IVUS). Underlying plaque morphology has not been described in these patients and may provide insight into the mechanisms ...
Downey Kate K CRUK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation - - 2014
In patients undergoing trachelectomy, to validate high-resolution endovaginal T2- and diffusion-weighted MRI measurements (tumor size, volume and length of uninvolved cervical canal) against histology. 55 consecutive patients 25-44yrs with cervical cancer being considered for trachelectomy were prospectively assessed with endovaginal T2-W and diffusion-weighted MRI. Two independent observers blinded to histology ...
Kumagai Gentaro G Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan, - - 2014
Radiographic findings may provide clues to the underlying cause of neck symptoms. However, these associations remain controversial. This study investigates the association between roentgenographic findings of the cervical spine and neck symptoms in a Japanese community population. A total of 762 volunteers participated in this study. Sagittal radiographs of the ...
Fingleton James J Medical Research Institute of New Zealand, Wellington, New - - 2014
Sharma Animesh N AN Endocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, - - 2014
How sex steroids modulate glucocorticoid feedback on the hypothalamic-pituitary-corticotrope (HPC) unit is controversial in humans. We postulated that testosterone (T) in men and estradiol (E2) in women govern unstressed cortisol-mediated negative feedback on ACTH secretion. To test this hypothesis, 24 men and 24 women age 58 ± 2.4 yr were ...
Klimek-Ochab Magdalena M Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeże Wyspiańskiego 27, Wrocław, 50-370, Poland, - - 2014
A psychrophilic fungal strain of Geomyces pannorum P15 was screened for its ability to utilize a range of synthetic and natural organophosphonate compounds as the sole source of phosphorus, nitrogen, or carbon. Only phosphonoacetic acid served as a phosphorus source for microbial growth in phosphate-independent manner. Substrate metabolism did not ...
Cruz-Martín Alberto A 1] Department of Neurosciences, University of California, San Diego, California 92093, USA [2] Neurobiology Section in the Division of Biological Sciences, University of California, San Diego, California 92093, - - 2014
How specific features in the environment are represented within the brain is an important unanswered question in neuroscience. A subset of retinal neurons, called direction-selective ganglion cells (DSGCs), are specialized for detecting motion along specific axes of the visual field. Despite extensive study of the retinal circuitry that endows DSGCs ...
Masuda Sawako S Department of Clinical Research, Mie National Hospital, Mie, Japan; Department of Otorhinolaryngology, Mie National Hospital, Mie, - - 2014
Background: Methylated catechin, one of the active ingredients in green tea, has been reported to ameliorate allergic reactions. We evaluated the efficacy of 'Benifuuki' green tea, which contains O-methylated epigallocatechin-3-O-[3-O-methyl] gallate (O-methylated EGCG), in alleviating Japanese cedar pollinosis (JCP). Methods: The study was a double-blind, randomized, placebo-controlled trial. The subjects ...
Mehanna R R University of Texas Health Science Center, Houston, TX, USA, - - 2014
A sizable proportion of medication refractory tremor patients may not respond satisfactorily to deep brain stimulation (DBS) to the ventralis intermedialis nucleus of the thalamus (Vim). Implanting a second DBS lead ipsilaterally to the first one is thought to be beneficial based on scarce and unblinded data. This article aims ...
Lee Jeong Woo JW Department of Urology, Guri Hospital, Hanyang University, 249-1, Gyomun-dong, Guri, 471-701, - - 2014
The aim of the study is to assess the methodological quality of randomized controlled trials (RCTs) published in Rheumatology International (RI) by using three types of analytical tools. MEDLINE was used to extract RCTs from original articles published in the RI from 1981 (vol. 1) to 2012 (vol. 32). The ...
Celebi Ali Riza Cenk AR Department of Ophthalmology, Republic of Turkey, Ministry of Health, Nigde State Hospital, Feridun Zeren Street, 51000, Nigde, Turkey, - - 2014
To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservative-free artificial tears (PFAT). This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer's Test, and OXFORD ...
George Stacey S Department of Rehabilitation, Aged and Extended Care, Flinders University, Daws Road, Daw Park, South Australia, Australia, - - 2014
Interventions to improve driving ability after stroke, including driving simulation and retraining visual skills, have limited evaluation of their effectiveness to guide policy and practice. To determine whether any intervention, with the specific aim of maximising driving skills, improves the driving performance of people after stroke. We searched the Cochrane ...
Park Hye-Ryoung HR 1Department of Physical Therapy, Gwangju City Rehabilitation Hospital, Gwangju, Republic of - - 2014
Objective:To identify the effects of action observation training (AOT) on the walking ability of subjects with post-stroke hemiparesis.Design:Randomized, single-blind, controlled pilot study.Setting:Inpatient rehabilitation hospital.Subjects:Twenty-one subjects with post-stroke hemiparesis were randomly allocated to either the experimental group (EG) or the control group (CG), with 11 and 10 patients, respectively.Interventions:The subjects in ...
Naidoo Kovin K African Vision Research Institute, University of Kwazulu-Natal, South Africa and Brien Holden Vision Institute, Sydney, NSW, - - 2014
To estimate the magnitude, temporal trends and subregional variation in the prevalence of blindness, and moderate/severe vision impairment (MSVI) in sub-Saharan Africa. A systematic review was conducted of published and unpublished population-based surveys as part of the Global Burden of Disease, Risk Factors and Injuries Study 2010. The prevalence of ...
Russo Patrizia Dello PD 1Institute of Medical Genetics, University Hospital of Udine, Udine, - - 2014
Background:Retinal vein occlusion (RVO) is the second most common retinal vein disease and an important cause of blindness and visual morbidity. Many conditions are associated with RVO but the real role of the thrombophilic mutations is still unclear.Aim:To evaluate the potential role of thrombophilic mutations in RVO.Methods:We have evaluated 113 ...
Pulman Jennifer J Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Clinical Sciences Centre for Research and Education, Lower Lane, Fazakerley, Liverpool, Merseyside, UK, L9 - - 2014
The majority of people with epilepsy have a good prognosis and their seizures are controlled by a single antiepileptic drug. However, up to 20% of patients from population-based studies and up to 30% from clinical series (not population-based) develop drug-resistant epilepsy, especially those with partial onset seizures. In this review ...
Assmus Birgit B Cardiology, Deptartment of Medicine III, Goethe University Frankfurt, Theodor-Stern-Kai 7, Frankfurt 60590, - - 2014
In the REPAIR-AMI trial, intracoronary infusion of bone marrow-derived cells (BMCs) was associated with a significantly greater recovery of contractile function in patients with acute myocardial infarction (AMI) at 4-month follow-up than placebo infusion. The current analysis investigates clinical outcome and predictors of event-free survival at 5 years. In the ...
Mejuto-Vázquez María J MJ Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation Universidad Rey Juan Carlos, Alcorcón, - - 2014
Study Design Randomized clinical trial. Objectives To determine the effects of trigger point dry needling (TrP-DN) on neck pain, widespread pressure pain sensitivity, and cervical range of motion in patients with acute mechanical neck pain and active trigger points (TrPs) in the upper trapezius muscle. Background TrP-DN seems to be ...
Dyka Frank M FM University of Florida, Ophthalmology, ARB RG-240, 1600 SW Archer road, Gainesville, Florida, United States, 32610, 352 318 6176 ; - - 2014
Usher syndrome 1B (USH1B) is a severe, autosomal recessive, deaf-blind disorder caused by mutations in MYO7A (myosin 7A). Patients are born profoundly deaf and exhibit progressive loss of vision starting in their first decade. MYO7A is expressed in human photoreceptors and RPE, but disease pathology begins in photoreceptors, highlighting the ...
Schnell D D Réanimation médicale, Hôpital Saint Louis, Assistance Publique Hôpitaux de Paris, Paris, France ;Paris 7, University, Paris, - - 2014
Background and objectives: Dopplerbased renal resistive index (RI) calculation may help in the early detection of acute kidney injury (AKI). Its feasibility and reproducibility by inexperienced operators remain unknown. The main objective of this study was to compare performances of junior and senior operators in assessing renal perfusion using both ...
Brut Marie - - 2014
Probing biomolecular flexibility with atomic-scale resolution is a challenging task in current computational biology for fundamental understanding and prediction of biomolecular interactions and associated functions. This paper makes use of the Static Mode method to study HIV-1 protease considered as a model system to investigate the full biomolecular flexibility at ...
Sugiyama T T Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, - - 2014
Based on the result of our previous study showing better overall survival (OS) at the lower dose (0.2 µg) of immunomodulator Z-100 than higher dose (40 µg) in patients with locally advanced cervical cancer who received radiotherapy, we conducted a placebo controlled double-blind randomized trial. Patients of stages IIB to ...
Philippon Mélanie M M Philippon, Endocrinology, Aix-Marseille université, Assistance-Publique-Hôpitaux de Marseille, centre de référence des maladies rares d'origine hypophysaire, Marseille, - - 2014
Introduction:Focused parathyroidectomy is the treatment of choice for patients with concordant positive imaging. Bilateral cervical exploration is performed for cases with discordant imaging, yet more than 70% of those cases are the result of a single gland disease. As focused parathyroidectomy is generally costless and harmless, for cases with discordant ...
Coppens Michiel M Population Health Research Institute, McMaster University, Hamilton, ON, - - 2014
The AVERROES double-blinded, randomized trial demonstrated that apixaban reduces the risk of stroke or systemic embolism (SSE) by 55% compared with aspirin without an increase in major bleeding in patients with atrial fibrillation either who previously tried but failed vitamin K antagonists (VKA) therapy or who were expected to be ...
Gobbo Massimiliano - - 2014
Transcutaneous neuromuscular electrical stimulation applied in clinical settings is currently characterized by a wide heterogeneity of stimulation protocols and modalities. Practitioners usually refer to anatomic charts (often provided with the user manuals of commercially available stimulators) for electrode positioning, which may lead to inconsistent outcomes, poor tolerance by the patients, ...
van Seeters Tom - - 2014
Prediction of clinical outcome in the acute stage of ischaemic stroke can be difficult when based on patient characteristics, clinical findings and on non-contrast CT. CT perfusion and CT angiography may provide additional prognostic information and guide treatment in the early stage. We present the study protocol of the Dutch ...
Monteiro Wuelton M - - 2014
Although G6PDd individuals are generally asymptomatic throughout their life, the clinical burden of this genetic condition includes a range of haematological conditions, including acute haemolytic anaemia (AHA), neonatal jaundice (NNJ) and chronic non-sphaerocytic anaemia (CNSA). In Latin America (LA), the huge knowledge gap regarding G6PDd is related to the scarce ...
Bos Jeannet C - - 2014
Streptococcus pneumoniae is the leading cause of community-acquired pneumonia in Africa. Antimicrobial resistance of S. pneumoniae to penicillin and other commonly used antibiotics has increased worldwide. However, prevalence data from the African region are sparse, especially with regard to adults. In this study, adult patients presenting at an urban referral ...
Kersten Roel Fmr - - 2014
Polyetheretherketone (PEEK) cages have been widely used in the treatment of lumbar degenerative disc disorders, and show good clinical results. Still, complications such as subsidence and migration of the cage are frequently seen. A lack of osteointegration and fibrous tissues surrounding PEEK cages are held responsible. Ceramic implants made of ...
Roaldset John O - - 2014
Biological factors have been associated with deliberate self-harm (DSH) but have not been integrated with clinical factors in routine risk assessments.This study aimed to examine the incremental validity of lipid levels and platelet serotonin when combined with psychosocial factors in risk assessments for repeated admissions due to DSH. In this ...
Aaronson Justine A - - 2014
Obstructive sleep apnea is a common sleep disorder in stroke patients. Obstructive sleep apnea is associated with stroke severity and poor functional outcome. Continuous positive airway pressure seems to improve functional recovery in stroke rehabilitation. To date, the effect of continuous positive airway pressure on cognitive functioning in stroke patients ...
Lees Dianne G - - 2014
Antisocial behaviour and adult criminality often have their origins in childhood and are best addressed early in the child's life using evidence-based treatments such as the 'Incredible Years Parent Programme'. However, families with additional risk factors who are at highest risk for poor outcomes do not always make sufficient change ...
Cao Qi - - 2014
Breast cancer is the second most lethal cancer in women. Understanding biological mechanisms that cause progression of this disease could yield new targets for prevention and treatment. Recent experimental studies suggest that brown adipose tissue (BAT) may play a key role in breast cancer progression. The primary objective for this ...
Doukky Rami - - 2014
Left ventricular diastolic impairment and consequently elevated filling pressure may contribute to stasis leading to left atrial appendage thrombus (LAAT) in nonvalvular atrial fibrillation (AF). We investigated whether transthoracic echocardiographic parameters can predict LAAT independent of traditional clinical predictors. We conducted a retrospective cohort study of 297 consecutive nonvalvular AF ...
Franklin Nina C NC Department of Physical Therapy, University of Illinois at Chicago, Chicago, IL; Integrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, - - 2014
To determine if lower extremity exercise-induced muscle injury (EMI) reduces vascular endothelial function of the upper extremity and if massage therapy (MT) improves peripheral vascular function after EMI. Randomized, blinded trial with evaluations at 90 minutes, 24 hours, 48 hours, and 72 hours. Clinical research center at an academic medical ...
Salman A A Department of Physics, SCE-Shamoon College of Engineering, Beer-Sheva 84100, Israel. Electronic address: - - 2014
Herpes viruses are involved in a variety of human disorders. Herpes Simplex Virus type 1 (HSV-1) is the most common among the herpes viruses and is primarily involved in human cutaneous disorders. Although the symptoms of infection by this virus are usually minimal, in some cases HSV-1 might cause serious ...
Wang Kaidi - - 2014
To report the clinical outcomes in Chinese patients with primary open-angle glaucoma and ocular hypertension treated with bimatoprost 0.03% therapy. Two hundred sixty-three Chinese patients with primary open-angle glaucoma and ocular hypertension who needed initial or additional intraocular pressure (IOP) lowering were recruited in this prospective, open-label, multicenter clinical study ...
Li Qian Q Department of Anesthesiology and Translational Neuroscience Center, West China Hospital of Sichuan University, Chengdu, - - 2014
Recovery time and quality after general anaesthesia is important for patient safety. This study aimed to determine whether intravenous lipid emulsion could improve recovery profiles from isoflurane anaesthesia in adult patients undergoing laparoscopic cholecystectomy. Sixty-six patients were enrolled. After anaesthesia induction, inspired isoflurane concentration was adjusted to maintain stable vital ...
Lauring Brett B Merck & Co. Inc., Whitehouse Station, NJ, - - 2014
Anacetrapib is a cholesteryl ester transfer protein inhibitor in Phase III development. This double-blind, double-dummy, randomized, placebo- and active-comparator-controlled, 4-period, balanced crossover study evaluated the effects of anacetrapib (100 mg and 800 mg) on QTcF interval in healthy subjects. QTcF measurements were made up to 24 h following administration of single doses of ...
Ellrichmann M M Interdisciplinary Endoscopy, Medical Department I, University Hospital Schleswig-Holstein, Kiel, - - 2014
Diagnosis of inflammatory bowel disease (IBD) is based on clinical presentation, colonoscopy and histology. Differentiation of Crohn's disease (CD) and ulcerative colitis (UC) can be difficult in some patients. Endoscopic ultrasound (EUS) provides high resolution images of the gastrointestinal wall (GI) and may be an alternative to differentiate CD/UC. EUS ...
Guha Nishan N Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, - - 2014
Context: The GH-2000 and GH-2004 research groups developed a method for detecting GH misuse in athletes based on the measurement of serum IGF-I and P-III-NP. There are reports that IGF-I is also misused by athletes but currently there is no internationally recognised test designed to detect recombinant human IGF-I misuse. ...
Hocking Christopher - - 2014
Loss of phosphatase and tensin homologue (PTEN) function evaluated by loss of PTEN protein expression on immunohistochemistry (IHC) has been reported as both prognostic in metastatic colorectal cancer and predictive of response to anti-EGFR monoclonal antibodies although results remain uncertain. Difficulties in the methodological assessment of PTEN are likely to ...
Wang Chu - - 2014
The objective of this study is to clarify the relationship between demographic and surgical factors and operating time, and thus operative difficulty, in patients undergoing laparoscopic anterior resection for mid-low rectal cancer, since different studies have derived different results. The records of patients with mid-low rectal cancer who underwent laparoscopic ...
Munthali Lumbani - - 2014
HIV infection reduces the likelihood that individuals with pulmonary tuberculosis are smear positive and that they have cavitatory disease. Antiretroviral therapy (ART) may shift the pattern of disease to be more similar to that of HIV negative patients. This would aid diagnosis- which often depends on sputum smears - but ...
Modrek Sepideh - - 2014
The World Health Organization now recommends parasitological confirmation for malaria case management. Rapid diagnostic tests (RDTs) for malaria are an accurate and simple diagnostic to confirm parasite presence in blood. However, where they have been deployed, adherence to RDT results has been poor, especially when the test result is negative. ...
Pitychoutis Pothitos M - - 2014
Many neuropsychiatric disorders, including stress-related mood disorders, are complex multi-parametric syndromes. Susceptibility to stress and depression is individually different. The best animal model of individual differences that can be used to study the neurobiology of affect regards spontaneous reactions to novelty. Experimentally, when naive rats are exposed to the stress ...
Viecili Paulo Ricardo Nazário PR Programa de Pós-Graduação em Atenção Integral à Saúde, Universidade de Cruz Alta, 98020-290 Cruz Alta, RS, Brazil; Centro de Ensino e Pesquisa, Instituto de Cardiologia de Cruz Alta, 98010-110 Cruz Alta, RS, - - 2014
In Brazil, the edible plant Campomanesia xanthocarpa Berg. (Myrtaceae), popularly known as "guavirova," has been studied in hypercholesterolemic individuals. The present work investigated the effects of C. xanthocarpa on inflammatory processes, oxidative stress, endothelial dysfunction and lipid biomarkers in hypercholesterolemic individuals. A total of 156 individuals were selected in a double-blind ...
Hosseini Seyed Mohammad Reza SM Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, South Kargar Street, Tehran 13337, - - 2014
Considering the role of neurohypophyseal peptides in normal development and function of higher cortical processes along with their proven abnormalities in schizophrenic patients, these pathways have recently attracted greater attention as treatment targets for schizophrenia. Desmopressin (DDAVP) is a synthetic analog of vasopressin. This study aimed to evaluate the efficacy ...
Mease Philip J PJ Swedish Medical Center and University of Washington, Seattle, WA, USA, - - 2014
Psoriatic arthritis (PsA) is a chronic, systemic inflammatory disease. Up to 40 % of patients with psoriasis will go on to develop PsA, usually within 5-10 years of cutaneous disease onset. Both conditions share common pathogenic mechanisms involving genetic and environmental factors. Because psoriasis is typically present for years before PsA-related joint ...
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