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Rands Sean A SA School of Biological Sciences, University of Bristol , Bristol , - - 2014
Models of collective animal behaviour frequently make assumptions about the effects of neighbours on the behaviour of focal individuals, but these assumptions are rarely tested. One such set of assumptions is that the switch between active and inactive behaviour seen in herding animals is influenced by the activity of close ...
Kismul Hallgeir H Centre for International Health, University of Bergen , - - 2014
The etiology of kwashiorkor remains enigmatic and longitudinal studies examining potential causes of kwashiorkor are scarce. Using historical, longitudinal study data from the rural area of Bwamanda, Democratic Republic of Congo, we investigated the potential causal association between diet and the development of kwashiorkor in 5 657 preschool children followed 3-monthly ...
Burgess Ian F IF Medical Entomology Centre, Insect Research & Development Limited , Quy Court, Stow-cum-Quy, Cambridge , - - 2014
Background. Many families find regular checking of children's heads for head louse infestation too onerous and would prefer to be able to prevent infestation by use of a topical application that deters lice from infesting the head. Identification in the laboratory of a repellent activity for piperonal provided the basis ...
Brookes Paul S PS Department of Anesthesiology, University of Rochester Medical Center , Rochester, NY , USA The author wishes to emphasize that the data collection for this research was conducted outside the boundaries of his position as a University of Rochester faculty member. The author assumes full responsibility for this work, and his affiliation with the University of Rochester does not represent an endorsement of this work by the - - 2014
Several online forums exist to facilitate open and/or anonymous discussion of the peer-reviewed scientific literature. Data integrity is a common discussion topic, and it is widely assumed that publicity surrounding such matters will accelerate correction of the scientific record. This study aimed to test this assumption by examining a collection ...
Smith Michael L ML Department of Neurobiology and Behavior, Cornell University , - - 2014
The Schmidt Sting Pain Index rates the painfulness of 78 Hymenoptera species, using the honey bee as a reference point. However, the question of how sting painfulness varies depending on body location remains unanswered. This study rated the painfulness of honey bee stings over 25 body locations in one subject ...
Emami Mohammad M Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, - - 2014
Recently, higher efficacy of the combination of long-acting beta2-adrenoceptor agonist and inhaled corticosteroids on controlling asthma symptoms has been hypothesized. This study aimed to examine the clinical effects of the combination of Budesonide with formoterol (Symbicort) and Budesonide (Pulmicort) alone in persistent asthma. In a randomized double-blinded clinical trial, 76 ...
Rowan Mark S MS School of Computer Science, University of Birmingham Birmingham, - - 2014
Cell death and synapse dysfunction are two likely causes of cognitive decline in AD. As cells die and synapses lose their drive, remaining cells suffer an initial decrease in activity. Neuronal homeostatic synaptic scaling then provides a feedback mechanism to restore activity. This homeostatic mechanism is believed to sense levels ...
Soudry Daniel D Laboratory for Network Biology Research, Department of Electrical Engineering Technion, Haifa, - - 2014
Many biological systems are modulated by unknown slow processes. This can severely hinder analysis - especially in excitable neurons, which are highly non-linear and stochastic systems. We show the analysis simplifies considerably if the input matches the sparse "spiky" nature of the output. In this case, a linearized spiking Input-Output ...
Seto Angela A Division of Medical Sciences, University of Victoria Victoria, BC, Canada ; Department of Biology, University of Victoria Victoria, BC, - - 2014
Anesthetics such as isoflurane are commonly used to sedate experimental animals during the induction of stroke. Since these agents are known to modulate synaptic excitability, inflammation and blood flow, they could hinder the development and discovery of new neuroprotection therapies. To address this issue, we developed a protocol for inducing ...
Lebedev Alexander V AV Department of Psychiatry, Centre for Age-Related Medicine, Stavanger University Hospital Stavanger, - - 2014
Cognitive impairment is a common non-motor feature of Parkinson's disease (PD). Understanding the neural mechanisms of this deficit is crucial for the development of efficient methods for treatment monitoring and augmentation of cognitive functions in PD patients. The current study aimed to investigate resting state fMRI correlates of cognitive impairment ...
Nguyen Su Q SQ University of Alabama School of Medicine , - - 2014
Background. While often first treated in the emergency department (ED), identification of sepsis is difficult. Electronic medical record (EMR) clinical decision tools offer a novel strategy for identifying patients with sepsis. The objective of this study was to test the accuracy of an EMR-based, automated sepsis identification system. Methods. We ...
Morina Nexhmedin N Department of Clinical Psychology, University of Amsterdam , Amsterdam , The - - 2014
Virtual reality exposure therapy (VRET) has been shown to be effective in treatment of anxiety disorders. Yet, there is lack of research on the extent to which interaction between the individual and virtual humans can be successfully implanted to increase levels of anxiety for therapeutic purposes. This proof-of-concept pilot study ...
Fonseca Cátia - - 2014
Allergies are nearly always triggered by protein molecules and the majority of individuals with documented immunologic reactions to foods exhibit IgE hypersensitivity reactions. In this study we aimed to understand if natural differences, at proteomic level, between maize populations, may induce different IgE binding proteins profiles among maize-allergic individuals. We ...
Parikakis Efstratios A EA 2nd Eye Clinic, Ophthalmiatrion Athinon, Athens, - - 2014
To report a case of spontaneous resolution of a long-standing serous macular detachment associated with an optic disc pit, leading to significant visual improvement. A 63-year-old female presented with a 6-month history of blurred vision and micropsia in her left eye. Her best-corrected visual acuity was 6/24 in the left ...
Chandrashekar Bs B Cutis Academy of Cutaneous Sciences, Centre for Advanced Dermatology and Post Graduate Training, Bangalore, Karnataka, - - 2014
Kang Joo-Eun JE Department of Anaesthesiology and Pain Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro (Hwayang-dong), Gwangjin-gu, Seoul 143-729, Republic of - - 2014
To reduce the incidence of postoperative pharyngolaryngeal adverse events, laryngeal mask airway (LMA) manufacturers recommend maximum cuff pressures not exceeding 60 cmH2O. We performed a prospective randomised study, comparing efficacy and adverse events among patients undergoing laparoscopic surgical procedures who were allocated randomly into low (limiting 25 cmH2O, L group) and high ...
Yousefi Mohammadmahdi R MR Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH 43210, USA. - - 2014
Perfect knowledge of the underlying state transition probabilities is necessary for designing an optimal intervention strategy for a given Markovian genetic regulatory network. However, in many practical situations, the complex nature of the network and/or identification costs limit the availability of such perfect knowledge. To address this difficulty, we propose ...
Hodjati Hossein H Trauma Research Center, General Surgery Department, Shiraz University of Medical Sciences, Shiraz, - - 2014
There is a wide array of articles in medical literature for and against the laser effect on wound healing but without discrete effect determination or conclusion. This experimental study aims to evaluate the efficacy of low-level laser therapy on wound healing. Thirty-four rabbits were randomly enrolled in two groups after ...
Garg Shilpa S Department of Dermatology, Army College of Medical Sciences, Base Hospital, Delhi Cantt, New Delhi, - - 2014
Scar formation is an inevitable consequence of wound healing from either a traumatic or a surgical intervention. The aesthetic appearance of a scar is the most important criteria to judge the surgical outcome. An understanding of the anatomy and wound healing along with experience, meticulous planning and technique can reduce ...
Sardana Kabir K Department of Dermatology, Maulana Azad Medical College and Lok Nayak Hospital, Delhi, India E-mail: - - 2014
Deepak Suresh H SH Consultant Dermatologist and Dermatosurgeon, Medinova Skin Care clinic and Newlook Skin and Laser Clinic, Infantry road, Shivajinagar, Bangalore-560001, Karnataka, India E-mail: - - 2014
Abdul Jabbar Alhassany Ali A Department of Neuroscience, East Kent Hospitals NHS Foundation Trust, Canterbury, - - 2014
We present an interesting case of combined vitamin A and copper deficiency after a history of gastric bypass surgery where symptoms improved after parenteral copper and vitamin A treatment. Gastric bypass surgery as a cause of fat soluble vitamin deficiency is generally under-reported. Copper deficiency has been reported after gastric ...
Katib Atif Abdulhamid AA Department of Urology, King Abdul-Aziz Hospital, Makkah, Saudi - - 2014
To present our center's experience in managing bladder outlet obstruction (BOO) conditions using bougie dilators. We described the dilation technique methodically for teaching purpose. Retrospectively, a total of 196 medical records over the last four years denoting BOO conditions in men, women, and children were retrieved for analysis. Data reviewed ...
Banyra Oleg O 2nd Lviv Municipal Polyclinic, Lviv, - - 2014
Renal cell carcinoma (RCC) is a widespread oncourological disease with a tendency towards a slow increase of incidence. In the recent decade, there has been development of numerous effective drugs targeted at different molecules that play a dominant role in RCC carcinogenesis. Understanding of RCC carcinogenesis confirms the key role ...
Hruska Carrie B CB Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. - - 2014
In an effort to reduce necessary acquisition time to perform molecular breast imaging (MBI), we compared diagnostic performance of MBI performed with standard 10-min-per-view acquisitions and half-time 5-min-per-view acquisitions, with and without wide beam reconstruction (WBR) processing. Eighty-two bilateral, two-view MBI studies were reviewed. Studies were performed with 300 MBq Tc-99 m ...
Ahmed Adil H AH 1Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. 2Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo Clinic, Rochester, MN. 3Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN. 4Division of Trauma, Critical Care and General Surgery, Mayo Clinic, Rochester, - - 2014
Acute respiratory distress syndrome is a common complication of critical illness, with high mortality and limited treatment options. Preliminary studies suggest that potentially preventable hospital exposures contribute to acute respiratory distress syndrome development. We aimed to determine the association between specific hospital exposures and the rate of acute respiratory distress ...
Alcântara Paula Cristina da Costa PC Department of Pediatric Dentistry and Orthodontics, Dental School, Federal University of Rio de Janeiro, RJ, - - 2014
This study compared in situ the application of 4% titanium tetrafluoride (TiF4) solution and 2% sodium fluoride (NaF) gel on artificial white-spot lesions in human enamel. A crossover, double-blind study using in situ caries models was carried out. Eleven volunteers used an intraoral appliance containing five demineralized human enamel blocks. ...
Goerke Monique M Department of Physiology (CBF), Charité - Universitätsmedizin Berlin, D-14195 Berlin, Germany ; German Center for Neurodegenerative Diseases (DZNE), D-39120 Magdeburg, Germany ; Department of Psychology, Humboldt-University, D-10099 Berlin, - - 2014
Rapid eye movement (REM) sleep is considered critical to the consolidation of procedural memory - the memory of skills and habits. Many antidepressants strongly suppress REM sleep, however, and procedural memory consolidation has been shown to be impaired in depressed patients on antidepressant therapy. As a result, it is important ...
Lavie Nilli N Institute of Cognitive Neuroscience, University College London, , London, - - 2014
What is the relationship between attention and conscious awareness? Awareness sometimes appears to be restricted to the contents of focused attention, yet at other times irrelevant distractors will dominate awareness. This contradictory relationship has also been reflected in an abundance of discrepant research findings leading to an enduring controversy in ...
Cai Wei Xin WX Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong - - 2014
Bioengineered bone substitutes might represent alternatives to autologous bone grafts in medically compromised patients due to reduced operation time and comorbidity. Due to the lack of an inherent vascular system their dimension is limited to the size of critical bone size defect. To overcome this shortcoming, the experiment tried to ...
Burska Agata N AN Leeds Institute of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Trust Teaching Hospital, Leeds LS9 7TF, - - 2014
Autoantibodies have been associated with human pathologies for a long time, particularly with autoimmune diseases (AIDs). Rheumatoid factor (RF) is known since the late 1930s to be associated with rheumatoid arthritis (RA). The discovery of anticitrullinated protein antibodies in the last century has changed this and other posttranslational modifications (PTM) ...
Wan Kirsty Y KY Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, , Wilberforce Road, Cambridge CB3 0WA, - - 2014
In a multitude of life's processes, cilia and flagella are found indispensable. Recently, the biflagellated chlorophyte alga Chlamydomonas has become a model organism for the study of ciliary motility and synchronization. Here, we use high-speed, high-resolution imaging of single pipette-held cells to quantify the rich dynamics exhibited by their flagella. ...
Liu Lei L Department of Ophthalmology, The First Affiliated Hospital, China Medical University, Shenyang City, Liaoning Province, China; Department of Epidemiology, School of Public Health, China Medical University, Shenyang City, Liaoning Province, - - 2014
Transforming growth factor-beta (TGF-β1) gene has been regarded as an important mechanism in angiogenesis, endothelial cell proliferation, adhesion,and the deposition of extracellular matrix. The TGF-β1 gene may be involved in the development of diabetic retinopathy (DR) through disrupting angiogenesis. However, studies investigating the relationship between -509C/T and +869T/C(L10P) polymorphisms and ...
Brown Lecia A M LA Department of Psychiatry and Behavioral Neurosciences, Neuroimmunology Laboratory, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America; Department of Molecular Medicine, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of - - 2014
Efavirenz (EFV) is among the most commonly used antiretroviral drugs globally, causes neurological symptoms that interfere with adherence and reduce tolerability, and may have central nervous system (CNS) effects that contribute in part to HIV associated neurocognitive disorders (HAND) in patients on combination antiretroviral therapy (cART). Thus we evaluated a ...
Castillejo Eduardo E Deusto Institute of Technology-DeustoTech, University of Deusto, Avda. Universidades 24,Bilbao 48007, Spain. - - 2014
The participation of users within AAL environments is increasing thanks to the capabilities of the current wearable devices. Furthermore, the significance of considering user's preferences, context conditions and device's capabilities help smart environments to personalize services and resources for them. Being aware of different characteristics of the entities participating in ...
Balaguer-Ballester Emili E Faculty of Science and Technology, Bournemouth University, United Kingdom; Bernstein Center for Computational Neuroscience, Medical Faculty Mannheim and Heidelberg University, Mannheim, - - 2014
Identifying sources of the apparent variability in non-stationary scenarios is a fundamental problem in many biological data analysis settings. For instance, neurophysiological responses to the same task often vary from each repetition of the same experiment (trial) to the next. The origin and functional role of this observed variability is ...
Gockel Christine C Department of Psychology, University of Fribourg, Fribourg, - - 2014
Temperature-related words such as cold-blooded and hot-headed can be used to describe criminal behavior. Words associated with coldness describe premeditated behavior and words associated with heat describe impulsive behavior. Building on recent research about the close interplay between physical and interpersonal coldness and warmth, we examined in a lab experiment ...
Bozek Andrzej A 0000-0003-2263-2263 Clinical Department of Internal Disease, Dermatology and Allergology, Medical University of Silesia, M Sklodowskiej Curie 10, 41-800 Zabrze, - - 2014
Background. Specific immunotherapy (SIT) with an ultrarush administration schedule with Purethal for tree pollen allergens has been evaluated to assess its efficacy and safety. Methods. The study group consisted of 22 patients with symptoms of allergic rhinitis and confirmed allergy to tree pollens. Patients were randomized and given an administration ...
Ling Chao C Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of - - 2014
Pituitary adenomas (PAs) are neoplasms that may cause a variety of neurological and endocrine effects. Although known causal contributors include heredity, hormonal influence and somatic mutations, the pathophysiologic mechanisms driving tumorigenesis and invasion of sporadic PAs remain unknown. We hypothesized that alterations in DNA methylation are associated with PA invasion ...
Günaydın Gökçe G Department of Laboratory Medicine, Division of Clinical Immunology and Transfusion Medicine, Karolinska Institute at Karolinska University Hospital, Stockholm, - - 2014
Rotavirus is an important pediatric pathogen, causing severe diarrhea and being associated with a high mortality rate causing approximately 500 000 deaths annually worldwide. Even though some vaccines are currently available, their efficacy is lower in the developing world, as compared to developed countries. Therefore, alternative or complementary treatment options ...
Karuppagounder Senthilkumar S SS 1] Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205. USA [2] Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205. USA [3] Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130-2685, - - 2014
c-Abl is activated in the brain of Parkinson's disease (PD) patients and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice where it inhibits parkin through tyrosine phosphorylation leading to the accumulation of parkin substrates, and neuronal cell death. In the present study, we evaluated the in vivo efficacy of nilotinib, a brain penetrant c-Abl ...
Saute Ricardo R Faculty of Medicine, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, - - 2014
Attention deficit hyperactivity disorder (ADHD) is a common comorbidity of childhood epilepsy, but the neuroanatomical correlates of ADHD in epilepsy have yet to be comprehensively characterized. Children with new and recent-onset epilepsy with (n = 18) and without (n = 36) ADHD, and healthy controls (n = 46) underwent high resolution MRI. Measures of cortical morphology ...
Yang Keun Suk KS Seoul St. Mary's Hospital, Department of Internal Medicine, College of Medicine, the Catholic University of Korea, Seoul, - - 2014
The manipulation of vascular endothelial growth factor (VEGF)-receptors (VEGFRs) in diabetic nephropathy is as controversial as issue as ever. It is known to be VEGF-A and VEGFR2 that regulate most of the cellular actions of VEGF in experimental diabetic nephropathy. On the other hand, such factors as VEGF-A, -B and ...
Hardiman Karin M KM Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States of - - 2014
Familial adenomatous polyposis (FAP) is often due to adenomatous polyposis coli (APC) gene germline mutations. Somatic APC defects are found in about 80% of colorectal cancers (CRCs) and adenomas. Rapamycin inhibits mammalian target of rapamycin (mTOR) protein, which is often expressed in human adenomas and CRCs. We sought to assess ...
Casati Daniela D Department of the Woman, Mother and Neonate, Children's Hospital Vittore Buzzi, Biomedical and Clinical Sciences School of Medicine University of Milan, Milan, - - 2014
Couplings between uterine contractions (UC) and fetal heart rate (fHR) provide important information on fetal condition during labor. At present, couplings between UC and fHR are assessed by visual analysis and interpretation of cardiotocography. The application of computerized approaches is restricted due to the non-stationarity of the signal, missing data ...
Ward Paul R PR Discipline of Public Health, Flinders University, Adelaide, South Australia, - - 2014
Trust is regarded as a necessary component for the smooth running of society, although societal and political modernising processes have been linked to an increase in mistrust, potentially signalling social and economic problems. Fukuyama developed the notion of 'high trust' and 'low trust' societies, as a way of understanding trust ...
Ardeljan Daniel D Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America; School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of - - 2014
Age-related macular degeneration (AMD) is a common yet complex retinal degeneration that causes irreversible central blindness in the elderly. Pathology is widely believed to follow loss of retinal pigment epithelium (RPE) and photoreceptor degeneration. Here we report aberrant expression of interleukin-17A (IL17A) and the receptor IL17RC in the macula of ...
Frampton John P JP Department of Biomedical Engineering, University of - - 2014
Accurate disease diagnosis, patient stratification and biomarker validation require the analysis of multiple biomarkers. This paper describes cross-reactivity-free multiplexing of enzyme-linked immunosorbent assays (ELISAs) using aqueous two-phase systems (ATPSs) to confine detection antibodies at specific locations in fully aqueous environments. Antibody cross-reactions are eliminated because the detection antibody solutions are ...
Tahir Humza J HJ Faculty of Life Sciences, University of Manchester, Manchester, United - - 2014
Technological advances have led to the development of powerful yet portable tablet computers whose touch-screen resolutions now permit the presentation of targets small enough to test the limits of normal visual acuity. Such devices have become ubiquitous in daily life and are moving into the clinical space. However, in order ...
Pontillo Maria M 1] Neuropsychology Unit, IRCCS Fondazione Santa Lucia, via Ardeatina 306, 00179 Rome, Italy [2] Psychology Department, Sapienza University of Rome, via dei Marsi, 78, 00185 Rome, - - 2014
A general problem in studying children with developmental dyslexia is how to separate inefficiency in learning on the one hand from exposure to written texts on the other. To evaluate dyslexic children's learning abilities with graphemic materials, we tested their improvement in a condition that minimized previous experience with words ...
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