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Huang Z S - - 1997
OBJECTIVE: To observe the effects of Yangshoudan(YSD) on the ability of learning and memories in experimental animals. METHODS: The tests of darkness-avoidance response in normal young mice and rats, aged mice, as well as in model mice with dysmnesia induced by anisodine, model rats with dysmnesia induced by scopolamine hydrobromide ...
Relevancy Score: Relevancy Score: 158
Beiko J - - 1997
A detailed behavioural analysis of water maze spatial performance in the rat was utilized to determine the effect of single and combined administration of p-chlorophenylalanine (PCPA; 1000 mg/kg, i.p.), an inhibitor of serotonin biosynthesis, and scopolamine hydrobromide (SCO; 1.0 mg/kg, i.p.), a muscarinic receptor antagonist. In some groups a water ...
Relevancy Score: Relevancy Score: 158
Sliundin D G - - 2007
The paper deals with the topical problem--study criminal clozapine intoxications that have recently ranked first in the total structure of criminal intoxications, by ousting poisoning by clofelin. Thus, in 2004 to 2006, the number of victims taken to the Prof. A. A. Ostroumov Moscow City Hospital No. 33 increased by ...
Relevancy Score: Relevancy Score: 158
Naidich Ariel - - 2006
The detection of Echinococcus granulosus in dogs is important for epidemiological surveillance and evaluation of cystic hydatic disease control programs. We report the efficacy of two PCR-based methods to detect patent and pre-patent infection in dogs experimentally infected with E. granulosus. The detection is based on amplification of a fragment ...
Relevancy Score: Relevancy Score: 158
Kitamura Y - - 1996
We studied the effects of buspirone and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) on duration of immobility in mice in the forced swim test. Buspirone [3-10 mg/kg, intraperitoneally (IP)] potently and dose dependently increased the duration of immobility in mice. In contrast, following a single dose of 8-OH-DPAT (1-3 mg/kg, IP), there was ...
Relevancy Score: Relevancy Score: 158
Hussar Daniel A - - 2004
OBJECTIVES: To provide information regarding the most important properties of the new therapeutic agents marketed in 2003. DATA SOURCES: Product labeling supplemented selectively with published studies and drug information reference sources. STUDY SELECTION: By the author. DATA EXTRACTION: By the author. DATA SYNTHESIS: The 28 new therapeutic agents marketed in ...
Relevancy Score: Relevancy Score: 158
Sessions G R - - 1998
The present study investigated the effects of scopolamine hydrobromide (SCOP: 0.06-1.0 mg/kg IP) and its quartenary analogue, scopolamine methylbromide (SCOPMB), on performance in a radial arm maze foraging task, to dissociate general drug-induced alterations of motor performance from measurement of impairments on more complex behaviors involving timing and memory. In ...
Relevancy Score: Relevancy Score: 158
Bayes M - - 2006
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the following tables have been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity, the drug discovery and development portal, http://integrity.prous.com. This issue focuses on the following ...
Relevancy Score: Relevancy Score: 158
Hayashi M - - 1981
Combined effects of restraint and hypoxia (9.5% O2 in N2) on heat production (M), heat loss (HL), colonic temperature (Tcol), and cardiovascular activity were studied in unanesthetized rats. In freely moving (F) rats, hypoxia decreased M, HL, Tcol, and heart rate (HR). In restrained (R) rats, however, hypoxia increased M, ...
Relevancy Score: Relevancy Score: 158
Doguc Duygu K - - 2012
Scopolamine has been used in neuropsychopharmacology as a standard drug that leads to symptoms mimicking cognitive deficits seen during the aging process in healthy humans and animals. Scopolamine is known to be a nonselective muscarinic receptor blocker, but its chronic effect on the expression of certain hippocampal receptors is not ...
Relevancy Score: Relevancy Score: 158
Albelda Noa - - 2011
During the last 30 years there have been many attempts to develop animal models of obsessive-compulsive disorder (OCD). Most models have not been studied further following the original publication, and in the past few years, most papers present studies employing a few established animal models, exploring the neural basis of ...
Relevancy Score: Relevancy Score: 158
Priftis Dimitrios - - 2012
The interactions between a series of oppositely charged polypeptide pairs are probed using Isothermal Titration Calorimetry (ITC) in combination with turbidity measurements and optical microscopy. Polypeptide complex coacervation is described as a sequence of two distinct binding steps using an empirical extension of a simple ITC binding model. The first ...
Relevancy Score: Relevancy Score: 158
Ziola B - - 1985
Viral antigen-induced blastogenesis of lymphocytes from multiple sclerosis (MS) patients was investigated to determine if the responses were actively suppressed. We found that depletion of adherent cells increased measles and herpes simplex I virus antigen-induced transformation of MS lymphocytes. Addition of indomethacin to cultures of unfractionated MS lymphocytes also caused ...
Relevancy Score: Relevancy Score: 158
Ravikumar K - - 2008
Molecules of eletriptan hydrobromide monohydrate (systematic name: (1S,2R)-1-methyl-2-{5-[2-(phenylsulfonyl)ethyl]-1H-indol-3-ylmethyl}pyrrolidinium bromide monohydrate), C(22)H(27)N(2)O(2)S(+) x Br(-) x H(2)O, (I), and naratriptan hydrochloride (systematic name: 1-methyl-4-{5-[2-(methylsulfamoyl)ethyl]-1H-indol-3-yl}piperidinium chloride), C(17)H(26)N(3)O(2)S(+) x Cl(-), (II), adopt conformations similar to other triptans. The C-2 and C-5 substituents of the indole ring, both of which are in a region of ...
Relevancy Score: Relevancy Score: 158
Albukhaty Salim - - 2013
Background: The magnetic nanoparticle-based transfection method is a relatively new technique for delivery of functional genes to target tissues. We aimed to evaluate the transfection efficiency of rat neural stem cell (NSC) using poly-L-lysine hydrobromide (PLL)-coated super paramagnetic iron oxide nanoparticles (SPION). Methods: The SPION was prepared and coated with ...
Relevancy Score: Relevancy Score: 158
Taverner D - - 1984
The rat renal papilla was selectively destroyed by 2-bromoethylamine hydrobromide; increasing doses produced a graded severity of histological damage, polyuria and a reduction in urinary prostaglandin E2 excretion. Destruction of at least half of the papilla caused significant hypertension, but plasma renin concentration and plasma creatinine did not change. After ...
Relevancy Score: Relevancy Score: 158
Huo Fu-Quan - - 2010
The present study examined the effect of serotonin 1A (5-HT(1A)) receptor activation in the ventrolateral orbital cortex (VLO) upon formalin-evoked flinching behavior and spinal Fos expression, and further determined whether activation of 5-HT(1A) receptors affected the spontaneous GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in rat VLO slice by pharmacologically separated ...
Relevancy Score: Relevancy Score: 158
Vincken Walter - - 2008
Bronchodilators are key drugs in symptomatic as well as maintenance treatment of obstructive lung diseases such as chronic obstructive pulmonary disease and asthma. The short-acting anticholinergic ipratropium bromide and the short-acting beta(2)-adrenergic receptor agonist fenoterol hydrobromide have been available for combined use both as a pressurized metered-dose inhaler and as ...
Relevancy Score: Relevancy Score: 158
Beatty W W - - 1985
The influence of the centrally active anticholinergic, scopolamine hydrobromide, on working and reference memory was studied in rats tested in a 12-arm radial maze. Both 0.25 and 0.5 mg/kg doses of the drug increased the number of working memory (WM) errors but had no effect on reference memory (RM) errors. ...
Relevancy Score: Relevancy Score: 158
Miyamoto K - - 1980
The antileukemic combined effect of reserpine with 1-gamma-chloropropyl-2-chloromethylpiperidine hydrobromide (CAP-2) and other antitumor agents was studied on mouse leukemia L1210 in comparison with the effects of other Rauwolfia alkaloids and sympatholytic drugs. When reserpine was administered by a single ip injection (2.5 mg/kg) on day 1, the effect of subsequent ...
Relevancy Score: Relevancy Score: 158
Bergström G - - 1992
OBJECTIVE: To investigate the role of the renal medulla in early hypertension in spontaneously hypertensive rats (SHR), and to explore whether the attenuated increase of pressure induced by enalapril treatment is affected by chemical medullectomy. DESIGN: Forty-four male SHR were studied from 5 to 18 weeks of age: 22 remained ...
Relevancy Score: Relevancy Score: 158
Flood J F - - 1984
Mice consumed solutions containing 0, 0.025, 0.050 or 0.075 mg/ml of arecoline hydrobromide (ARE) one week prior to training (T-maze, footshock, active avoidance) and a total of two weeks prior to testing memory retention. The mean daily doses of ARE were estimated to be 0, 157, 302, or 500 micrograms ...
Relevancy Score: Relevancy Score: 158
Hlinák Zdenek - - 2002
In mice, the elevated plus-maze paradigm was used to investigate the effect of scopolamine hydrobromide and diazepam and their interaction with oxiracetam on the retrieval of spatial memory trace. This paradigm measures (using the transfer latency) an animal's capacity to escape from the open arm to the enclosed one. The ...
Relevancy Score: Relevancy Score: 158
Aarthi D - - 2004
The complete inactivation of Foot and Mouth Disease (FMD) virus is a critical requirement in the production of FMD vaccine to ensure the safety of the product. Binary ethyleneimine (BEI) is an aziridine compound, produced from bromoethylamine hydrobromide (BEA) commonly used for the inactivation of FMD virus during vaccine manufacturing. ...
Relevancy Score: Relevancy Score: 158
Maksimenko A V - - 2001
Properties of native and aldehyde dextran-modified hyaluronidase (with surface amino group modification about 98%) were investigated. Optimal endoglycosidase activity of the native enzyme was observed at 0.15 M NaCl and pH 5.5 and electrostatic interactions influenced the enzyme activity. The inhibitory effect of heparin on hyaluronidase activity slightly differed at ...
Relevancy Score: Relevancy Score: 158
Gollamudi R - - 1993
Two synthetic racemic nipecotamides, 1-decyl-3-(N,N- diethylcarbamoyl)piperidine hydrobromide (1) and alpha, alpha'-bis[3-(N-benzyl-N-methylcarbamoyl)piperidino]-p-xylene dihydrobromide (2) were resolved on a chiral alpha 1-acid glycoprotein semipreparative HPLC column. Thus, rac.1 was resolved into two enantiomers 1A-(+) and 1B-(-); rac.2 was separated into the optical antipodes 2A-(-) and 2C-(+), and the meso diastereomer 2B-(0). Also ...
Relevancy Score: Relevancy Score: 158
Yoshioka K - - 1980
Electric birefringence and circular dichroism measurements have been made on solutions of two po!y (L-lysine) homologs. The specific Kerr constant and the molar ellipticity at 222 nm of poly (L-alpha, gamma-diaminobutyric acid hydrochloride) in methanol/water mixtures underwent an abrupt change between 75 and 80 vol% methanol at 25 degrees C, ...
Relevancy Score: Relevancy Score: 158
Koshiura R - - 1980
Combined effect of twenty-one central nervous system depressants with several antitumor agents was studied in the in vitro and in vivo experimental systems, using rat ascites hepatoma call lines, AH13 and AH44, sensitive and insensitive to alkylating agents, respectively. Reserpine remarkably enhanced the cytotoxic effect of 1-(gamma-chloropropyl)-2-chloromethylpiperidine hydrobromide (CAP-2) both ...
Relevancy Score: Relevancy Score: 158
Keeler R - - 1989
The renal responses to acute expansion of the blood volume (20%), acute saline loading (5% body wt), or administration of atrial natriuretic peptide (ANP) were investigated in rats 7-10 days after inducing experimental renal papillary necrosis by the injection of bromoethylamine hydrobromide. In normal rats, urinary Na output (UNaV) increased ...
Relevancy Score: Relevancy Score: 158
Vasudev Prema G - - 2009
Gabapentin, a widely used antiepileptic drug, crystallizes in multiple polymorphic forms. A new crystal form of gabapentin monohydrate in the space group Pbca is reported and the packing arrangement compared with that of a previously reported polymorph in the space group P2(1)/c [Ibers, J.A. (2001) Acta Crystallogr; C57:641]. Gabapentin polymorphs ...
Relevancy Score: Relevancy Score: 158
Rogóz Zofia - - 2003
The aim of the present study was to examine a potential anxiolytic-like action of (+)-7-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (7-OH-DPAT), a preferential dopamine D(3) receptor agonist, and (N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthylcarboxamide (BP 897), partial dopamine D(3) receptor agonist. Diazepam was used as a reference compound. The anxiolytic-like effect of those drugs was tested in the conflict ...
Relevancy Score: Relevancy Score: 158
Pilcher J J - - 1997
The effects of scopolamine hydrobromide on performance in uninterrupted and delayed radial maze trials were studied in the rat. In addition to defining errors as incorrect arm entries, errors were defined by incorrect nose pokes in a food trough and were summed across the number of correct choices remaining. The ...
Relevancy Score: Relevancy Score: 158
Namkung-Matthai H - - 2000
Nitric oxide (NO) is synthesised by a group of enzymes called nitric oxide synthases (NOS) and oxidizes to its stable end-products nitrite (NO2-) and nitrate (NO3-) We have previously reported in an in vivo rat model that NO is an important regulator for rat bone fracture healing. This study examines ...
Relevancy Score: Relevancy Score: 158
Puglisi-Allegra S - - 1981
The effects of drugs that antagonize or potentiate the action of brain gamma-aminobutyric acid (GABA) on shock-induced aggressive behavior in mice were investigated. In previous studies it has been shown that in C57 BL/6 strain shock-induced aggressive behavior is absent up to the 10th week of age and rises to ...
Relevancy Score: Relevancy Score: 158
Elmosallamy Mohamed A F MA Chemistry Department, Faculty of Science, Zagazig - - 2014
New, simple and convenient potentiometric and spectrophotometric methods are described for the determination of dextromethorphan hydrobromide (DXM) in pharmaceutical preparations. The potentiometric technique is based on developing a potentiometric sensor incorporating the dextromethorphan tetrakis(p-chlorophenyl)borate ion-pair complex as an electroactive species in a plasticized PVC matrix membrane with o-nitophenyl octyl ether ...
Relevancy Score: Relevancy Score: 158
Piper J R - - 1983
Methotrexate poly-gamma-glutamates bearing two and three glutamate units above that present in methotrexate have been synthesized by extension of a previously described route by which the lower congener bearing one added glutamate unit was synthesized. Key steps in the sequence are the peptide coupling of N-[4-[[(benzyloxy)-carbonyl]methylamino]benzoyl]-L-glutamic acid alpha-benzyl ester (5) ...
Relevancy Score: Relevancy Score: 158
Sabatini S - - 1981
The functional expression of papillary necrosis was investigated in rats following administration of 2-bromoethylamine hydrobromide (BEA). The percentage of filtering superficial and juxtamedullary nephrons was assessed using the qualitative Hanssen technique. There was a marked decrease in the percentage of filtering juxtamedullary nephrons 24 h after the induction of papillary ...
Relevancy Score: Relevancy Score: 158
Bartel P - - 1988
There is increasing evidence that the P 100 peak of the pattern-reversal visual-evoked potential (VEP-PR) is delayed by drug-induced dopamine antagonism and in Parkinson's disease. Recent studies have reported that components of the flash-VEP (VEP-F) are delayed by an anticholinergic which does not affect the VEP-PR. The present study found ...
Relevancy Score: Relevancy Score: 158
Bayés M - - 2003
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Studies Knowledge Area of Prous Science Integrity, the drug discovery and development portal, http://integrity.prous.com. This issue focuses on the following ...
Relevancy Score: Relevancy Score: 158
Bayés M - - 2004
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity(R), the drug discovery and development portal, http://integrity.prous.com. This issue focuses on the following ...
Relevancy Score: Relevancy Score: 158
Alimohammadi H - - 2000
The peripheral chemoreceptors of the trigeminal system in the nasal cavity are presumed to be free nerve endings arising from Adelta and C fibers. These fibers appear to be scattered throughout the nasal epithelium, and arise from the nasopalatine and ethmoid branches of the trigeminal nerve. In the present study, ...
Relevancy Score: Relevancy Score: 158
Grunewald G L - - 1982
A series of analogues of dopamine (DA) with varying degrees of conformational flexibility have been examined as potential substrates or competitive inhibitors of the enzyme norepinephrine N-methyltransferase (NMT). A conformationally defined (rigid) analogue of the fully extended conformation of DA, 2-amino-6,7-dihydroxybenzonorbornene hydrobromide (3; 6,7-D2HX) proved to be a better substrate ...
Relevancy Score: Relevancy Score: 158
Cassel J C - - 1989
Long-Evans female rats were "trained" in an 8-arm radial maze and subsequently tested under systemic treatment with physostigmine (0.05 mg/kg, IP), scopolamine methylbromide (MBr) and scopolamine hydrobromide (HBr; 0.5 mg/kg, IP), whose effects were compared to those of aspirative lesions of the fimbria-fornix pathways. During the predrug trials, rats with ...
Relevancy Score: Relevancy Score: 158
Wakusawa S - - 1982
The influence of two antidepressants, iproniazid and imipramine, was examined on the antileukemic combination effect of reserpine with 1-gamma-chloropropyl-2-chloromethylpiperidine hydrobromide (CAP-2), mitomycin C, or vinblastine on L1210. While reserpine synergistically increased the life span at the dose of 2.5 mg/kg in combination with these antitumor agents, the mice given reserpine ...
Relevancy Score: Relevancy Score: 158
Ryan T J - - 1976
The lysyl ester analogue p-nitrophenyl alpha-amino-p-toluate hydrobromide was synthesized, and its reactions with thrombin, trypsin, and plasmin were studied by stopped-flow and conventional methods. Kinetic parameters were compared with those determined for the arginyl ester analogue, p-nitrophenyl p-guanidinobenzoate hydrochloride, with these enzymes. By following nitrophenol release or proflavin absorption changes ...
Relevancy Score: Relevancy Score: 158
Zhou Yongqiang - - 2011
Radix Salvia miltiorrhiza (RSM), a traditional Chinese medicinal herb, has been alleged to possess therapeutic effects against senile dementia, also known as Alzheimer's disease (AD). However, the effects of the major components in RSM on cytotoxicity induced by amyloid-β peptide (Aβ) and on acetylcholinesterase activity have not been studied in ...
Relevancy Score: Relevancy Score: 158
Gelbart S M - - 1976
Control cultures were taken at laporatomy of the stomach or stomach remnant, jejunum, and ileum of 26 adult dogs, 8 of which had had gastric surgery 1 yr earlier. Two wk after the control cultures were taken, 17 of the 26 dogs, including all 8 which had had prior surgery, ...
Relevancy Score: Relevancy Score: 158
Mazur L - - 1985
On the first day of gestation, Porton mice were injected intraperitoneally with AET (2-aminoethylisothiouronium bromide hydrobromide), MEA (cysteamine hydrochloride,) or 5-HT (serotonin-creatinine sulphate), in a dose of 40 mg/kg of bodyweight. On the nineteenth day of pregnancy, the fresh weight of both heart and kidneys of foetuses, as well as ...
Relevancy Score: Relevancy Score: 158
Clinch Keith - - 2013
Cyclic pyranopterin monophosphate (1), isolated from bacterial culture, has previously been shown to be effective in restoring normal function of molybdenum enzymes in molybdenum cofactor (MoCo) deficient mice and human patients. Described here is a synthesis of 1 hydrobromide (1 HBr) employing in the key step a Viscontini reaction between ...
Relevancy Score: Relevancy Score: 158
Niggemann J - - 1993
By the use of the N-iodosuccinimide (NIS)-procedure, various glycals could be converted into 2-deoxy-2-iodoglycosyl phosphates. Treatment of glycals 1 and 7 with NIS and dibenzyl phosphate gave the corresponding alpha-1,2-trans-diaxial 2-deoxy-2-iodoglycosyl phosphates 2 and 8 as the main products. The beta-1,2-trans-diequatorial compounds 3 and 9 were isolated as by-products. Analogous ...
Relevancy Score: Relevancy Score: 158
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