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Miró Lluïsa L Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona (UB), and Institut de Recerca en Nutrició i Seguretat Alimentària, Facultat de Farmàcia, Universitat de Barcelona (UB), Av. Joan XXIII s/n, 08028, Barcelona, Spain - - 2014
Arginine vasopressin (AVP) has trophic effects on the rat distal colon, increasing the growth of pericryptal myofibroblasts and reducing the colonic crypt wall permeability. This study aimed to reproduce in vitro the effects of AVP observed in vivo using cultures of human CCD-18Co myofibroblasts and T84 colonic epithelial cells. Myofibroblasts ...
Arabpour Mohammad M Department of Pharmaceutical Gene Modulation, University of Groningen, Groningen, The - - 2014
Progressive liver fibrosis is the result of chronic liver injury and characterized by excessive accumulation of extracellular matrix that may result in liver failure. Activated Hepatic Stellate Cells are known to play a central role in this process and their elimination is a crucial step towards the resolution and reversion ...
Kang Ping P Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha 410125, China - - 2014
This trail was conducted to study the effect of L-proline on the growth performance, and blood parameter in the weaned lipopolysaccharide (LPS)-challenged pigs. Thirty six pigs (9.13±0.85 kg) were assigned randomly to dietary treatments in a 2×3 factorial arrangement in a 20-d growth assay. Factors were intraperitoneal injection with saline ...
Gazos-Lopes Felipe F The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso (UTEP), El Paso, Texas, United States of - - 2014
Trypanosoma cruzi is the causative agent of the life-threatening Chagas disease, in which increased platelet aggregation related to myocarditis is observed. Platelet-activating factor (PAF) is a potent intercellular lipid mediator and second messenger that exerts its activity through a PAF-specific receptor (PAFR). Previous data from our group suggested that T. ...
Tringali Cristina - - 2014
In addition to alterations concerning the expression of oncogenes and onco-suppressors, melanoma is characterized by the presence of distinctive gangliosides (sialic acid carrying glycosphingolipids). Gangliosides strongly control cell surface dynamics and signaling; therefore, it could be assumed that these alterations are linked to modifications of cell behavior acquired by the ...
Hirose Takashi T Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of - - 2014
The proper regulation of apoptosis requires precise spatial and temporal control of gene expression. While the transcriptional and translational activation of pro-apoptotic genes is known to be crucial to triggering apoptosis, how different mechanisms cooperate to drive apoptosis is largely unexplored. Here we report that pro-apoptotic transcriptional and translational regulators ...
Gunewardene Niliksha N Department of Otolaryngology, University of Melbourne , East Melbourne, Victoria, Australia - - 2014
Emerging therapies for sensorineural hearing loss include replacing damaged auditory neurons (ANs) using stem cells. Ultimately, it is important that these replacement cells can be patient-matched to avoid immunorejection. As human induced pluripotent stem cells (hiPSCs) can be obtained directly from the patient, they offer an opportunity to generate patient-matched ...
Cohen Gadi G Faculty of Medicine, School of Pharmacy Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, 91120, - - 2014
Nerve growth factor (NGF) treatment causes a profound down-regulation of epidermal growth factor (EGF) receptors (EGFR) during the neuronal differentiation of PC12 cells. This process was characterized by a progressive decrease in EGFR level, as measured by (125)I-EGF binding and Scatchard analysis, tyrosine phosphorylation, Western blotting, and bio-imaging using EGF-labeled ...
Hudak Carolyn S CS Department of Nutritional Sciences & Toxicology, 119 Morgan Hall, University of California, Berkeley, CA 94720, - - 2014
Pref-1 is an EGF-repeat-containing protein that inhibits adipocyte differentiation. To better understand the origin and development of white adipose tissue (WAT), we generated transgenic mouse models for transient or permanent fluorescent labeling of cells using the Pref-1 promoter, facilitating inducible ablation. We show that Pref-1-marked cells retain proliferative capacity and ...
Yang Chao C 1 National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University , Chengdu, 610041, China - - 2014
Abstract Trauma or degenerative diseases of the central nervous system (CNS) cause the loss of neurons or glial cells. Stem cell transplantation has become a vital strategy for CNS regeneration. It is necessary to effectively induce nonneurogenic stem cells to differentiate into neurogenic cell lineages because of the limited source ...
Parks Eileen E EE University of Louisville, United - - 2014
TThere is an established role for the endocytic pathway in regulation of epidermal growth factor receptor (EGFR) signaling to downstream effectors. However, since ligand-mediated EGFR endocytosis utilizes multiple moving parts, dissecting the spatial versus temporal contributions has been challenging. Blocking all endocytic trafficking can have unintended effects on other receptors ...
Barta Pavel P Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology, Hyerovskeho 1203, 50005 Hradec Kralove, Czech Republic. Electronic address: - - 2014
Competitive binding assays can be used to decipher not only the binding kinetics of studied ligands but also the binding site preference. Such assays are an essential step in the characterization of radioligands. However, the currently used competition assays require high concentrations of usually expensive ligands and still provide only ...
Cho In-Hee - - 2014
Eotaxin proteins are a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases. Since inflammation is often associated with an increased generation of reactive oxygen species (ROS), oxidative stress is a mechanistically imperative factor in asthma. Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity and newly ...
Pan Christopher C CC Ohio State University, United - - 2014
Endoglin is a transforming growth factor beta (TGF-β) co-receptor essential for angiogenesis and tumor vascularization. Endoglin modulates the crucial balance between pro- and anti-angiogenic signaling by activin receptor-like kinase (ALK) 1, 5, and TGF-β type II (TβRII) receptors. Despite its established role in physiology and disease, the mechanism of endoglin ...
De Sarmishtha S Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH - - 2014
Activation of nuclear factor κB (NFκB) is a central event in the responses of normal cells to inflammatory signals, and the abnormal constitutive activation of NFκB is important for the survival of most cancer cells. In nonmalignant human cells, EGF stimulates robust activation of NFκB. The kinase activity of the ...
Sreekumar Bharath K BK From the *Department of Medicine, Yale University School of Medicine, New Haven, CT; †Second Department of Internal Medicine, Klinikum rechts der Isar, Technical University, Munich, Germany; ‡Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI; and §Veterans Administration CT Healthcare System, West Haven, - - 2014
A functional vacuolar adenosine triphosphatase (v-ATPase) complex regulates canonical Wnt/β-catenin signaling. The goal of this study was to identify the distribution of the v-ATPase in human and murine models of pancreatic intraepithelial neoplasms (PanINs) and assess its role in Wnt/β-catenin signaling. We evaluated the immunolabeling pattern of the v-ATPase in ...
Cho Hanbyoul - - 2014
The apoptosis inhibitor-5 (API5), anti-apoptosis protein, is considered a key molecule in the tumor progression and malignant phenotype of tumor cells. Here, we investigated API5 expression in cervical cancer, its clinical significance, and its relationship with phosphorylated extracellular signal-regulated kinase 1 and 2 (pERK1/2) in development and progression of cervical ...
Hollmen Maria E - - 2014
Neutrophil gelatinase-associated lipocalin (NGAL) is a marker for acute kidney injury. We studied whether serum NGAL predicts delayed graft function (DGF) and recovery of kidney function after transplantation. Serum NGAL was analyzed using commercial ELISA and point-of-care (POC) (Triage(R), Biosite) methods. Serum samples were collected from 176 consecutive, deceased-donor kidney ...
Rintala Jukka M JM 1 Transplantation Laboratory, University of Helsinki, Helsinki, Finland. 2 Helsinki University Central Hospital, Transplantation and Liver Surgery Unit, Helsinki, Finland. 3 Helsinki University Central Hospital, Department of Medicine, Division of Nephrology, Helsinki, Finland. 4 Address correspondence to: Jukka M. Rintala, M.D., Transplantation Laboratory, PO Box 400 (Haartmaninkatu 3) 00029, Hospital District of Helsinki and Uusimaa (HUS), - - 2014
Chronic allograft injury remains a major problem in clinical kidney transplantation and different growth factors participate in its development. Epidermal growth factor (EGF) affects cell proliferation and mitogenesis through its tyrosine kinase receptor. Erlotinib is an orally administered tyrosine kinase inhibitor used in clinical oncology to inhibit EGF signaling. We ...
Fossati Matteo M BIOMETRA Department, CNR Institute of Neuroscience, Università degli Studi di Milano, Milano, - - 2014
The Golgi complex and ER are dynamically connected by anterograde and retrograde trafficking pathways. To what extent and by what mechanism outward-bound cargo proteins escape retrograde trafficking has been poorly investigated. Here, we analysed the behaviour of several membrane proteins at the ER/Golgi interface in live cells. When Golgi-to-plasma membrane ...
Bora Adriana A Department of Molecular and Comparative Pathobiology-Retrovirus Laboratory, Baltimore, - - 2014
We identified and measured proteins in the cerebral spinal fluid (CSF) involved in HIV-associated neurological disorders. Protein levels were determined by mass spectrometry (MS) in pooled CSF taken from three patient groups (human immunodeficiency virus (HIV)-1-infected patients that developed HIV-associated neurocognitive disorders (HANDs), HIV-1-infected patients without HAND, and healthy controls). ...
Sóñora Cecilia C Immunology Laboratory, School of Sciences/School of Chemistry, Montevideo, Uruguay; EUTM-School of Medicine UDELAR, Montevideo, - - 2014
Women with celiac disease (CD) are often affected by atypical presentations of the disease associated with reproductive disorders as a main extra-digestive complaint. Here, we analyzed if autoantibodies against tissue transglutaminase (tTG) in sera from CD patients with reproductive disorders could display direct effects through their interaction with tTG expressed ...
Miyata Kohei K Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Department of Biochemistry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan; Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, - - 2014
Ovarian clear cell carcinoma (OCCC) is a worst histological subtype than other ovarian malignant tumor. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for ovarian cancer therapy. The aims of this study were to validate the efficacy of HB-EGF-targeted therapy for OCCC and to identify the transcription ...
Jouinot Anne A AP-HP, groupe hospitalier Cochin-Port-Royal, université Paris-Descartes, service de cancérologie, 75014 Paris, - - 2014
The treatment of metastatic colorectal cancer has been transformed during the last decade with biotherapies, two of them were marketed in 2013. Four agents are monoclonal antibodies, while the fifth agent is a tyrosine kinase inhibitor. Two agents are inhibitors of the EGF-receptor pathway, cetuximab and panitumumab, and have as ...
Wolle Daniel D Nemours Center for Childhood Cancer Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, - - 2014
Epidermal growth factor (EGF) signaling regulates cell growth, proliferation, and differentiation. Upon receptor binding, EGF triggers cascades of downstream signaling, including the MAPK and phosphoinositide-3-kinase (PI3K)/Akt signaling pathways. Aberrant expression/activation of EGFR is found in multiple human cancers, including medulloblastoma, the most prevalent pediatric brain cancer, and often has been ...
Lou Xiangxin X Department of Bioengineering, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai, 201620, - - 2014
We have demonstrated that selected growth factors (GFs) are involved in regulating survival and proliferation of progenitor cells derived from the neonatal rat organ of Corti (OC). The protective and regenerative effects of these defined growth factors (GFs) on the injured organ of Corti were therefore investigated. The organ of ...
Coaxum Sonya D SD Medical University of South - - 2014
Epidermal growth factor (EGF) is linked to the pathogenesis of polycystic kidney disease (PKD). We explored signaling pathways activated by EGF in orpk cilia (-) collecting duct cell line derived from a mouse model of PKD (hypomorph of the Tg737/Ift88 gene) with severely stunted cilia, and in a control orpk ...
Staruschenko Alexander A Medical College of Wisconsin - - 2014
This editorial focus highlights the accepted manuscript by Gooz et al. (Am J Physiol Renal Physiol. 2014, DOI: 10.1152/ajprenal.00218.2014) entitled "ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease".
Le Bras Grégoire F GF Department of Surgery, Vanderbilt University, Nashville, - - 2014
The TGFβ signaling pathway is essential to epithelial homeostasis and is often inhibited during progression of esophageal squamous cell carcinoma. Recently, an important role for TGFβ signaling has been described in the crosstalk between epithelial and stromal cells regulating squamous tumor cell invasion in mouse models of head-and-neck squamous cell ...
Smiljanic Katarina K Department of Biochemistry, Faculty of Chemistry, University of Belgrade, Studentski trg 16, 11000, Belgrade, Serbia, - - 2014
In this study, the role of epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK1/2), heparin-binding EGF-like growth factor (HB-EGF), general metalloproteinases, matrix metalloproteinases-2 (MMP-2) in mediating the mitogenic action of thrombin in rat vascular smooth muscle cells (VSMC) was investigated. The incubation of rat VSMC with thrombin (1 U/ml) for ...
Munoz Jessian L JL Medicine-Hematology/Oncology, Rutgers- New Jersey Medical - - 2014
Glioblastoma multiforme (GBM) commonly resists the frontline chemotherapy, temozolomide (TMZ). The multidrug resistance gene (MDR1) and its protein, P-glycoprotein (P-gp), are associated with chemoresistance. This study investigated the mechanisms underlying MDR1-mediated resistance by GBM to TMZ. P-gp trafficking was studied by flow cytometry and western blot, MDR1 expression was analyzed ...
Russell Jeffery S - - 2014
Endothelial progenitor cells (EPCs) have been demonstrated to have stem-cell like as well as mature endothelial functions. However, controversy remains as to their origins, immunophenotypic markings, and contribution to the tumor vascular network and tumor survival. Flow cytometric analysis and sorting was used to isolate Flk-1+/c-Kit+/CD45- cells. Matrigel and methycellulose ...
Huat Tee Jong - - 2014
There has been increasing interest recently in the plasticity of mesenchymal stem cells (MSCs) and their potential to differentiate into neural lineages. To unravel the roles and effects of different growth factors in the differentiation of MSCs into neural lineages, we have differentiated MSCs into neural lineages using different combinations ...
Kiani Narsis A - - 2014
Network inference deals with the reconstruction of molecular networks from experimental data. Given N molecular species, the challenge is to find the underlying network. Due to data limitations, this typically is an ill-posed problem, and requires the integration of prior biological knowledge or strong regularization. We here focus on the ...
Benner Christopher - - 2014
Insulin producing beta cell and glucagon producing alpha cells are colocalized in pancreatic islets in an arrangement that facilitates the coordinated release of the two principal hormones that regulate glucose homeostasis and prevent both hypoglycemia and diabetes. However, this intricate organization has also complicated the determination of the cellular source(s) ...
Mallia Rupananda J RJ Princess Margaret Cancer Centre, University Health Network, Toronto, ON, - - 2014
Aim: As the possibilities of molecular imaging in personalized medicine evolve rapidly, the optical advantages of extremely narrow and intense spectral bands makes surface-enhanced Raman scattering (SERS) an appealing candidate for multiplexed recognition of targeted biomarkers over other optical imaging modalities. Materials & methods: In this proof-of-concept study, we report ...
Milán Marco M ICREA and Institute for Research in Biomedicine, Parc Cientific de Barcelona, Baldiri Reixac, 10-12, 08028 Barcelona, Spain. Electronic address: - - 2014
Stromal cells play a supportive role in the initiation and progression of carcinomas. A new study in Drosophila implicates mesenchymal cells in supporting EGF receptor-driven tumor growth and cellular transformation of epithelial tissues.
Qian YingYing - - 2014
Lung cancer in nonsmokers tends to be driven by a single somatic mutation or a gene fusion. KIF5B-RET fusion is an oncogene identified in non-small cell lung cancers. In this study, we verified the oncogenic activity of KIF5B-RET fusion and investigated how KIF5B-RET activates the specific signaling pathways for cellular ...
Hu Yang-Hong YH Department of Burns and Plastic Surgery, First Affiliated Hospital1, Nanchang University, Nanchang 330006, China; 2Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China. E-mail: - - 2014
To screen differentially expressed genes in hyperplastic scar to explore the pathogenesis of hyperplastic scar and identify new therapeutic targets. Three pairs of surgical specimens of hyperplastic scar and adjacent normal skin tissues were collected to investigate the differentially expressed genes in hyperplastic scar using Agilent gene oligonucletide microarray and ...
Bai Yu Y Institution of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, - - 2014
MicroRNAs (miRNAs) are endogenous non-coding small RNAs that negatively regulate gene expression at the post-transcriptional level by base pairing with target mRNAs. Many miRNAs have been proven to regulate a broad range of processes, including proliferation, differentiation, development and apoptosis. miR126 is encoded by intron 7 of the EGF- like ...
Hofmann Elisabeth - - 2014
The capacity of the recombinant Vaccinia virus GLV-1h68 as a single agent to efficiently treat different human or canine cancers has been shown in several preclinical studies. Currently, its human safety and efficacy are investigated in phase I/II clinical trials. In this study we set out to evaluate the oncolytic ...
Garcia Tarcyane Barata TB Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany; Institute of Biological Sciences, Federal University of Pará, Belém, - - 2014
Osmotic swelling of neurons and glial cells contributes to the development of retinal edema and neurodegeneration. We show that nerve growth factor (NGF) inhibits the swelling of glial (Müller) and bipolar cells in rat retinal slices induced by barium-containing hypoosmotic solution. NGF also reduced Müller and bipolar cell swelling in ...
Kim Guen Tae GT Department of Biological Sciences, College of Life Science and Nano Technology, Hannam University, Yuseong-gu, Daejeon 305-811, Republic of - - 2014
Abnormal metastasis of carcinoma is associated with the loss of epithelial features and the acquisition of a mesenchymal phenotype. The stimulation of cells with epidermal growth factor (EGF) resulted in morphological changes and induced epithelial-mesenchymal transition (EMT). EGF stimulation resulted in increased mobility along with upregulated actin polarization related proteins, ...
Ding Qunli Q Department of Respiratory Medicine, Affiliated Hospital of School of Medicine, Ningbo University, Ningbo, 315020, - - 2014
Involvement of epidermal growth factor (EGF) is reported in diseases caused by hypoxia. Its functional polymorphism may alter its transcription, affecting EGF expression, contributing to obstructive sleep apnea (OSA). The aim of this study was to investigate associations of EGF+61 polymorphism and risk of OSA. Two hundred two participants were ...
Hiradate Yuuki - - 2014
Neurotensin (NT) has multiple functions, ranging from acting as a neurotransmitter to regulating intestinal movement. However, its function in reproductive physiology is unknown. Here, we investigated the functions of NT receptors (NTR1/2) and effect of NT on sperm function using mouse epididymal spermatozoa. Sperm protein tyrosine phosphorylation, one of the ...
Shan Changliang C Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University, Atlanta, GA 30322, - - 2014
Although the oxidative pentose phosphate pathway is important for tumor growth, how 6-phosphogluconate dehydrogenase (6PGD) in this pathway is upregulated in human cancers is unknown. We found that 6PGD is commonly activated in EGF-stimulated cells and human cancer cells by lysine acetylation. Acetylation at K76 and K294 of 6PGD promotes ...
Nair Sajitha - - 2014
Inhibitor of DNA binding/Differentiation 1 (ID1) is a helix loop helix transcription factor that lacks the basic DNA binding domain. Over-expression of ID1 has been correlated with a variety of human cancers; our earlier studies had shown that reported ID1 is induced by nicotine or EGF stimulation of non-small cell ...
Liu Minji - - 2014
As a novel candidate metastasis suppressor gene, Nasopharyngeal carcinoma-associated gene 6 (NGX6) is involved in cellular growth, cell cycle progression and tumor angiogenesis. Previous studies have shown that NGX6 gene is down-regulated in colorectal cancer (CRC). However, little is known about its transcriptional regulation. We defined the minimal promoter of ...
Jaldety Yael Y The Mina & Everard Faculty of Life-Sciences,Bar-Ilan - - 2014
Summary Mammalian sperm acquire fertilization capacity after residing in the female reproductive tract for a few hours in a process called capacitation. Only capacitated sperm can bind the zona pellucida (ZP) of the egg and undergo the acrosome reaction, a process that allows penetration and fertilization. Extracellular signal regulated kinase ...
Kiewisz Jolanta J Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland; Faculty of Medical Sciences, Department of Histology and Embryology, University of Warmia and Mazury, Olsztyn, - - 2014
The objective of the study was to investigate transcriptomic profile of pig endometrium on Days 12 and 16 of pregnancy in comparison with the respective days of the estrous cycle. Labeled complementary DNA was hybridized to Porcine Long Oligo microarray containing 13,297 oligonucleotide probes, which represented complementary DNA and expressed ...
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