Search Results
Results 93751 - 93800 of 530945

Current sort is by relevancy. Click to sort by publication date

< 1871 1872 1873 1874 1875 1876 1877 1878 1879 1880 1881 >
Xie Chang-Ying - - 2012
To report the 5-year follow-up results of a randomized controlled trial comparing bipolar transurethral resection of the prostate (TURP) with standard monopolar TURP for the treatment of benign prostatic obstruction (BPO). A total of 220 patients were randomized to bipolar plasmakinetic TURP (PK-TURP) or monopolar TURP (M-TURP). Catheterization time was ...
Relevancy Score: Relevancy Score: 141
Rebsomen L - - 2008
The C-peptide of proinsulin is important for the biosynthesis of insulin and has for a long time been considered to be biologically inert. Animal studies have shown that some of the renal effects of the C-peptide may in part be explained by its ability to stimulate the Na,K-ATPase activity. Precisely, ...
Relevancy Score: Relevancy Score: 141
Khatri Natasha N Department of Biology, Boston University , Boston, MA , USA ; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine , Boston, MA , - - 2013
Powered by glucose metabolism, the brain is the most energy-demanding organ in our body. Adequate ATP production and regulation of the metabolic processes are essential for the maintenance of synaptic transmission and neuronal function. Glutamatergic synaptic activity utilizes the largest portion of bioenergy for synaptic events including neurotransmitter synthesis, vesicle ...
Relevancy Score: Relevancy Score: 141
Cheng Mary Hongying MH Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, United States of - - 2014
Neurotransmitter: sodium symporters (NSSs) regulate neuronal signal transmission by clearing excess neurotransmitters from the synapse, assisted by the co-transport of sodium ions. Extensive structural data have been collected in recent years for several members of the NSS family, which opened the way to structure-based studies for a mechanistic understanding of ...
Relevancy Score: Relevancy Score: 141
Deng Wang - - 2012
Stimulation of epithelial sodium channel (ENaC) increases Na(+) transport, a driving force of alveolar fluid clearance (AFC) to keep alveolar spaces free of edema fluid that is beneficial for acute lung injury (ALI). It is well recognized that regulation of ENaC by insulin via PI3K pathway, but the mechanism of ...
Relevancy Score: Relevancy Score: 141
Gumber Sanjeev - - 2007
Mycobacterium paratuberculosis causes Johne's disease, a chronic bowel disease in ruminants worldwide and is currently incurable. This study was conducted to compare methods for examining the proteome of M. paratuberculosis. SDS-PAGE, native PAGE and SELDI-TOF-MS were compared and the efficacy of various lysis buffers was assessed. Chaotropic agents (Urea CHAPS ...
Relevancy Score: Relevancy Score: 141
Gabel D - - 1998
To make clinical trials of boron neutron capture therapy safe for patients, it is necessary to know the relative biological effectiveness (RBE) of the radiation components and the compound factor of the boron carrier to be used. Here a method is derived to determine the RBE of recoil protons and ...
Relevancy Score: Relevancy Score: 141
Kobayashi Motomu - - 2007
Although propofol and thiopental are commonly used as neuroprotective agents, it has not been determined which is more neuroprotective. This study was designed to quantitatively evaluate the neuroprotective effects of thiopental, propofol, and halothane on brain ischemia by determining P50, ischemic time necessary for causing 50% neuronal damage. Gerbils were ...
Relevancy Score: Relevancy Score: 141
Langleben David - - 2004
Sitaxsentan (SITAX; Thelin, Encysive Corporation, Bellaire, TX, U.S.A.) is a highly selective oral endothelin-A receptor antagonist. STRIDE-1, a 12-week randomized, doubleblind, placebo-controlled trial of sitaxsentan for pulmonary arterial hypertension showed significant benefit in 6-minute walk distance, functional class and hemodynamics. Pulmonary arterial hypertension clinical trials traditionally limit enrolment to class ...
Relevancy Score: Relevancy Score: 141
Kulcsár G - - 2000
Despite global immune system abnormalities in the autoimmune deficiency syndrome, the incidence of only a few tumor types increases, and the degree of immunosuppression does not seem to be critical in the development of these tumors, indicating that the immune system does not prevent tumor development. Consequently, because tumors do ...
Relevancy Score: Relevancy Score: 141
Sugiyama M - - 1993
The effect of the cell-permeable metal chelator o-phenanthroline (OP) on the formation of chromium(V), DNA breaks, alkali-labile sites, and enzyme inhibition of chromium(VI) was studied using Chinese hamster V-79 cells. Alkaline elution assays demonstrated that treatment with OP (100-500 microM) resulted in a dose-dependent decrease in cellular levels of either ...
Relevancy Score: Relevancy Score: 141
Wiesner E - - 1981
An explanation of the functions of both vitamin E and selenium in metabolism and an account of the correlations between them is followed by reference to the results obtained by the authors of this paper from studies into the effects of dl-alpha-tocopherol on selenium levels in the M. longissimus dorsi, ...
Relevancy Score: Relevancy Score: 141
Nickel J Curtis - - 2012
OBJECTIVE: To gain additional safety and effectiveness information regarding intravesical 2% chondroitin sulfate in subjects with interstitial cystitis/bladder pain syndrome (IC/BPS) in a controlled clinical trial. METHODS: Women with IC/BPS were randomized to receive either 8 weekly bladder instillations of 20 mL of 2% chondroitin sulfate or 20 mL of ...
Relevancy Score: Relevancy Score: 141
Yanagita Toshihiko - - 2011
Insulin-like growth factor-1 (IGF-1) plays important roles in the regulation of neuronal development. The electrical activity of Na(+) channels is crucial for the regulation of synaptic formation and maintenance/repair of neuronal circuits. Here, we examined the effects of chronic IGF-1 treatment on cell surface expression and function of Na(+) channels. ...
Relevancy Score: Relevancy Score: 141
Davidsson Lena - - 2005
BACKGROUND: Phytic acid is a strong inhibitor of iron absorption from fortified foods. In adults, this inhibitory effect can be overcome by adding ascorbic acid with the iron fortificant or by using a "protected" iron compound such as NaFeEDTA. In addition, the use of NaFeEDTA as an iron fortificant has ...
Relevancy Score: Relevancy Score: 141
Wang Yuying - - 2011
We recently reported that merging key structural pharmacophores of the anticonvulsant drugs lacosamide (a functionalized amino acid) with safinamide (an α-aminoamide) resulted in novel compounds with anticonvulsant activities superior to that of either drug alone. Here, we examined the effects of six such chimeric compounds on Na(+)-channel function in central ...
Relevancy Score: Relevancy Score: 141
Nwamba Charles O - - 2013
We investigate the interaction of Ca2+ (0-500 µM) and a membrane mimic (0.60 mM SDS) with both the R- and mixed spin states hemoglobin S (HbS) as a function of time. These interactions were carried out at pH 5.0. We aim at ascertaining if there is or are differences in the UV-Visible ...
Relevancy Score: Relevancy Score: 141
Maiorino R M - - 1996
The binding of 2,3-dimercapto-1-propanesulfonate (DMPS) in plasma was determined in three healthy young adults after a single 300-mg p.o. dose. By 5 hr after DMPS administration, 62.5% of the total plasma DMPS was bound to proteins. The remainder consisted of nonprotein associated DMPS disulfides (36.6%) and unaltered DMPS (0.9%). Protein-bound ...
Relevancy Score: Relevancy Score: 141
Wang Bo - - 2008
We aimed to synthesise evidence to assess the effect and safety of NaFeEDTA on Hb and serum ferritin in Fe-deficient populations. We performed a systematic review, identifying potential studies by searching the electronic databases of Medline, Cochrane Library, Embase, WHO Library and China National Knowledge Infrastructure. We also hand-searched relevant ...
Relevancy Score: Relevancy Score: 141
Cannon G W - - 2000
OBJECTIVE: To compare the clinical efficacy of rofecoxib, a specific inhibitor of cyclooxygenase 2 (COX-2), with that of diclofenac in patients with osteoarthritis (OA) and to evaluate the safety and tolerability of rofecoxib. METHODS: We performed a randomized, double-blind, active comparator-controlled trial in 784 adults with OA of the knee ...
Relevancy Score: Relevancy Score: 141
McGhee Pamela - - 2011
We tested the MICs of fusidic acid (CEM-102) plus other agents against 40 methicillin-resistant Staphylococcus aureus (MRSA) isolates from cystic fibrosis patients and the activities of fusidic acid with or without tobramycin or amikacin against Pseudomonas aeruginosa, MRSA, and Burkholderia cepacia isolates from cystic fibrosis patients in a 24-h time-kill ...
Relevancy Score: Relevancy Score: 141
MacGregor I R - - 1985
Three human volunteers were injected with a range of doses of pentosan polysulphate, SP54, i.v. or s.c. A competitive binding assay (CBA) for sulphated polysaccharides was used to detect circulating SP54 after doses as low as 1 mg i.v. and a linear relationship was observed between the peak plasma concentration ...
Relevancy Score: Relevancy Score: 141
Cercamondi Colin I - - 2013
Home fortification with lipid-based nutrient supplements (LNSs) is a promising approach to improve bioavailable iron and energy intake of young children in developing countries. To optimize iron bioavailability from an LNS named complementary food fortificant (CFF), 3 stable isotope studies were conducted in 52 young Beninese children. Test meals consisted ...
Relevancy Score: Relevancy Score: 141
Minami M - - 1985
Present study was undertaken to elucidate the effects of E-643, on blood pressure, urinary electrolyte (U-Na, U-K) and catecholamines excretion rates in stroke-prone spontaneously hypertensive rats (SHRSP). An attempt was also made to clarify the effects of E-643 on plasma catecholamine concentration and sympathetic efferent nerve discharges including renal and ...
Relevancy Score: Relevancy Score: 141
Lansdowne Jennifer L - - 2005
OBJECTIVE: To determine the relationship between epidural cranial migration and injectate volume of an isotonic solution containing dye in laterally recumbent foal cadavers and evaluate the cranial migration and dermatome analgesia of an epidural dye solution during conditions of laparoscopy in foals. ANIMALS: 19 foal cadavers and 8 pony foals. ...
Relevancy Score: Relevancy Score: 141
Karadas Nurgul N Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Ankara, Turkey; Hitit University, Faculty of Science and Arts, Department of Chemistry, Corum, - - 2014
Electrochemical oxidation of pemetrexed (PMX) was studied on bare, carboxylic acid functionalized multi-walled carbon nanotubes and over-oxidized polypyrrole modified (oo-PPy/MWCNTs-COOH/GCE) glassy carbon electrodes by cyclic and adsorptive stripping differential pulse voltammetric techniques. The oo-PPy/MWCNTs-COOH/GCE is very sensitive to the oxidation of PMX. The results proved that the over-oxidation of the ...
Relevancy Score: Relevancy Score: 141
Ishida H - - 1999
The prophylactic action of scymnol in a rat peripheral arterial occlusion model, involving injection of 5% lactic acid into the femoral artery, was investigated. Increases in serum lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) activities and in plasma levels of thrombin and antithrombin III complex ...
Relevancy Score: Relevancy Score: 141
Büntzel J - - 1999
The principle of cytoprotection became a new supportive strategy in oncology during the last decade. Two principal ways of cytoprotection are well known in practice: the addition of external free thiols (for example amifostine) or the activation of internal detoxification-pathways (for example the activation of glutathione peroxidase) by administration of ...
Relevancy Score: Relevancy Score: 141
Eisenreich Karen M - - 2012
Perchlorate is a surface and groundwater contaminant found in areas associated with munitions and rocket manufacturing and use. It is a thyroid-inhibiting compound, preventing uptake of iodide by the thyroid gland, ultimately reducing thyroid hormone production. As thyroid hormones influence metabolism, growth, and development, perchlorate exposure during the embryonic period ...
Relevancy Score: Relevancy Score: 141
Guidolin D D - - 2001
OBJECTIVE: Histomorphometric study on cartilage samples taken from osteoarthritic human knees before and 6 months after intraarticular injections of a specific fraction (500-730 kDa) of hyaluronan. The results obtained with hyaluronan were compared with the results of methylprednisolone acetate treatment. METHODS: Twenty-four subjects with primary osteoarthritis (OA) of the knee ...
Relevancy Score: Relevancy Score: 141
Tanizawa Yukio Y Yamaguchi University Graduate School of Medicine, Division of Endocrinology, Metabolism, Hematological Science and Therapeutics , 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505 , Japan +81 836 22 2250 (office) ; +81 836 22 2256 ; - - 2014
Objective: To evaluate long-term safety and efficacy of tofogliflozin in Japanese patients with type 2 diabetes as monotherapy or in combination with other oral antidiabetic agents, we conducted 52-week, open-label, randomized controlled trials. Research design and methods: The single-agent trial included patients with inadequate glycemic control on diet and exercise, ...
Relevancy Score: Relevancy Score: 141
Onoda Akira - - 2002
Three new polynuclear Ca(II)- and Na(I) phosphate complexes with two strategically oriented bulky amide groups, 2,6-(PhCONH)(2)C(6)H(3)OPO(3)H(2), were synthesized, including one with a zigzag-chain, [Ca(II)[O(3)POC(6)H(3)-2,6-(NHCOPh)(2)](H(2)O)(4)(EtOH)](n), a cyclic-octanuclear form, [Ca(II)(8)[O(3)POC(6)H(3)-2,6-(NHCOPh)(2)](8)(O=CHNMe(2))(8)(H(2)O)(12)], and a hexanuclear complex, (NHEt(3))[Na(3)[O(3)POC(6)H(3)-2,6-(NHCOPh)(2)](2)(H(2)O)(MeOH)(7)]. X-ray crystallography revealed that all have an unsymmetric ligand position due to the bulky amide groups. A ...
Relevancy Score: Relevancy Score: 141
Cercamondi Colin I - - 2013
In addition to phytate, polyphenols (PP) might contribute to low Fe bioavailability from sorghum-based foods. To investigate the inhibitory effects of sorghum PP on Fe absorption and the potential enhancing effects of ascorbic acid (AA), NaFeEDTA and the PP oxidase enzyme laccase, we carried out three Fe absorption studies in ...
Relevancy Score: Relevancy Score: 141
Mohammadi Bahareh - - 2011
In High Performance Liquid Chromatographic (HPLC) determination of chemicals with acidic functions, different labeling agents are used to improve sensitivity of the assay. 9-Fluorenylmethyl chloroformate (FMOC-Cl), on the other hand, is a suitable labeling agent, which reacts with both primary and secondary amines and less readily with hydroxyl groups in ...
Relevancy Score: Relevancy Score: 141
Bussmann C - - 2001
Hyponatraemia in patients with an acute central nervous system disease can be caused by two different mechanisms: (1) retention [corrected] of free water, i.e. the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and (2) excessive sodium retention [corrected], i.e., the cerebral salt wasting syndrome (CSW). Although the concept of ...
Relevancy Score: Relevancy Score: 141
Miyamori I - - 1987
1. Plasma concentrations of human alpha-atrial natriuretic polypeptide (h-alpha ANP) during escape from the effects of mineralocorticoid excess were determined in six healthy volunteers. 2. Escape, as indicated by an abrupt increase in sodium excretion on the third to sixth day of 9 alpha-fludrocortisone acetate administration (0.6 mg/day), was observed ...
Relevancy Score: Relevancy Score: 141
Chen Xiao-chun - - 2010
Cyclic adenosine monophosphate (cAMP) was synthesized through the purine salvage synthesis pathway by Arthrobacter A302. Results showed that hypoxanthine was the best of the precursors, and the cAMP concentration reached 4.06 g/L. For inhibition of the glycolytic pathway, sodium fluoride was found the optimal effector, which was further studied on ...
Relevancy Score: Relevancy Score: 141
Hadad Ghada M - - 2008
Multivariate spectrophotometric calibration and liquid chromatographic (LC) methods were applied to the determination of 2 multicomponent mixtures containing diprophylline, guaiphenesin, methylparaben, and propylparaben (Mixture 1), or clobutinol, orciprenaline, saccharin sodium, and sodium benzoate (Mixture 2). For the multivariate spectrophotometric calibration methods, principal component regression (PCR) and partial least-squares regression (PLS-1), ...
Relevancy Score: Relevancy Score: 141
Guo S B - - 1989
A single subcutaneous injection of sodium selenite at the dose of 20 mumol/kg body weight induced bilateral nuclear cataracts in suckling rats. This selenite-induced cataract incidence can be increased by pretreating animals with a glutathione synthesis inhibitor. Sodium dodecyl sulfate polyacrylamide electrophoresis of urea-soluble proteins from selenite-induced cataractous lenses showed ...
Relevancy Score: Relevancy Score: 141
McGiff J C - - 1975
1. The effects of two vasodilator polypeptides, bradykinin and eledoisin, were studied in isolated blood-perfused canine kidneys before and after administration of indomethacin, an inhibitor of prostaglandin synthesis, Bradykinin, but not eledoisin, releases renal prostaglandins. 2. Before administration of indomethacin, bradykinin decreased urinary osmolality and increased free qater clearance, whereas ...
Relevancy Score: Relevancy Score: 141
Ashizawa K - - 1988
X-ray microprobe analysis was performed to investigate the changes of elemental concentrations around or on the membrane of the head, midpiece, and principal piece regions of individual fowl spermatozoa during maturation in the male reproductive tract and after storage in vitro at 4 degrees C. The pattern of change of ...
Relevancy Score: Relevancy Score: 141
Magee J C - - 1995
Activation of dendritic voltage-gated ion channels by local synaptic input was tested by simultaneous dendrite-attached patch-clamp recordings and whole-cell somatic voltage recordings made from CA1 pyramidal neurons in hippocampal slices. Schaffer collateral stimulation elicited subthreshold excitatory postsynaptic potentials (EPSPs) that opened voltage-gated sodium and calcium channels in the apical dendrites. ...
Relevancy Score: Relevancy Score: 141
Zhao Yong - - 2004
Voltage-gated sodium channels are members of a large family with similar pore structures. The mechanism of opening and closing is unknown, but structural studies suggest gating via bending of the inner pore helix at a glycine hinge. Here we provide functional evidence for this gating model for the bacterial sodium ...
Relevancy Score: Relevancy Score: 141
Niarchos A P - - 1982
The hemodynamic and plasma catecholamine responses to isometric exercise and head up tilt were investigated in normotensive and hypertensive subjects during normal and low sodium intake and before and during the administration of the converting enzyme inhibitors teprotide or captopril. Although teprotide and captopril decreased significantly the mean arterial pressure ...
Relevancy Score: Relevancy Score: 141
Abad Vivien C - - 2004
Narcolepsy is characterised by excessive daytime sleepiness, usually associated with cataplexy, hypnagogic hallucinations, sleep paralysis and fragmented nocturnal sleep. Although uncommon, it results in significant disability. Most cases occur sporadically, but genetic factors probably form a susceptibility background on which unknown environmental triggers act. The hypocretin system is strongly implicated ...
Relevancy Score: Relevancy Score: 141
Puche R C - - 1987
The composition of 24 h urine samples collected by 50 normal controls and 76 stone formers (30 hypercalciurics, 13 hyperuricosurics and 33 patients without metabolic abnormalities) were studied. Statistically significant multiple regression equations were obtained between calciuria and the urinary excretions of sulfate, citrate, sodium and creatinine. The three former ...
Relevancy Score: Relevancy Score: 141
Tanioka Y - - 1996
To clarify how synthesized ATP is utilized to maintain cellular integrity during preservation by the two-layer method, we examined the effect of ouabain, inhibitor of ATP dependent Na+/K+ pump, on ATP tissue levels, graft weight, and vascular endothelial cells during 48 hr preservation by the two-layer method and pancreatic tissue ...
Relevancy Score: Relevancy Score: 141
Cancilla P A - - 1983
An A and L system of neutral amino acid transport has been demonstrated previously in cerebral microvessels in vivo and in isolated microvessels in vitro. This report describes the neutral amino acid transport properties of cultured cerebral endothelial cells and investigates the influence of astroglia on the transport process. These ...
Relevancy Score: Relevancy Score: 141
Takahashi H - - 1986
The origin of an endogenous digitalis-like substance in rats was investigated. The tissue content of the substance measured by radio-immunoassay was highest in the pituitary gland, with a decreasing gradient through the hypothalamus, forebrain, cerebellum, brain stem, heart, liver and kidney. Sodium loading decreased the content in the hypothalamus and ...
Relevancy Score: Relevancy Score: 141
Heidenreich O - - 1975
In 14 dogs during experimentally induced haemorrhagic shock the effects of 6% solutions of hydroxyethyl starch and Dextran-60 were compared. As main parameters of the renal function the arterial and venous pressures, renal blood flow, creatinine-clearance as measure of the glomerular filtration rate, urinary flow rate and urinary excretion of ...
Relevancy Score: Relevancy Score: 141
< 1871 1872 1873 1874 1875 1876 1877 1878 1879 1880 1881 >