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< 1870 1871 1872 1873 1874 1875 1876 1877 1878 1879 1880 >
Sulman Tatiana - - 2008
A mathematical model of the cardiomyocyte electromechanical function is used to study contribution of mechanical factors to rhythm disturbances in the case of the cardiomyocyte calcium overload. Particular attention is paid to the overload caused by diminished activity of the sodium-potassium pump. It is shown in the framework of the ...
Relevancy Score: Relevancy Score: 141
Daugaard G - - 1988
The effect of three cycles of high-dose cisplatin (40 mg/m2 day for 5 days) on renal tubular function was evaluated in 30 patients. A significant impairment of proximal tubular salt and water reabsorption rates was observed, but also distal tubular function seemed to be affected. These changes were also present ...
Relevancy Score: Relevancy Score: 141
Hynes A C - - 2000
The uptake of myo-inositol and its incorporation into the phosphoinositides and inositol phosphates of the phosphatidylinositol (PtdIns) signal transduction system by in vivo preimplantation cattle embryos was investigated using [(3)H] myo-inositol. Uptake of inositol was examined in two-cell and four-cell embryos (day 2 after insemination), morulae (day 6) and early ...
Relevancy Score: Relevancy Score: 141
Schnapp P - - 1989
Following a two-week placebo period a group of 10 elderly men (63-76 years) received a 20 mg nifedipine tablet each. Twelve hours later nifedipine, as compared to placebo, significantly raised diuresis, urine sodium excretion, and tubular sodium rejection, but had no effect on GFR and urine potassium excretion. A significant ...
Relevancy Score: Relevancy Score: 141
Shirreffs Susan M - - 2004
For a person undertaking regular exercise, any fluid deficit that is incurred during one exercise session can potentially compromise the next exercise session if adequate fluid replacement does not occur. Fluid replacement after exercise can, therefore, frequently be thought of as hydration before the next exercise bout. The importance of ...
Relevancy Score: Relevancy Score: 141
Lobene R R - - 1990
A 3-month, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of a dentifrice containing 0.3% triclosan and 2.0% of a copolymer, as compared to a placebo dentifrice. Subjects were initially stratified into two balanced groups based on their Volpe-Manhold Index calculus scores ...
Relevancy Score: Relevancy Score: 141
Ocaña J A - - 2001
A sensitive time-resolved luminescence method for the determination of trovafloxacin is described. The method is based on the time-resolved luminescence signal from the terbium(III)-trovafloxacin complex, in a micellar solution of sodium dodecyl sulfate (SDS), using a chemical deoxygenation agent (Na(2)SO(3)). The method allows the determination of 20-450 ng ml(-1) of ...
Relevancy Score: Relevancy Score: 141
Ishihara Keiichi - - 2004
We have shown that sodium salicylate activates the heat shock promoter and induces the expression of heat shock proteins (hsps), with a concomitant increase in the thermotolerance of cells. To determine whether these effects are generally displayed by nonsteroidal anti-inflammatory drugs (NSAIDs), we examined the effects of a cyclooxygenase inhibitor, ...
Relevancy Score: Relevancy Score: 141
Darbon H - - 1999
Animal venoms contain various toxins which act on ion-channels, responsible for either sodium, potassium, calcium or chloride permeation. Structure determination of these toxins demonstrate that they are organised around two different structural motifs: potassium and sodium channel effectors are organised around an alpha-helix connected by two disulfide bridges to a ...
Relevancy Score: Relevancy Score: 141
Otsuka M - - 1995
The physicochemical properties of phenytoin (PHT) combined with various kinds of surfactants at 40 w/w % such as sodium lauryl sulfate (SLS), sodium deoxycholate (DCNa), and the sucrose ester of stearic acid (SE) by a cogrinding method were investigated by X-ray diffraction analysis, Fourier transformed infrared (FT-IR) spectroscopy, differential scanning ...
Relevancy Score: Relevancy Score: 141
Riepe Felix G - - 2009
Pseudohypoaldosteronism (PHA) is a rare heterogeneous syndrome of mineralocorticoid resistance causing insufficient potassium and hydrogen secretion. PHA type 1 (PHA1) causes neonatal salt loss, failure to thrive, dehydration and circulatory shock. Two different forms of PHA1 can be distinguished on the clinical and genetic level, showing either a systemic or ...
Relevancy Score: Relevancy Score: 141
Chassard D - - 1996
We have examined changes in plasma concentrations of calcium in seven anaesthetized pigs during i.v. infusion of irrigating fluid containing 1.5% glycine. Volumes infused were 875 ml at 20 min (22 ml kg-1), 1475 ml at 40 min and 2075 ml at 60 min (75 ml kg-1). Plasma concentrations of ...
Relevancy Score: Relevancy Score: 141
Clarke R M - - 1977
Isotonic solutions of substrate were infused into surgically prepared sacs of upper small intestine in conscious unrestrained rats which fed normally via the gut-in-continuity. Infusion of glucose, galactose or sodium chloride all caused a local increase in villus height, while alpha-methyl glucoside and mannose had no effect. Glucose, galactose and ...
Relevancy Score: Relevancy Score: 141
Rehulka J - - 2004
Rainbow trout at a weight of 223+/-12 g (mean+/-SD) were experimentally injected with a technical mixture of Delor 103 to evaluate the red blood cell indices (red blood cell count, haematocrit, haemoglobin, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration) and some biochemical and enzyme parameters of the ...
Relevancy Score: Relevancy Score: 141
Pallone Thomas L - - 2002
Accumulating evidence favors the notion that perfusion of the medulla of the kidney is regulated through the effects of nitric oxide. Reduction of nitric oxide production in the medulla by local tissue infusion of nitric oxide synthase blockers leads to reduction of medullary blood flow, salt retention and hypertension. Conversely, ...
Relevancy Score: Relevancy Score: 141
Zhi Wenbo - - 2004
A study was made of the partition and purification of alpha-amylase from a culture supernatant of Bacillus subtilis in the polyethylene glycol (PEG)--citrate aqueous two-phase system (ATPS). Factors that influenced the partition of the protein in this system, including the molecular weight of the PEG, the tie line length of ...
Relevancy Score: Relevancy Score: 141
Coraboeuf E - - 1976
The major ionic conductances underlying electrical activity in cardiac tissues are described. The participation of electrogenic active transport in electrical phenomenon and the influence of metabolic inhibition on cardiac action potentials are briefly summarized. Some electrophysiological effects of lactate and acidosis, such as might be induced by ischemia, are described. ...
Relevancy Score: Relevancy Score: 141
Ryan Fiona - - 2006
The morbidity related to caustic soda (sodium hydroxide) ingestion is well described in the literature. The majority of publications have concentrated on the effects to the trachea and gastrointestinal tract, with little reference to the oral and peri-oral areas. Accidental ingestion of sodium hydroxide-containing substances is fortunately rare; however the ...
Relevancy Score: Relevancy Score: 141
Mbiti M J - - 1994
Serum levels for sodium, potassium, calcium, inorganic phosphate, urea nitrogen and creatinine were determined in 1101 male and 181 female patients aged 50 years and above. The determinations were carried out on the SMA II (Technicon Instruments Corp. Tarrytown, NY 10591) with a view to establish the reference intervals for ...
Relevancy Score: Relevancy Score: 141
Wolpers H G - - 1984
An animal experimental study on seven thoracotomized dogs was designed to investigate the effects of intracoronarily injected sodium meglumine diatrizoate on myocardial electrophysiology and to evaluate the contribution of the corresponding changes of electrolyte levels in coronary blood. For this purpose the effects of alterations in the Na+-, K+- and ...
Relevancy Score: Relevancy Score: 141
Ivashkin V T - - 1988
The effect of lithium preparations (lithium carbonate, lithium oxybutyrate), calcium channel blocking agents (verapamil, nifedipine), beta 2-adrenoagonist (salbutamol), cromolyn sodium and cimetidine on clinical efficacy and frequency of ulcer cicatrization was assessed in 201 patients (33 women, 168 men) with endoscopically verified stomach ulcer (52 patients) and duodenal ulcer (166 ...
Relevancy Score: Relevancy Score: 141
Boldhane Sanjay P - - 2010
Metoprolol succinate (MS) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Box-Behnken model was followed using novel combinations of sodium alginate (SA), sodium carboxymethylcellulose (NaCMC), magnesium alumino metasilicate (MAS) as independent variables. Floating lag time (Flag), t25, t50, t75, diffusion exponent ...
Relevancy Score: Relevancy Score: 141
Hof D - - 1984
The modification of the ultraviolet blocking of sodium channels and of the ultraviolet-induced potential shift of the gating parameters by means of the sulfhydryl compounds l-cysteine and 2-mercaptoethanol was investigated in the node of Ranvier under voltage-clamp conditions. The UV wavelength was 280 nm. The radiation-induced potential shift of the ...
Relevancy Score: Relevancy Score: 141
Goy-Thollot I - - 2002
The aim of this study was to evaluate the role of aldosterone as an initiating and/or perpetuating factor in hypertension associated with pituitary-dependent hyperadrenocorticism (PDH) in dogs. Thirteen dogs with PDH and 11 healthy control dogs were used. In all dogs, arterial blood pressure and plasma sodium, potassium, basal aldosterone, ...
Relevancy Score: Relevancy Score: 141
Ya Yu - - 1982
In several animal species, constriction of the thoracic inferior vena cava (TIVCC) is known to increase proximal sodium reabsorption and inhibit natriuresis following saline loading, leading to edema. To eluicidate the role of adrenal and hypophyseal hormones in the development of edema, kidney and liver functions after TIVCC were compared ...
Relevancy Score: Relevancy Score: 141
Ji Zhao-Ning - - 2002
This article examines the effect of daidzin on PC12 cell apoptosis induced by serum-free medium. PC12 cell survival was measured by MTT assay. The DNA content and percentage of apoptosis were monitored by flow cytometry and DNA fragmentation was analyzed by agarose gel electrophoresis. The results showed that serum-free (12 ...
Relevancy Score: Relevancy Score: 141
Baxevanis A D - - 1990
The circular dichroism (CD) of freshly prepared chicken erythrocyte core histones has been reexamined in high concentrations of ammonium sulfate and sodium chloride, conditions which cause drastic changes in the solubility and aggregative properties of these proteins. After sample clarification by ultracentrifugation, no significant net changes are detected in the ...
Relevancy Score: Relevancy Score: 141
Hara Y - - 1986
Proton transport catalyzed by the sodium pump was demonstrated using proteoliposomes reconstituted with purified pig kidney Na+,K+-ATPase. Intravesicular pH was monitored with fluorescence from fluorescein isothiocyanate dextran introduced into the vesicles. An ATP-induced ouabain-sensitive acidification of the intravesicular medium was observed, when the vesicles were incubated with ATP and without ...
Relevancy Score: Relevancy Score: 141
van der Voet G B - - 1999
The role of fluoride in aluminium neurotoxicity was studied using an in vitro system of cultured hippocampal neurons from foetal rats. Sodium fluoride (50 microM) and aluminium chloride (12.5 microM) were administered alone or in a specific combination (50 + 12.5 microM) in a 14-day culture in a chemically defined ...
Relevancy Score: Relevancy Score: 141
O'Hagan K P - - 1990
The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal denervation ...
Relevancy Score: Relevancy Score: 141
Quinkler M - - 2002
Progesterone (P) given intramuscularly increases renal sodium excretion. We tested the in vitro capacity of P to bind to the human mineralocorticoid receptor (MR) with a reticulocyte lysate system and Ps transactivation potency in transfected CV-1 cells. Progesterone binds with higher affinity to the MR than aldosterone, but shows only ...
Relevancy Score: Relevancy Score: 141
Oxford G S - - 1977
Squid giant axons were photosensitized by dyes applied internally or externally in air saturated solutions and photochemically modified by visible light. For most dyes the modifications included an irreversible block of sodium channels, a destruction of inactivation in some of the unblocked channels, and a slowing of inactivation. Internal application ...
Relevancy Score: Relevancy Score: 141
Rosa R M - - 1980
Because the formation of sickle cells is dependent on the intracellular concentration of deoxyhemoglobin S, we investigated the possibility of altering or preventing sickle-cell crises by reducing serum sodium so as to cause red cells to swell. In three patients with sickle-cell anemia who had been disabled by recurrent painful ...
Relevancy Score: Relevancy Score: 141
Janicka L - - 1995
We have investigated the effect of intraperitoneal gentamicin on dialysis efficiency in 10 intermittent peritoneal dialysis (IPD) patients. The following parameters were measured: net ultrafiltration (UF); concentration ratios (D/P) of urea, creatinine, potassium; peritoneal clearances (ml/min) of urea, creatinine, potassium; mass transfer of sodium (MTNa); sodium sieving index (SCNa). It ...
Relevancy Score: Relevancy Score: 141
Radulescu Dan - - 2007
It is well documented in literature that a majority of small-cell lung cancers are associated with paraneoplastic phenomena. We report the case of a 63-year-old man diagnosed with small-cell lung carcinoma, in whom a severe hyponatremia and renal sodium loss with inappropriate antidiuresis were also found during a routine laboratory ...
Relevancy Score: Relevancy Score: 141
Koch M C - - 1991
Paramyotonia congenita (PC), an autosomal dominant non-progressive muscle disorder, is characterised by cold-induced stiffness followed by muscle weakness. The weakness is caused by a dysfunction of the sodium channel in muscle fibre. Parts of the gene coding for the alpha-subunit of the sodium channel of the adult human skeletal muscle ...
Relevancy Score: Relevancy Score: 141
Berridge M J - - 1976
1. Potassium is the major cation in the secretion of the salivary glands of Calliphora and is necessary for full secretory rates. 2. Other ions (rubidium and sodium) can support secretion in the absence of potassium. 39. During stimulation with 5-HT a Nernst plot of the basal membrane potential has ...
Relevancy Score: Relevancy Score: 141
Goy-Thollot Isabelle - - 2007
The present study aimed at investigating the effects of aging on the adrenal cortex response of cortisol and aldosterone in dogs. A population of healthy adult Beagles was evaluated twice at a five-year interval. At each evaluation, plasma basal cortisol and aldosterone, cortisol and aldosterone following ACTH-stimulation, sodium, and potassium ...
Relevancy Score: Relevancy Score: 141
Ishiguro H - - 2001
The mechanisms that lead to mitochondrial damage under oxidative stress conditions were examined in primary and cultured cells as well as in the nematode Caenorhabditis elegans (C. elegans) treated simultaneously with electron transport inhibitors and oxygen gas. Oxygen loading enhanced the damage of PC 12 cells by thenoyltrifluoroacetone (TTFA, a ...
Relevancy Score: Relevancy Score: 141
Schnitzler C M - - 1987
In the search for a simple method of assessing the therapeutic efficacy of sodium fluoride, a prospective study of vertebral radiography during such treatment was carried out. Treatment of osteoporosis with sodium fluoride, calcium and vitamin D was found to enhance the vertical markings of the vertebral trabecular pattern in ...
Relevancy Score: Relevancy Score: 141
Niitsu Ai - - 2008
The lipid-soluble veratrum alkaloids, veratridine and cevadine, are plant neurotoxins that are agonists of voltage-gated sodium channel. Their conformations in a hydrophobic environment were analyzed by NMR spectroscopy in solution phase chloroform at low temperatures. The conformations around the 3-carboxylic esters which is essential for their neurotoxicity, was completely different ...
Relevancy Score: Relevancy Score: 141
Yasuda J - - 1980
The following amendments have been introduced to the Minimum Requirements for Human Serum Albumin (HSA) and Plasma Protein Fraction (PPF): 1) The upper limit of sodium content was fixed at 3.7 mg/ml; 2) test for chloride content was introduced; 3) sodium and chloride contents were required to be stated on ...
Relevancy Score: Relevancy Score: 141
Himmelsbach Markus - - 2007
In the present paper we report, for the first time, the successful on-line coupling of microemulsion electrokinetic chromatography (MEEKC) with mass spectrometric (MS) detection using an atmospheric pressure photoionization interface. Microemulsions (MEs) including mostly volatile ingredients and classical MEs based on nonvolatile buffer components and sodium dodecyl sulfate (SDS) as ...
Relevancy Score: Relevancy Score: 141
Geithe H P - - 1981
A vegetalizing factor which induces the formation of endodermal and mesodermal organs in amphibian gastrula ectoderm was purified from chicken embryos. Preparative sodium dodecyl sulfate polyacrylamide electrophoresis and gel permeation chromatography on sephadex with different eluants were employed. In buffer containing 6 M urea the molecular weight of the factor ...
Relevancy Score: Relevancy Score: 141
Cullen E I - - 1986
Ascorbic acid uptake in AtT-20 tumor cells and primary cultures of rat anterior and intermediate pituitary was sodium-dependent and showed half-maximal saturation between 9 and 18 microM ascorbate. When incubated in [14C]ascorbic acid at concentrations similar to those in serum (50 microM), all of the cells concentrated ascorbate 20- to ...
Relevancy Score: Relevancy Score: 141
Petrosian E A - - 2001
Twenty-five patients with pyoinflammatory maxillofacial diseases treated in an inpatient setting in the Regional Dentistry Clinic of Krasnodar and 8 healthy volunteers were examined. After opening and draining of the purulent focus the patients were divided into 2 groups. Group 1 consisted of 21 patients treated by intravenous 0.04% sodium ...
Relevancy Score: Relevancy Score: 141
Vierhapper H - - 1985
To define the role of insulin in blood pressure regulation, the hormone's action on renal sodium handling, potassium balance, pressor reactivity, and the release of catecholamines and aldosterone are summarized. Insulin-stimulated renal sodium reabsorption induces expansion of the extracellular volume, increase in cardiac output, and ultimately, hypertension. On the other ...
Relevancy Score: Relevancy Score: 141
Chemaitilly W - - 2005
The correlation of genotype to phenotype in congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency has been investigated thoroughly since the mapping of the CYP21 gene to the short arm of chromosome 6. In most instances, it is possible to accurately predict the phenotype based on genoytpe; however, in a ...
Relevancy Score: Relevancy Score: 141
Haikel Y - - 1994
The use of irrigating solutions is widely accepted as a necessary adjunct to biomechanical preparation to obtain adequate cleansing of the root canal system. In this study, the efficiency of three solutions was tested in an in vitro experimental system for the removal of protein from apatite surfaces: Salvizol (a ...
Relevancy Score: Relevancy Score: 141
Valentich J D - - 1986
This study investigates the transepithelial electrophysiological properties of two mouse kidney medullary thick ascending limb cell lines developed in our laboratory. By using a modified Ussing chamber, the transepithelial voltage, transepithelial resistance, and short-circuit current of monolayer cultures were determined. Normal transport functions of the medullary thick ascending limb were ...
Relevancy Score: Relevancy Score: 141
< 1870 1871 1872 1873 1874 1875 1876 1877 1878 1879 1880 >