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< 1870 1871 1872 1873 1874 1875 1876 1877 1878 1879 1880 >
Uri J V - - 1986
Cefatrizine (SK & F 60771; BL--S640), like most other phenylglycine-type cephalosporins, has a tendency to lose potency in aqueous solutions and in normal sera even at low temperatures. Cefatrizine can be stabilized during storage by sodium metabisulphite (Na2S2O5), a reducing agent partially in tap water, better in deionized water, and ...
Relevancy Score: Relevancy Score: 141
MacPherson R D - - 1991
Ear artery segments removed from urethane-anaesthetized rabbits were mounted, perfused with Krebs solution, and pressurized before constriction with extraluminal noradrenaline. Vessel diameter was measured using a diode array mounted above the artery. After the degree of dilatation in response to intraluminal acetylcholine and glyceryl trinitrate was measured, vessels were perfused ...
Relevancy Score: Relevancy Score: 141
Zuccaro Gregory G - - 2007
Clinical studies are used to make generalizations about a population of interest. Bias can be defined as the systematic error in study design or implementation, leading to inaccurate generalizations about this population. There is a potential for bias in all of the clinical studies on sodium phosphate colonoscopy preparation, and ...
Relevancy Score: Relevancy Score: 141
Suzuki Yasumitsu - - 2009
As the first step to understand the reaction mechanism and diastereoselectivity of sodium borohydride reduction of ketones, ab initio Car-Parrinello molecular dynamics simulation has been performed on a solution of NaBH4 in liquid methanol. According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, it was strongly suggested that Na+ ...
Relevancy Score: Relevancy Score: 141
McBlain W A - - 1981
The transformation of glucocorticoid--receptor complex in the cytosol from lactating mouse mammary tissue was studied by using elevated temperature and KCl as promoters of the transformation reaction. The transformed receptor was identified from the nontransformed receptor by the following criteria: (a) increased binding to DNA--cellulose, (b) increased binding to ATP--Sepharose, ...
Relevancy Score: Relevancy Score: 141
Akintonwa A - - 1990
The effect of added saline cathartics (sodium sulfate and magnesium sulfate) on the in vitro adsorption of sulphamethoxazole to activated charcoal was determined. Sulphamethoxazole, at 0.00125, 0.0025 and 0.005 mg/ml, had a 56.77 to 91.70 per cent adsorption to 50 mg and 200 mg activated charcoal. As the concentration of ...
Relevancy Score: Relevancy Score: 141
Tooson J D - - 1996
A review of the relevant English-language literature on bowel cleansing before colonoscopy yielded results of randomized trials comparing a variety of regimens, including polyethylene glycol (PEG)-electrolyte lavage, 3-day clear liquid diet with laxatives or prokinetics, and oral sodium phosphate, as well as these regimens combined with agents such as metoclopramide, ...
Relevancy Score: Relevancy Score: 141
PerederiÄ­ V G - - 1990
Clinical and immunologic efficacies of some immunostimulants (levamisole, sodium nucleinate, thymic preparations) included in therapeutic schemes in nonspecific ulcerous colitis both separately and in various combinations were under study. The efficacy of these stimulants was found to depend on the disease severity and proved to be the highest in the ...
Relevancy Score: Relevancy Score: 141
Ikeda M - - 1999
A formal total synthesis of (-)-cephalotaxine (1) has been achieved. The key step is an intramolecular aldol condensation of the diketone 9, which in turn was obtained in three steps from the azabicyclic compound 6 derived from D-proline according to Seebach's procedure. Treatment of 9 with a catalytic amount of ...
Relevancy Score: Relevancy Score: 141
Kurup Ravi Kumar - - 2003
The present study assessed the biochemical differences in lipid metabolism between right hemispheric dominant and left hemispheric dominant individuals. The HMG CoA reductase activity and the serum isoprenoidal metabolities--digoxin, dolichol, and ubiquinone--were studied. The results showed that right hemispheric dominant individuals had (i) increased HMG CoA reductase activity, (ii) elevated ...
Relevancy Score: Relevancy Score: 141
Lancaster Kristie J - - 2004
Most patients with chronic kidney disease (CKD) also have hypertension. It is critical to control blood pressure in CKD to decrease the risk of negative outcomes. Modification of diet can reduce blood pressure, most notably in people with hypertension and in older adults. Current guidelines recommend reducing sodium intake to ...
Relevancy Score: Relevancy Score: 141
Vasigar Prathap P Department of Anatomy, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, - - 2013
To evaluate the anti-inflammatory effect of the third-generation CCB, lercanidipine. The ability of lercanidipine to reduce inflammation in carrageenan-induced paw edema in rats was evaluated, using different doses and its anti-inflammatory effect was compared with that of diclofenac sodium. Mast cell degranulation effect of lercanidipine was also carried out. Lercanidipine ...
Relevancy Score: Relevancy Score: 141
Arslan Hakan - - 2012
The aim of this study was to investigate whether the smear layer influences the removal of calcium hydroxide from the root canal with manual or rotary instruments. The root canals of 48 freshly extracted single-rooted maxillary incisors were prepared to apical size 40 (n=40) and finally irrigated with sodium hypochlorite ...
Relevancy Score: Relevancy Score: 141
Bradbury M W - - 1972
1. Samples of cisternal cerebrospinal fluid (c.s.f.) and blood plasma have been obtained nearly simultaneously from foetal sheep of different ages, the foetus having been exteriorized and maintained in a normal state with respect to its blood gases and arterial pH. The brains were removed from these foetuses and also ...
Relevancy Score: Relevancy Score: 141
Daniels Stephen - - 2009
BACKGROUND: Celecoxib, a cyclooxygenase-2 inhibitor, has established analgesic efficacy for the treatment of acute pain resulting from a variety of causes. OBJECTIVE: This article describes 2 studies designed to assess the efficacy and tolerability of celecoxib in patients with primary dysmenorrhea. METHODS: Two identical, 3-day, multiple-dose, randomized, double-blind, active- and ...
Relevancy Score: Relevancy Score: 141
Johns E J - - 1988
1. Normotensive Sprague-Dawley and spontaneously hypertensive rats anaesthetized with sodium pentobarbitone were used to determine the systemic and renal actions of amlodipine, a new calcium channel blocking drug. 2. Amlodipine, 200 micrograms kg-1 plus 50 micrograms kg-1 h-1, decreased blood pressure by 12 +/- 3 mmHg in normotensive rats, although ...
Relevancy Score: Relevancy Score: 141
Reed S - - 1995
1. To test the hypothesis that basal renin angiotensin aldosterone system (RAAS) activity impairs the acute natriuretic response to frusemide in patients with mild or moderate congestive heart failure (CHF), we studied eight adult volunteers with preserved renal function, stable New York Heart Association Class II or III CHF, and ...
Relevancy Score: Relevancy Score: 141
Atherton J C - - 1968
1. The time course and extent of changes in urinary flow and in the outputs of urea, Na(+), K(+), and NH(4) (+) over a period of 7(1/2) hr in conscious rats during water and osmotic (mannitol) diuresis were determined, and compared with spontaneous changes in non-diuretic animals.2. In non-diuretic rats, ...
Relevancy Score: Relevancy Score: 141
Gao Feng - - 2009
To test the hypothesis that activation of the transient receptor potential vanilloid 4 (TRPV4) channel conveys a hypotensive effect that is enhanced during salt load, male Wistar rats fed a normal-sodium (0.5%) or high-sodium (HS; 4%) diet for 3 weeks were given 4 alpha-phorbol 12,13-didecanoate (4 alpha-PDD), a specific TRPV4 ...
Relevancy Score: Relevancy Score: 141
Gaboury C L - - 1994
To test the hypothesis that the hypertension associated with insulin resistance is secondary to an altered responsiveness of the vasculature to pressor agents, we evaluated the relationship between insulin resistance and pressor responses to angiotensin II (AII) in 21 hypertensive (HT) and 8 normotensive (NT) subjects on both a high ...
Relevancy Score: Relevancy Score: 141
Schrier Robert W - - 2006
Hyponatremia (serum sodium concentration, <135 mmol per liter) is a predictor of death among patients with chronic heart failure and cirrhosis. At present, therapy for acute and chronic hyponatremia is often ineffective and poorly tolerated. We investigated whether tolvaptan, an orally active vasopressin V(2)-receptor antagonist that promotes aquaresis--excretion of electrolyte-free ...
Relevancy Score: Relevancy Score: 141
Crump John A - - 2005
To compare the effect on prevalence of diarrhoea and mortality of household based treatment of drinking water with flocculant-disinfectant, sodium hypochlorite, and standard practices in areas with turbid water source in Africa. Cluster randomised controlled trial over 20 weeks. Family compounds, each containing several houses, in rural western Kenya. 6650 ...
Relevancy Score: Relevancy Score: 141
Gariepy C E - - 2000
The role of the endothelin-B receptor (ET(B)) in vascular homeostasis is controversial because the receptor has both pressor and depressor effects in vivo. Spotting lethal (sl) rats carry a naturally occurring deletion in the ET(B) gene that completely abrogates functional receptor expression. Rats homozygous for this mutation die shortly after ...
Relevancy Score: Relevancy Score: 141
Murphy Theresa - - 2009
INTRODUCTION: Hyponatremia frequently complicates acute brain injury and may precipitate neurological worsening by promoting cerebral edema. An increase in brain water may be better managed through water excretion than with fluid restriction or hypertonic fluids. Vasopressin-receptor antagonists such as conivaptan, which promote free water excretion, may be ideal agents to ...
Relevancy Score: Relevancy Score: 141
Shen Zhi-Wei - - 2012
To evaluate the feasibility of quantifying liver choline concentrations in both normal and apoptotic rabbit livers in vivo, using 1H magnetic resonance spectroscopy (1H-MRS). 1H-MRS was performed in 18 rabbits using a 1.5T GE MR system with an eight-channel head/neck receiving coil. Fifteen rabbits were injected with sodium selenite at ...
Relevancy Score: Relevancy Score: 141
Manhiani M Marlina - - 2012
We showed recently that sustained natriuresis in type 1 diabetic dogs was attributed to the decrease in insulin rather than the hyperglycemia alone. The sodium-retaining action of insulin appeared to require hyperglycemia, and it completely reversed the diabetic natriuresis and diuresis. This study tested whether the sodium-retaining effect was attributed ...
Relevancy Score: Relevancy Score: 141
Tomić Melanija - - 2011
Several receptors linked to the adenylyl cyclase signaling pathway stimulate electrical activity and calcium influx in endocrine pituitary cells, and a role for an unidentified sodium-conducting channel in this process has been proposed. Here we show that forskolin dose-dependently increases cAMP production and facilitates calcium influx in about 30% of ...
Relevancy Score: Relevancy Score: 141
Mina Yair Y Neufeld Cardiac Research Institute, Sackler Faculty of Medicine, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer, - - 2013
Myocarditis is a life-threatening heart disease characterized by myocardial inflammation, necrosis, and chronic fibrosis. While mast cell inhibition has been suggested to prevent fibrosis in rat myocarditis, little is known about its effectiveness in attenuating cardiac remodeling and dysfunction in myocarditis. Thus, we sought to test the hypothesis that mast ...
Relevancy Score: Relevancy Score: 141
Wardale A - - 1978
Not all fluctuating hearing loss is due to Eustachian insufficiency. Not all sensorineural loss is untreatable. Fluctuating hearing loss due to endolymphatic hydrops is discussed, and the use of a low sodium diet, diuretics and vasodilators in the treatment of this disorder is described. To be effective, the treatment must ...
Relevancy Score: Relevancy Score: 141
Reid Fiona - - 2003
In this double-blind crossover study, the effects of bolus infusions of 0.9% saline (NaCl) and Hartmann's solution on serum albumin, haematocrit and serum and urinary biochemistry were compared in healthy subjects. Nine young adult male volunteers received 2-litre intravenous infusions of 0.9% saline and Hartmann's solution on separate occasions, in ...
Relevancy Score: Relevancy Score: 141
Wilhelm D - - 1991
1. In isolated cardiac muscle, submicromolar concentrations of R 56865 (N-[1-[4-(4-fluorophenoxy)-butyl]-4-piperidinyl]-N-methyl-2- benzothiazolamine) have been shown to attenuate the toxicity of cardiac glycosides. 2. We studied the influence of R 56865 on calcium and sodium currents in single isolated ventricular cardiomyocytes. The effect of R 56865 on action potential and contractile ...
Relevancy Score: Relevancy Score: 141
Yamasaki Masahiro - - 2009
Valinomycin and salinomycin-Na, 2 ionophorous antibiotics, exhibited in vitro antibabesial activities against Babesia gibsoni that infected normal canine erythrocytes containing low potassium (LK) and high sodium concentrations, i.e., LK erythrocytes, which completely lack Na,K-ATPase activity. The level of parasitemia of B. gibsoni was significantly decreased when the parasites were incubated ...
Relevancy Score: Relevancy Score: 141
Kloiber L L - - 1996
OBJECTIVE: To determine the incidence of late hyponatremia in very-low-birth-weight infants and to identify associated risk factors. Low serum sodium concentration in otherwise healthy premature infants beyond 2 weeks of life is referred to as the hyponatremia. DESIGN: Retrospective cohort review. SETTING/SUBJECTS: The intensive care nursery at St Luke's Hospital ...
Relevancy Score: Relevancy Score: 141
Gerevich Z - - 2001
Our aim was to investigate the mechanisms involved in the high intracellular sodium-induced transmitter release in the CNS through the characterisation of the veratridine-evoked (40 microM) noradrenaline release from rat hippocampal slices. The response to veratridine was completely inhibited by tetrodotoxin (1 microM), indicating that the effect is due to ...
Relevancy Score: Relevancy Score: 141
Scott Adam C - - 2003
BACKGROUND: An important role of the increased stimulation of skeletal muscle ergoreceptors (intramuscular afferents sensitive to products of muscle work) in the genesis of symptoms of exertion intolerance in chronic heart failure (CHF) has been proposed. With the use of selective infusions and dietary manipulation methods, we sought to identify ...
Relevancy Score: Relevancy Score: 141
Delézay O - - 1995
The sodium-dependent glucose transporter SGLT1 is expressed on the apical plasma membrane of fully differentiated enterocytes. Recently, we have found that the cotransport function appears gradually during the process of differentiation of the human intestinal epithelial cell clone HT-29-D4. However, the SGLT1 protein was detected in both undifferentiated and differentiated ...
Relevancy Score: Relevancy Score: 141
Molteni A - - 1972
Administration of 10 mg of methylandrostenediol for 10 weeks to uninephrectomized, salt drinking, female Sprague Dawley rats caused severe hypertension with extensive renal and cardiovascular damage. The hypertension was accompanied by increased consumption of sodium, high sodium levels in peripheral plasma, decreased weight of the pituitary, thymus, adrenals and ovaries ...
Relevancy Score: Relevancy Score: 141
Ratcliffe J M - - 1988
The major metabolic response to open-heart surgery using cardiopulmonary bypass has been shown in adults to be modified by the components of the pump priming fluid. This effect is likely to be more significant in children. Data on 29 children less than 15 kg body weight are presented. Patients were ...
Relevancy Score: Relevancy Score: 141
Swensen Andrew M - - 2003
Cerebellar Purkinje neurons have intrinsic membrane properties that favor burst firing, seen not only during complex spikes elicited by climbing fiber input but also with direct electrical stimulation of cell bodies. We examined the ionic conductances that underlie all-or-none burst firing elicited in acutely dissociated mouse Purkinje neurons by short ...
Relevancy Score: Relevancy Score: 141
Yarger W E - - 1976
In order to study renal salt-retaining mechanisms during the early stages of ascites formation, rats were subjected to bile duct ligation. After this procedure, plasma volumes were found to be reduced and hematocrits slightly increased. The whole-kidney glomberular filtration rate and plasma flows were reduced to 59 and 57% of ...
Relevancy Score: Relevancy Score: 141
Li X - - 1997
Although the inhibition of nitric oxide (NO) synthesis is known to induce systemic hypertension, the underlying mechanisms mediating this type of hypertension are incompletely understood. In the present study we investigated the influence of sodium intake on the pressor effect of long-term administration of the NO synthesis inhibitor, NG-nitro-L-arginine methyl ...
Relevancy Score: Relevancy Score: 141
Lowance D C - - 1972
Balance studies have been carried out to evaluate the influence of vasopressin-induced volume expansion on acid-base equilibrium in normal dogs and in dogs with steady-state metabolic acidosis induced by the administration of 5-7 mmoles/kg per day of hydrochloric acid.Hypotonic expansion in dogs with metabolic acidosis (mean plasma bicarbonate concentration 14 ...
Relevancy Score: Relevancy Score: 141
Fedorova Olga V - - 2005
OBJECTIVE: In NaCl-loaded Dahl salt-sensitive (DS) rats the transient stimulation of brain endogenous ouabain (EO) precedes the increase in renal excretion of marinobufagenin (MBG), a vasoconstrictor and natriuretic. In hypertensive DS rats, EO raises blood pressure (BP) via an ATII-sensitive pathway. We hypothesized that an NaCl-induced increase in MBG is ...
Relevancy Score: Relevancy Score: 141
Mandal A - - 2001
This paper describes the development of a functional assay system to express crustacean epithelial electrogenic 2Na(+)/1H(+) antiporters in Xenopus laevis oocytes. Subsequent publications will use this assay method to establish nucleotide and amino acid sequence information about this transporter by functionally screening an hepatopancreatic cDNA library. In this method, oocytes ...
Relevancy Score: Relevancy Score: 141
Buck B - - 1966
1. Tracer movements and ionic composition have been observed in the smooth muscle of the guinea-pig taenia coli in vitro at 4, and 35 degrees C. The muscle was quiescent at 4 degrees C, and did not show spontaneous electrical nor mechanical activity for 25 min after re-warming. It was ...
Relevancy Score: Relevancy Score: 141
Vieira-Coelho M A - - 2000
The present study evaluated renal and intestinal adaptations in sodium handling in uninephrectomized (Unx) rats and the role of dopamine. Two weeks after uninephrectomy, the remnant kidney in Unx rats weighed 33 +/- 2% more than the corresponding kidney in sham-operated (Sham) animals. This was accompanied by increases in urinary ...
Relevancy Score: Relevancy Score: 141
St John S J - - 2000
One mechanism of salt taste transduction by gustatory receptor cells involves the influx of cations through epithelial sodium channels that can be blocked by oral application of amiloride. A second mechanism is less clearly defined but seems to depend on electroneutral diffusion of the salt through the tight junctions between ...
Relevancy Score: Relevancy Score: 141
Mackraj Irene - - 2008
AIM OF THE STUDY: The in vivo effects of Tulbhagia violacea on systemic arterial blood pressure and on the renin-angiotensin system in a Dahl salt-sensitive rat model were investigated. MATERIALS AND METHODS: Animals were treated for 14 days intraperitoneally as follows: Tulbhagia violacea (Tvl) (50mg/kg b.w.), captopril (Cap) (10mg/kg b.w.) ...
Relevancy Score: Relevancy Score: 141
Banday Anees A - - 2008
Renal dopamine plays an important role in maintaining sodium homeostasis and blood pressure (BP) during increased sodium intake. The present study was carried out to determine whether renal dopamine D1 receptor (D1R) dysfunction contributes to increase in salt sensitivity during oxidative stress. Male Sprague-Dawley rats, divided into various groups, received ...
Relevancy Score: Relevancy Score: 141
Santibañez G P - - 1979
The presence of nuclear bodies in the glomerular zone of the rat adrenal cortex has been shown both in normal conditions and after the stimulus of low sodium diets causing an increase in their number. These results indicate that these organelles are a normal nuclear component of the cells of ...
Relevancy Score: Relevancy Score: 141
< 1870 1871 1872 1873 1874 1875 1876 1877 1878 1879 1880 >