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Petrella Robert - - 2004
OBJECTIVE: To assess the efficacy and safety of celecoxib and naproxen in the treatment of acute ankle sprain. DESIGN: Double-blind, parallel-group, randomized trial. SETTING: Multicenter outpatient. PATIENTS: Adult patients (n = 397) with acute first-degree or second-degree ankle sprain. INTERVENTIONS: Patients randomized to celecoxib 200 mg b.i.d. (n = 198) ...
Relevancy Score: Relevancy Score: 464
Lanza F L - - 1979
The effects of various nonsteroidal antiinflammatory drugs on the gastric mucosa were endoscopically evaluated in 40 normal volunteers. Eight groups, each containing five subjects were designed: aspirin (3600 mg/d); placebo; ibuprofen (1600 mg/d); ibuprofen (2400 mg/d); indomethacin (100 mg/d); indomethacin (150 mg/d); naproxen (500 mg/d); and naproxen (750 mg/d). All ...
Relevancy Score: Relevancy Score: 464
Abbott C J - - 1980
Ninety-eight patients were admitted to a single-blind parallel study comparing the efficacy of naproxen sodium with a paracetamol/dextropropoxyphene combination in the treatment of soft-tissue disorders. The two study groups were well matched in all respects. After seven days of treatment patients in the naproxen sodium group had less residual symptoms ...
Relevancy Score: Relevancy Score: 463
Vakily Majid - - 2005
Drugs prescribed for rheumatoid arthritis are often associated with gastrointestinal toxicity, and proton pump inhibitors may be coadministered for gastroprotection. In this open-label study, the effect of lansoprazole 30 mg qd and naproxen 500 mg bid on the pharmacokinetic profile of methotrexate was investigated. Twenty-seven adult rheumatoid arthritis patients on ...
Relevancy Score: Relevancy Score: 463
van der Vijver R J - - 2013
BACKGROUND: Non-steroid anti-inflammatory drugs such as the cyclooxygenase isoenzyme inhibitors diclofenac and naproxen are increasingly used for perioperative pain relief, while their potential effects on wound healing are scarcely investigated. METHODS: In 104 male Wistar rats, an anastomosis was constructed in both colon and ileum. The rats were divided into ...
Relevancy Score: Relevancy Score: 463
Shell William E - - 2012
To study the safety and efficacy of a new medical food (Theramine) in the treatment of low back pain, we performed a 28-day double-blind randomized controlled trial in 129 patients. Back pain was present for at least 6 weeks and was not mild. Patients were randomly assigned to receive medical ...
Relevancy Score: Relevancy Score: 462
Banerjee Tuhina - - 2006
Binding of the drugs naproxen (which is an anti-inflammatory) and amitriptyline (which is an anti-depressant) to bovine serum albumin (BSA) has been studied using isothermal titration calorimetry (ITC), in combination with fluorescence and circular dichroism spectroscopies. Naproxen is observed to bind more strongly to BSA than amitriptyline. The temperature-dependent ITC ...
Relevancy Score: Relevancy Score: 462
Hinz B - - 2008
OBJECTIVE: Over the last few years, there has been concern regarding the cardiovascular safety of selective cyclooxygenase (COX)-2 inhibitors and high-dose regimens of nonsteroidal anti-inflammatory drugs (NSAIDs). On the other hand, those compounds which elicit an almost complete (> 95%) and continuous suppression of platelet COX-1 may represent an exception. ...
Relevancy Score: Relevancy Score: 462
Hashim N H - - 2011
The enantiospecific fate of three common pharmaceuticals was monitored in a laboratory-scale membrane bioreactor (MBR). The MBR was operated with a hydraulic retention time of 24 h and a mixed liquor suspended solids concentration of 8.6-10 g/L. Standard solutions of ibuprofen, ketoprofen and naproxen were dosed into the synthetic feed of the ...
Relevancy Score: Relevancy Score: 462
Khosravi M B - - 2014
Gabapentin is an analogue of the gamma amino butyric acid (GABA), which regulates the conductance of calcium channels. In this study, we compared the efficacy of gabapentin the one of naproxen in the treatment of failed laminectomy syndrome. In this controlled trial, patients who had had elective lumbar discectomy or ...
Relevancy Score: Relevancy Score: 462
Doherty N S - - 1977
Acute inflammation was induced in rats by subcutaneous implantation of plastic sponges, and the penetration of salicylate and naproxen into the inflammatory exudate was studied after oral dosing with these compounds. The penetration of intravenously administered 22Na and 125I-albumin was also studied. It was found that salicylate and 22Na penetrated ...
Relevancy Score: Relevancy Score: 461
Grafova V N - - 2001
A comparative study of the effects of two nonsteroidal antiinflammatory drugs paracetamol and naproxen on the pain syndrome models of various etiology showed that paracetamol is more effective in the case of spinal and neuropathic pain syndromes (in which the leading pathogenic mechanisms are related to the formation of hyperactive ...
Relevancy Score: Relevancy Score: 461
Dasgupta A - - 1996
Displacement of valproic acid (90-95% bound to albumin) and carbamazepine (80% bound to albumin) by salicylate, leading to higher concentrations of pharmacologically active free drugs, has been reported. We studied the possibility of displacement of valproic acid and carbamazepine by other strongly albumin-bound nonsteroidal antiinflammatory drugs tolmetin, ibuprofen, and naproxen. ...
Relevancy Score: Relevancy Score: 460
Tiong Ngiik - - 2009
The aim of this study was to investigate the use of liquisolid technique in improving the dissolution profiles of naproxen in a solid dosage form. This study was designed to evaluate the effects of different formulation variables, i.e. type of non-volatile liquid vehicles and drug concentrations, on drug dissolution rates. ...
Relevancy Score: Relevancy Score: 459
Mura Paola - - 2003
The purpose of the present study was to investigate the combined effect of hydroxypropyl-beta-cyclodextrin and different aminoacids (L-lysine, LYS; L-valine, VAL; L-iso-leucine, LEU; and L-arginine, ARG) on the solubility of naproxen, a poorly water-soluble anti-inflammatory drug. Aqueous solubilities of naproxen in binary and ternary systems with hydroxypropyl-beta-cyclodextrin and each aminoacid ...
Relevancy Score: Relevancy Score: 459
Slattery J T - - 1979
The purpose of this investigation was to determine the effect of the nonsteroidal anti-inflammatory drug naproxen on the elimination kinetics and anticoagulant activity of warfarin. Ten healthy men received one oral dose of 50 mg racemic warfarin alone and with naproxen, 375 mg twice daily for 17 days beginning 10 ...
Relevancy Score: Relevancy Score: 459
Karabayirli Safinaz - - 2012
OBJECTIVE: To compare the analgesic efficacy of oral tramadol and naproxen sodium on pain during insertion of an intrauterine device (IUD). DESIGN: Randomized, double-blinded, clinical trial (Canadian Task Force classification I). SETTING: University-affiliated hospital. Single-center. PATIENTS: One hundred three patients scheduled for insertion of an IUD. INTERVENTIONS: Patients were randomly ...
Relevancy Score: Relevancy Score: 459
Stange Ulrike U Freeze Drying Focus Group (FDFG), Division of Pharmaceutics, University of Erlangen, Erlangen, 91058, - - 2014
The purpose of this study was to develop and manufacture novel freeze-dried orally disintegrating tablets (ODTs) for migraine therapy containing taste-masked naproxen sodium and naratriptan hydrochloride. The formulation was optimized based on freeze-drying of sucrose solutions with different binders (hydroxyethylstarch, sodium alginate, methylcellulose, and gelatin) and varying amounts of Eudragit® ...
Relevancy Score: Relevancy Score: 459
Singh R R - - 1986
Relevancy Score: Relevancy Score: 459
Nader D A - - 1983
Relevancy Score: Relevancy Score: 459
Habbema L - - 1987
Relevancy Score: Relevancy Score: 459
Anttila M - - 1977
Relevancy Score: Relevancy Score: 459
Sandler R - - 1993
Relevancy Score: Relevancy Score: 459
Eyman E - - 1980
Relevancy Score: Relevancy Score: 459
Szmyd L L - - 1985
Relevancy Score: Relevancy Score: 459
Krogsgaard K - - 1980
Relevancy Score: Relevancy Score: 459
Burns D A - - 1987
Relevancy Score: Relevancy Score: 459
Diffey B L - - 1988
Relevancy Score: Relevancy Score: 459
Welch K M - - 1986
Relevancy Score: Relevancy Score: 459
Katz F H - - 1978
Relevancy Score: Relevancy Score: 459
Barnes C G - - 1975
Twenty-two patients with osteoarthrosis of one or both knee joints and 28 patients with osteoarthrosis of one or both hips completed a double-blind trial of 500 mg naproxen daily versus 100 mg indomethacin daily. All patients had been on other active medication up to the start of the trial. Identical ...
Relevancy Score: Relevancy Score: 458
Velazquez M M - - 1995
Photophysical properties of a non-steroidal anti-inflammatory drug, Naproxen (6-methoxy alpha-methyl-2-naphthalene acetic acid sodium salt), were investigated in solvents of different polarity, hydrogen donor ability and also in cyclodextrins. The results indicate that in all cases the emitting state is the 1L(b) singlet. In alcoholic solvents, an intermolecular hydrogen bond is ...
Relevancy Score: Relevancy Score: 458
Thometz J G - - 1996
Caffey's disease (infantile cortical hyperostosis) is considered to be a benign self-limiting disease of uncertain etiology that typically appears in early infancy. The following case of Caffey's disease in a young girl is significant from 2 standpoints. First, the course of the disease is atypical because of its severe recurrent ...
Relevancy Score: Relevancy Score: 458
Brater D C - - 1985
In contrast to other nonsteroidal anti-inflammatory drugs (NSAIDs), sulindac has been reported to inhibit systemic prostaglandins (PGs) while not affecting renal PGs. We studied 11 normal volunteers who received placebo, ibuprofen, naproxen, or sulindac in a randomized, double-blind fashion. After control periods assessing the effect of the NSAIDs alone, 40 ...
Relevancy Score: Relevancy Score: 458
Carrasco-Portugal Miriam del Carmen Mdel - - 2006
The bioavailability of naproxen sodium (CAS 26159-34-2) after administration of two oral suspensions, reference or test (Pactens), was compared in 24 healthy subjects. The volunteers received an oral dose of 250 mg (10 ml) in two separate sessions under fasting conditions according to a randomized cross-over design and blood samples ...
Relevancy Score: Relevancy Score: 458
Daniels Stephen E SE Scirex Corporation, 3200 Red River, Suite 300, Austin, TX 78705, USA. - - 2005
To compare the analgesic efficacy of valdecoxib with placebo and naproxen sodium for relieving menstrual cramping and pain due to primary dysmenorrhea. Single-center, double-blind study with a 4-period, 4-sequence crossover design. Patients assessed pain intensity and pain relief at regular intervals up to 12 hours following the initial dose. Privately ...
Relevancy Score: Relevancy Score: 458
Aeidler H - - 1975
In a multicenter double-blind cross-over trial the therapeutic effect and the tolerance of d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) and indometacin were compared including 46 patients with rheumatoid arthritis, 35 patients with ankylosing spondylitis and 19 patients with osteoarthrosis. Duration of treatment with both drugs was two to four weeks each. The daily ...
Relevancy Score: Relevancy Score: 458
Lohmander L S - - 2005
OBJECTIVE: To evaluate the gastrointestinal safety and efficacy of the COX inhibiting nitric oxide donator AZD3582 in patients with hip or knee osteoarthritis. METHODS: 970 patients were randomised (7:7:2) to AZD3582 750 mg twice daily, naproxen 500 mg twice daily, or placebo twice daily in a double blind study. The ...
Relevancy Score: Relevancy Score: 458
Farkouh Michael E - - 2008
The 52-week Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET) investigated the gastrointestinal and cardiovascular safety profile of lumiracoxib 400 mg once daily compared with 2 traditional nonsteroidal anti-inflammatory drugs (NSAIDs): ibuprofen 800 mg 3 times daily and naproxen 500 mg twice daily. Data from TARGET were analyzed to examine ...
Relevancy Score: Relevancy Score: 457
Vause Carrie V CV Missouri State University, Springfield, MO 65806, - - 2012
The goal of this study was to use protein array analysis to investigate temporal regulation of stimulated cytokine expression in trigeminal ganglia and the spinal trigeminal nucleus in response to co-treatment of sumatriptan and naproxen sodium or individual drug. Activation of neurons and glia in trigeminal ganglia and the spinal ...
Relevancy Score: Relevancy Score: 456
Milsom Ian - - 2002
BACKGROUND: Dysmenorrhea is the most common menstrual complaint in young women, with a prevalence as high as 90%. It is responsible for substantial repeated short-term absenteeism from school and work in young women. Effective treatments are available, including nonsteroidal anti-inflammatory drugs (NSAIDs). In many countries, a variety of NSAIDs have ...
Relevancy Score: Relevancy Score: 456
Pilloni A P - - 1999
The purpose of this study was to determine the in vitro susceptibility to cetyltrimethylammonium naproxenate for various aerobic and anaerobic micro-organisms responsible for oral and pharyngeal diseases by assessing the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) or minimum fungicidal concentrations (MFCs) and by determining kill-times. The MICs ...
Relevancy Score: Relevancy Score: 456
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