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Manthorpe R - - 2006
The purpose of this review is to give a modern view and an update of important areas in primary Sjögren's syndrome (SS), which may be the most common of the autoimmune systemic rheumatic diseases. Interest in aspects of primary SS including clinical manifestations, pathogenesis, aetiology, treatment, prognosis, etc has increased ...
Relevancy Score: Relevancy Score: 52
Tezuka Mikio - - 2007
We compared the growth rate of locally recurrent hepatocellular carcinoma (HCC) with that of primary HCC. After the first treatment by transcatheter arterial chemoembolization (TACE), 60 locally recurrent HCC nodules were reviewed. The tumor volume doubling time (DT) of locally recurrent HCC was significantly shorter than that of primary HCC. ...
Relevancy Score: Relevancy Score: 52
Szelenyi I - - 1986
The role of the gastric nonwettable hydrophobic layer (surfactant) was investigated in the mucosal protection against the damage induced by ethanol in the rat. Although aluminium hydroxide inhibited the development of ethanol-produced gastric hemorrhagic lesions, it did not increase the mucosal phospholipid content. Ambroxol, a known stimulant of pulmonary surfactant ...
Relevancy Score: Relevancy Score: 52
Chitano P - - 1989
To follow up previous observations that airway hyperresponsiveness induced by ozone is linked to airway inflammation and particularly to the release of arachidonic acid metabolites, we investigated the effect of ambroxol (a mucoactive and surfactant-stimulating drug that has recently been discovered to inhibit the release of arachidonic acid from cell ...
Relevancy Score: Relevancy Score: 52
Aurnhammer W - - 1977
In a double-blind cross-over study the effect of two secretolytic agents on the mucociliary clearance was tested in 8 patients with mild chronic obstructive bronchitis. Clearance was assessed from the removal rate of previously inhaled sulfur colloid particles, tagged with 99Tcm. For the interpreatation of the results, obtained by this ...
Relevancy Score: Relevancy Score: 52
Weiss T - - 1981
The effect of clenbuterol, a beta adrenergic drug, and ambroxol, a secretolytic agent, on regional mucociliary clearance and pulmonary radioaerosol distribution was investigated in two groups of 15 patients with COLD in a double-blind cross-over trial with placebo. Clearance rates of inhaled 99mTc-labelled human serum albumin minimicrospheres (HAMM) were determined ...
Relevancy Score: Relevancy Score: 52
Lazzarin A - - 1984
An increase in the infection rate both in mother and newborn after antenatal administration of corticosteroids for prevention of RDS has been shown. The aim of this study was to compare PMN functions in two groups of premature infants whose mothers had received betamethasone or ambroxol for prevention of RDS. ...
Relevancy Score: Relevancy Score: 52
Van Petten G R - - 1978
The effect of fetal administration of NA872, metabolite VIII of Bisolvon, on the lecithin/sphingomyelin (L/S) ratio of ovine tracheal fluid and of its administration to the pregnant doe on the fetal rabbit pulmonary pressure-volume relationship was determined. Intravenous administration of NA872 in the long-term cannulated lamb fetus in a dose ...
Relevancy Score: Relevancy Score: 52
Bjerrum K - - 1990
Forty patients with primary Sjögren's syndrome were interviewed to clarify the onset and course of the disease. In 50% of the cases, the first subjective signs of disease were recorded at age 30 to 50 years. A large variation was, however, observed, and some patients even recalled symptoms as early ...
Relevancy Score: Relevancy Score: 52
Egberts J - - 1976
Metabolite VIII of Bisolvon (Met. VIII) was administered to six pregnant ewes (i.m. daily 5 or 10 mg/kg for 7-9 days). The treatment was started at the 116th/117th or 117th/118th day of gestation and in one case the drug was given to the fetus (i.v. 2 mg/ml/h). Fetal lung fluid ...
Relevancy Score: Relevancy Score: 52
Luerti M - - 1984
Several studies showed that ambroxol is efficacious in enhancing fetal lung maturation, provided large doses are given. We investigated cord blood levels of PRL and thyroid hormones in 31 infants born after antenatal administration of betamethasone, in 31 infants born to mothers treated with ambroxol for prevention of RDS and ...
Relevancy Score: Relevancy Score: 52
Sepúlveda J - - 1982
The techniques of light and electron microscopy were used to study the sequence of changes in the fine structure of the developing nonciliated bronchiolar cells in the last quarter of gestation in the mouse, and up to the 3rd postnatal day. Control animals were compared with two groups that received ...
Relevancy Score: Relevancy Score: 52
Couet W - - 1989
Ambroxol and clenbuterol are two drugs with potential pharmacological synergy. The objective of this study was to compare the apparent bioavailabilities at steady-state of these two compounds administered alone or in combination (CHF-023). Nine healthy male volunteers participated in the study. They received 30 mg of ambroxol alone (one Fluibron ...
Relevancy Score: Relevancy Score: 52
Melillo G - - 1986
Ambroxol is a new compound which increases secretion of phosphatidylcholine by type II pneumocytes. The secretion of phosphatidylcholine could affect bronchial hyperreactivity in two ways: by increasing lysophosphatidylcholine turnover and/or by modifying the layer of bronchial secretion that covers airway receptors. To see whether ambroxol affects bronchial hyperreactivity, we carried ...
Relevancy Score: Relevancy Score: 52
Vranic E - - 2003
This article deals with the simultaneous determination of three dissolution profiles in the same pharmaceutical formulation. The officially proposed procedure from the pharmacopoeias is adapted to the FIA methodology to obtain the officially recommended profile or "global profile", and two "individual" profiles, corresponding to dissolution rate of two different active ...
Relevancy Score: Relevancy Score: 52
Drescher Robert - - 2008
Mediastinal pancreatic pseudocysts represent a rare complication of acute or chronic pancreatitis. A 55-year-old man with a history of chronic pancreatitis was admitted with intermittent dyspnea, dysphagia and weight loss. Chest X-ray, computed tomography and magnetic resonance imaging revealed a large paracardial pancreatic pseudocyst causing cardiac and esophageal compression. Mediastinal ...
Relevancy Score: Relevancy Score: 49
Isogai Hideto H Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 147 Shimokasuya, Isehara, Kanagawa 259-1143, - - 2013
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug hypersensitivities with high mortality. Typical over-the-counter drugs of cold medicines are suggested to be causative. As multiple ingredients are generally contained in cold medicines, it is of particular interest to investigate which ingredients are responsible for SJS/TEN. However, experimental ...
Relevancy Score: Relevancy Score: 48
Miyata T - - 1986
The mechanism of action of secretagogic expectorants (ex., ambroxol) has not been clarified. Recently, attention has been directed to the relationship of their action to pulmonary surfactants. In the present study, the fatty acid (FA) composition of phosphatidylcholine (PC), which is the main physiological surfactant, was investigated using sputum, respiratory ...
Relevancy Score: Relevancy Score: 45
Brown D T - - 1985
Otitis media with effusion (OME) is characterized by the production and accumulation in the middle ear of mucus secretions, whose physicochemical properties are an important feature in the etiology and treatment of the disease. Many types of pharmaceutical agents, including anti-inflammatory agents, antihistamines, antibiotics, and mucolytics, have been used in ...
Relevancy Score: Relevancy Score: 45
Olivieri D - - 1987
In a 6-month, double-blind multicenter trial conducted over the winter, the effects of daily administration of ambroxol retard (75 mg) were compared with those of placebo in preventing exacerbations and improving symptoms and clinical signs in chronic bronchitis patients. The trial was completed by 110 patients in the ambroxol group ...
Relevancy Score: Relevancy Score: 45
Perrott S - - 2010
OBJECTIVES: Single centre series have suggested that endovascular aneurysm repair (EVAR) for ruptured abdominal aortic aneurysms (rAAA) may reduce mortality versus open surgery. This has not been substantiated in the only randomized controlled trial, leading to suggestion that anatomical suitability for rEVAR may independently improve prognosis of rAAA. Our aim ...
Relevancy Score: Relevancy Score: 45
Salzer H - - 1986
In a multicenter, randomized double-blind study, the effect of Betamethasone and Ambroxol, both used for prenatal prevention of RDS in premature and newborn infants, is compared in a total of 185 patients with premature labour or an induced termination of pregnancy between the 28 and 36th week of gestation. The ...
Relevancy Score: Relevancy Score: 45
Arsić Stojanka - - 2010
Reconstruction of lost, damaged or distorted mandibular bone presents a challenge from the functional side, as well as from the esthetic point of view. The aim of this study was to determinate potential differences between values of the basic linear moprhometric parameters (LMPs) obtained by direct and indirect manual measurement ...
Relevancy Score: Relevancy Score: 45
Celiktas Medih - - 2009
INTRODUCTION: We evaluated a possible effect of the amount of retroperitoneal fat tissue on testicular venous drainage to shed light on the mechanism of varicocele occurrence. PATIENTS AND METHODS: A total of 132 patients with no fertility complaints were included in this study. Retroperitoneal fat thickness (RPFT) was measured during ...
Relevancy Score: Relevancy Score: 45
Jayaram S - - 2000
The present study was undertaken to study the comparative safety and efficacy of two cough formulas viz, Ascoril expectorant and other cough formula in the management of cough associated with respiratory disorders. Fifty patients having cough associated with various respiratory disorders like bronchitis and upper or lower respiratory tract infections ...
Relevancy Score: Relevancy Score: 45
Meerbach W - - 1982
The influence of chronic administration of ambroxol on the phospholipid-(PL-) content and ultrastructure of lungs has been studied and compared with the effect of chlorphentermine (chlph.). Both drugs are amphiphilic substances. The causative factor of the well-known chlph. induced phospholipidosis-like alterations was suggested to be an inhibition of enzymatic degradation ...
Relevancy Score: Relevancy Score: 45
Malíková H - - 2007
According to WHO declaration, tuberculosis is considered the world health danger. Almost 1% of world population is infected by tuberculosis every year and up to 3 millions of new cases are registered in the south-east Asia only. Prevalence of extra-pulmonary tuberculosis is rising, which is probably caused by the rising ...
Relevancy Score: Relevancy Score: 45
Caltagirone S - - 1981
Controlled clinical research has been carried out on the activity and tolerance of a new active principle, guacetisal (Broncaspin) obtained from the esterification of acetylsalicylic acid with guaiacol, in the treatment of chronic bronchitis. The drug's therapeutic response was evaluated with respect to that of bromexine. Guacetisal was generally well ...
Relevancy Score: Relevancy Score: 45
Schmidt H - - 1998
The purpose of the present clinical studies was to determine the clinical efficacy of a combined parenteral and oral treatment with Bisolvon in combination with antibiotics in bovines suffering from acute respiratory disease. To this end four trials were conducted in respiratory diseased bovines; a total of 619 animals were ...
Relevancy Score: Relevancy Score: 45
Luerti M - - 1987
The results are reported of a multicenter randomized study of the effectiveness of maternal administration of betamethasone versus ambroxol, a substance of the group of the benzylamines, for prevention of RDS in preterm infants. Women of 27 to 34 weeks gestation with threatened premature delivery or planned premature delivery were ...
Relevancy Score: Relevancy Score: 45
Maloney J E - - 1980
15 fetal lambs were instrumented on approximately day 100 (term 147 days) with small catheters in their jugular veins, carotid arteries and tracheas and fine electrodes in their diaphragms and on the lateral surfaces of their thoraces. Measurements were made intermittently of carotid arterial pressure, jugular venous pressure, amniotic fluid ...
Relevancy Score: Relevancy Score: 45
Lubberink M - - 2008
Iodine-124 is a positron-emitting iodine isotope, enabling measurement of iodine uptake using positron emission tomography (PET). There is a number of situations where the use of (124)I-PET/computed tomography (CT) can improve the current clinical practice in the diagnosis and treatment of thyroid cancer. Firstly, (124)I-PET/CT can aid in the staging ...
Relevancy Score: Relevancy Score: 45
Wilke A - - 1987
Ambroxol, a drug capable of elevating the phospholipid content in healthy rabbit lungs, was tested on two models of experimental lung injury, lung changes in sepsis induced by a peritonitis and in bromcarbamide intoxication. The phospholipid content of the lungs and the synthesis of the individual phospholipids phosphatidylcholine (PC) and ...
Relevancy Score: Relevancy Score: 45
Hooper C - - 2008
Prescription of mucoactive drugs for chronic obstructive pulmonary disease (COPD) is increasing. This development in clinical practice arises, at least in part, from a growing understanding of the important role that exacerbation frequency, systemic inflammation and oxidative stress play in the pathogenesis of respiratory disease. S-carboxymethylcysteine (carbocisteine) is the most ...
Relevancy Score: Relevancy Score: 42
Kirschberg Oliver - - 2010
We describe a rare case of diffuse macroscopic discoloration and chemical gastritis due to chronic bromazepam intake. The chemical composition of pharmaceuticals has to be considered at endoscopy and it is evident that some chemical substances damage the epithelial tissue and lead to clinical symptoms. Endoscopy was performed in an ...
Relevancy Score: Relevancy Score: 42
Calkovska A - - 2009
Beside neonatal respiratory distress syndrome, secondary surfactant deficiency may occur in patients with mature lungs. Recent studies revealed quantitative and qualitative changes of lung surfactant in pulmonary thromboembolism (PTE) concerning the total phospholipids content in BAL fluid, alterations in surfactant phospholipids classes and a large-to-small aggregates ratio. Reduced expression of ...
Relevancy Score: Relevancy Score: 39
Morrison H M - - 1984
The inhibitory function of alpha 1 antitrypsin (alpha 1AT) has been studied in the lung secretions of 31 patients with chronic obstructive bronchitis. The inhibitory capacity for a single sample showed a wide range (median 0.13 micrograms porcine pancreatic elastase (PPE) inhibited per microgram alpha 1 antitrypsin; range 0-0.55 micrograms), ...
Relevancy Score: Relevancy Score: 37
Spector Matthew E - - 2012
Despite better prognosis, there is a group of oropharyngeal squamous cell carcinoma (SCC) human papillomavirus (HPV)+ patients who experience treatment failure and succumb to distant metastasis. Seventy-eight previously untreated patients nested in a concurrent chemoradiation protocol were reviewed to correlate patterns of local-regional tumor extent to distant metastasis. Biomarker assessment ...
Relevancy Score: Relevancy Score: 37
Meyers Bryan F - - 2006
OBJECTIVE: Accurate preoperative staging is essential for the optimal management of patients with lung cancer. An important goal of preoperative staging is to identify mediastinal lymph node metastasis. Computed tomography and positron emission tomography may identify mediastinal lymph node metastasis with sufficient sensitivity to allow omission of mediastinoscopy. This study ...
Relevancy Score: Relevancy Score: 37
Kadam A U - - 2008
An oral controlled release suspension of chlorpheniramine maleate was prepared using ion-exchange resin technology. A strong cation exchange resin Indion 244 was utilized for the sorption of the drug and the drug resinates was evaluated for various physical and chemical parameters. The drug-resinate complex was microencapsulated with a polymer Eudragit ...
Relevancy Score: Relevancy Score: 35
Muralidharan Selvadurai - - 2013
A high-performance liquid chromatographic (HPLC) and ultraviolet (UV) methods were developed and validated for the quantitative determination of Ambroxol hydrochloride (AMH) in pharmaceutical dosage form. HPLC was carried out by reversed phase (RP) technique on an RP-18 column with a mobile phase composed of acetonitrile and water (pH 3.5 adjusted ...
Relevancy Score: Relevancy Score: 35
Mutneja Puneet - - 2012
Menopause is associated with a large number of symptoms ranging from physical to psychological. These symptoms may unfavorably affect oral health and treatment needs requiring dentists to be aware of the symptoms and health care needs of peri-menopausal/menopausal/postmenopausal women. This article attempts to provide an insight into the multifarious oral ...
Relevancy Score: Relevancy Score: 35
Chen Xiankun X Evidence-Based Medicine & Clinical Research Service Group, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, - - 2014
This systematic review evaluated the effects of Chinese herbal medicine (CHM) plus routine pharmacotherapy (RP) on the objective outcome measures BODE index, 6-minute walk test (6MWT), and 6-minute walk distance (6MWD) in individuals with stable chronic obstructive pulmonary disease (COPD). Searches were conducted of six English and Chinese databases (PubMed, ...
Relevancy Score: Relevancy Score: 31
Luo Hui - - 2012
Background. There is no curative treatment for primary Sjögren's syndrome (PSS). Chinese herbal medicine (CHM) is widely used in the treatment of PSS in China. Objective. To evaluate the effectiveness and safety of CHM for PSS. Methods. PubMed, Cochrane Library, China Knowledge Resource Integrated Database, Chinese Biomedical Database, Wanfang Data, ...
Relevancy Score: Relevancy Score: 30
Dorj Gereltuya - - 2013
Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality in all age groups worldwide. It may be classified as mild/moderate or severe, the latter usually requiring hospitalisation. Although, there are many studies reported in relation to CAP, there is relatively little known about the treatment of CAP and ...
Relevancy Score: Relevancy Score: 29
Kumar Palakurthi Ashok - - 2013
A simple, fast, and efficient RP-HPLC method has been developed and validated for the simultaneous estimation of Levodropropizine, Chloropheniramine, Methylparaben, Propylparaben, and the quantification of Levodropropizine impurities in the Reswas syrup dosage form. A gradient elution method was used for the separation of all the actives and Levodropropizine impurities by ...
Relevancy Score: Relevancy Score: 28
Cho C W - - 2012
To avoid the systemic adverse effects that might occur after oral administration, transdermal delivery of ambroxol was studied as a method for maintaining proper blood levels for an extended period. Release of ambroxol according to concentration and temperature was determined, and permeation of drug through rat skin was studied using ...
Relevancy Score: Relevancy Score: 28
Giang Do T do - - 2010
Reversed-phase HPLC and UV spectrophotometric techniques using water as solvent have been developed and validated for the simultaneous determination of amoxicillin and cloxacillin in capsules. For both techniques, the linearity range of 60.073x2013;140.0 µg/mL was studied. The spectrophotometric data show that non-derivative techniques, such as absorbance ratio and compensation, and ...
Relevancy Score: Relevancy Score: 28
Shah S - - 2010
Ondansetron is a serotonin 5HT3 antagonist; anti-emetic drug. Bitter taste of the ondansetron is a major problem in ensuring patient compliance. The study was designed to formulate tasteless complexes of ondansetron with ion exchange resin and evaluate molecular properties of drug complex. The drug-loading process was carried out using various ...
Relevancy Score: Relevancy Score: 28
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