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Traykova M - - 2003
The antioxidant properties of galantamine hydrobromide ((4alpha,6beta)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide) were studied in vitro, using luminol-dependent chemiluminescence and spectrophotometry. It was found that this compound was a scavenger of reactive oxygen species (ROS). By comparing the antioxidant effects of galantamine ((4alpha,6beta)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol), galantamine hydrobromide, narwedine (4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one), and narwedine hydrobromide it was found that ...
Relevancy Score: Relevancy Score: 1000
- - 1969
Relevancy Score: Relevancy Score: 939
Patel Amit V AV Department of Quality Assurance, Shri Sarvajanik Pharmacy College, Near Aravind Baug, Mehsana, Gujarat, - - 2013
To develop a simple, accurate, sensitive, rapid and precise method for the determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form. The method employs wavelength detection and determination of galantamine hydrobromide at excitation wavelength 282 nm and emission wavelength 607 nm in a solution of simple distilled water. ...
Relevancy Score: Relevancy Score: 928
Brannon W L - - 1975
The method of preparation of scopolamine hydrobromide affects the infrared (IR) spectrum of the product. A column chromatographic procedure is used to both isolate the drug from tablets and injections and form the hydrobromide salt. This yields reproducible IR spectra and thus constitutes an identity test for scopolamine hydrobromide.
Relevancy Score: Relevancy Score: 926
- - 2001
Relevancy Score: Relevancy Score: 919
Elliott Eric L - - 2005
[reaction: see text] The first syntheses of the pyridazinoindazolium alkaloids nigellicine and nigeglanine hydrobromide via a common intermediate are described. Ortho-lithiation/acylation and the direct amination of an isatin ring system are the key steps in the synthesis.
Relevancy Score: Relevancy Score: 862
Todd K S KS - - 1978
Uredofos, niclosamide, bunamidine hydrochloride, and arecoline hydrobromide were given at various doses to dogs experimentally infected with Mesocestoides corti. The highest efficacies were obtained with bunamidine hydrochloride and uredofos. Variable results were obtained with arecoline hydrobromide and niclosamide.
Relevancy Score: Relevancy Score: 810
Crider A M - - 1984
3-(3,4-Dihydroxyphenyl)-1-n-propylpyrrolidine hydrobromide was synthesized by a six-step reaction sequence and was evaluated, and compared with apomorphine, for central dopaminergic agonist activity. The compound produced behavioral and biochemical changes characteristic of central dopaminergic stimulation. Administration of 3-(3,4-dihydroxyphenyl)-1-n-propylpyrrolidine hydrobromide to rats resulted in the reversal of the reserpine syndrome, stereotypic behavior, contralateral ...
Relevancy Score: Relevancy Score: 799
Chen T M - - 1988
An ion-pair reversed-phase high-pressure liquid chromatographic assay is developed that allows simultaneous quantitation of guaifenesin, dextromethorphan hydrobromide, and sodium benzoate in an expectorant syrup. The method is rapid and accurate. Average recoveries of 99.6, 99.8, and 99.7% with relative standard deviations of 0.5, 0.9, and 0.2% are obtained for guaifenesin, ...
Relevancy Score: Relevancy Score: 786
Fierens C - - 2009
Liquid preparations for oral use containing dextromethorphan hydrobromide were verified on identity, content and microbiological quality. The assay method was previously validated according to international guidelines. All examined products complied with the postulated requirements.
Relevancy Score: Relevancy Score: 784
THOMSON W - - 1955
Relevancy Score: Relevancy Score: 784
PEARLMAN W M - - 1948
Relevancy Score: Relevancy Score: 784
Snorrason E - - 1991
Relevancy Score: Relevancy Score: 784
Fleming P M - - 1986
Relevancy Score: Relevancy Score: 764
Contacts: Sciences Sinin:esb:innorg:3833306750
Abstract: A resource-saving technology was designed to extract lappaconitine alkaloid, contained in ~0.1-0.2 % concentrations in the roots of the Aconitum septentrionale Koelle plant (northern monk's-hood), which grows everywhere in Siberia. Production of lappaconitine hydrobromide is required for the clinical use of an effective domestic medicinal drug for preventing and ...
Relevancy Score: Relevancy Score: 759
Diab Mohammad - - 2009
Bullous pemphigoid (BP) is an acquired autoimmune disease commonly attributed as idiopathic, especially in elderly patients, characterized by subepidermal vesicles and bullae with linear deposits of IgG autoantibodies and complement along the epidermal basement membrane. It also is now commonly accepted that BP can be caused by or associated with ...
Relevancy Score: Relevancy Score: 755
Ceyhan T - - 2001
An accurate, simple, reproducible and sensitive method for the determination of atropine sulfate and scopolamine hydrobromide has been developed and validated. Atropine sulfate and scopolamine hydrobromide were separated using a microBondapack C(18) column by isocratic elution with flow rate 1.0 ml/min. The mobile phase composition was methanol, water, formic acid ...
Relevancy Score: Relevancy Score: 752
Zarotsky Victoria - - 2003
The pharmacology, dosage, adverse effects, efficacy, and economics of galantamine hydrobromide are discussed. Galantamine hydrobromide is a tertiary alkaloid that has been extracted from plant sources and is now synthesized for use in the treatment of mild to moderate Alzheimer's disease (AD). Galantamine acts both as a reversible competitive inhibitor ...
Relevancy Score: Relevancy Score: 750
Reddy Damodara N - - 2011
5,6-Dihydro-4H-1,3-oxazine hydrobromides have been synthesized by the nucleophilic autocyclo-O-alkylation of N-(3-bromopropyl)amides under neutral conditions in chloroform. It is found that electron-donating amide α-substituents influence the autocyclization efficiency.
Relevancy Score: Relevancy Score: 732
Zhou Jun-Hui - - 2011
Ranaconitine is an important diterpenoid alkaloid from Aconitum sinomontanum Nakai. The absolute configuration of natural ranaconitine was determined through an X-ray structure analysis of hydrated ranaconitine hydrobromide. The crystal presents a monoclinic system, space group P2(1) with Z = 2, unit cell dimensions: a = 10.6604(12) Å, b = 12.3674(14) Å, c = 12.2938(13) Å and β = 91.056(2)°. The chirality of the ...
Relevancy Score: Relevancy Score: 728
Gupta Vishnu D VD - - 2009
The chemical stability of scopolamine hydrobromide in nasal solution has been studied by using a stability-indicating high-performance liquid chromatographic assay method that was developed in our laboratory. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation based on five injections was 0.4. ...
Relevancy Score: Relevancy Score: 728
Madasu Suri Babu - - 2012
Eletriptan hydrobromide (1) is a selective serotonin (5-HT(1)) agonist, used for the acute treatment of the headache phase of migraine attacks. During the manufacture of eletriptan hydrobromide the formation of various impurities were observed and identified by LC-MS. To control the formation of these impurities during the preparation of active ...
Relevancy Score: Relevancy Score: 723
LIPSIUS E I - - 1952
Relevancy Score: Relevancy Score: 707
Hussar Daniel A - - 2014
Relevancy Score: Relevancy Score: 707
Li Ke - - 2005
A simple and reliable reversed-phase high performance liquid chromatographic method (HPLC) for the routine analysis of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in composite pseudoephedrine hydrochloride dry suspension has been established. HPLC determination for the drug was performed in a Lichrospher C6H6 column and detected at 220 nm. Acetonitrile-H2O-H3PO4 (50:50:0.1, v/v, ...
Relevancy Score: Relevancy Score: 706
Ticehurst M D - - 2000
Micronised particles of revatropate hydrobromide were observed to agglomerate when stored in uncontrolled conditions. Dynamic vapour sorption (DVS), isothermal microcalorimetry, microscopy and particle size measurement by laser diffraction have been used to study micronised revatropate hydrobromide. The rate and extent of agglomeration were dependent on the energy of the micronisation ...
Relevancy Score: Relevancy Score: 706
Steen S N - - 1977
Fenoterol hydrobromide (Berotec; formerly Th 1165a) is a sympathomimetic bronchodilator drug. Twenty subjects with mild to moderate reversible bronchospasm completed a double-blind multiple crossover study of single doses of 5 mg, 7.5 mg, and 10 mg of fenoterol hydrobromide, 24 mg of ephedrine, and placebo. Spirometric and body-plethysmographic measurements were ...
Relevancy Score: Relevancy Score: 706
Soine W H - - 1981
A common contaminant of illicit phencyclidine, 1-piperidinocyclohexanecarbonitrile (I), is a very weak base compared to tertiary amines such as phencyclidine, 1-(cyclohexenyl)piperidine, and piperidine. Compound I and its hydrobromide salt can be selectively detected and quantitated in the presence of synthetic contaminants by nonaqueous titration with perchloric acid in acetonitrile. This ...
Relevancy Score: Relevancy Score: 703
Kubiak E J - - 1980
The chromatographic retention behavior of dextromethorphan hydrobromide on an octadecylsilane column was investigated as a function of the pairing ion and the mobile phase composition. Dramatic increases in the capacity factor were observed with pairing ions containing more than eight carbons and with decreasing organic modifier (acetonitrile) concentration. Several pharmaceutically ...
Relevancy Score: Relevancy Score: 695
McEwen John - - 2007
An outbreak of hyoscine hydrobromide toxicity was detected through the Australian pharmacovigilance system. The unexpectedly wide variation in hyoscine hydrobromide content between individual tablets within single packets created difficulties in initially explaining the clinical experiences. Strict time requirements for review of incoming adverse drug reaction reports and close involvement of ...
Relevancy Score: Relevancy Score: 695
Trejos A - - 1975
A controlled trial involving 122 dogs experimentally infected with Echinococcus granulosus was carried out to compare the efficiency of arecoline hydrobromide and bunamidine hydrochloride. A single treatment with arecoline hydrobromide at a dose rate of 4 mg/kg or with bunamidine hydrochloride at 50 mg/kg gave a similar degree of efficiency ...
Relevancy Score: Relevancy Score: 695
ROBERTSON J H - - 1950
Relevancy Score: Relevancy Score: 686
DJERASSI C - - 1948
Relevancy Score: Relevancy Score: 686
Van Sassenbroeck Diederik K - - 2005
We report three patients with anticholinergic poisoning caused by the substitution of hyoscine hydrobromide for hyoscine butylbromide in preparations compounded by two different pharmacists. The patients took the preparations for gastrointes tinal discomfort and presented with altered mental status tachycardia, facial flushing, dilated pupils, and dry skin shortly after the ...
Relevancy Score: Relevancy Score: 681
Zhang Guoqing - - 2011
Crystal phase transition and isothermal crystallization kinetics of bupropion hydrobromide is studied by thermal analysis, X-ray powder diffractometry, and scanning electron microscopy. As well known, bupropion hydrobromide has two stable polymorphic forms, form I and form II, during the production. Here it is found that form II will convert into ...
Relevancy Score: Relevancy Score: 681
Meyyanathan Subramania Nainar - - 2008
Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. The studies indicated that the ...
Relevancy Score: Relevancy Score: 681
Lipshitz J - - 1977
Fenoterol hydrobromide was administered as a 5 mg tablet to 10 patients in oxytocin-induced labour and the effects on uterine activity and on the cardiovascular system of mother and baby were evaluated. The drug took effect within 30 minutes in 8 of the 10 patients and it reduced uterine activity ...
Relevancy Score: Relevancy Score: 678
Walters M J - - 1978
A reverse phase high pressure liquid chromatographic (HPLC) system utilizing ion-pairing, similar to that previously reported for methscopolamine bromide, was developed for the quantitation of atropine sulfate and scopolamine hydrobromide in tablets. This HPLC system is capable of differentiating the major tropane alkaloids, with the exception of the atropine-hyoscyamine optical ...
Relevancy Score: Relevancy Score: 675
Tang X C - - 1983
Relevancy Score: Relevancy Score: 666
DARLEY L H - - 1955
Relevancy Score: Relevancy Score: 666
Sather Aaron C - - 2012
The single-step synthesis of fused tricyclic pyridazino[1,2-a]indazolium ring systems is described. Structural details revealed by crystallography explain the unexpected reactivity. The method is applied to the gram scale synthesis of nigeglanine hydrobromide.
Relevancy Score: Relevancy Score: 657
Traunecker W - - 1986
The bronchospasmolytic and cardiovascular effects of fenoterol hydrobromide and ipratropium bromide alone and in combination were investigated using metered aerosols in guinea pigs and dogs and intravenous injection in dogs. The additive effect of the combination on bronchospasmolysis could be demonstrated. The slight cardiovascular side-effects of fenoterol hydrobromide alone were ...
Relevancy Score: Relevancy Score: 656
Mihailova D - - 1987
The metabolism of galanthamine hydrobromide (Nivalin) was investigated in rat and rabbit liver homogenates. Experiments were carried out varying several parameters of incubation: substrate (galanthamine hydrobromide, galanthamine, galanthaminone and epigalanthamine), cofactor enrichment (NADPH, NADP/G-6-P, NAD), pH (7.4 and 9.3), time of incubation. Substrates and metabolites were identified and quantitatively determined ...
Relevancy Score: Relevancy Score: 656
Ali S I - - 1999
[reaction: see text] Pyridinium hydrobromide perbromide (Py x HBr3) catalyzes effectively the aziridination of electron-deficient as well as electron-rich olefins using Chloramine-T (N-chloro-N-sodio-p-toluenesulfonamide) as a nitrogen source to afford the corresponding aziridines in moderate to good yields.
Relevancy Score: Relevancy Score: 653
Ramachander G - - 1977
A method is described for the estimation of dextrorphan, a metabolite of dextromethorphan, in plasma. The bioavailability of dextromethorphan hydrobromide after 30 mg po, as measured by the concentration of total (free and conjugated) dextrorphan in the plasma, was determined in six human volunteers with this procedure.
Relevancy Score: Relevancy Score: 653
Ramachander G - - 1978
The effect of salicylamide and acetaminophen on the metabolic fate of dextrorphan, the primary metabolite of dextromethorphan, was studied in vivo in the rat. Plasma dextrorphan levels were measured at 5-min intervals up to 20 min and at longer intervals up to 2 hr after dextromethorphan hydrobromide was administered orally ...
Relevancy Score: Relevancy Score: 651
Raza Asad - - 2006
Study was carried out to develop two simple, fast, accurate and sensitive spectrophotometric methods (A and B) for the determination of citalopram hydrobromide in commercial tablet formulations. In method A, UV spectrophotometer determined the contents of citalopram hydrobromide in tablets at 240 nm in methanol solvent. The linear range was ...
Relevancy Score: Relevancy Score: 651
McBride W G - - 1982
When 100 or 200 microgram of scopolamine hydrobromide were injected into hen eggs after they had been incubated for 96 h the major malformations of the embryo found were gastroschisis, exencephaly, reduction deformities of the limbs, microphthalmia and buphthalmia when the eggs were opened on the 12th day of incubation. ...
Relevancy Score: Relevancy Score: 651
Gemmell M A - - 1973
Arecoline hydrobromide has been used for almost half a century for the treatment of Echinococcus granulosus in dogs. Trials in New Zealand showed that it had real limitations for this purpose. Its main value lies in its use as a diagnostic agent for detecting infections in dogs on a group ...
Relevancy Score: Relevancy Score: 651
Kast A - - 1985
The toxicity of fenoterol hydrobromide, a beta-adrenoceptor stimulant, was studied in newborn and adult SD-rats dosed with 0 (control), 2.5, 75 and 600 mg/kg/day by gavage for 35 days. 600 mg/kg was lethal for both age groups: newborn rats died either from gastro-intestinal disorders during the lactation period or from ...
Relevancy Score: Relevancy Score: 651
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