| The serum protein α2–Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification | |
Abstract/OtherAbstract
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Ectopic calcification is a frequent complication of many degenerative diseases. Here we identify the serum protein α2–Heremans-Schmid glycoprotein (Ahsg, also known as fetuin-A) as an important inhibitor of ectopic calcification acting on the systemic level. Ahsg-deficient mice are phenotypically normal, but develop severe calcification of various organs on a mineral and vitamin D–rich diet and on a normal diet when the deficiency is combined with a DBA/2 genetic background. This phenotype is not associated with apparent changes in calcium and phosphate homeostasis, but with a decreased inhibitory activity of the Ahsg-deficient extracellular fluid on mineral formation. The same underlying principle may contribute to many calcifying disorders including calciphylaxis, a syndrome of severe systemic calcification in patients with chronic renal failure. Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases. |
Authors
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Schäfer, Cora, Heiss, Alexander, Schwarz, Anke, Westenfeld, Ralf, Ketteler, Markus, Floege, Jürgen, Müller-Esterl, Werner, Schinke, Thorsten, Jahnen-Dechent, Willi |
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Publisher : American Society for Clinical Investigation Type : Text Format : - |
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Copyright © 2003, American Society for Clinical Investigation |
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Languages : en |
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