Document Detail
The role of angiotensinogen in the pathophysiology of hypertension.
Abstract/OtherAbstract :
Essential hypertension is an important cause of human cardiovascular morbidity and mortality in most developed countries. Analysis of hypertensive siblings has revealed significant genetic linkage and alleilic association between angiotensinogen, the precursor of angiotensin II, and essential hypertension. Angiotensinogen is one of the components of the renin-angiotensin system that plays a central role in blood pressure regulation. Beside the circulating system, multiple tissue renin-angiotensin system including in arterial wall, heart, brain, and kidney have been described. Transgenic models confirmed a direct, causal relationship between increased angiotensinogen gene copy number and increased arterial pressure. Nevertheless, the site of action of angiotensinogen overexpression on increased pressure remains only speculative. We proposed to identify the role that individual renin-angiotensin systems have on the hypertensive phenotype by creating animal models with altered tissue-specific angiotensinogen expression. Furthermore, for a better understanding of the renal system, we will investigate the regulation and its interaction with other systems involved in blood pressure homeostatsis., Doctor of Philosophy;
Authors :
Gociman, Barbu Razvan.
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Contributors :
Human Genetics;, School of Medicine;, University of Utah;
Publication Detail :
Publisher :  University of Utah;     Type :  text;, dissertation;     Format :  application/pdf    
Date Detail :
Subject :
Physiopathology; Kallikrein;, Hypertension; Angiotensins;
Coverage :
Relation :
Digital reproduction of “The role of angiotensinogen in the pathophysiology of hypertension.” Spencer S. Eccles Health Sciences Library. <br><br> Print version of “The role of angiotensinogen in the pathophysiology of hypertension.” available at J. Willard Marriott Library Special Collection. RC39.5 2004 .G63
Source :
Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Copyright Information :
© Barbu Razvan Gociman.
Other Details :
Languages :  eng;    
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