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Résistance primaire de Mycobacterium tuberculosis aux anti-tuberculeux à Kinshasa, République Démocratique du Congo
Abstract/OtherAbstract :
In a descriptive cross-sectional study carried out in Kinshasa between July 2003 and January 2004, we determined the prevalence of the primary resistance of M. tuberculosis to first-line anti-tuberculosis drugs. The antibiogram was performed with the proportion method on 301 isolats from patients who all had a first episode of pulmonary tuberculosis with positive microscopy (TPM+) and who had not received any anti-tuberculosis treatment before. The primary resistance rate reached 43.5%; it reached 31.6% in 1990. The multi-drug-resistance rate (MDR-TB) notified as resistant to both rifamicine and isoniazide rose to 5.3%. This rate of primary resistance is among the highest in Africa. The emergence of the resistant strains and specially the multi-drug-resistant strains (MDR-TB) in Kinshasa requires a regular assessment of these phenomena which threaten seriously the implementation of the national tuberculosis control programme
Authors :
Kabedi, M. J., Kashongwe, M., Kayembe, J. M., Mumba Ngoyi, D., Mampasi, P., Mbaya, P., Fissette, K., Verhaegen, J., Portaels, F., Muyembe-Tamfum, J. J.
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Date Detail :
2007-12-06, 2007-12-06, 2007
Subject :
Bacterial diseases, Tuberculosis, Mycobacterium tuberculosis, Drug resistance, Multidrug resistance, Rates, Strains, Congo-Kinshasa, Africa, Central
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Languages :  French    
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