| Uncoupling proteins 2 and 3 alter mitochondrial membrane phospholipid fatty acyl composition in yeast | |
Abstract/OtherAbstract
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Mouse UCP1, human UCP2 and UCP3 were expressed in yeast (<i>Saccharomyces cerevisiae</i>). Total phospholipids were extracted and their fatty acyl composition was analysed. Expression of hUCP2 and hUCP3 significantly altered the mitochondrial phospholipid fatty acyl composition. Palmitoleoyl groups (16:1(n-7)) decreased while oleoyl groups (18:1(n-9)) increased, leading to a significant increase in the 18:1(n-9)/16:1(n-7) ratio and in the average chain length. Expression of mUCP1 did not cause any significant changes in fatty acyl composition <BR><BR> Keywords: yeast, <i>Saccharomyces cerevisiae</i>, phospholipid, fatty acyl group, uncoupling protein, adenine nucleotide translocase, desaturase<BR> <i> Biokemistri</i> Vol. 17(2) 2005: 83-94 |
Authors
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Ocloo, Augustine; Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, United Kingdom; |
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Contributors
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Publication Detail
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Publisher : Biokemistri Association of Crop Science, Uganda Type : Peer-Reviewed Article, Format : - |
Date Detail
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2006-06-01 |
Subject
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- , |
Coverage
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; ; |
Relation
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- |
Source
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Biokemistri - Biokemistri; Vol. 17, No. 2 (2005) |
Copyright Information
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©Nigerian Society for Experimental Biology |
Other Details
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Languages : en |
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