| α-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling | |
Abstract/OtherAbstract
:
|
Malignant mesothelioma (MM) cells enhanced proliferation of endothelial cells (ECs) as well as their angiogenesis in vitro by secretion of fibroblast growth factor-2 (FGF2). This effect was suppressed by pre-treating MM cells with greek small letter alpha-tocopheryl succinate (greek small letter alpha-TOS), which inhibited FGF2 secretion by inducing mitochondria-dependent generation of reactive oxygen species. The role of FGF2 was confirmed by its down-regulation by treating MM cells with siRNA, abolishing EC proliferation and wound healing enhancement afforded by MM cells. We conclude that greek small letter alpha-TOS disrupts angiogenesis mediated by MM cells by inhibiting FGF2 paracrine signalling., Yes, Yes |
Authors
:
|
Neuzil, Jiri, Cowie, Emma Angela, Wang, Xiufang, Dong, Lan-feng, Stapelberg, Michael |
Contributors
:
|
Felix Wieland |
Publication Detail
:
|
Publisher : http://dx.doi.org/10.1016/j.febslet.2007.08.051, Elsevier, Germany, http://www.elsevier.com/wps/find/journaldescription.cws_home/506085/description#description Type : c1, Journal Articles (Refereed Article), Full-text link or file Format : - |
Date Detail
:
|
2008-02-28, 2008-12-10, 2008-12-10, 2007 |
Subject
:
|
Griffith Health Faculty, 320305, Heart Foundation Research Centre, Medical Biochemistry: Proteins and Peptides |
Coverage
:
|
- |
Relation
:
|
FEBS Letters, 4611, 4615, N, 581 |
Source
:
|
- |
Copyright Information
:
|
Y |
Other Details
:
|
Languages : en_AU |
Export Citation
:
|
APA/MLA Format Download EndNote Download BibTex |
Previous Document: Saving by freezing? Oxygen consumption rates of Adamussium colbecki in a latitudinal context
Next Document: Egg development, hatching rhythm and moult patterns in Paralomos spinosissima (Decapoda: Anomura: Pa...