| Tissue Carnitine Accretion and Fat Metabolism in Rats Supplemented with Carnitine, Choline and Caffeine Regardless of Exercise | |
Abstract/OtherAbstract
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The objective of this study was to determine if the combination of carnitine, choline and caffeine supplementation would alter the concentrations of carnitine in various rats tissues (i.e., liver, heart, kidneys, brain, and testes) with or without exercise. Male, 7 week old Sprague-Dawley rats were given free access to a nonpurified diet with or without supplementation of carnitine, choline and caffeine at concentration of 5, 11.5 and 0.1 g kg‾<sup>1</sup> diet, respectively for 4 weeks. One half of each dietary group was assigned to exercise on a treadmill for 3 weeks. Results showed that the concentration of nonesterified and total carnitine was higher in serum, urine and all tissues of the supplemented rats. Exercise further promoted this effect in the liver and kidney. There was variable effect of supplement and exercise on the other fractions of carnitine in tissues except that short-chain acylcarnitines were consistently higher in the in skeletal and cardiac muscles and reflected in the serum and urine of the supplemented animals. Serum aspartate aminotransferase (AST) and alanine amino transferase (ALT), liver proteins and DNA were not adversely altered by the supplement. In conclusion, the oral feeding of carnitine, choline and caffeine (ccc) supplement to rats promotes carnitine influx in all tissues and changes in acylcarnitines of skeletal and cardiac muscles indicating enhanced fatty acid oxidation, which is supported by the changes in serum and urinary acylcarnitine profiles and loss of adipose tissue mass. |
Authors
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Nobuko Hongu, Dileep S. Sachan |
Contributors
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Publication Detail
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Publisher : Asian Network for Scientific Information, Pakistan Type : - Format : - |
Date Detail
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2002 |
Subject
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Carnitine, choline, caffeine, tissue, exercise, rats |
Coverage
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Relation
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Source
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Journal of Medical Sciences |
Copyright Information
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- |
Other Details
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Languages : eng |
Export Citation
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