| Relationship of Selected Functions of Activated Macrophages | |
Abstract/OtherAbstract
:
|
The objective of this project was to examine relationships of selected metabolic capabilities and key immunological functions of activated marcrophages. Consistent association or a single example of dissociation between two parameters would indicate or eliminate the possibility of common induction pathways or functional interdependence of these parameters. Results indicate that thiol production, capacity to produce H2O2, and tumor cytotoxicity are often induced by the same stimuli, but, in one case, H2O2 production was not affected by stimuli which increased the other two parameters. The commonly accepted idea that highly activated (tumoricidal) macrophages are poor antigen processing and presenting cells was confirmed, but some tumoricidal activity was noted in macrophages which were excellent antigen processing and presenting cells. Keywords: Macrophage, Nitric oxide, Nitrite, Nitrate, Tumor cytolysis, Listeria monocytogenes, Immunotoxicology. |
Authors
:
|
Pruett, Stephen B. |
Related Documents
:
|
0004604199 - Studies on typhus and spotted fever. 0032994879 - Ifnγ: issuing macrophages a license to kill 0010997979 - P85α subunit of class ia pi-3 kinase is crucial for macrophage growth and migration 0008051259 - The expression and function of g3bps in macrophages / 0010540089 - Replication of yersinia pestis in interferon γ-activated macrophages requires ripa, a ... 0000205089 - Immune function keeps endosymbionts under control 0000855549 - Lonomycin-activated calpain triggers apoptosis - a probable role for bcl-2 family members 0033378149 - Dismantling cell–cell contacts during apoptosis is coupled to a caspase-dependent pro... |
Contributors
:
|
MISSISSIPPI STATE UNIV MISSISSIPPI STATE DEPT OF BIOLOGICAL SCIENCES |
Publication Detail
:
|
Publisher : - Type : Text Format : text/html |
Date Detail
:
|
1990-08-10 |
Subject
:
|
MEDICINE AND MEDICAL RESEARCH, *MACROPHAGES, FUNCTIONS, ACTIVATION, PRODUCTION, PARAMETERS, PROCESSING, NEOPLASMS, METABOLISM, CONSISTENCY, CYTOTOXINS, NITRITES, LISTERIA MONOCYTOGENES, CYTOLOGY, THIOLS, NITRATES, PATHOLOGY, STIMULI, IMMUNOLOGY, NITROGEN OXIDES, DISSOCIATION, ANTIGENS, INDUCTION SYSTEMS., PE61102F, WUAFOSR2312A5 |
Coverage
:
|
- |
Relation
:
|
- |
Source
:
|
DTIC AND NTIS |
Copyright Information
:
|
Approved for public release; distribution is unlimited. |
Other Details
:
|
Languages : en |
Export Citation
:
|
APA/MLA Format Download EndNote Download BibTex |
Previous Document: Drug Retention during Animal Inhalation Exposure by FT-IR Spectroscopy
Next Document: Free-Field Ground Shock Pressures from Buried Detonations in Saturated and Unsaturated Soils