Document Detail
New-onset diabetes and anti hypertensive drugs
Abstract/OtherAbstract :
Observational studies have provided evidence that a consistent fraction (approximately 15-20%) of hypertensive patients displays a glucose intolerance state that may be aggravated by anti hypertensive drug regimens based on thiazide diuretics or beta-blockers. This review examines the relative and absolute diabetogenic effects of anti hypertensive drugs, by comparing the impact of 'new' (calcium antagonists, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists) versus 'old' (diuretics and beta-blockers) drugs on new-onset diabetes in recent clinical trials. Evidence is provided that compared with diuretics and beta-blockers, new-onset diabetes is less common with 'new' drugs, and that conventional antihypertensive compounds, particularly when combined together, may amplify the natural time-dependent tendency towards the development of this metabolic disease. This paper provides new insights into the potential mechanisms responsible for the phenomenon and the clinical significance of anti hypertensive drug-induced diabetes., Mancia, G; Grassi, G; Zanchetti, A, 3
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Publication Detail :
Publisher :  LIPPINCOTT WILLIAMS & WILKINS, PHILADELPHIA     Type :  Articolo su rivista, Rilevanza internazionale, Articolo, Con referee, Con Impact Factor ISI, Pubblicato     Format :  -    
Date Detail :
2008-08-27, 2008-08-27, 2006-01
Subject :
angiotensin-converting enzyme inhibitors; angiotensin inhibitors; beta-blockers; calcium antagonists; clinical trials; diabetes; diuretics, Settore MED/09 - Medicina Interna (1451)
Coverage :
Relation :
JOURNAL OF HYPERTENSION, 24, 1, 3, 10, 0263-6352
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Languages :  eng    
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