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New accents in the pathogenesis of acne vulgaris
Abstract/OtherAbstract :
Background: Acne is a chronic inflammatory disorder of the pilosebaceous unit (PSU). The PSU is an immunocompetent organ, and the sebaceous gland (SG) exhibits an independent peripheral endocrine function and expresses receptors for neuropeptides (NP). The presence of a complete corticotrophin-releasing hormone (CRH)/CRH receptor (CRHR) system in human sebocytes has also been confirmed. The capability of hypothalamic CRH to induce lipid synthesis, steroidogenesis and to interact with testosterone and growth hormone implicates a possibility of CRH involvement in the clinical development of acne. The purpose of this study was to make cartography of CRH expression in acne, especially in SG in comparison with physiologically normal non-acne-prone skin and skin from persons without acne and to identify a possible CRH involvement in acne pathogenesis. Materials and Methods: 33 patients with acne and 8 age-matched volunteers without acne participated in the study. Skin biopsies were obtained from the acne-involved face, non-involved thigh skin of the same patients with acne and from normal human skin. Expression of CRH was analyzed by immuno-histochemistry. Results: A very strong positive reaction to CRH was observed in all types of SG cells in acne skin. All control and normal skin SGs demonstrated a weaker staining depending on the differentiation stage of SG cells. Conclusions: CRH is abundant in acne-involved SG and possibly through the CRH-Rs activated pathway can affect immune
Authors :
Gancevičienė, Rūta
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Dermatologija, Spuogai, Dermatology, Acne
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Languages :  eng    
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