| IκB, NF-κB Regulation Model: Simulation Analysis of Small Number of Molecules | |
Abstract/OtherAbstract
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The regulation of IκB, NF-κB is of foremost interest in biology as the transcription factor NF-κB has multiple target genes. We have modeled a previously published model by Hoffmann et al. (2002) of IκB, NF-κB mathematically as discrete reaction systems. We have used stochastic algorithm to compare the results when there are large and small numbers of molecules available in a finite volume for each protein. Our results for small number of molecules show that with continuous presence of stimulation, nuclear NF-κB oscillates continuously in every individual cell rather than damping, which was observed in cell population results. This characteristic of the system is missed when averaged behavior is studied. |
Authors
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Anamika Sarkar, Marina Meila, Robert B. Franza |
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Publication Detail
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Publisher : Hindawi Publishing Corporation Type : - Format : - |
Date Detail
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2008 |
Subject
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Source
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EURASIP Journal on Bioinformatics and Systems Biology |
Copyright Information
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Other Details
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Languages : eng |
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