Document Detail
IκB, NF-κB Regulation Model: Simulation Analysis of Small Number of Molecules
Abstract/OtherAbstract :
The regulation of IκB, NF-κB is of foremost interest in biology as the transcription factor NF-κB has multiple target genes. We have modeled a previously published model by Hoffmann et al. (2002) of IκB, NF-κB mathematically as discrete reaction systems. We have used stochastic algorithm to compare the results when there are large and small numbers of molecules available in a finite volume for each protein. Our results for small number of molecules show that with continuous presence of stimulation, nuclear NF-κB oscillates continuously in every individual cell rather than damping, which was observed in cell population results. This characteristic of the system is missed when averaged behavior is studied.
Authors :
Anamika Sarkar, Marina Meila, Robert B. Franza
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Publication Detail :
Publisher :  Hindawi Publishing Corporation     Type :  -     Format :  -    
Date Detail :
2008
Subject :
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Coverage :
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Source :
EURASIP Journal on Bioinformatics and Systems Biology
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Languages :  eng    
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