| Involvement of p53-Mediated Mitochondrial Stress in the Apoptosis Induced by Flavonoids Purified from Rhus verniciflua Stokes in Human Osteosarcoma Cells | |
Abstract/OtherAbstract
:
|
Dietary flavonoids have antioxidant and antitumor promoting effects. Rhus verniciflua Stokes (RVS) is a flavonoid-rich herbal medicine and has long been used as a food additive and an antitumor agent in Korea. Previous study demonstrated that a purified flavonoid fraction prepared from RVS, herein named RCMF (the RVS chloroform-methanol fraction), exhibited growth inhibition and induced apoptosis in human osteosarcoma(HOS) cells. This study evaluated if p53-mediated pathway is associated with the RCMF-induced apoptosis in HOS cells. RCMF was shown to be capable of inducing apoptosis of the cells, as expected, and transparently increased p53 expression in the cells. However, the RCMF-induced cytotoxicity was suppressed by transfecting the cells with antisense p53 oligonucleotide, which also inhibited the decrease of Bcl-2 and the increase of Bax in mitochondria, and the release of cytochrome c into cytosol. This finding suggests that p53-mediated mitochondrial stress is required for RCMF-induced apoptosis in HOS cells. |
Authors
:
|
Chung, Song-Woo, Lee, Seung-Ah, Park, Jong-Sun, Ryu, Kwon-Woo, Jang, Mun-Ju, Park, Song-Soo, Lee, Choon-Bong, Kim, Jong-Ghee, Jeon, Young-Mi, Lee, Jeong-Chae |
Related Documents
:
|
0010815569 - P53-induced apoptosis occurs in the absence of p14arf in malignant pleural mesothelioma1 0011028029 - P73α is a candidate effector in the p53 independent apoptosis pathway of cisplatin dam... 0008394629 - Mechanisms of apoptosis modulation and their contribution to genomic instability in tum... 0004609009 - Relationship of selected functions of activated macrophages 0008822759 - Evaluation of polyethylene glycol modified adenovirus for innate response reduction and... 0029846569 - β2-adrenoceptor agonists inhibit release of eosinophil-activating cytokines from human... |
Contributors
:
|
- |
Publication Detail
:
|
Publisher : The Korean Society of Pharmacognosy Type : - Format : pdf |
Date Detail
:
|
2008-01-29 |
Subject
:
|
6154 |
Coverage
:
|
- |
Relation
:
|
- |
Source
:
|
- |
Copyright Information
:
|
- |
Other Details
:
|
Languages : en |
Export Citation
:
|
APA/MLA Format Download EndNote Download BibTex |
Previous Document: Overexpression of Arabidopsis Phytochelatin Synthase (AtPCS1) Does Not Change the Maximum Capacity f...
Next Document: Evaluation of Antidiabetic and Antihyperlipidemic Activity of Luffa tuberosa (Roxb.) Fruits in Strep...