| Interferon-α promotes heat-induced apoptosis in human myeloid leukemia cells | |
Abstract/OtherAbstract
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The effects of interferon-α (IFN α) treatment on following heat-induced apoptosis were evaluated in human myeloid leukemia cell line, U937. Incubation of U937 with 1000 U/ml of IFN α promoted heat-induced apoptosis in a dose- and time-dependent manner. Another human leukemia cell line, HL60, was also sensitized to heat-induced apoptosis by pretreatment with IFNα. To investigate the mechanism of sensitization, effects of IFNα on the expression of HSP70 and BCL-2, two major anti-apoptotic proteins, were evaluated. Both protains were upregulated by heat treatment, but irrespective of the presence or absence of IFNα. These results suggests that IFNα promotes heat-induced apoptosis in human myeloid leukemia cells through the mechanism whereby HSP70 or BCL-2 is not involved. |
Authors
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Masato Seguchi |
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Contributors
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山口大学 |
Publication Detail
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Publisher : Yamaguchi University School of Medicine Type : text, Departmental Bulletin Paper Format : application/pdf |
Date Detail
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2006-03-07 |
Subject
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interferon-α / heat / apoptosis, 医学 |
Coverage
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Relation
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Source
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Copyright Information
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Other Details
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Languages : eng |
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