| Inhibitory effects of trans-resveratrol analogues molecules on the proliferation and the cell cycle progression of human colon tumoral cells | |
Abstract/OtherAbstract
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Resveratrol may function as a cancer chemopreventive agent. However, few data are available on the antitumoral activities of its dimer, epsilon-viniferin, also present in human diet. So, the effects of resveratrol, epsilon-viniferin, of their acetylated forms (resveratrol triacetate, epsilon-viniferin pentaacetate) and of vineatrol (a wine grape extract) were compared on human adenocarcinoma colon cells. Resveratrol and resveratrol triacetate inhibit cell proliferation and arrest cell cycle. epsilon-viniferin and epsilon-viniferin pentaacetate slightly reduce cell proliferation. Vineatrol inhibits cell proliferation and favors an accumulation in the S phase of the cell cycle. Consequently, resveratrol triacetate and vineatrol could constitute new putative anticancer agents on colon carcinoma. |
Authors
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Marel, Anna-Kristina, Lizard, Gérard, Izard, Jean-Claude, Latruffe, Norbert, Delmas, Dominique |
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Contributors
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Publication Detail
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Publisher : HAL - CCSD Type : - Format : - |
Date Detail
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2008-06-09 |
Subject
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Life Sciences/Biochemistry, Molecular Biology, colon cancer, cell cycle, polyphenols, resveratrol, vineatrol |
Coverage
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Relation
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http://hal.archives-ouvertes.fr/docs/00/28/15/70/PDF/DelmasMolNutr_FoodRes2008_52_5_538-48.pdf |
Source
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- |
Copyright Information
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Other Details
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Languages : EN |
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