| Inhibition of Telomerase Activity in U937 Human Monocytic Leukemia Cells by Compound K, a Ginseng Saponin Metabolite | |
Abstract/OtherAbstract
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Telomerase activation is detected in most cancerous cells; hence, telomerase is a highly selective target for cancer therapy, which plays an important role in the apoptotic process. We have previously reported that the ginseng saponin metabolite, Compound K (20-O-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits cell proliferation by inducing apoptosis and cell cycle arrest at the <TEX>$G_1$</TEX> phase. The present study investigated the regulation of telomerase activity in Compound K treated U937 cells. Compound K treatment caused a reduction in telomerase activity and down-regulated the human telomerase reverse transcriptase (hTERT) gene, resulting in the decreased expressions of its protein, and of the c-Myc and Spl proteins (transcription factors of hTERT). These results indicate that the anticancer activity of Compound K could be mediated by inhibition of the telomerase activity. |
Authors
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Kang, Kyoung-Ah, Lee, Kyoung-Hwa, Chae, Sung-Wook, Kim, Jeong-Ki, Seo, Jung-Yeon, Ham, Yong-Ho, Lee, Kee-Ho, Kim, Bum-Joon, Kim, Hee-Sun, Kim, Dong-Hyun, Hyun, Jin Won |
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Publication Detail
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Publisher : Korean Society for Biotechnology and Bioengineering Type : - Format : pdf |
Date Detail
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2008-01-29 |
Subject
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6606 |
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Languages : en |
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