| Influence of maternal diet on the developmental profile of postnatal glucose transporters | |
Abstract/OtherAbstract
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To test the hypothesis that maternal dietary glucose restriction throughout pregnancy and lactation would perturb glucose transporter (GLUT) protein levels in offspring, isoenergetic diets containing graded levels of glucose (0, 12, 24 and 60%) were fed to pregnant rats and their offspring from gestation day (gd) 0 through postnatal day (pd) 49. Diets were defined as deficient (0%), restricted (12, 24%) or adequate (60%) in glucose. Plasma, small intestine, liver and kidney tissues were collected perinatally (gd20, birth, 12--24hrs postnatal), during lactation (pd7, 15, 21), post-weaning (pd28, 35, 49) and in adult controls. The proximal and distal regions of the small intestine responded differently to the dietary glucose restriction. Proximal small intestine GLUT2 protein levels did not change throughout postnatal development and remained unaltered with dietary glucose restriction, while distal small intestine GLUT2 protein expression changed throughout postnatal development and with dietary glucose restriction. These findings, together with information from the literature, indicate a dissociation between small intestine GLUT2 mRNA expression, GLUT2 protein levels and small intestine glycogen reserves. |
Authors
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Whitmore, Erika. |
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Contributors
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Koski, K. G. (advisor) |
Publication Detail
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Publisher : McGill University Type : Electronic Thesis or Dissertation Format : application/pdf |
Date Detail
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1998 |
Subject
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Pregnancy -- Nutritional aspects., Glucose -- Metabolism., Low-carbohydrate diet., Gastrointestinal system -- Growth., Rats -- Development. |
Coverage
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- |
Relation
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alephsysno: 001657859, proquestno: MQ50906 |
Source
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- |
Copyright Information
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© Erika Whitmore, 1998 |
Other Details
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Languages : en |
Export Citation
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