Document Detail
Influence of long-term cadmium ions exposure on mitotic and apoptotic activities and protein synthesis in mouse liver
Abstract/OtherAbstract :
The aim of this study was to evaluate in vivo the effects of long-term exposure to cadmium ions (Cd2+) on cell death, mitotic activity and translational machinery of mouse liver cells. It was determined that after intraperitoneal injections of cadmium chloride solution (0.16 mg Cd2+ per 1 kg of body mass) for six weeks, three times per week, the number of TUNEL positive cells containing fragmented nuclei was significantly higher than in control (p < 0.0001); the median score was 1. Cadmium-induced cell death was accompanied by activation of mitosis. These data indicate an activation of liver regeneration during sub-chronic exposure to Cd2+. Examination of liver translation showed that Cd2+ reduced both the incorporation of [14C]-labeled leucine into newly synthesized peptides and proteins and the acceptor activity of tRNALeu. In comparison with the control, liver exposure to Cd2+ caused activation of leucyl-tRNA synthetase.
Authors :
Stanevičienė, Inga
Contributors :
Publication Detail :
Publisher :  -     Type :  -     Format :  -    
Date Detail :
Subject :
Kadmis, Mitozė, Biosintezė, Baltymai, Ribonukleino rūgštis, Cadmium, Mitosis, Biosynthesis, Proteins, RNA
Coverage :
Relation :
Source :
Copyright Information :
All rights reserved
Other Details :
Languages :  eng    
Export Citation :
APA/MLA Format     Download EndNote     Download BibTex

Previous Document:  RegB endoribonuclease is involved in the processing of transcripts from mobD gene cluster of bacteri...
Next Document:  ‘Chromosome painting’ by fluorescent in situ hybridization (FISH) in hybrids and introgressions ...