Document Detail
Influence of long-term cadmium ions exposure on mitotic and apoptotic activities and protein synthesis in mouse liver
Abstract/OtherAbstract :
The aim of this study was to evaluate in vivo the effects of long-term exposure to cadmium ions (Cd2+) on cell death, mitotic activity and translational machinery of mouse liver cells. It was determined that after intraperitoneal injections of cadmium chloride solution (0.16 mg Cd2+ per 1 kg of body mass) for six weeks, three times per week, the number of TUNEL positive cells containing fragmented nuclei was significantly higher than in control (p < 0.0001); the median score was 1. Cadmium-induced cell death was accompanied by activation of mitosis. These data indicate an activation of liver regeneration during sub-chronic exposure to Cd2+. Examination of liver translation showed that Cd2+ reduced both the incorporation of [14C]-labeled leucine into newly synthesized peptides and proteins and the acceptor activity of tRNALeu. In comparison with the control, liver exposure to Cd2+ caused activation of leucyl-tRNA synthetase.
Authors :
Stanevičienė, Inga
Contributors :
-
Publication Detail :
Publisher :  -     Type :  -     Format :  -    
Date Detail :
20080315
Subject :
Kadmis, Mitozė, Biosintezė, Baltymai, Ribonukleino rūgštis, Cadmium, Mitosis, Biosynthesis, Proteins, RNA
Coverage :
-
Relation :
-
Source :
http://vddb.library.lt/obj/LT-eLABa-0001:J.04~2006~ISSN_1392-0146.N_3.PG_118-122
Copyright Information :
All rights reserved
Other Details :
Languages :  eng    
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