| Infection with Toxoplasma gondii does not Alter TNFα and IL-6 Secretion by A human Astrocytoma Cell Line | |
Abstract/OtherAbstract
:
|
The secretion of tumour necrosis factor-α (TNFα), interleukin-1α (IL-α) and interleukin-6 (IL-6) by a human astrocytoma cell fine was studied 1 h, 3 h, 6 h and 24 h after infection with tachyzoites from three Toxoplasma gondii strains (virulent, RH; cystogentc, 76K and Prugniaud strains). The astrocytoma cell fine constitutively secreted TNFα and IL-6, but no IL-1α. A positive control was obtained by stimulation with phorbol esters inducing a significant increase (p < 0.05) in TNFα and IL- 6 secretion but not in IL-1α, while lipopolysaccharide (alone and after priming), interferon gamma, ionophore A 23187 and sera positive to T. gondii did not induce any increase in cytokine levels. None of the tachyzoites, whatever their virulence, induced a significant increase in cytokine production at any time in the study. Tachyzoites did not inhibit the secretion induced by phorbol esters. |
Authors
:
|
Pelloux, H., Ricard, J., Nissou, M.-F., Renversez, J.-C., Vuillez, J.-P., Meunier, A., Ambroise-Thomas, P. |
Related Documents
:
|
0033552667 - The status of mir-21 in apoptosis 0010984647 - P75ntr mediates neurotrophin-induced apoptosis of vascular smooth muscle cells 0040142497 - Nucleotide supplementation eliminates leukocyte dna damage induced by t-2 toxin and deo... |
Contributors
:
|
- |
Publication Detail
:
|
Publisher : Hindawi Publishing Corporation Type : Text Format : - |
Date Detail
:
|
- |
Subject
:
|
Research Article |
Coverage
:
|
- |
Relation
:
|
- |
Source
:
|
- |
Copyright Information
:
|
- |
Other Details
:
|
Languages : en |
Export Citation
:
|
APA/MLA Format Download EndNote Download BibTex |
Previous Document: A novel Mutein of TNFα Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine
Next Document: Membrane Potentials of Vallisneria Leaf Cells and Their Relation to Photosynthesis 1