| ELECTROPORATION BY STRONG INTERNAL DEFIBRILLATION SHOCK IN INTACT STRUCTURALLY NORMAL AND CHRONICALLY INFARCTED RABBIT HEARTS | |
Abstract/OtherAbstract
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A strong internal defibrillation shock may damage the heart via disruption of cell membranes (electroporation). The spatial distribution and extent of electroporation were characterized in intact rabbit hearts with and without chronic (>4 weeks) left ventricular myocardial infarction (MI). An implantable defibrillator was inserted in the right ventricle, and one monophasic shock (+300-V, 8-ms) was delivered by a 150-μF capacitor clinical defibrillator. Electroporation was assessed by uptake of membrane-impermeant propidium iodide into ventricular myocardium through electropores. In control (n=2) and MI (n=2) groups without shock, PI uptake was minimal. In both control (n=5) and MI (n=5) groups with shock, electroporation mostly occurred near the shock electrode, distributed along the active region of the shock electrode. In the MI group with shock, shock-induced electroporation was significantly increased (p<0.05) in the surviving epicardial layer of the infarcted region. Between the control and MI groups, the overall extent of electroporation was similar. |
Authors
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Kim, Seok Chan |
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Contributors
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Publication Detail
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Publisher : Case Western Reserve University / OhioLINK Type : text Format : - |
Date Detail
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2008 |
Subject
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Electroporation, Defibrillation, Myocardial Infarction, |
Coverage
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Relation
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Source
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http://rave.ohiolink.edu/etdc/view?acc_num=case1196122659 |
Copyright Information
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unrestricted, Copyright and permissions information available at the source archive |
Other Details
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Languages : English |
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