| The Effects of Storage on Irradiated Red Blood Cells: An In Vitro and In Vivo Study | |
Abstract/OtherAbstract
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Irradiation of red blood cell units has recently become a topic of special concern as the result of increasing reports of graft versus host disease in immunocompetent blood transfusion recipients. This study was designed to evaluate the potassium elevations observed in stored irradiated red blood cells and to evaluate the in vivo survival of stored irradiated red blood cells using a dog model. In the in vitro study ten units of human CPDA-1 packed red blood cells were made into paired aliquots; one aliquot of each pair was irradiated with 3000 rads of gamma radiation and the potassium content measured at points throughout 35 days of storage. A significant increase in potassium levels in the irradiated aliquots was observed from the first day after irradiation and continued through the entire storage period. |
Authors
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Knoll, Susan E. |
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Contributors
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AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH |
Publication Detail
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Publisher : - Type : Text Format : text/html |
Date Detail
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1991-08 |
Subject
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MEDICINE AND MEDICAL RESEARCH, *MODELS, DISEASES, SURVIVAL(GENERAL), IN VITRO ANALYSIS, GAMMA RAYS, IRRADIATION, STORAGE, ELEVATION, IN VIVO ANALYSIS, ERYTHROCYTES, POTASSIUM, TRANSPLANTATION, DOGS, HOSTS(BIOLOGY), REPORTS |
Coverage
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- |
Relation
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- |
Source
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DTIC AND NTIS |
Copyright Information
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Approved for public release; distribution is unlimited. |
Other Details
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Languages : en |
Export Citation
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