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Effects of Colostrum Basic Protein from Colostrum Whey Protein: Increases in Osteoblast Proliferation and Bone Metabolism
Abstract/OtherAbstract :
Colostrum basic proteins (CBP) (MW 1<TEX>$\sim$</TEX>30 kDa) were isolated from bovine colostrum using a series of ultrafiltration processes and their effects on osteoblast cell proliferation and bone metabolism were investigated in cell line and animal models. Treatments with CBP (1, 10, 100 <TEX>$\mu$</TEX>g/mL) dose-dependently increased cell proliferation of osteoblastic MC3T3 cells. Alkaline phosphatase activity, a marker of osteoblastic phenotype, in the cells was also increased after treatments with CBP in a dose-dependent manner. Significant increases in bone density were observed in femur of ovariectomized rats which were fed a diet with 1% and 10% CBP, compared to rats fed a normal diet. These results suggest that CBP may increase bone mass and density and be useful for the prevention of bone-related diseases.
Authors :
Lee, Jeong-Rai, Kim, Hyun-Mi, Choi, Hee-Sun, Hong, Jeong-Hwa
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Publisher :  The Korean Society of Food Science and Nutrition     Type :  -     Format :  pdf    
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6132, 664
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Languages :  en    
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